Cell and molecular biology: concepts and experiments
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Wiley
1999
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Getr. Zählung Ill., graph. Darst. |
| ISBN: | 0471192791 |
Internformat
MARC
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Datensatz im Suchindex
| _version_ | 1804127555560669184 |
|---|---|
| adam_text | CELL AND
MOLECULAR BIOLOGY
CONCEPTS AND EXPERIMENTS
Second Edition
Gerald Karp
John Wiley amp; Sons, Inc
New York • Chichester • Weinheim • Brisbane • Toronto • Singapore
BRIEF TABLE OF CONTENTS
Chapter 1 Introduction to the Study of Cell Biology 1
Chapter 2 The Chemical Basis of Life 31
Chapter 3 Bioenergetics, Enzymes, and Metabolism 80
Chapter 4 The Structure and Function of the Plasma Membrane 22
Chapter 5 Aerobic Respiration and the Mitochondrion 182
Chapter 6 Photosynthesis and the Chloroplast 223
Chapter 7 Interactions Between Cells and Their Environment 253
Chapter 8 Cytoplasmic Membrane Systems: Structure, Function, and
Membrane Trafficking 292
Chapter 9 The Cytoskeleton and Cell Motility 344
Chapter 10 The Nature of the Gene and the Genome 413
Chapter 11 Expression of Genetic Information: From Transcription to
Translation 457
Chapter 12 The Cell Nucleus and the Control of Gene Expression 514
Chapter 13 DNA Replication and Repair 575
Chapter 14 Cellular Reproduction 608
Chapter 15 _ Cell Signaling: Communication Between Cells and Their
Environment 655
Chapter 16 Cancer 700
Chapter 17 The Immune Response 733
Chapter 18 Techniques in Cell and Molecular Biology 768
Glossary G-l
Answers to Odd-Numbered Analytic Questions A-l
Index 1-1
xm
CONTENTS
CHAPTER 1 INTRODUCTION TO THE STUDY
OF CELL BIOLOCY 1
1 1 The Discovery of Cells 2
1 2 Basic Properties of Cells 3
Cells Are Highly Complex and Organized 3
Cells Possess a Genetic Program and the Means
to Use It 5
Cells Are Capable of Producing More
of Themselves 5
Cells Acquire and Utilize Energy 5
Cells Carry Out a Variety of Chemical
Reactions 6
Cells Engage in Numerous Mechanical
Activities 6
Cells Are Able to Respond to Stimuli 6
Cells Are Capable of Self-Regulation 6
1 3 Two Fundamentally Different Classes
of Cells 9
Characteristics That Distinguish Prokaryotic and
Eukaryotic Cells 9
Types of Prokaryotic Cells 13
Types of Eukaryotic Cells: Cell
Specialization 14
The Sizes of Cells and Their Components 17
1 4 Viruses 18
Viroids 22
The Human Persp ectivei Mad Cows and Human Prion
Diseases 22
Experimental Pathioays: The Origin of Eukaryotic
Cells 25
CHAPTER 2 THE CHEMICAL BASIS OF LIFE 31
2 1 Covalent Bonds 32
Polar and Nonpolar Molecules 32
Ionization 34
2 2 Noncovalent Bonds 34
Ionic Bonds: Attractions Betzveen Charged
Atoms 34
Hydrogen Bonds 35
The Human Perspective: Free Radicals as a Cause of Aging
and Disease 36
Hydrophobic Interactions and van der Waals
Forces 37
The Life-Supporting Properties of Water 38
2 3 Acids, Bases, and Buffers 39
The Nature of Biological Molecules 41
Hydrocarbons 41
Functional Groups 42-
A Classification of Biological Molecules
by Function 42
Four Types of Biological Molecules 43
Carbohydrates 45
Lipids 49
Proteins 51
Nucleic Acids 69
2 6 The Formation of Complex Macromolecular
Structures 71
The Assembly of Tobacco Mosaic Virus Particles
and Ribosomal Subimits 71
Experimental Pathways: Chaperones: Helping Proteins
Reach Their Proper Folded State 73
