Marijuana and medicine: assessing the science base
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Washington, D.C.
National Acad. Press
1999
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVI, 267 S.: Ill., graph. Darst. |
| ISBN: | 0309071550 |
Staff View
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| 245 | 1 | 0 | |a Marijuana and medicine |b assessing the science base |c Janet E. Joy ..., ed. |
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| 300 | |a XVI, 267 S.: Ill., graph. Darst. | ||
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| 650 | 4 | |a Herbal Medicine | |
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Record in the Search Index
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| adam_text | Contents
EXECUTIVE SUMMARY 1
1 INTRODUCTION 13
How This Study Was Conducted, 15
Marijuana Today, 16
Marijuana and Medicine, 19
Who Uses Medical Marijuana? 20
Cannabis and the Cannabinoids, 24
Organization of the Report, 30
2 CANNABINOIDS AND ANIMAL PHYSIOLOGY 33
Introduction, 33
Cannabinoid Receptors, 39
The Endogenous Cannabinoid System, 43
Sites of Action, 48
Cannabinoid Receptors and Brain Functions, 51
Chronic Effects of THC, 56
Cannabinoids and the Immune System, 59
Conclusions and Recommendations, 69
3 FIRST, DO NO HARM: CONSEQUENCES OF
MARIJUANA USE AND ABUSE 83
The Marijuana High, 83
Drug Dynamics, 84
jriii
Xiv CONTENTS
Marijuana Use and Dependence, 92
Link Between Medical Use and Drug Abuse, 101
Psychological Harms, 104
Physiological Harms: Tissue and Organ Damage, 109
Summary and Conclusions, 125
4 THE MEDICAL VALUE OF MARIJUANA AND
RELATED SUBSTANCES 137
Standards for Evaluating Clinical Trials, 138
Analgesia, 139
Nausea and Vomiting, 145
Wasting Syndrome and Appetite Stimulation, 154
Neurological Disorders, 159
Glaucoma, 173
Summary, 177
Other Reports on Marijuana as Medicine, 180
5 DEVELOPMENT OF CANNABINOID DRUGS 193
Federal Drug Development Policy, 194
Development and Marketing of Marinol, 202
Market Outlook for Cannabinoids, 208
Regulation of and Market Outlook for Marijuana, 213
Conclusions, 218
APPENDIXES
A Individuals and Organizations That Spoke or Wrote to the
Institute of Medicine About Marijuana and Medicine 225
B Workshop Agendas 232
C Scheduling Definitions 240
D Statement of Task 242
E Recommendations Made in Recent Reports on the
Medical Use of Marijuana 244
F Rescheduling Criteria 256
INDEX 259
List of Tables and Figures
TABLES
1.1 Self Reported Disorders Treated with Marijuana by Members of
San Francisco Cannabis Cultivators Club, 21
1.2 Self Reported Disorders Treated with Marijuana by Members of
Los Angeles Cannabis Resource Center (LACRC), According to
Center Staff, 22
1.3 Summary of Reports to IOM Study Team by 43 Individuals, 23
1.4 Primary Symptoms of 43 Individuals Who Reported to IOM Study
Team, 24
1.5 Cannabinoids Identified in Marijuana, 25
2.1 Landmark Discoveries Since the 1982 IOM Report, 34
2.2 Compounds That Bind to Cannabinoid Receptors, 44
2.3 Comparison of Cannabinoid Receptor Agonists, 46
2.4 Cellular Processes That Can Be Targeted for Drug
Development, 48
2.5 Brain Regions in Which Cannabinoid Receptors Are Abundant, 49
2.6 Cannabinoid Receptors, 51
2.7 Effects of Cannabinoids on the Immune System, 60
2.8 Historical Comparisons Between Cannabinoids and Opiates, 69
3.1 Psychoactive Doses of THC in Humans, 85
3.2 Drug Withdrawal Symptoms, 90
3.3 Factors That Are Correlated with Drug Dependence, 94
xv
XVi LIST OF TABLES AND FIGURES
3.4 Prevalence of Drug Use and Dependence in the General
Population, 95
3.5 Relative Prevalence of Diagnoses of Psychiatric Disorders
Associated with Drug Use Among Children, 96
3.6 Effect of Decriminalization on Marijuana Use in Emergency Room
(ER) Cases, 103
