Biology of phosphoinositides:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Oxford [u.a.]
Oxford Univ. Press
2000
|
| Edition: | 1. publ. |
| Series: | Frontiers in molecular biology
27 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXV, 341 S. Ill., graph. Darst. |
| ISBN: | 0199637644 0199637652 |
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| 245 | 1 | 0 | |a Biology of phosphoinositides |c ed. by Shamshad Cockcroft |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Oxford [u.a.] |b Oxford Univ. Press |c 2000 | |
| 300 | |a XXV, 341 S. |b Ill., graph. Darst. | ||
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| 337 | |b n |2 rdamedia | ||
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| 490 | 1 | |a Frontiers in molecular biology |v 27 | |
| 650 | 7 | |a Fosfoinositiden |2 gtt | |
| 650 | 4 | |a Phospho-inositides - Effets physiologiques | |
| 650 | 7 | |a Signaalverwerking |2 gtt | |
| 650 | 4 | |a Transduction du signal cellulaire | |
| 650 | 4 | |a Cellular signal transduction | |
| 650 | 4 | |a Lipids | |
| 650 | 4 | |a Phosphatidylinositols |x physiology | |
| 650 | 4 | |a Phosphoinositides |x Physiological effect | |
| 650 | 4 | |a Signal Transduction | |
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Record in the Search Index
| _version_ | 1804127813798723584 |
|---|---|
| adam_text | Contents
List of contributors xvii
Abbreviations xxi
1 Regulation of phosphoinositide specific phospholipase
C isozymes i
SUH COO RH Kl :, BLNOI T POU1IN, SANG IK)N(. III., AND 1 U|IO SI KIYA
1. Introduction 1
2. PLC isoforms and structural organization 2
3. Structure of PLC ftl and reaction mechanism of PLC 4
4. Activation of PLC 7 by receptor PTKs 7
5. Activation of PLC 7 by non receptor PTKs in response to antigen
receptors 10
6. Activation of PLC 7 by non receptor PTKs in response to
G protein coupled receptors 14
7. Activation of PLC 7 by other lipid derived messengers 15
8. PLC 7 and mitogenic signalling 17
9. Activation of PLC (3 by Gaq subunits 18
10. Activation of PLC p by G(i7 subunits 20
11. Targeted disruption of PLC (3 genes 21
12. Activation of PLC 8 isozymes 22
13. A requirement for phosphatidylinositol transfer protein in PLC
signalling 22
References 22
2 Phosphoinositide 3 kinases: regulation by cell surface
receptors and function of 3 phosphorylated lipids 32
LEX STEPHENS. ALEX MCGREGOR, AND PHILIP HAWKINS
1. Receptor regulated phosphoinositide 3 kinases 32
2. Phosphoinositides 32
x CONTENTS
3. Types of PBKs 33
3.1 Type I PBKs 34
3.2 Type II PBKs 34
3.3 Type III PBKs 35
4. Metabolic relationships between 3 phosphoryIated phosphoinositides 36
4.1 PtdIns(3)P synthesis 36
4.2 PtdIns(3,5)P, synthesis 37
4.3 PtdIns(3,4)P, synthesis 37
4.4 Synthesis of PtdIns(3,4,5)P, 37
5. Metabolism of 3 phosphorylated phosphoinositides 38
5.1 PtdIns(3,4,5)P3 directed phosphomonoesterases 38
5.2 PtdIns(3,4)P2 and PtdIns(3)P directed phosphatases 39
6. Hormone stimulated changes in 3 phosphorylated phosphoinositides 39
7. The protein kinase activity of PBKs 42
7.1 Mechanisms of regulation of type I PBKs 43
7.2 Autophosphorylation 43
7.3 Downstream of receptor activated tyrosine kinases 43
7.4 PtdIns(3,4,5)P3 binding 45
7.5 Ceramide binding 45
7.6 Rho family GTPases 45
7.7 SH3 domains and proline rich motifs 46
7.8 Heterotrimeric G protein P7 subunits 47
7.9 Ras 48
8. Downstream signalling 49
8.1 What strategies? 49
8.2 The downstream targets 51
9. Type I PI3Ks in cell signalling pathways 57
9.1 Other PKB kinases 62
9.2 Targets of PKB 63
9.3 Other targets of PDK 1 64
10. Regulation of PKCs downstream of PDK 1 and type I PI3Ks 64
10.1 Conventional, or classical PKCs (a, pi, (MI, ?) 65