CHAPTER 3 BIOENERCETICS, ENZYMES AND
METABOLISM 80
3 1 Bioenergetics 81
The Laws of Thermodynamics and the Concept
of Entropy 82
Free Energy 85
3 2 Enzymes as Biological Catalysts 90
The Properties of Enzymes 91
Overcoming the Activation Energy Barrier 92
The Active Site and Molecular Specificity 94
Mechanisms of Enzyme Catalysis 94
Enzyme Kinetics 98
The Human Perspective: The Growing Problem
of Antibiotic Resistance 98
3 3 Metabolism 104
An Overview of Metabolism 104
Oxidation and Reduction: A Matter
of Electrons 105
The Capture and Utilization of Energy 106
Metabolic Regulation 111
Experimental Pathzvays: Determining the Mechanism
of Lysozyme Action 115
C HA ITER 4 THE STRUCTURE AND FUNCTION OF
THE PLASMA MEMBRANE 122
4 1 An Overview of Membrane Functions 123
42A Brief History of Studies on Plasma
Membrane Structure 125
xiv
Contents xv
4 3 The Chemical Composition
of Membranes 127
Membrane Lipids 127
Membrane Carbohydrates 132
Membrane Proteins 133
4 4 Membrane Lipids and Membrane
Fluidity 139
The Importance of Membrane Fluidity 141
Maintaining Membrane Fluidity 141
The Asymmetry of Membrane Lipids 142
4 5 The Dynamic Nature of the Plasma
Membrane 143
The Diffusion of Membrane Proteins After Cell
Fusion 143
Patterns of Protein Mobility 145
The Plasma Membrane of the Red Blood
Cell 147
4 6 The Movement of Substances Across Cell
Membranes 150
The Energetics of Solute Movement 150
Dijfusion of Substances Through
Membranes 151
Facilitated Dijfusion 157
Active Transport 158
The Human Perspective: The Clinical Significance
of Membrane Transport 162
4 7 Membrane Potentials and Nerve
Impulses 165
The Action Potential 166
Propagation of Action Potentials as an
Impulse 168
Neurotransmission: Jumping the Synaptic
Cleft 172
Experimental Pathways: The Acetylcholine
Receptor 172
CHAPTER 5 AEROBIC RESPIRATION AND THE
MITOCHONDRION 182
5 1 Mitochondrial Structure and Function 183
Mitochondrial Membranes 184
The Mitochondrial Matrix 185
5 2 Oxidative Metabolism in the
Mitochondrion 186
The Tricarboxylic Acid (TCA) Cycle 188
The Importance of Reduced Coenzymes in the
Formation of ATP 188
5 3 The Role of Mitochondria in the Formation
of ATP 191
Oxidation-Reduction Potentials 191
The Human Perspective: The Role of Anaerobic and
Aerobic Metabolism in Exercise 192
Electron Transport 194
5 4 Translocation of Protons and the
Establishment of a Proton-motive
Force 201
5 5 The Machinery for ATP Formation 202
The Structure of ATP Synthase 2 03
The Basis of ATP Formation According to the
Binding Change Mechanism 204
Other Roles for the Proton-motive Force in
Addition to ATP Synthesis 207
5 6 Importing Mitochondrial Proteins 208
5 7 Peroxisomes 211
The Human Perspective: Diseases That Result
from Abnormal Mitochondrial or Peroxisomal
Function 213
Experimental Pathways: Coupling Oxidation
to Phosphorylation 215
CHAITER 6 PHOTOSYNTHESIS AND THE
CHLOROPLAST 223
6 1 Chloroplast Structure and Function 224
6 2 An Overview of Photosynthetic
Metabolism 226
6 3 The Absorption of Light 228
Photosynthetic Pigments 228
6 4 Photosynthetic Units and Reaction
Centers 230
Oxygen Evolution: Coordinating the Action
of Two Different Photosynthetic
Systems 230
Killing Weeds by Inhibiting Electron
Transport 238
6 5 Photophosphorylation 238
Noncyclic versus Cyclic
Photophosphorylation 239
6 6 Carbon Dioxide Fixation and the Synthesis of
