Endogenous and exogenous regulation and control of physiological systems:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Boca Raton [u.a.]
Chapman & Hall [u.a.]
2000
|
| Series: | Biomedical engineering series
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 452 S. Ill., graph. Darst. |
| ISBN: | 0849396948 |
Staff View
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Record in the Search Index
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| adam_text | IMAGE 1
TABLE OF CONTENTS
CHAPTER 1 INTRODUCTION TO PHYSIOLOGICAL REGULATORS AND CONTROL SYSTEMS 1
1.0 INTRODUCTION 1
1.1 PHYSIOLOGY AND PHYSIOLOGICAL REGULATION DEFINED 2
1.2 THE PURPOSES OF MODELING 3
1.3 SOME GENERAL PROPERTIES OF PRCS 4
1.4 SOME GENERAL PROPERTIES OF LINEAR, TIME-VARYING, AND NONLINEAR
SYSTEMS 8
1.4.1 INTRODUCTION 8
1.4.2 PROPERTIES OF TIME-INVARIANT LINEAR SYSTEMS 8
1.4.3 TIME-VARIABLE LINEAR SYSTEMS 10
1.4.4 PROPERTIES OF NONLINEAR SYSTEMS 11
1.5 PARAMETRIC CONTROL 15
1.6 CHAPTER SUMMARY 25
PROBLEMS 27
CHAPTER 2 PHYSICAL AND CHEMICAL FACTORS GOVERNING THE BEHAVIOR OF
PHYSIOLOGICAL REGULATORS AND CONTROL SYSTEMS 31
2.0 INTRODUCTION 31
2.1 BEHAVIOR OF FLUIDIC SYSTEMS UNDER LAMINAR FLOW CONDITIONS 31 2.1.1
FLUID RESISTANCE 32
2.1.2 FLUID CAPACITANCE 32
2.1.3 FLUID INERTANCE 34
2.1.4 TRANSFER FUNCTIONS OF FLUIDIC SYSTEMS 35
2.2 DIFFUSION DYNAMICS AND FICK S FIRST LAW 38
2.3 MASS-ACTION KINETICS IN CHEMICAL SYSTEMS 41
2.3.1 EXAMPLES OF MASS-ACTION KINETICS 41
2.4 CHAPTER SUMMARY 45
PROBLEMS 46
CHAPTER 3 INTRODUCTION TO SISO CONTROL SYSTEMS AND SYSTEMS WITH DELAYS
55 3.0 INTRODUCTION 55
3.1 CONVENTIONAL CONTROLLERS FOR LINEAR PLANTS WITH REAL POLES 56 3.2
THE USE OF ROOT LOCUS IN LINEAR CONTROL SYSTEM DESIGN 60
3.3 SOME TESTS FOR STABILITY IN LINEAR AND CERTAIN CLASSES OF NONLINEAR
CONTROL SYSTEMS 73
3.3.1 INTRODUCTION 73
IMAGE 2
3.3.2 THE ROUTH-HURWITZ STABILITY TEST 74
3.3.3 THE NYQUIST STABILITY CRITERION 77
3.3.4 DESCRIBING FUNCTIONS AND STABILITY 90
3.3.5 POPOV S STABILITY CRITERION 102
3.4 LINEAR CLOSED-LOOP SYSTEMS WITH DELAY: STABILITY PROBLEMS 107 3.5
CHAPTER SUMMARY 121
PROBLEMS 121
CHAPTER 4 INTRODUCTION TO COMPARTMENTAL MODELING AND PHARMACOKINETIC
SYSTEMS 127 4.0 INTRODUCTION 127
4.1 BASIC COMPARTMENTAL ANALYSIS 128
4.2 THE USE OF WASHOUT CURVES AND BOLUS INPUTS TO IDENTIFY THE
PARAMETERS OF SIMPLE CPK SYSTEMS 140
4.3 OVERVIEW OF DRUG INPUT CONTROLLERS 145
4.4 CHAPTER SUMMARY 146
PROBLEMS 146
CHAPTER 5 SPECIAL TYPES OF CLOSED-LOOP DRUG INPUT CONTROLLERS 153
5.0 INTRODUCTION 153