10.2 Novel and atypical PKCs (8, «, e, t), and (,, ) 65
11. PDK 1 mediated phosphorylation of p70S6K 66
11.1 Type I PBK dependent phosphorylation of p70ShK and PKCS 66
11.2 Additional potentially PBK dependent inputs to p70S6K 67
12. Type I PI3K regulated Ca2+entry 69
13. Type I PBK dependent activation of Rho family monomeric GTPases 71
CONTENTS xi
14. Type I PI3K dependent activation of p42 MAPK pathways 76
15. Type I PI3K dependent regulation of RasGAPs 77
16. Integrin mediated activation of type I PI3K dependent signalling 78
17. Type I PI3K dependent regulation of ARF GEFs 81
18. Type I PBKs and ARF GAPs 82
19. Type I PBKs and the cell cycle 83
19.1 Type I PI3K dependent regulation of cell cycle machinery 84
19.2 Type I PBKs and cell survival 86
20. Some cellular responses to receptor activation involving PBKs 88
20.1 Receptor activated superoxide formation 88
20.2 Chemotaxis 90
21. Conclusions 91
22 The future 92
22.1 The family of receptor sensitive PBKs 92
22.2 3 Phosphorylated lipids as signals 92
References 93
3 Enzymes involved in the synthesis of PtdIns(4,5)P2 and
their regulation: Ptdlns kinases and PtdlnsP kinases 109
KIMBERLEY F. TOLIAS AND CHRISTOPHER L. CARPENTER
1. Introduction 109
2. Synthetic pathway 1: PtdIns(4,5)P2 production via a PtdIns(4)P
intermediate 111
2.1 Phosphatidylinositol 4 kinases 111
2.2 Phosphatidylinositol 4 phosphate 5 kinases 114
3. Synthetic pathway 2: PtdIns(4,5)P2 production via a PtdIns(5)P
118intermediate 118
3.1 Enzymes that synthesize Ptdlns(5)P 118
3.2 Phosphatidylinositol 5 phosphate 4 kinases 118
4. Cellular functions of PtdIns(4,5)P2 120
4.1 Actin cytoskeleton 120
4.2 Vesicle trafficking 121
4.3 Other potential roles for PtdIns(4,5)P2 121
5. Conclusion 121
Acknowledgements 122
References 122
xii CONTENTS
4 Pleckstrin homology domains: phosphoinositide
regulated membrane tethers 131
MARK A. LEMMON AND KATHRYN M. FERGUSON
1. Introduction 131
2. The structure of PH domains 133
2.1 Basic architecture 133
2.2 PH domains are electrostatically polarized 136
2.3 A disease causing mutation functionally implicates one face of
PH domains 136
3. PH domain ligands 137
3.1 PH domain distribution suggests a role in membrane association 137
3.2 The search for protein ligands for PH domains 137
3.3 PH domains bind to phosphoinositides 138
4. Membrane association of PH domains 143
4.1 Isolated PH domains can bind to cellular membranes 143
4.2 Signal dependent membrane recruitment of PH domains by binding
to PI 3 kinase products 143
5. Requirements for specific phosphoinositide recognition by
PH domains 148
5.1 Structural considerations 148
5.2 Sequence predictors of high affinity phosphoinositide binding 150
6. Promiscuous phosphoinositide binding by many PH domains 152
7. Physiological relevance of promiscuous phosphoinositide binding
by class II PH domains 153
7.1 Cooperation of PH domains with other targeting modules 153
7.2 Specific modulation of PH domain avidity as a mechanism for regulated
membrane association 154
8. PH domains as intramolecular allosteric regulators 155
8.1 Kinases 155
8.2 Guanine nucleotide exchange factors for Rho family GTPases 155
9. Conclusions 157
Acknowledgements 158
References 158
5 Regulation of cytoskeletal proteins by inositol lipids 166
LISA A. FLANAGAN AND PAUL A. JANMEY
1. Introduction 166
CONTENTS iii
2. Classes of cytoskeletal proteins that bind polyphosphoinositides
(PPIs) 166
2.1 Monomer binding proteins and F actin severing and capping proteins 166
2.2 Proteins that link actin to membrane adhesion complexes 168
2.3 Other F actin binding proteins 169
2.4 Other cytoskeletal proteins 170
3. Structures of PtdIns(4,5)P2 binding sites in cytoskeletal proteins 170