Carbohydrate 239
Carbohydrate Synthesis in C3 Plants 240
Carbohydrate Synthesis in C4 Plants 242
Carbohydrate Synthesis in CAM Plants 244
Peroxisomes and Photorespiration 244
6 7 Importing Proteins into the
Chloroplast 245
Experimental Pathways: Organization of the Thylakoid
Membrane 247
xvi Contents
CHAPTER 7 INTERACTIONS BETWEEN CELLS
AND THEIR ENVIRONMENT 253
7 1 The Extracellular Space 254
The Extracellular Matrix 255
7 2 Interactions of Cells with Noncellular
Substrates 263
Integrins 263
Focal Contacts and Hemidesmosomes: Anchoring
Cells to Their Substratum 265
7 3 Interactions of Cells with Other Cells 268
Selectins 268
Immunoglobulins and Integrins 270
Cadherins 271
Adherens Junctions and Desmosomes: Anchoring
Cells to Other Cells 272
The Role of Cell Adhesion Receptors in
Transmembrane Signaling 275
The Human Perspective: The Role of Cell Adhesion in
Inflammation and Metastasis 277
7A Tight Junctions: Sealing the Extracellular
Space 278
7 5 Gap Junctions and Plasmodesmata: Mediating
Intercellular Communication 280
Plasmodesmata 283
7 6 Cell Walls 283
Experimental Pathways: The Role of Gap Junctions
in Intercellular Communication 286
CHAPTER 8 CYTOPLASMIC MEMBRANE
SYSTEMS: STRUCTURETFUNCTION, AND
MEMBRANE TRAFFICKING 292
8 1 An Overview of the Endomembrane
System 293
82A Few Approaches to the Study
of Cytomembranes 295
Insights Gained from Autoradiography 295
Insights Gained from the Biochemical Analysis
of S ubcell ular Fractions 297
Insights Gained from the Study of Genetic
Mutants 297
8 3 The Endoplasmic Reticulum 300
The Smooth Endoplasmic Reticulum 300
Functions of the Rough Endoplasmic
Reticulum 302
8 4 The Golgi Complex 311
Glycosylation in the Golgi Complex 313
Vesicular Transport Within the Golgi
Complex 313
8 5 Types of Vesicle Transport and Their
Functions 315
COPII-Coated Vesicles: Transporting Cargo
from the ER to the Golgi Complex 316
COPI-Coated Vesicles: Transporting Escaped
Proteins back to the ER 317
Clathrin-Coated Vesicles: Targeting Proteins
from the TGN 319
Targeting Vesicles to a Particular
Compartment 320
Exocytosis: The Terminal Stage
of Secretion 321
8 6 Lysosomes 323
The Human Perspective: Disorders Resulting from Defects
in Lysosomal Function 326
8 7 Protein Destruction in Proteasomes 327
8 8 Plant Cell Vacuoles 329
8 9 Cellular Uptake of Particles and
Macromolecules 329
Phagocytosis 330
Endocytosis 331
Experimental Pathways: Receptor-Mediated
Endocytosis 337
CHAPTER 9 THE CYTOSKELETON AND
CELL MOTILITY 344
9 1 Overview of the Major Functions of the
Cytoskeleton 345
9 2 The Study of the Cytoskeleton 346
The Use of Fluorescence Microscopy 346
The Use of Video Microscopy and In Vitro
Motility Assays 347
The Use of Electron Microscopic Techniques 349
9 3 Molecular Motors 349
9 4 Microtubules 350
Structure and Composition 350
Microtubule-Associated Proteins 351
Function 352
Microtubular Motors and In Vitro Motility
Assays 355
Microtubule-Organizing Centers
(MTOCs) 358
The Dynamic Properties of Microtubules 362
Cilia and Flagella: Structure and Function 366
9 5 Intermediate Filaments 374
Intermediate Filament Assembly and
Disassembly 375
Types and Functions of Intermediate
Filaments 376
Contents xvii
Microfilaments 378
Microfilament Assembly and Disassembly
Myosin: The Molecular Motor for Actin
Filaments 382
Muscle Contractility 384
The Sliding Filament Model of Muscle
Contraction 386
