Kainate and AMPA receptor binding in brains of seizure prone DBA/2J and seizure resistant C57BL/6J mice:
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
1999
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 70 S. graph. Darst. |
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MARC
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| 245 | 1 | 0 | |a Kainate and AMPA receptor binding in brains of seizure prone DBA/2J and seizure resistant C57BL/6J mice |c vorgelegt von Veit-Christian Kürschner |
| 264 | 1 | |c 1999 | |
| 300 | |a 70 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Berlin, Freie Univ., Diss., 1999 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-008946192 | |
Record in the Search Index
| _version_ | 1807504856616796160 |
|---|---|
| adam_text |
CONTENTS
1
INTRODUCTION
.
8
1.1
GLUTAMATE
AS
AN
EXCITATORY
NEUROTRANSMITTER
AND
ITS
ROLE
IN
NEUROLOGICAL
DISORDERS
.
8
1.2
THE
GLUTAMATE
RECEPTORS
.
10
1.2.1
CLASSIFICATION
.
10
1.2.1.1
IONOTROPIC
RECEPTORS
.
10
1.2.1.1.1
NMDA
RECEPTORS
.
14
1.2.1.1.2
KAINATE
RECEPTORS
AND
KAINATE
AS
RESEARCH
TOOL
.
14
1.2.1.1.3
AMPA
RECEPTORS
.
16
1.2.1.1.4
KAINATE
AND
AMPA
ANTAGONISTS
.
17
1.2.1.2
METABOTROPIC
RECEPTORS
.
19
1.3
HUMAN
TEMPORAL
LOBE
EPILEPSY
.
20
1.3.1
CLINICAL
AND
NEUROPATHOLOGICAL
ASPECTS
.
20
1.3.2
PHARMACOLOGICAL
APPROACHES
FOR
THERAPY
.
21
1.4
ANIMAL
MODELS
IN
EPILEPSY
RESEARCH
USING
DBA/2J
AND
C57BL/6J
MICE
.
23
1.5
SPECIFIC
AIMS
.
25
2
MATERIALS
AND
METHODS
.
26
2.1
MATERIALS
.
26
2.1.1
ANIMALS
.
26
2.1.2
EQUIPMENT
.
26
2.1.3
CHEMICALS
.
26
2.1.4
SOFTWARE
.
27
2.2
METHODS
.
27
2.2.1
GENERAL
CONSIDERATIONS:
THE
RECEPTOR
BINDING
ASSAY
.
27
2.2.2
BRAIN
DISSECTION
.
30
2.2.3
RECEPTOR
BINDING
METHODOLOGY
.
30
2.2.3.1
MEMBRANE
PREPARATIONS
.
30
2.2.3.2
[
3
H]KAINATE
BINDING
ASSAY
.
30
2.2.3.3
[
3
H]AMPA
BINDING
ASSAY
.
31
2.2.3.4
SCINTILLATION
COUNTING
.
31
2.2.4
PROTEIN
ANALYSIS
.
31
2.2.5
DATA
ANALYSIS
.
31
CONTENTS
7
3
RESULTS
.
33
3.1
[
3
H]KAINATE
BINDING
.
33
3.2
[
3
H]AMPA
BINDING
.
33
4
DISCUSSION
.
38
5A
SUMMARY
.
43
5B
ZUSAMMENFASSUNG
(GERMAN
SUMMARY)
.
46
6
REFERENCES
.
49
7
ACKNOWLEDGEMENTS
.
56
8
CURRICULUM
VITAE
.
57
9
APPENDIX
.
58
9.1
TABLES
OF
[
3
H]KAINATE
SATURATION
DATA
.
58
9.2
TABLES
OF
[
3
H]AMPA
SATURATION
DATA
.
64
9.3
ABBREVIATIONS
.
70 |
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| author_facet | Kürschner, Veit-Christian 1971- |
| author_role | aut |
| author_sort | Kürschner, Veit-Christian 1971- |
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| building | Verbundindex |
| bvnumber | BV013131558 |
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| discipline | Medizin |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV013131558 |
| illustrated | Illustrated |
| indexdate | 2024-08-16T01:15:58Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008946192 |
| oclc_num | 76093353 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-188 |
| owner_facet | DE-355 DE-BY-UBR DE-188 |
| physical | 70 S. graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
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| spelling | Kürschner, Veit-Christian 1971- Verfasser (DE-588)121902692 aut Kainate and AMPA receptor binding in brains of seizure prone DBA/2J and seizure resistant C57BL/6J mice vorgelegt von Veit-Christian Kürschner 1999 70 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Berlin, Freie Univ., Diss., 1999 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008946192&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Kürschner, Veit-Christian 1971- Kainate and AMPA receptor binding in brains of seizure prone DBA/2J and seizure resistant C57BL/6J mice |
| subject_GND | (DE-588)4113937-9 |
| title | Kainate and AMPA receptor binding in brains of seizure prone DBA/2J and seizure resistant C57BL/6J mice |
| title_auth | Kainate and AMPA receptor binding in brains of seizure prone DBA/2J and seizure resistant C57BL/6J mice |
| title_exact_search | Kainate and AMPA receptor binding in brains of seizure prone DBA/2J and seizure resistant C57BL/6J mice |
| title_full | Kainate and AMPA receptor binding in brains of seizure prone DBA/2J and seizure resistant C57BL/6J mice vorgelegt von Veit-Christian Kürschner |
| title_fullStr | Kainate and AMPA receptor binding in brains of seizure prone DBA/2J and seizure resistant C57BL/6J mice vorgelegt von Veit-Christian Kürschner |
| title_full_unstemmed | Kainate and AMPA receptor binding in brains of seizure prone DBA/2J and seizure resistant C57BL/6J mice vorgelegt von Veit-Christian Kürschner |
| title_short | Kainate and AMPA receptor binding in brains of seizure prone DBA/2J and seizure resistant C57BL/6J mice |
| title_sort | kainate and ampa receptor binding in brains of seizure prone dba 2j and seizure resistant c57bl 6j mice |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008946192&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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