Foreign DNA in mammalian systems:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | German |
| Published: |
Weinheim [u.a.]
Wiley-VCH
2000
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIII, 181 S. Ill., graph. Darst. |
| ISBN: | 3527300899 |
Staff View
MARC
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| 300 | |a XIII, 181 S. |b Ill., graph. Darst. | ||
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| 650 | 4 | |a Adenoviridae |x genetics | |
| 650 | 4 | |a Adenoviruses | |
| 650 | 4 | |a Cell Transformation, Viral |x genetics | |
| 650 | 4 | |a DNA | |
| 650 | 4 | |a DNA Methylation | |
| 650 | 4 | |a DNA, Viral | |
| 650 | 4 | |a Genetic transformation | |
| 650 | 4 | |a Mammals |x Genetics | |
| 650 | 4 | |a Mammals |x genetics | |
| 650 | 4 | |a Virus Integration | |
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Record in the Search Index
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| adam_text | Contents
Preface VII
1 Introduction 1
1.1 Further reading 3
2 Foreign DNA 5
2.1 Foreign DNA in the environment 5
2.2 Uptake and modes of persistence of foreign DNA in mammalian
cells 6
2.3 Further reading 11
3 Methods to detect integrated foreign DNA 13
3.1 Parameters of foreign DNA integration 13
3.2 The fluorescent in situ hybridization method 14
3.3 Detection of foreign DNA by Southern DNA transfer and DNA
DNA hybridization 15
3.4 Detection of foreign DNA sequences by the polymerase chain
reaction (PCR) 20
3.5 Recloning of junction fragments and the determination of their
nucleotide sequences 22
3.6 Equilibirum sedimentation in alkaline CsCl gradients and DNA
DNA hybridization 24
3.7 Further reading 26
4 The adenovirus paradigm 27
4.1 An introduction to the adenovirus system 27
4.1.1 Clinical background 27
4.1.2 Virion structure 28
4.1.3 Classification 29
4.1.4 Multiplication during productive infection 30
4.1.5 Abortive infection 32
4.2 An example: Adl2 DNA integration in the Adl2 transformed
hamster cell line T637 32
4.3 The state of the viral DNA in different cell systems 34
4.3.1 Productive infection 34
4.3.2 Abortive infection 34
4.3.3 Transformation of cells in culture 35
X Contents
4.3.4 Tumor induction by Adl2 in newborn hamsters 36
4.3.5 Tumor cells in culture 36
4.3.6 Loss of previously integrated Adl2 DNA sequences 37
4.4 Adenovirus infection, DNA transfection or DNA microinjection 39
4.5 Integration of adenovirus DNA in human cells significance for
human somatic gene therapy 40
4.6 Studies on integrative recombination of adenovirus DNA in a cell
free system 41
4.7 Further reading 43
5 Conclusions derived from a survey of junction sites 47
5.1 On the characteristics of junction sequences 47
5.2 Persistence of integrated foreign DNA a novel functional type of
insertional mutagenesis 51
5.3 Adenovirus DNA: chromosomal association covalent genomic
integration 52
5.4 Further reading 55
6 Adenovirus induced tumor cells and revertants 57
6.1 Clonal origin of Adl2 induced tumors 57
6.2 Stability instability 57
6.2.1 Hit and run mechanism of viral oncogenesis? 60
6.2.2 General implications of a hit and run mechanism 61
6.3 Further reading 61
7 Comparisons with other viral systems 63
7.1 Integration of viral DNA 63
7.2 Transcription of integrated viral genomes 64
7.3 Virus induced tumors 79
7.4 Replication and integration of the retroviral genome 82
7.5 Endogenous retroviral genomes 84
7.6 The viral archetype: integration of bacteriophage X DNA 85
7.6.1 The most important regulatory functions in the phage X genome 89
7.6.2 Control of transcription at the right operator OR of phage
X DNA 90
7.6.3 A closer look at the integration and excision of the bacteriophage
X genome 92
7.7 Further reading 95
8 Non viral systems 97
8.1 Exchange of genetic information with extracellular DNA in I
pneumococci 98
8.2 IS elements and transposons 98
