Handbook of drug metabolism:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
Dekker
1999
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XI, 596 S. Ill., graph. Darst |
| ISBN: | 0824702298 |
Staff View
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| 245 | 1 | 0 | |a Handbook of drug metabolism |c ed. by Thomas F. Woolf |
| 264 | 1 | |a New York [u.a.] |b Dekker |c 1999 | |
| 300 | |a XI, 596 S. |b Ill., graph. Darst | ||
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| 650 | 2 | |a Préparations pharmaceutiques - Métabolisme | |
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Record in the Search Index
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| adam_text | Contents
Preface Hi
Contributors ix
Part 1 Fundamental Aspects of Drug Metabolism
1. Pharmacokinetics of Drug Metabolites 1
Philip C. Smith
2. Oxidative Metabolic Bioactivation of Xenobiotics 49
Stephane Mabic, Kay Castagnoli, and Neal Castagnoli, Jr.
3. Morphofunctional Aspects of the Hepatic Architecture: Functional and
Subcellular Correlates 81
Felix A. de la Iglesia, Donald G. Robertson, and Jeffrey R. Haskins
4. The Cytochrome P450 Oxidative System 109
Paul R. Ortiz de Montellano
5. Transformation Enzymes: Oxidative; Non P450 131
Allen E. Rettie and Michael B. Fisher
6. Transformation Reactions: Glucuronidation 153
Brian Burchell
Part 2 Factors Affecting Drug Metabolism
7. Pharmacogenetics 175
Ann K. Daly
v
vi Contents
8. Inhibition of Drag Metabolizing Enzymes: Molecular and Biochemical
Aspects 203
F. Peter Guengerich
9. Metabolic Drug Interactions 229
Wayne D. Hooper
10. Induction of Human Drug Metabolizing Enzymes: Mechanisms and
Implications 239
Martin J. J. Ronis and Magnus Ingelman Sundberg
11. Sites of Metabolism: Lung 263
Garold S. Yost
Part 3 Technologies
12. Applications of Heterologous Expressed and Purified Human
Drag Metabolizing Enzymes: An Industrial Perspective 279
A. David Rodrigues
13. In Vivo and In Vitro Recombinant DNA Technology as a Powerful Tool
in Drug Development 321
Thomas Friedberg, C. J. Henderson, M. P. Pritchard, and C. R. Wolf
14. In Vitro Metabolism: Subcellular Fractions 363
Sean Ekins, Jukka Mdenpdd, and Steven A. Wrighton
15. In Vitro Metabolism: Hepatocytes 401
Michael W. Sinz
16. The Isolated Perfused Liver as a Tool in Drug Metabolism Studies 425
Marian Kukan
17. Metabolic Models of Cytotoxicity 443
Munir Pirmohamed and B. Kevin Park
18. In Vitro Metabolism: FMO and Related Oxygenations 477
John R. Cashman
19. Applications of Caco 2 Cells in Drug Discovery and Development 507
Shiyin Yee and Wesley W. Day
20. The Role of Nuclear Magnetic Resonance Spectroscopy in Drag
Metabolism 523
/. D. Wilson, J. K. Nicholson, and J C. Lindon
Contents vii
Part 4 Metabolism in Drug Discovery and Development
21. Preclinical Drug Metabolism Studies and Strategies 551
Philip B. Inskeep and Wesley W. Day
22. Clinical Drug Metabolism Studies 577
William F. Pool
Index 589
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:36:31Z |
| institution | BVB |
| isbn | 0824702298 |
| language | English |
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| physical | XI, 596 S. Ill., graph. Darst |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Dekker |
| record_format | marc |
| spelling | Handbook of drug metabolism ed. by Thomas F. Woolf New York [u.a.] Dekker 1999 XI, 596 S. Ill., graph. Darst txt rdacontent n rdamedia nc rdacarrier Farmacokinetica gtt Geneesmiddelen gtt Médicaments - Métabolisme Médicaments - Métabolisme - Guides, manuels, etc ram Préparations pharmaceutiques - Métabolisme Drugs Metabolism Pharmaceutical Preparations metabolism Arzneimittel (DE-588)4003115-9 gnd rswk-swf Stoffwechsel (DE-588)4057699-1 gnd rswk-swf Arzneimittel (DE-588)4003115-9 s Stoffwechsel (DE-588)4057699-1 s DE-604 Woolf, Thomas F. Sonstige (DE-588)173305008 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008815442&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Handbook of drug metabolism Farmacokinetica gtt Geneesmiddelen gtt Médicaments - Métabolisme Médicaments - Métabolisme - Guides, manuels, etc ram Préparations pharmaceutiques - Métabolisme Drugs Metabolism Pharmaceutical Preparations metabolism Arzneimittel (DE-588)4003115-9 gnd Stoffwechsel (DE-588)4057699-1 gnd |
| subject_GND | (DE-588)4003115-9 (DE-588)4057699-1 |
| title | Handbook of drug metabolism |
| title_auth | Handbook of drug metabolism |
| title_exact_search | Handbook of drug metabolism |
| title_full | Handbook of drug metabolism ed. by Thomas F. Woolf |
| title_fullStr | Handbook of drug metabolism ed. by Thomas F. Woolf |
| title_full_unstemmed | Handbook of drug metabolism ed. by Thomas F. Woolf |
| title_short | Handbook of drug metabolism |
| title_sort | handbook of drug metabolism |
| topic | Farmacokinetica gtt Geneesmiddelen gtt Médicaments - Métabolisme Médicaments - Métabolisme - Guides, manuels, etc ram Préparations pharmaceutiques - Métabolisme Drugs Metabolism Pharmaceutical Preparations metabolism Arzneimittel (DE-588)4003115-9 gnd Stoffwechsel (DE-588)4057699-1 gnd |
| topic_facet | Farmacokinetica Geneesmiddelen Médicaments - Métabolisme Médicaments - Métabolisme - Guides, manuels, etc Préparations pharmaceutiques - Métabolisme Drugs Metabolism Pharmaceutical Preparations metabolism Arzneimittel Stoffwechsel |
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