4. Chemical specificity of the protein lipid interaction 171
5. Effects of PPIs on actin assembly in vivo 171
5.1 Triggering actin assembly in cell extracts 171
5.2 Altering PtdIns(4,5)P2 levels in platelets and fibroblasts 172
5.3 Enhancing and blocking PPI synthesis in cells 173
6. Convergence of small GTPases and PPI signals to the cytoskeleton 174
7. Conclusions and unanswered questions 176
Acknowledgements 177
References 177
6 Physiological functions of phosphatidylinositol
transfer proteins i83
MARCOS P. RIVAS, XINMIN LI, AND VYTAS A. I3ANKAITIS
1. Introduction 183
2. Phospholipid transfer proteins: operational definitions 185
2.1 Lipid transfer assays 186
2.2 Categories of phospholipid transfer proteins 188
3. Phosphatidylinositol transfer proteins (PITPs) 189
3.1 Mammalian PITP function and neurodegeneration 190
3.2 Intracellular functions for mammalian PITP 191
3.3 Mammalian PITP activity: potential mode of regulation 194
4. Integral membrane PITPs: retinal degeneration in Drosophila 195
5. PITP function in the yeast secretory pathway 198
5.1 Secl4ps of dimorphic fungi 201
6. Higher plant PITPs and PITP like molecules 202
7. Structural architecture of a PITP 204
8. Summary 205
Acknowledgements 205
References 205
xiv CONTENTS
7 Glycosylphosphatidylinositol anchored proteins and
their phospholipases 210
MARTIN G. LOW
1. Introduction 210
2. Distribution of GPI anchors 210
3. Structure of GPI anchors 212
3.1 The phosphatidylinositol group 213
3.2 The conserved glycan 213
3.3 Variable side chains 214
4. Biosynthesis of GPI anchored proteins 214
4.1 GPI biosynthesis 214
4.2 Attachment of GPI to proteins 217
4.3 Physiological consequences of GPI deficiency 219
5. Function of GPI anchors 220
5.1 GPI anchors provide stable binding to the cell surface 221
5.2 GPI anchors and lipid microdomains 222
5.3 GPI anchors and cell signalling 223
6. GPI specific phospholipases 225
6.1 Bacteria] phosphatidylinositol specific phospholipase C 226
6.2 GPI specific phospholipase C 228
6.3 GPI specific phospholipase D 230
References 231
8 Phosphatidylinositol 3 kinase and membrane
trafficking 239
HARALD STENMARK
1. Introduction 239
2. PI 3 kinase and its lipid products 241
3. Experimental evidence for the involvement of PI 3 kinase in membrane
trafficking 244
3.1 PI 3 kinase and membrane trafficking in yeast 245
3.2 PI 3 kinase and membrane trafficking in mammalian cells 245
4. Effectors of PI 3 kinase products in membrane trafficking 249
4.1 Effectors of PtdIns(3,4)P2 and PtdIns(3,4,5)P3 249
4.2 The C2 domain 251
4.3 Effectors of PtdIns(3)P 252
CONTENTS xv
5. Conclusions and perspectives 258
Acknowledgements 260
References 260
9 Regulation of phospholipase D signalling by
phosphoinositides 268
VICKI A. SCIORRA, MICHAEL A. FROHMAN, AND ANDREW J. MORRIS
1. Introduction 268
2. Structure and regulation of PLD 269
2.1 The superfamily of PLD enzymes: common structural features and
catalytic mechanism 269
2.2 Complex regulation of PLD activity by GTP binding proteins and
protein kinases 273
2.3 Possible functions of PLD in cellular signalling and control of
membrane transport 277
3. Direct and indirect regulation of PLD activity by phosphoinositides 281
3.1 Roles for phosphoinositides in regulation of PLD activity 282
3.2 Direct activation of PLD1 and PLD2 by phosphoinositides 282
3.3 Upstream roles for phosphoinositides in regulation of PLD activity 283
4. Concluding comments 287
Acknowledgements 288
References 288
10 Regulation of chloride channel conductance by
Ins(3,4,5,6)P4; a phosphoinositide initiated signalling
pathway that acts downstream of Ins(l,4/5)P3 298
MELLISA VV.Y.HO, MARK A.CARCVV, X1AONIAN YANG, AND STI IMICX SHIARS
1. Introduction 298