The Human Perspective: The Molecular Basis of Muscular
Dystrophy 392
9 8 Nonmuscle Motility 393
Actin-Binding Proteins 394
Examples of Nonmuscle Motility and
Contractility 397
Experimental Pathways: The Molecular Motor That Drives
Fast Axonal Transport 405
CHAPTER 10 THE NATURE OF THE CENE AND
THE GENOME 413
The Concept of a Gene as a Unit of
Inheritance 414
Chromosomes: The Physical Carriers of the
Genes 415
The Discovery of Chromosomes 415
The Chromosomes as the Carriers of Genetic
Information 416
Genetic Analysis in Drosophila 417
Crossing Over and Recombination 417
Mutagenesis and Giant Chromosomes 418
The Chemical Natureofthe
Gene 420
The Structure of DNA 420
The Watson-Crick Proposal 423
The Structure of the Genome 428
The Complexity of the Genome 435
The Human Perspective: Diseases That Result from
Expansion of Trinucleotide Repeats 435
The Stability of the Genome 437
Duplication and Modification of DNA
Sequences 437
Mobile Genetic Elements 440
Molecular Maps of the Genome 443
Restriction Endonucleases 444
The Human Perspective: Sequencing the Human
Genome 447
Experimental Pathways: The Chemical Nature
of the Gene 448
CHAPTER 11 EXPRESSION OF GENETIC
INFORMATION: FROM TRANSCRIPTION
TO TRANSLATION 457
11 1 The Relationship Between Genes and
Proteins 458
An Overview of the Flow of Information
Through the Cell 460
11 2 Transcription: The Basic Process 461
Transcription in Prokaryotes 463
11 3 Transcription and RNA Processing
in Eukaryotic Cells 465
Ribosomal RNAs 465
Transfer RNAs 472
Messenger RNAs 472
Evolutionary Implications of Split Genes and
RNA Splicing 488
Creating New Ribozymes in the
Laboratory 490
The Human Perspective: Clinical Applications
of Ribozymes and Antisense Oligonucleotides 491
11 4 Encoding Genetic Information 492
The Properties of the Genetic Code 493
Decoding the Codons: The Role of the
Transfer RNAs 495
The Structure of tRNAs 495
Translating Genetic Information 499
Initiation 499
Elongation 501
Termination 503
Experimental Pathways: The Role of RNA as a
Catalyst 506
CHAPTER 12 THE CELL NUCLEUS AND THE
CONTROL OF GENE EXPRESSION 514
12 1 The Nucleus of a Eukaryotic Cell:
An Overview 515
The Nuclear Envelope 515
Chromosomes 519
The Human Perspective: Chromosomal Aberrations 532
The Nucleus as an Organized Organelle 534
12 2 Control of Gene Expression
in Prokaryotes 537
The Bacterial Operon 538
12 3 Control of Gene Expression in Eukaryotes:
An Overview 542
Transcriptional-Level Control 544
Processing-Level Control 558
Translational-Level Control 560
xviii Contents
Experimental Pathways: Genes That Control Embryonic
Development 565
CHAPTER 13 DNA REPLICATION AND
REPAIR 575
13 1 DNA Replication 576
Semiconservative Replication 576
Replication in Bacterial Cells 578
The Structure and Functions of DNA
Polymerases 587
Replication in Eukaryotic Cells 590
13 2 DNA Repair 596
Nucleotide Excision Repair 597
Base Excision Repair 598
Mismatch Repair 599
The Human Perspective: Human Nucleotide Excision
Repair Deficiencies 599
Experimental Pathways: The Role of Human NER
Deficiencies in DNA Repair Research 601
CHAPTER 14 CELLULAR REPRODUCTION 608
14 1 The Cell Cycle 609
Cell Cycles in Vivo 610
Cell Cycle Synthetic Activities 610
Control of the Cell Cycle 611
14 2 M Phase: Mitosis and Cytokinesis 616
Prophase 618
Prometaphase 622
-Metaphase 623
Anaphase 626~ —
Telophase 628