5.1 DESIGN OF ON/OFF LIMIT-CYCLING CONTROLLERS FOR CPK/P SYSTEMS 154 5.2
NONLINEAR DECOUPLING CONTROLLERS FOR TWO-INPUT/TWO-OUTPUT CPK SYSTEMS
162
5.3 INTEGRAL PULSE-FREQUENCY MODULATION (BOLUS) CONTROLLERS 170 5.4
INTRODUCTION TO NONLINEAR PARAMETER-SWITCHING CONTROLLERS: ANALYSIS IN
THE PHASE PLANE 184
5.5 CHAPTER SUMMARY 209
PROBLEMS 210
CHAPTER 6 HORMONAL REGULATION OF SODIUM, POTASSIUM, CALCIUM, AND
MAGNESIUM IONS ...217 6.0 INTRODUCTION 217
6.1 IMPLICIT SUMMING POINTS IN HORMONAL REGULATION 219
6.2 INTRODUCTION TO THE PHYSIOLOGY OF THE KIDNEYS 222
6.3 THE REGULATION OF PLASMA SODIUM ION CONCENTRATION AND OSMOLARITY 227
6.4 REGULATION OF PLASMA POTASSIUM IONS BY THE ALDOSTERONE SYSTEM 233
6.5 CALCIUM ION REGULATION 237
6.6 MAGNESIUM ION REGULATION 244
6.7 CHAPTER SUMMARY 245
PROBLEMS 245
IMAGE 3
CHAPTER 7
REGULATION OF BLOOD GLUCOSE 247
7.0 INTRODUCTION 247
7.1 MOLECULES IMPORTANT IN NORMOGLYCEMIC REGULATION 248
7.2 THE NORMAL BLOOD GLUCOSE REGULATION SYSTEM 249
7.3 A MODEL FOR NORMAL BLOOD GLUCOSE REGULATION 254
7.4 THE COBELLI AND MARI MODEL FOR GLUCOREGULATION 266
7.5 DIABETES MELLITUS 272
7.6 EXOGENOUS GLUCOREGULATION: THE ARTIFICIAL BETA CELL 273
7.6.1 INTRODUCTION 273
7.6.2 EARLY TYPE 0 ARTIFICIAL BETA CELLS 275
7.6.3 TYPE 1 CONTROLLERS FOR ARTIFICIAL BETA CELLS 282
7.7 CHAPTER SUMMARY 289
PROBLEMS 290
CHAPTER 8 CONTROL OF MEAN ARTERIAL PRESSURE BY SODIUM NITROPRUSSIDE
INJECTION 295 8.0 INTRODUCTION 295
8.1 THE PHARMACOLOGY AND PHARMACOKINETICS OF SNP 297
8.2 MAP/SNP CONTROLLERS USING PROPORTIONAL-PIUS-INTEGRAL PROCESSING AND
SMITH DELAY COMPENSATION 300
8.3 ADAPTIVE AND SELF-TUNING CONTROLLERS FOR MAP 304
8.4 CHAPTER SUMMARY , 319
PROBLEMS 321
CHAPTER 9 CONTROL OF POSTOPERATIVE PAIN BY SELF-ADMINISTERED OPIOIDS 325
9.0 INTRODUCTION 325
9.1 THE NEUROPHYSIOLOGICAL AND PHARMACOLOGICAL BASIS FOR PAIN 326 9.1.1
SOURCES OF PAIN 326
9.1.2 THE NEUROANATOMY OF PAIN 327
9.1.3 THE PHARMACOLOGY OF PAIN 330
9.2 THE PCA SYSTEM OF REASBECK AND JACOBS 333
9.2.1 THE PHARMACOLOGY OF IV FENTANYL 333
9.2.2 THE BUTTON-PRESSING MODEL OF REASBECK AND JACOBS 336 9.2.3 THE
DRUG INJECTION CONTROLLER 338
9.3 THE PCA MODEL OF LIU AND NORTHROP 341
9.3.1 THE PATIENT PAIN MODEL OF LIU AND NORTHROP 341
9.3.2 MODEL VALIDATION BY SIMULATION 344
9.3.3 IPFM/SMITH DELAY COMPENSATOR CONTROLLER DESIGN 344 9.3.4 RESULTS
OF SIMULATIONS 346
9.4 CHAPTER SUMMARY 347
PROBLEMS 349
IMAGE 4
CHAPTER 10
THE HUMAN IMMUNE SYSTEM SEEN FROM A BIOMEDICAL ENGINEERING VIEWPOINT 353
10.0 INTRODUCTION 353
10.1 IMMUNE SYSTEM CELLS 355
10. 10.
10. 10. 10.
