DNA virus replication:
"This book provides a comprehensive analysis of protein - protein interactions in DNA virus replication. It covers the replication of all the major DNA virus groups: hepatitis B virus, papillomavirus, herpes simplex virus, Epstein Barr virus, Kaposi's sarcoma herpes virus (KSHV), human cyt...
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Oxford [u.a.]
Oxford Univ. Press
2000
|
| Series: | Frontiers in molecular biology
26 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Summary: | "This book provides a comprehensive analysis of protein - protein interactions in DNA virus replication. It covers the replication of all the major DNA virus groups: hepatitis B virus, papillomavirus, herpes simplex virus, Epstein Barr virus, Kaposi's sarcoma herpes virus (KSHV), human cytomegalovirus, and adenoviruses. The lessons learned are important not only for virologists but also for researchers studying DNA replication in other systems and protein: protein interaction more generally."--BOOK JACKET. |
| Physical Description: | XVI, 232 S. Ill., graph. Darst. |
| ISBN: | 019963713X |
Staff View
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Record in the Search Index
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|---|---|
| adam_text | Contents
List of contributors xiii
Abbreviations xv
1 Macromolecular interactions in hepatitis B virus
replication and particle assembly l
MICHAEL NASSAL
1. Introduction 1
2. The HBV infectious cycle 3
3. Experimental systems to study HBV replication 6
3.1 Animal models 6
3.2 Transfection of cloned hepadnavirus DNA 10
3.3 Reconstituting hepadnavirus reverse transcription in vitro 15
4. Assembly of virus particles 22
4.1 Envelope containing particles 22
4.2 The nucleocapsid 23
5. The enigma of HBx 28
6. Conclusions and perspectives 30
Acknowledgements 31
References 31
2. Protein protein interactions in papillomavirus
replication 41
DENNIS J. MCCANCE
1. Introduction 41
2. Early HPV proteins 42
2.1 HPV 16E6 42
2.2 HPV 16E7 45
2.3 HPV 16E5 50
viii | CONTENTS
2.4 Summary of the roles of E6, E7, and E5 in keratinocyte differentiation
and cell cycle control 52
3. Viral proteins involved in viral DNA replication 54
3.1 El and E2 proteins 55
3.2 Maintenance and amplification of HPV genomes 57
4. Summary 57
Acknowledgements 58
References 58
3 Molecular interactions in herpes simplex virus DNA
replication 66
NIGEL D. STOW
1. Introduction 66
2. Identification of the c/s acting signals and rrfltts acting proteins
involved in HSV 1 DNA synthesis 67
3. Models for HSV 1 DNA replication 71
4. Molecular interactions involved in HSV 1 DNA synthesis 74
5. Interactions involved in unwinding the replication origins 74
5.1 ICP8 75
5.2 HSV 1 DNA replication origins 76
5.3 Interaction of UL9 with the viral origins 78
5.4 DNA helicase activity of UL9 and interaction with ICP8 80
5.5 Unwinding of the replication origins 81
5.6 Regulation of origin activity 82
6. Interactions involved in the initiation of DNA synthesis 83
6.1 The helicase primase complex 83
6.2 Effect of ICP8 on the helicase primase complex 84
6.3 The HSV 1 DNA polymerase holoenzyme 84
6.4 Interaction between UL8 and UL9 87
6.5 Interactions of the HSV 1 DNA polymerase with UL8 and UL9 87
6.6 Interaction of host DNA polymerase a with UL9 88
7. A model for the establishment of the HSV 1 replication fork 88
8. Other interactions involving HSV 1 ICP8 91
9. Intranuclear localization of HSV 1 DNA synthesis 92
10. Concluding remarks 94
References 94
CONTENTS | ix
4 Epstein Barr virus proteins involved in cell
immortalization 105
MARTIN ROWE AND J. EIKE FLOETTMANN
1. Introduction 105
2. The nuclear proteins expressed in EBV transformed B cells 106
2.1 The EBV nuclear antigen 1, EBNA1 106
2.2 The EBV nuclear antigen 2, EBNA2 108
2.3 The EBV leader protein, EBNA LP 110
2.4 The EBV nuclear antigen 3 family, EBNA3A, EBNA3B, and EBNA3C 111
3. Latent membrane proteins expressed in EBV transformed B cells 114
3.1 The latent membrane protein 1, LMP1 114
3.2 The latent membrane protein 2, LMP2 118
4. Conclusions 119
References 120
5 Molecular piracy by KSHV: a strategy of live and
let live 133
SUKHANYA JAYACHANDRA, YUAN CHANG, AND PATRICK S. MOORE
1. Introduction 133
2. KSHV as a model for molecular piracy 133
3. Immunomodulatory proteins encoded by KSHV 135
3.1 Viral interleukin 6 (vIL 6) 135
3.2 Viral macrophage inflammatory proteins (vMIPs) 137
3.3 Viral G protein coupled receptor (vGCR) 139
3.4 Viral interferon regulatory factor (vIRF) 141
4. KSHV proteins affecting the cell cycle and apoptosis 143
4.1 Viral cyclin (v Cyc) 143
4.2 Viral Bcl 2 (vBcl 2) 144
4.3 Viral FLIP (vFLIP) 145
5. Novel ORFs encoded by KSHV 146
5.1 ORFK1 146
5.2 Kaposin 147
6. Conclusions 147
Acknowledgements 148
References 148
x I CONTENTS