Forces Required for Mitotic Movements 628
Cytokinesis 631
14 3 Meiosis 635
The Stages of Meiosis 637
The Human Perspective: Meiotic Nondisjunction and
Its Consequences 642
Genetic Recombination During Meiosis 644
Experimental Pathways: The Discovery and
Characterization ofMPF 647
CHAPTER 15 CELL SIGNALING:
COMMUNICATION BETWEEN CELLS AND
THEIR ENVIRONMENT 655
15 1 Basic Characteristics of Cell-Signaling
Systems 656
15 2 Second Messengers and G Protein-Coupled
Receptors 658
The Discovery of a Second Messenger:
Cyclic AMP 658
Glucose Mobilization: An Example of a Response
Induced by cAMP 659
The Structure and Function of G Protein-Coupled
Receptors 663
The Human Perspective: Disorders Associated with G
Protein-Coupled Receptors 666
Lipid-Derived Second Messengers 668
15 3 The Role of Calcium as a Second
Messenger 671
Regulating Calcium Concentrations in Plant
Cells 673
15 4 Receptor Tyrosine Kinases: A Second Major
Type of Signaling Pathway 675
The Mechanism of Action of Insulin: Signaling
by an RTK 675
The Role ofRTKs in Other Cellular
Activities 677
15 5 Signals That Originate from Contacts Between
the Cell Surface and the Substratum 680
Controlling the Assembly of Focal
Adhesions 682
15 6 Convergence, Divergence, and Crosstalk
Among Different Signaling Pathways 684
An Example of Convergent Signaling
Pathways 684
An Example of Divergent Signaling
Pathways 685
An Example of Crosstalk Between Signaling
Pathways 686
15 7 Other Signaling Pathways 686
The Role of NO and CO as Cellular
Messengers 687
The Role of Phosphatases in Cell Signaling 688
Pathways That Lead to Cell Death 688
Signaling Pathways in Plants 690
Experimental Pathways: The Discovery and
Characterization of GTP-Binding Proteins 691
CHAPTER 16 CANCER 700
16 1 The Biology of Cancer 701
The Phenotype of a Cancer Cell 702
16 2 The Causes of Cancer 704
16 3 The Genetics of Cancer 705
Tumor-Suppressor Genes and Oncogenes: Brakes
and Accelerators 707
16 4 New Strategies for Combating Cancer 720
Immunotherapy 721
Gene Therapy 722
Contents xix
Inhibiting the Activity of Cancer-Promoting
Proteins 722
Inhibiting the Formation of Blood Vessels 723
Experimental Pathways: The Discovery
of Oncogenes 725
CHAPTER 17 THE IMMUNE RESPONSE 733
17 1 An Overview of the Immune Response 734
Innate Immune Responses 734
Acquired Immune Responses 736
17 2 The Clonal Selection Theory as It Applies
to B Cells 737
Vaccination 740
17 3 T Lymphocytes: Activation and Mechanism
of Action 740
17 4 Selected Topics on the Cellular and Molecular
Basis of Immunity 743
The Modular Structure of Antibodies 743
DNA Rearrangement of Genes Encoding B- and
T-Cell Antigen Receptors 746
Membrane-Bound Antigen Receptor
Complexes 750
The Major Histocompatibility Complex 750
Distinguishing Self from Nonself 755
Lymphocytes Are Activated by Cell-Surface
Signals 756
Signal Transduction Pathways Used in
Lymphocyte Activation 757
The Human Perspective: Autoimmune Diseases 759
Experimental Pathways: The Role of the Major
Histocompatibility Complex in Antigen
Presentation 761 -
CHAPTER I« TECHNIQUES IN CELL AND
MOLECULAR BIOLOGY 768
18 1 The Light Microscope 769
Resolution 769
Visibility 770
Phase-Contrast Microscopy 771
Fluorescence Microscopy 773
Polarization Microscopy 773
Video Microscopy and Image Processing 774
Confocal Scanning Microscopy 774
Preparation of Specimens for Light
Microscopy 775
