Cardiac ischemia: from injury to protection
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Boston [u.a.]
Kluwer
1999
|
| Series: | Basic science for the cardiologist
4 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVI, 173 S. graph. Darst. |
| ISBN: | 0792386426 |
Staff View
MARC
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| 245 | 1 | 0 | |a Cardiac ischemia |b from injury to protection |c by Bohuslav Os̆t'ádal and Frantis̆ek Kolár̆ |
| 264 | 1 | |a Boston [u.a.] |b Kluwer |c 1999 | |
| 300 | |a XVI, 173 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a Basic science for the cardiologist |v 4 | |
| 650 | 4 | |a Coronary heart disease |x Pathophysiology | |
| 650 | 4 | |a Myocardial Ischemia |x metabolism | |
| 650 | 4 | |a Myocardial Ischemia |x physiopathology | |
| 650 | 4 | |a Myocardial Ischemia |x prevention & control | |
| 650 | 4 | |a Myocardial Reperfusion Injury |x physiopathology | |
| 650 | 4 | |a Myocardial Reperfusion Injury |x prevention & control | |
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Record in the Search Index
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| adam_text | CONTENTS
PREFACE xi
ACKNOWLEDGEMENTS xv
1 MYOCARDIAL HYPOXIA AND ISCHEMIA 1
1.1 Definition l
1.2 Animal Models 3
1.2.1 Experimental animals 4
1.2.2 In vivo models 4
1.2.3 In vitro models 6
1.2.4 Isolated cardiac myocytes 8
1.2.5 Chronic models 8
1.2.6 Animal models in the future 9
1.2.7 Gender difference 9
1.3 METABOLISM OF THE ISCHEMIC HEART 10
1.3.1 Early consequences of coronary occlusion 12
1.3.1.1 Ischemia and glucose metabolism 13
1.3.1.2 Ischemia and lipid metabolism 15
1.3.1.3 Calcium homeostasis 16
1.3.2 Metabolism during late phase of ischemia 17
1.4 EFFECT OF ISCHEMIA ON MYOCARDIAL
FUNCTION 17
1.4.1 Ischemic impairment of ventricular contraction 17
1.4.2 Silent ischemia 20
1.4.3 Stunning 20
1.4.3.1 Abnormalities of calcium homeostasis
(calcium hypothesis) 22
1.4.3.2 Generation of oxygen derived free radicals
(oxyradical hypothesis); 23
1.4.4 Hibernation 27
VI
1.4.4.1 Short term hibernation 27
1.4.4.2 Long term hibernation 28
1.4.4.3 Cellular mechanisms of hibernation 29
1.4.4.4 Detecting hibernating myocardium 30
1.4.4.5 Hibernation vs. stunning 30
1.5 ELECTROPHYSIOLOGICAL CONSEQUENCES
OF ISCHEMIA 31
1.5.1 Role of potassium ions 32
1.5.2 Roles of sodium, calcium and magnesium ions 35
1.5.3 Role of amphipathic lipid metabolites 37
1.5.4 Role of catecholamines 37
1.5.5 Role of circulating peptides 38
1.5.6 Heterogeneity of ionic and metabolic changes 38
1.5.7 Summary of ischemia induced
electrophysiological changes 39
1.5.8 Ischemia related ventricular arrhythmias 40
2 IRREVERSIBLE MYOCARDIAL ISCHEMIC
INJURY 45
2.1 THE MECHANISMS OF CARDIOMYOCYTE
DEATH IN ISCHEMIA 45
2.1.1 Necrosis and apoptosis 47
2.1.2 Induction of apoptosis 50
2.1.3 Infarct size determination 51
2.2 ROLE OF CALCIUM IN ISCHEMIC INJURY 52
2.2.1 General significance of calcium in cell death
2.2.2 The concept of calcium antagonism 52
2.2.2.1 Cardioprotective effects of calcium antagonists 53
2.3 ROLE OF OXYGEN DERIVED FREE
RADICALS IN ISCHEMIC INJURY 55
2.4 VENTRICULAR REMODELING FOLLOWING
INFARCTION 57
VII
2.4.1 Hypertrophic response 57
2.4.2 Hyperplasia of viable myocytes 60
2.4.3 Myocardial fibrosis 61
2.4.4 Myocardial infarction and ventricular loading 62
3 REPERFUSION INDUCED INJURY 65
3.1 REPERFUSION INDUCED ARRHYTHMIAS 66
3.2 LETHAL REPERFUSION INDUCED INJURY 67
3.2.1 General characteristics and controversies 67
3.2.2 Possible mechanisms 69
3.2.2.1 Role of re energization 70
3.2.2.2 Role of rapid normalization of tissue pH 71
3.2.2.3 Role of rapid normalization of tissue osmolality 73
3.2.3 Spreading of necrosis 74
3.3 REPERFUSION INDUCED ACCELERATION
OF NECROSIS 74
3.4 CLINICAL RELEVANCE OF REPERFUSION
INJURY 76
3.5 PREVENTION OF REPERFUSION INJURY 77
4 MYOCARDIAL VASCULATURE DURING
ISCHEMIA AND REPERFUSION 81
4.1 NO REFLOW PHENOMENON 81
4.2 MICROVASCULAR INJURY 82
4.3 RESPONSE OF THE CAPILLARY NETWORK
TO INFARCTION 85
4.4 ANGIOGENESIS IN ISCHEMIC HEART DISEASE 86
5 CARDIAC PROTECTION 89
5.1 ADAPTATION TO CHRONIC HYPOXIA 90
5.1.1 Definition, experimental model 90
VIII
5.1.2 Protective effects of adaptation 91
5.1.3 Possible protective mechanisms 93
5.1.3.1 Oxygen transport 93
5.1.3.2 Energy metabolism 95
5.1.3.3 Neurohumoral factors 96
5.1.3.4 Stress proteins 97
5.1.3.5 Prostaglandins 97
5.1.3.6 Adenosine 98
5.1.3.7 ATP sensitive potassium channels 99
5.1.3.8 Other possible mechanisms 100
5.1.4 Adverse effects of adaptation 101
5.1.4.1 Pulmonary hypertension 101
5.1.4.2 Right ventricular hypertrophy 102
5.1.5 Regression of adaptive changes 103
5.2 ISCHEMIC PRECONDITIONING 104
5.2.1 History and definition 104
5.2.2 Induction of ischemic preconditioning 108
