Estrogens, estrogen receptor, and breast cancer:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
IOS Press [u.a.]
2000
|
| Schriftenreihe: | Biomedical and health research
36 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VIII, 263 S. Ill. |
| ISBN: | 096733554X 4274903117 |
Internformat
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| 245 | 1 | 0 | |a Estrogens, estrogen receptor, and breast cancer |c by Fritz F. Parl |
| 264 | 1 | |a Amsterdam [u.a.] |b IOS Press [u.a.] |c 2000 | |
| 300 | |a VIII, 263 S. |b Ill. | ||
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| 490 | 1 | |a Biomedical and health research |v 36 | |
| 650 | 4 | |a Breast - Cancer | |
| 650 | 4 | |a Breast - Cancer - Prevention | |
| 650 | 4 | |a Estrogen - Physiological effect | |
| 650 | 4 | |a Estrogen - Receptors | |
| 650 | 4 | |a Sein - Cancer - Physiopathologie | |
| 650 | 4 | |a Œstrogènes - Physiopathologie | |
| 650 | 4 | |a Œstrogènes - Récepteurs - Physiopathologie | |
| 650 | 4 | |a Breast Neoplasms | |
| 650 | 4 | |a Breast |x Cancer |x Pathophysiology | |
| 650 | 4 | |a Estrogen |x Pathophysiology | |
| 650 | 4 | |a Estrogen |x Receptors |x Pathophysiology | |
| 650 | 4 | |a Estrogens |x metabolism | |
| 650 | 4 | |a Receptors, Estrogen | |
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Datensatz im Suchindex
| _version_ | 1804127583409799168 |
|---|---|
| adam_text | Contents
1. Introduction 1
References 17
2. Estrogen Synthesis and Metabolism 21
1. Overview 21
2. P450 Aromatase 23
3. 173 HydroxysteroidDehydrogenase 28
4. Estrogen Sulfotransferase and Estrone Sulfatase 31
5. Oxidative Estrogen Metabolism 33
6. CytochromeP4501Al(CYPlAl) 36
7. CytochromeP4501Bl(CYPlBl) 39
8. CYP1A2 and other Cytochromes P450 42
9. Conclusion 43
10. References 44
3. Estrogen Receptor 57
1. Overview 57
2. Ligand Binding Domain (LBD) 59
3. DNA Binding Domain (DBD) 66
4. Transcription Activation Function (AF) 69
5. Promoter Region 71
6. ERE Structure and Interaction with ER 75
7. Role of Estrogen in ER Transformation and ER ERE Interaction 78
8. ER Mediated Gene Transcription 81
9. ER Interaction with Basal Transcription Factors, Coactivators
and Cointegrators 86
10. Chromatin and Estrogen Dependent Transcription 91
11. References 94
4. Estrogen Action 111
1. Overview 111
2. Development and Differentiation 112
3. Cell Cycle 113
4. Carcinogenesis 117
5. References 125
5. Estrogen Receptor Expression in Breast Cancer 135
1. Overview 135
2. Determination of ER Status 137
3. ER Gene, mRNA, and Protein Abnormalities 143
4. Mechanisms Affecting ER Expression 154
5. ER as Marker of Hormone Dependence and Prognostic Indicator 160
6. References 174
viii
6. Estrogens as Breast Cancer Risk Factor 205
1. Endogenous Estrogens 205
2. Exogenous Estrogens 213
3. Oral Contraceptives 213
4. Estrogen Replacement Therapy 217
5. Phytoestrogens 221
6. Xenoestrogens 224
7. References 228
7. Estrogens, Estrogen Receptor, and Breast Cancer — a Unified Model 243
References 247
Subject Index 249
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:35:39Z |
| institution | BVB |
| isbn | 096733554X 4274903117 |
| language | English |
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| physical | VIII, 263 S. Ill. |
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| series | Biomedical and health research |
| series2 | Biomedical and health research |
| spelling | Parl, Fritz F. Verfasser aut Estrogens, estrogen receptor, and breast cancer by Fritz F. Parl Amsterdam [u.a.] IOS Press [u.a.] 2000 VIII, 263 S. Ill. txt rdacontent n rdamedia nc rdacarrier Biomedical and health research 36 Breast - Cancer Breast - Cancer - Prevention Estrogen - Physiological effect Estrogen - Receptors Sein - Cancer - Physiopathologie Œstrogènes - Physiopathologie Œstrogènes - Récepteurs - Physiopathologie Breast Neoplasms Breast Cancer Pathophysiology Estrogen Pathophysiology Estrogen Receptors Pathophysiology Estrogens metabolism Receptors, Estrogen Östrogene (DE-588)4075616-6 gnd rswk-swf Östrogenrezeptor (DE-588)4172467-7 gnd rswk-swf Brustkrebs (DE-588)4008528-4 gnd rswk-swf Brustkrebs (DE-588)4008528-4 s Östrogene (DE-588)4075616-6 s DE-604 Östrogenrezeptor (DE-588)4172467-7 s Biomedical and health research 36 (DE-604)BV009680083 36 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008778781&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Parl, Fritz F. Estrogens, estrogen receptor, and breast cancer Biomedical and health research Breast - Cancer Breast - Cancer - Prevention Estrogen - Physiological effect Estrogen - Receptors Sein - Cancer - Physiopathologie Œstrogènes - Physiopathologie Œstrogènes - Récepteurs - Physiopathologie Breast Neoplasms Breast Cancer Pathophysiology Estrogen Pathophysiology Estrogen Receptors Pathophysiology Estrogens metabolism Receptors, Estrogen Östrogene (DE-588)4075616-6 gnd Östrogenrezeptor (DE-588)4172467-7 gnd Brustkrebs (DE-588)4008528-4 gnd |
| subject_GND | (DE-588)4075616-6 (DE-588)4172467-7 (DE-588)4008528-4 |
| title | Estrogens, estrogen receptor, and breast cancer |
| title_auth | Estrogens, estrogen receptor, and breast cancer |
| title_exact_search | Estrogens, estrogen receptor, and breast cancer |
| title_full | Estrogens, estrogen receptor, and breast cancer by Fritz F. Parl |
| title_fullStr | Estrogens, estrogen receptor, and breast cancer by Fritz F. Parl |
| title_full_unstemmed | Estrogens, estrogen receptor, and breast cancer by Fritz F. Parl |
| title_short | Estrogens, estrogen receptor, and breast cancer |
| title_sort | estrogens estrogen receptor and breast cancer |
| topic | Breast - Cancer Breast - Cancer - Prevention Estrogen - Physiological effect Estrogen - Receptors Sein - Cancer - Physiopathologie Œstrogènes - Physiopathologie Œstrogènes - Récepteurs - Physiopathologie Breast Neoplasms Breast Cancer Pathophysiology Estrogen Pathophysiology Estrogen Receptors Pathophysiology Estrogens metabolism Receptors, Estrogen Östrogene (DE-588)4075616-6 gnd Östrogenrezeptor (DE-588)4172467-7 gnd Brustkrebs (DE-588)4008528-4 gnd |
| topic_facet | Breast - Cancer Breast - Cancer - Prevention Estrogen - Physiological effect Estrogen - Receptors Sein - Cancer - Physiopathologie Œstrogènes - Physiopathologie Œstrogènes - Récepteurs - Physiopathologie Breast Neoplasms Breast Cancer Pathophysiology Estrogen Pathophysiology Estrogen Receptors Pathophysiology Estrogens metabolism Receptors, Estrogen Östrogene Östrogenrezeptor Brustkrebs |
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