2. Receptor mediated regulation of Ins(3,4,5,6)P4 turnover 299
3. Identification of Ins(3,4,5,6)P4 as an inhibitor of Cr secretion 302
4. Ins(3,4,5,6)P4 inhibits Ca2+ activated Cl channels 304
5. Molecular and biophysical characterization of Ca2+ activated
Cr channels 308
6. Specificity and cooperativity of Ins(3,4,5,6)P4 action 309
7. Mechanism of Ins(3,4,5,6)P4 action 310
xvi CONTENTS
8. Antagonizing Ins(3,4,5,6)P4: a potential therapy for cystic fibrosis? 313
9. Conclusions 313
References 314
11 Inositol phosphatases: constructive destruction of
phosphoinositides and inositol phosphates 320
RUDIGER WOSCHOLSKI AND PETER J. PARKER
1. Introduction 320
2. 1 Phosphatases 322
3. 3 Phosphatases 324
4. 4 Phosphatases 325
5. Type I 5 phosphatase 325
6. GAP domain containing phosphatases (GlPs) 326
7. SHIPs 327
8. SCIPs 328
9. Inositol phosphatases and membrane trafficking 329
10. Inositol phosphatases and cell signalling 330
References 331
Index 339
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| id | DE-604.BV013114774 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:39:19Z |
| institution | BVB |
| isbn | 0199637644 0199637652 |
| language | English |
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| physical | XXV, 341 S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Oxford Univ. Press |
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| series | Frontiers in molecular biology |
| series2 | Frontiers in molecular biology |
| spelling | Biology of phosphoinositides ed. by Shamshad Cockcroft 1. publ. Oxford [u.a.] Oxford Univ. Press 2000 XXV, 341 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Frontiers in molecular biology 27 Fosfoinositiden gtt Phospho-inositides - Effets physiologiques Signaalverwerking gtt Transduction du signal cellulaire Cellular signal transduction Lipids Phosphatidylinositols physiology Phosphoinositides Physiological effect Signal Transduction Phosphoinositide (DE-588)4346034-3 gnd rswk-swf Phosphoinositide (DE-588)4346034-3 s DE-604 Cockcroft, Shamshad Sonstige oth Frontiers in molecular biology 27 (DE-604)BV010329078 27 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008935096&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biology of phosphoinositides Frontiers in molecular biology Fosfoinositiden gtt Phospho-inositides - Effets physiologiques Signaalverwerking gtt Transduction du signal cellulaire Cellular signal transduction Lipids Phosphatidylinositols physiology Phosphoinositides Physiological effect Signal Transduction Phosphoinositide (DE-588)4346034-3 gnd |
| subject_GND | (DE-588)4346034-3 |
| title | Biology of phosphoinositides |
| title_auth | Biology of phosphoinositides |
| title_exact_search | Biology of phosphoinositides |
| title_full | Biology of phosphoinositides ed. by Shamshad Cockcroft |
| title_fullStr | Biology of phosphoinositides ed. by Shamshad Cockcroft |
| title_full_unstemmed | Biology of phosphoinositides ed. by Shamshad Cockcroft |
| title_short | Biology of phosphoinositides |
| title_sort | biology of phosphoinositides |
| topic | Fosfoinositiden gtt Phospho-inositides - Effets physiologiques Signaalverwerking gtt Transduction du signal cellulaire Cellular signal transduction Lipids Phosphatidylinositols physiology Phosphoinositides Physiological effect Signal Transduction Phosphoinositide (DE-588)4346034-3 gnd |
| topic_facet | Fosfoinositiden Phospho-inositides - Effets physiologiques Signaalverwerking Transduction du signal cellulaire Cellular signal transduction Lipids Phosphatidylinositols physiology Phosphoinositides Physiological effect Signal Transduction Phosphoinositide |
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