Contents XI
8.3 Thoughts on the mechanism of foreign DNA integration 99
8.4 Expression of integrated foreign DNA 100
8.5 Fixation of foreign DNA in transgenic animals 101
8.6 Critical evaluation of the results obtained with transgenic ani¬
mals 103
8.7 Further reading 104
9 Patterns of DNA methylation in the human and in viral genomes 105
9.1 Introduction 105
9.2 Methods available for the study of DNA methylation 106
9.3 Patterns of DNA methylation 109
9.4 A long term signal for promoter inactivation 111
9.5 DNA methylation, an important parameter in genetic imprin¬
ting 114
9.6 Chromatin structure and patterns of DNA methylation 115
9.7 Patterns of DNA methylation in selected segments of the human
genome 116
9.7.1 Tumor necrosis factors a and p 116
9.7.2 Human gene for the interleukin 2 receptor a chain (IL 2Ra) 116
9.7.3 Prader Labhart Willi/Angelman syndrome region on human chromo¬
some 15qll 13 117
9.7.4 Alu sequences 118
9.7.5 Wide range of human randomly selected DNA sequences 118
9.7.6 Selected human genes in different Hodgkin s lymphoma and leukemia
cell lines and in normal human lymphocytes 119
9.7.7 RET protooncogene 119
9.8 Patterns of methylation in viral DNA 120
9.8.1 Human adenovirus types 2 and 12 120
9.8.2 Frog virus 3 123
9.8.3 Autographa californica nuclear polyhedrosis virus (AcNPV) 123
9.8.4 Human cytomegalovirus 124
9.8.5 General considerations 124
9.9 Further reading 125
10 Consequences of foreign DNA integration and persistence 129
10.1 De novo methylation of integrated foreign DNA 129
10.2 De novo methylation of targeted versus randomly integrated foreign
genes 131
10.3 The insertion of foreign DNA into an established mammalian genome
can alter patterns of methylation in cellular genome segments 134
10.3.1 Introduction 134
10.3.2 Integration of Adl2 DNA or bacteriophage X DNA into the hamster
genome: consequences for the stability of the targeted genome 135
10.3.3 Alterations in cellular methylation patterns 137
XII Contents S
10.3.4 Foreign DNA integration and cellular chromatin structure 141
10.3.5 General implications 142 *
10.4 De novo methylation of foreign DNA a hypothetical ancient defense
mechanism 143
10.5 Malignancy a chromatin disease? 144
10.6 Further reading 146
11 Uptake of foreign DNA from the environment: the gastrointestinal tract and
the placenta as portals of entry 147
11.1 Summary 147
11.2 Foreign DNA is abundant in our environment 147
11.3 The epithelia of the gastrointestinal tract are constantly exposed to
large amounts of foreign DNA and proteins 148
11.4 Foreign DNA orally ingested by mice reaches peripheral white blood
cells, spleen and liver via the intestinal epithelia and can be covalently
linked to mouse DNA 149
11.5 The fate of orally ingested foreign DNA in mice: chromosomal asso¬
ciation and placental transmission to the fetus 152
11.6 Possible functional consequences 154
11.7 Concerns for and fears of foreign DNA by the public 155
11.8 Further reading 156
12 Relevance in applied molecular biology: an overview 159
12.1 Gene transfer to mammalian cells via artificial chromosomes 159
12.2 Human somatic gene therapy 160
12.3 Injection of promoter fused gene constructs into animals and DNA
vaccines 162
12.4 Further reading 163
13 Future research 165
13.1 The mechanism of the uptake of foreign DNA by mammalian
cells 165
13.2 The fate of foreign DNA upon injection into animals 165
13.3 Response against foreign DNA 166
13.4 Mechanisms of foreign DNA integration into the host genome 166
13.5 The secrets of de novo methylation 166
13.6 Alterations of methylation in cellular DNA segments upon foreign
DNA insertion 167
14 Studies on the biological significance of DNA methylation by using adeno
virus DNA as a model 169
14.1 De novo methylation of integrated adenovirus DNA 169
Contents XIII