4.1 Studies on the Effects of Marijuana and Cannabinoids in Multiple
Sclerosis, 163
4.2 Classes of Antispasticity Drugs, 164
4.3 Drugs Used to Treat Movement Disorders, 168
4.4 Clinical Trials of Cannabidiol (CBD) in Epileptics, 171
4.5 Anticonvulsant Drugs for Various Types of Seizures, 172
4.6 Classes of Drugs Used to Treat Glaucoma, 176
5.1 Cannabinoids and Related Compounds Commonly Used in
Research, 201
5.2 Cannabinoids Under Development for Human Use, 209
FIGURES
1.1 Cannabinoid biosynthesis, 26
2.1 Diagram of neuron with synapse, 38
2.2 Cannabinoid receptors, 40
2.3 Cannabinoid agonists trigger a series of reactions within cells, 41
2.4 Chemical structures of selected cannabinoid agonists, 45
2.5 Locations of brain regions in which cannabinoid receptors are
abundant, 50
2.6 Diagrams showing motor regions of the brain, 52
3.1 Age distribution of marijuana users among the general
population, 93
4.1 Emesis stimulating pathways, 146
4.2 Effect of nabilone on multiple sclerosis symptoms, 162
5.1 Stages of clinical testing, 196
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| language | English |
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| physical | XVI, 267 S.: Ill., graph. Darst. |
| publishDate | 1999 |
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| spelling | Marijuana and medicine assessing the science base Janet E. Joy ..., ed. Washington, D.C. National Acad. Press 1999 XVI, 267 S.: Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cannabis - Physiologie Cannabis - usage thérapeutique Geneeskrachtige planten gtt Geneesmiddelen gtt Hasjisj gtt Hennep gtt Therapeutische werking gtt Cannabinoids Therapeutic use Cannabis Herbal Medicine Marijuana Therapeutic use Phytotherapy Risk Assessment Medizin (DE-588)4038243-6 gnd rswk-swf Marihuana (DE-588)4037558-4 gnd rswk-swf Marihuana (DE-588)4037558-4 s Medizin (DE-588)4038243-6 s DE-604 Joy, Janet E. 1953- Sonstige (DE-588)173323618 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008814866&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Marijuana and medicine assessing the science base Cannabis - Physiologie Cannabis - usage thérapeutique Geneeskrachtige planten gtt Geneesmiddelen gtt Hasjisj gtt Hennep gtt Therapeutische werking gtt Cannabinoids Therapeutic use Cannabis Herbal Medicine Marijuana Therapeutic use Phytotherapy Risk Assessment Medizin (DE-588)4038243-6 gnd Marihuana (DE-588)4037558-4 gnd |
| subject_GND | (DE-588)4038243-6 (DE-588)4037558-4 |
| title | Marijuana and medicine assessing the science base |
| title_auth | Marijuana and medicine assessing the science base |
| title_exact_search | Marijuana and medicine assessing the science base |
| title_full | Marijuana and medicine assessing the science base Janet E. Joy ..., ed. |
| title_fullStr | Marijuana and medicine assessing the science base Janet E. Joy ..., ed. |
| title_full_unstemmed | Marijuana and medicine assessing the science base Janet E. Joy ..., ed. |
| title_short | Marijuana and medicine |
| title_sort | marijuana and medicine assessing the science base |
| title_sub | assessing the science base |
| topic | Cannabis - Physiologie Cannabis - usage thérapeutique Geneeskrachtige planten gtt Geneesmiddelen gtt Hasjisj gtt Hennep gtt Therapeutische werking gtt Cannabinoids Therapeutic use Cannabis Herbal Medicine Marijuana Therapeutic use Phytotherapy Risk Assessment Medizin (DE-588)4038243-6 gnd Marihuana (DE-588)4037558-4 gnd |
| topic_facet | Cannabis - Physiologie Cannabis - usage thérapeutique Geneeskrachtige planten Geneesmiddelen Hasjisj Hennep Therapeutische werking Cannabinoids Therapeutic use Cannabis Herbal Medicine Marijuana Therapeutic use Phytotherapy Risk Assessment Medizin Marihuana |
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