5.2.3 End points of ischemic preconditioning 109
5.2.4 Models of ischemic preconditioning 112
5.2.5 Triggers of ischemic preconditioning 113
5.2.6 Postreceptor signaling pathway 116
5.2.6.1 Protein kinase C 116
5.2.6.2 Tyrosine kinase and mitogen activated protein
kinases 117
5.2.7 The end effector: possible role of ATP sensitive
potassium channels 117
5.2.8 Other pathways 118
5.2.9 Delayed preconditioning 121
5.2.9.1 General characteristics 121
5.2.9.2 Triggers of delayed preconditioning 122
5.2.9.3 Signaling pathway and end effector of delayed
preconditioning 123
5.2.10 Pharmacological preconditioning 124
5.2.10.1 Mimic the trigger 124
5.2.10.2 Modulation of the trigger 125
IX
5.2.10.3 Activation of intracellular signaling 125
5.2.10.4 Modulation of the end effector (KATP channels) 126
5.2.10.5 Manipulation with second window of protection 127
5.2.11 Clinical relevance of ischemic preconditioning 127
5.2.12 Preconditioning in the diseased heart 130
5.2.13 Ischemic preconditioning vs. adaptation
to chronic hypoxia 132
6 DEVELOPMENTAL ASPECTS OF CARDIAC
ISCHEMIA AND PROTECTION 135
6.1 COMPARATIVE ASPECTS 136
6.1.1 Myocardial blood supply 136
6.1.2 Myocardial energy supply 137
6.1.3 Cardiac sensitivity to oxygen deprivation 138
6.2 ONTOGENETIC ASPECTS 139
6.2.1 Myocardial blood supply 13 9
6.2.2 Myocardial energy supply 140
6.2.3 Cardiac sensitivity to oxygen deprivation 141
6.2.4 Possible mechanisms of higher tolerance of the
immature heart 143
6.3 PROTECTION OF THE DEVELOPING HEART 146
6.3.1 Adaptation of the immature heart to chronic
hypoxia 146
6.3.2 Ischemic preconditioning of the immature heart 147
REFERENCES 149
INDEX 169
|
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| isbn | 0792386426 |
| language | English |
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| physical | XVI, 173 S. graph. Darst. |
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| series | Basic science for the cardiologist |
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| spelling | Ošťádal, Bohuslav Verfasser aut Cardiac ischemia from injury to protection by Bohuslav Os̆t'ádal and Frantis̆ek Kolár̆ Boston [u.a.] Kluwer 1999 XVI, 173 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Basic science for the cardiologist 4 Coronary heart disease Pathophysiology Myocardial Ischemia metabolism Myocardial Ischemia physiopathology Myocardial Ischemia prevention & control Myocardial Reperfusion Injury physiopathology Myocardial Reperfusion Injury prevention & control Ischämie (DE-588)4162456-7 gnd rswk-swf Herzkrankheit (DE-588)4024663-2 gnd rswk-swf Herzkrankheit (DE-588)4024663-2 s Ischämie (DE-588)4162456-7 s DE-604 Kolář, František Verfasser aut Basic science for the cardiologist 4 (DE-604)BV012774326 4 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008830939&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ošťádal, Bohuslav Kolář, František Cardiac ischemia from injury to protection Basic science for the cardiologist Coronary heart disease Pathophysiology Myocardial Ischemia metabolism Myocardial Ischemia physiopathology Myocardial Ischemia prevention & control Myocardial Reperfusion Injury physiopathology Myocardial Reperfusion Injury prevention & control Ischämie (DE-588)4162456-7 gnd Herzkrankheit (DE-588)4024663-2 gnd |
| subject_GND | (DE-588)4162456-7 (DE-588)4024663-2 |
| title | Cardiac ischemia from injury to protection |
| title_auth | Cardiac ischemia from injury to protection |
| title_exact_search | Cardiac ischemia from injury to protection |
| title_full | Cardiac ischemia from injury to protection by Bohuslav Os̆t'ádal and Frantis̆ek Kolár̆ |
| title_fullStr | Cardiac ischemia from injury to protection by Bohuslav Os̆t'ádal and Frantis̆ek Kolár̆ |
| title_full_unstemmed | Cardiac ischemia from injury to protection by Bohuslav Os̆t'ádal and Frantis̆ek Kolár̆ |
| title_short | Cardiac ischemia |
| title_sort | cardiac ischemia from injury to protection |
| title_sub | from injury to protection |
| topic | Coronary heart disease Pathophysiology Myocardial Ischemia metabolism Myocardial Ischemia physiopathology Myocardial Ischemia prevention & control Myocardial Reperfusion Injury physiopathology Myocardial Reperfusion Injury prevention & control Ischämie (DE-588)4162456-7 gnd Herzkrankheit (DE-588)4024663-2 gnd |
| topic_facet | Coronary heart disease Pathophysiology Myocardial Ischemia metabolism Myocardial Ischemia physiopathology Myocardial Ischemia prevention & control Myocardial Reperfusion Injury physiopathology Myocardial Reperfusion Injury prevention & control Ischämie Herzkrankheit |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008830939&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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