.1 MACROPHAGES 356
.2 T-LYMPHOCYTES: HELPER T-CELLS, CYTOTOXIC T-CELLS, SUPPRESSOR T-CELLS
357
.3 B-CELLS AND ANTIBODIES 360
.4 NATURAL KILLER CELLS 363
1.5 MAST CELLS, PLATELETS, AND COMPLEMENT 365
10.2 ANTIGEN PRESENTATION 368
10.3 IMMUNOCYTOKINES: THEIR SOURCES, EFFECTS, AND TARGETS 370 10.3.1 THE
INTERLEUKINS 372
10.3.2 THE INTERFERONS 376
10.3.3 TUMOR NECROSIS FACTORS 376
10.3.4 PROSTAGLANDINS AND OTHER EICOSANOIDS 377
10.3.5 SECTION SUMMARY 380
10.4 APOPTOSIS IN THE IMMUNE SYSTEM 381
10.5 THE ART OF MATHEMATICALLY MODELING SCENARIOS IN THE IMMUNE SYSTEM
382
10.5.1 INTRODUCTION 382
10.5.2 THE IMMUNE SYSTEM VS. CANCER 385
10.5.3 MODELS OF HIV INFECTION AND AIDS 394
10.6 CHAPTER SUMMARY 424
PROBLEMS 427
BIBLIOGRAPHY AND REFERENCES 435
APPENDIX: DISCUSSION OF SIMULATION LANGUAGES FOR PHYSIOLOGICAL/
PHARMACOKINETIC AND CHEMICAL KINETIC SYSTEMS 445
INDEX 449
|
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| spelling | Northrop, Robert B. Verfasser aut Endogenous and exogenous regulation and control of physiological systems Robert B. Northrop Boca Raton [u.a.] Chapman & Hall [u.a.] 2000 452 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biomedical engineering series Controlesystemen gtt Fysiologie gtt Génie biomédical ram Homéostasie ram Pharmacocinétique ram Régulation (biologie) ram Biological control systems Biomedical Engineering Biomedical engineering Homeostasis Pharmacokinetics Physiological Phenomena Physiologie (DE-588)4045981-0 gnd rswk-swf Biologisches System (DE-588)4122930-7 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 gnd rswk-swf Regulation (DE-588)4049075-0 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 s Physiologie (DE-588)4045981-0 s DE-604 Biologisches System (DE-588)4122930-7 s Regulation (DE-588)4049075-0 s SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008816128&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Northrop, Robert B. Endogenous and exogenous regulation and control of physiological systems Controlesystemen gtt Fysiologie gtt Génie biomédical ram Homéostasie ram Pharmacocinétique ram Régulation (biologie) ram Biological control systems Biomedical Engineering Biomedical engineering Homeostasis Pharmacokinetics Physiological Phenomena Physiologie (DE-588)4045981-0 gnd Biologisches System (DE-588)4122930-7 gnd Pharmakokinetik (DE-588)4115557-9 gnd Regulation (DE-588)4049075-0 gnd |
| subject_GND | (DE-588)4045981-0 (DE-588)4122930-7 (DE-588)4115557-9 (DE-588)4049075-0 |
| title | Endogenous and exogenous regulation and control of physiological systems |
| title_auth | Endogenous and exogenous regulation and control of physiological systems |
| title_exact_search | Endogenous and exogenous regulation and control of physiological systems |
| title_full | Endogenous and exogenous regulation and control of physiological systems Robert B. Northrop |
| title_fullStr | Endogenous and exogenous regulation and control of physiological systems Robert B. Northrop |
| title_full_unstemmed | Endogenous and exogenous regulation and control of physiological systems Robert B. Northrop |
| title_short | Endogenous and exogenous regulation and control of physiological systems |
| title_sort | endogenous and exogenous regulation and control of physiological systems |
| topic | Controlesystemen gtt Fysiologie gtt Génie biomédical ram Homéostasie ram Pharmacocinétique ram Régulation (biologie) ram Biological control systems Biomedical Engineering Biomedical engineering Homeostasis Pharmacokinetics Physiological Phenomena Physiologie (DE-588)4045981-0 gnd Biologisches System (DE-588)4122930-7 gnd Pharmakokinetik (DE-588)4115557-9 gnd Regulation (DE-588)4049075-0 gnd |
| topic_facet | Controlesystemen Fysiologie Génie biomédical Homéostasie Pharmacocinétique Régulation (biologie) Biological control systems Biomedical Engineering Biomedical engineering Homeostasis Pharmacokinetics Physiological Phenomena Physiologie Biologisches System Pharmakokinetik Regulation |
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