14.2 Inverse correlations between the extent
of (promoter) methylation and the state of promoter activity 170
14.3 Reconstruction experiments: gene transfer
and transient or long term expression of unmethylated or
premethylated promoter indicator gene constructs 170
14.4 Release of the inhibitory effect of promoter methylation by gene
products of the adenovirus El region or by the presence of a strong
enhancer from human cytomegalovirus in the construct 171
14.5 Bibliography: DNA methylation in the adenovirus and related
systems 171
Acknowledgments 174
Index 177
Color plates 65 75
|
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| id | DE-604.BV012898628 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:35:41Z |
| institution | BVB |
| isbn | 3527300899 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008779761 |
| oclc_num | 41301422 |
| open_access_boolean | |
| owner | DE-20 DE-29T DE-703 DE-M49 DE-BY-TUM |
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| physical | XIII, 181 S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Doerfler, Walter 1933- Verfasser (DE-588)104580569 aut Foreign DNA in mammalian systems Walter Doerfler Weinheim [u.a.] Wiley-VCH 2000 XIII, 181 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Adenoviridae genetics Adenoviruses Cell Transformation, Viral genetics DNA DNA Methylation DNA, Viral Genetic transformation Mammals Genetics Mammals genetics Virus Integration DNS (DE-588)4070512-2 gnd rswk-swf Tumorviren (DE-588)4186431-1 gnd rswk-swf Säugetiere (DE-588)4051253-8 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Adenoviren (DE-588)4141412-3 gnd rswk-swf Fremd-DNS (DE-588)4576304-5 gnd rswk-swf Säugetiere (DE-588)4051253-8 s Adenoviren (DE-588)4141412-3 s DNS (DE-588)4070512-2 s DE-604 Tumorviren (DE-588)4186431-1 s Molekularbiologie (DE-588)4039983-7 s Fremd-DNS (DE-588)4576304-5 s HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008779761&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Doerfler, Walter 1933- Foreign DNA in mammalian systems Adenoviridae genetics Adenoviruses Cell Transformation, Viral genetics DNA DNA Methylation DNA, Viral Genetic transformation Mammals Genetics Mammals genetics Virus Integration DNS (DE-588)4070512-2 gnd Tumorviren (DE-588)4186431-1 gnd Säugetiere (DE-588)4051253-8 gnd Molekularbiologie (DE-588)4039983-7 gnd Adenoviren (DE-588)4141412-3 gnd Fremd-DNS (DE-588)4576304-5 gnd |
| subject_GND | (DE-588)4070512-2 (DE-588)4186431-1 (DE-588)4051253-8 (DE-588)4039983-7 (DE-588)4141412-3 (DE-588)4576304-5 |
| title | Foreign DNA in mammalian systems |
| title_auth | Foreign DNA in mammalian systems |
| title_exact_search | Foreign DNA in mammalian systems |
| title_full | Foreign DNA in mammalian systems Walter Doerfler |
| title_fullStr | Foreign DNA in mammalian systems Walter Doerfler |
| title_full_unstemmed | Foreign DNA in mammalian systems Walter Doerfler |
| title_short | Foreign DNA in mammalian systems |
| title_sort | foreign dna in mammalian systems |
| topic | Adenoviridae genetics Adenoviruses Cell Transformation, Viral genetics DNA DNA Methylation DNA, Viral Genetic transformation Mammals Genetics Mammals genetics Virus Integration DNS (DE-588)4070512-2 gnd Tumorviren (DE-588)4186431-1 gnd Säugetiere (DE-588)4051253-8 gnd Molekularbiologie (DE-588)4039983-7 gnd Adenoviren (DE-588)4141412-3 gnd Fremd-DNS (DE-588)4576304-5 gnd |
| topic_facet | Adenoviridae genetics Adenoviruses Cell Transformation, Viral genetics DNA DNA Methylation DNA, Viral Genetic transformation Mammals Genetics Mammals genetics Virus Integration DNS Tumorviren Säugetiere Molekularbiologie Adenoviren Fremd-DNS |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008779761&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT doerflerwalter foreigndnainmammaliansystems |