18 2 Transmission Electron Microscopy 775
Specimen Preparation for Electron
Microscopy 777
18 3 Scanning Electron Microscopy 781
18 4 The Use of Radioisotopes 783
Autoradiography 785
18 5 Cell Culture 785
18 6 The Fractionation of a Cell s Contents
by Differential Centrifugation 788
18 7 Isolation, Purification, and Fractionation
of Proteins 789
Selective Precipitation 790
Chromatography 790
Polyacrylamide Gel Electrophoresis 792
18 8 Determination of Protein Structure by X-Ray
Diffraction Analysis - 794
18 9 Purification and Fractionation
of Nucleic Acids 795
Separation of DNAs by Gel
Electrophoresis 796
18 10 Measurements of Protein and Nucleic Acid
Concentration by Spectrophotometry 796
18 11 Ultracentrifugation 796
Sedimentation Behavior of Nucleic Acids 798
18 12 Nucleic Acid Hybridization 799
18 13 Recombinant DNA Technology 800
DNA Cloning 802
Chemical Synthesis and Site-Directed
Mutagenesis 807
Gene Transfer into Eukaryotic Cells and
Mammalian Embryos 807
Enzymatic Amplification of DNA by PCR 811
DNA Sequencing 812
18 14 The Use of Antibodies 814
|
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| genre | (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV012871421 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:35:13Z |
| institution | BVB |
| isbn | 0471192791 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008760283 |
| oclc_num | 245936030 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-11 |
| owner_facet | DE-19 DE-BY-UBM DE-11 |
| physical | Getr. Zählung Ill., graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Wiley |
| record_format | marc |
| spelling | Karp, Gerald Verfasser aut Cell and molecular biology concepts and experiments Gerald Karp 2. ed. New York [u.a.] Wiley 1999 Getr. Zählung Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Zelle (DE-588)4067537-3 gnd rswk-swf Cytologie (DE-588)4070177-3 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Cytologie (DE-588)4070177-3 s DE-604 Zelle (DE-588)4067537-3 s Molekularbiologie (DE-588)4039983-7 s 1\p DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008760283&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Karp, Gerald Cell and molecular biology concepts and experiments Molekularbiologie (DE-588)4039983-7 gnd Zelle (DE-588)4067537-3 gnd Cytologie (DE-588)4070177-3 gnd |
| subject_GND | (DE-588)4039983-7 (DE-588)4067537-3 (DE-588)4070177-3 (DE-588)4123623-3 |
| title | Cell and molecular biology concepts and experiments |
| title_auth | Cell and molecular biology concepts and experiments |
| title_exact_search | Cell and molecular biology concepts and experiments |
| title_full | Cell and molecular biology concepts and experiments Gerald Karp |
| title_fullStr | Cell and molecular biology concepts and experiments Gerald Karp |
| title_full_unstemmed | Cell and molecular biology concepts and experiments Gerald Karp |
| title_short | Cell and molecular biology |
| title_sort | cell and molecular biology concepts and experiments |
| title_sub | concepts and experiments |
| topic | Molekularbiologie (DE-588)4039983-7 gnd Zelle (DE-588)4067537-3 gnd Cytologie (DE-588)4070177-3 gnd |
| topic_facet | Molekularbiologie Zelle Cytologie Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008760283&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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