Chromatin: structure and function
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
San Diego [u.a.]
Acad. Press
1998
|
| Edition: | 3. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 447 S. Ill., graph. Darst. |
| ISBN: | 0127619151 0127619143 |
Staff View
MARC
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| 100 | 1 | |a Wolffe, Alan |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Chromatin |b structure and function |c A. Wolffe |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a San Diego [u.a.] |b Acad. Press |c 1998 | |
| 300 | |a XIV, 447 S. |b Ill., graph. Darst. | ||
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Record in the Search Index
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| adam_text | Contents
Preface to the first edition ix
Preface to the second edition xi
Preface to the third edition xiii
1 Overview 1
1.1 Introductory comments 1
1.2 Development of research into chromatin structure and
function 2
2 Chromatin Structure 7
2.1 DNA and histones 7
2.1.1 DNA structure 8
2.1.2 The histones 15
2.2 The nucleosome 19
2.2.1 The nucleosome hypothesis 19
2.2.2 The organization of DNA and histones in the
nucleosome 20
2.2.3 The structure of DNA in the nucleosome 26
2.2.4 The position of the core histones in the nucleosome 30
2.2.5 DNA sequence directed positioning of nucleosomes 41
2.3 The organization of nucleosomes into the chromatin fibre 50
2.3.1 Histone HI and the compaction of nucleosomal
arrays 50
2.3.2 The chromatin fibre 58
vi Contents
2.4 Chromosomal architecture 66
2.4.1 The radial loop and helical folding models of
chromosome structure 67
2.4.2 The nuclear infrastructure, the centromere,
telomeres, protein components and their function 71
2.4.3 Lampbrush and polytene chromosomes 84
2.5 Modulation of chromosomal structure 87
2.5.1 Histone variants 88
2.5.2 Post translational modification of core histones 97
2.5.3 Linker histone phosphorylation 108
2.5.4 Activators and repressors that make use of
chromatin modifications to regulate transcription 111
2.5.5 Remodelling of chromatin during spermatogenesis 126
2.5.6 Heterochromatin, position effect, locus control
regions and insulators 128
2.5.7 DNA methylation and chromatin 141
2.5.8 The HMGs and related proteins 151
2.5.9 Functional compartmentalization of the nucleus 157
3 Chromatin and Nuclear Assembly 173
3.1 Interactions between nuclear structure and cytoplasm 173
3.1.1 Nuclear transplantation, remodelling and assembly 174
3.1.2 Heterokaryons 187
3.2 Chromatin assembly 189
3.2.1 Chromatin assembly on replicating endogenous
chromosomal DNA in vivo 190
3.2.2 Chromatin assembly in vitro 195
3.3 Experimental approaches towards the reconstirution of
transcriptionally active and silent states 203
3.3.1 Purified systems 203
3.3.2 Chromatin assembly and transcription in Xenopus
eggs and oocytes 206
3.3.3 Chromatin assembly on DNA introduced into
somatic cells 215
3.3.4 Yeast minichromosomes 220
3.4 Modulation of the chromosomal environment during
development 224
3.4.1 Tetrahymena 224
3.4.2 Xenopus and sea urchin 226
3.4.3 The mouse 232
3.4.4 Developmental regulation of long range chromatin
structure 234
1
Contents vii
4 How do Nuclear Processes Occur in Chromatin? 240
4.1 Overview of nuclear processes 240
4.1.1 The problem of specificity 241
4.1.2 Action at a distance 246
4.1.3 The transcriptional machinery 249
4.1.4 Stable and unstable transcription complexes 260
4.1.5 Regulation of gene activity 266
4.1.6 Sequence specific DNA binding proteins 269
4.1.7 Problems for nuclear processes in chromatin 274
4.2. Interaction of trans acting factors with chromatin 275
4.2.1 Non specific interactions 276
4.2.2 Specific trans acting factors and non specific
chromatin 279
4.2.3 Specific trans acting factors and specific chromatin 286
4.2.4 Trans acting factors, DNase I sensitivity, DNase I
hypersensitive sites and chromosomal architecture 299
4.2.5 Trans acting factors and the local organization of
chromatin structure 311
4.3 Processive enzyme complexes and chromatin structure 315
4.3.1 Replication and the access of transcription factors
to DNA 316
4.3.2 The fate of nucleosomes and transcription
complexes during replication 320
4.3.3 Chromatin structure and DNA replication 326
4.3.4 Transcription and chromatin integrity in vivo 328
4.3.5 Transcription and chromatin integrity in vitro 333
4.4 Chromatin structure and DNA repair 337
4.4.1 Influence of chromatin structure on DNA damage 338
4.4.2 Repairing DNA and chromatin 339
5 Future Prospects 342
5.1 Local chromatin structure 342
5.2 Long range chromatin and chromosomal structure 345
References 348
Index 434
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:32:30Z |
| institution | BVB |
| isbn | 0127619151 0127619143 |
| language | English |
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| physical | XIV, 447 S. Ill., graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Acad. Press |
| record_format | marc |
| spelling | Wolffe, Alan Verfasser aut Chromatin structure and function A. Wolffe 3. ed. San Diego [u.a.] Acad. Press 1998 XIV, 447 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Chromatine Chromatine - Physiologie Chromatine - Ultrastructure Chromatine gtt Chromatin Chromatin physiology Chromatin ultrastructure Chromosomes DNA Chromatin (DE-588)4010152-6 gnd rswk-swf Chromatin (DE-588)4010152-6 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008647511&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wolffe, Alan Chromatin structure and function Chromatine Chromatine - Physiologie Chromatine - Ultrastructure Chromatine gtt Chromatin Chromatin physiology Chromatin ultrastructure Chromosomes DNA Chromatin (DE-588)4010152-6 gnd |
| subject_GND | (DE-588)4010152-6 |
| title | Chromatin structure and function |
| title_auth | Chromatin structure and function |
| title_exact_search | Chromatin structure and function |
| title_full | Chromatin structure and function A. Wolffe |
| title_fullStr | Chromatin structure and function A. Wolffe |
| title_full_unstemmed | Chromatin structure and function A. Wolffe |
| title_short | Chromatin |
| title_sort | chromatin structure and function |
| title_sub | structure and function |
| topic | Chromatine Chromatine - Physiologie Chromatine - Ultrastructure Chromatine gtt Chromatin Chromatin physiology Chromatin ultrastructure Chromosomes DNA Chromatin (DE-588)4010152-6 gnd |
| topic_facet | Chromatine Chromatine - Physiologie Chromatine - Ultrastructure Chromatin Chromatin physiology Chromatin ultrastructure Chromosomes DNA |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008647511&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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