6 Cellular sites and mechanisms of human
cytomegalovirus latency 156
JOHN SINCLAIR
1. Introduction 156
2. Cells of the myeloid lineage are an important site of carriage of HCMV 157
3. Viral gene expression associated with latency 158
4. Permissiveness of peripheral blood cells for HCMV infection requires
differentiation 159
5. Bone marrow—a reservoir of virus in the healthy carrier 160
6. Conditionally permissive cell lines as models for factors controlling
latency and reactivation 161
7. Many cell types are infected during viraemia—does this reflect other
sites of latency? 165
8. Conclusions 166
Acknowledgements 167
References 168
7. Control of transcription by adenovirus ElA proteins 173
ALT ZANTEMA AND ALEX J. VAN DER EB
1. Introduction 173
2. The adenovirus El A proteins 173
3. Transcriptional regulation 174
3.1 Regulation of transcription initiation 175
4. Binding of El A to the retinoblastoma and related proteins 177
4.1 Effect of pocket proteins on E2F 179
4.2 Binding of pRb to other cellular proteins 181
5. Binding of E1A to p300 and related proteins 184
5.1 Role of p300/CBP in transcription regulation 186
5.2 The intrinsic and associated acetyltransferase activity of p300/CBP 187
5.3 Role of p300/CBP in cell growth and differentiation 188
5.4 Role of the individual p300/CBP members 189
6. Other proteins associating with E1A 190
Acknowledgements 190
References 191
CONTENTS i xi
8. Adenovirus proteins that regulate apoptosis 200
WILLIAM S. M. WOLD AND G. CHINNADURAI
1. Introduction 200
2. Course of adenovirus infection 200
3. E3 coded proteins that inhibit immune mediated apoptosis 204
4. Induction of apoptosis by E1A 208
5. Inhibition of apoptosis by the E1B 19K protein 212
6. Inhibition of apoptosis by the E1B 55K protein 216
7. Apoptosis regulation by E4 proteins 218
8. Inhibition of the antiviral effects of interferons 219
9. Induction of cell lysis and virus release by the adenovirus death
protein (ADP) 220
10. Concluding remarks 220
Acknowledgements 222
References 222
Index 233
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| spelling | DNA virus replication ed. by Alan J. Cann Oxford [u.a.] Oxford Univ. Press 2000 XVI, 232 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Frontiers in molecular biology 26 "This book provides a comprehensive analysis of protein - protein interactions in DNA virus replication. It covers the replication of all the major DNA virus groups: hepatitis B virus, papillomavirus, herpes simplex virus, Epstein Barr virus, Kaposi's sarcoma herpes virus (KSHV), human cytomegalovirus, and adenoviruses. The lessons learned are important not only for virologists but also for researchers studying DNA replication in other systems and protein: protein interaction more generally."--BOOK JACKET. ADN - Réplication ram DNA replication DNA-protein interactions Interaction ADN proteines ram Protéines virales Virus - Reproduction Virus - Reproduction ram Virus à ADN DNA Replication DNA viruses DNA, Viral Viral Proteins Viral proteins Virus Replication Viruses Reproduction Replikation (DE-588)4153174-7 gnd rswk-swf DNS (DE-588)4070512-2 gnd rswk-swf Viren (DE-588)4063589-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Viren (DE-588)4063589-2 s DNS (DE-588)4070512-2 s Replikation (DE-588)4153174-7 s DE-604 Cann, Alan ca. 20./21. Jh. Sonstige (DE-588)1089177542 oth Frontiers in molecular biology 26 (DE-604)BV010329078 26 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008918039&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | DNA virus replication Frontiers in molecular biology ADN - Réplication ram DNA replication DNA-protein interactions Interaction ADN proteines ram Protéines virales Virus - Reproduction Virus - Reproduction ram Virus à ADN DNA Replication DNA viruses DNA, Viral Viral Proteins Viral proteins Virus Replication Viruses Reproduction Replikation (DE-588)4153174-7 gnd DNS (DE-588)4070512-2 gnd Viren (DE-588)4063589-2 gnd |
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| title | DNA virus replication |
| title_auth | DNA virus replication |
| title_exact_search | DNA virus replication |
| title_full | DNA virus replication ed. by Alan J. Cann |
| title_fullStr | DNA virus replication ed. by Alan J. Cann |
| title_full_unstemmed | DNA virus replication ed. by Alan J. Cann |
| title_short | DNA virus replication |
| title_sort | dna virus replication |
| topic | ADN - Réplication ram DNA replication DNA-protein interactions Interaction ADN proteines ram Protéines virales Virus - Reproduction Virus - Reproduction ram Virus à ADN DNA Replication DNA viruses DNA, Viral Viral Proteins Viral proteins Virus Replication Viruses Reproduction Replikation (DE-588)4153174-7 gnd DNS (DE-588)4070512-2 gnd Viren (DE-588)4063589-2 gnd |
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