Proton therapy and radiosurgery: with 60 tables
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| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
2000
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVI, 288 S. Ill., graph. Darst. |
| ISBN: | 3540641009 |
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MARC
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| 100 | 1 | |a Breuer, Hans |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Proton therapy and radiosurgery |b with 60 tables |c Hans Breuer ; Berend J. Smit |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2000 | |
| 300 | |a XVI, 288 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| _version_ | 1804127378926993408 |
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| adam_text | Parti Radiation Physics
A General Aspects 1
A. 1 A Brief History of Charged Particle Radiotherapy 1
A.2 Heavy Charged Particle Radiotherapy Facilities 2
A.2.1 Proton Radiotherapy Facilities in Operation 2
A.2.2 Heavy Charged Particle Facilities in Operation 3
A.2.3 Facilities under Construction
or at the Planning Stage 3
B Basics 5
B.I Protons 5
B.I.I Physical Properties 5
B. 1.2 The Proton s Position in the Hierarchy of Particles 5
B.1.3 Proton Radiotherapy 5
B.2 Sources of Protons 7
B.2.1 Proton Accelerators 8
B.2.la General Requirements 8
B.2. lb Proton Accelerators Suitable for Radiotherapy 9
B.2.2 Comparison of Existing Proton Accelerator Types 10
B.3 The Proton Beam Line 10
B.3.1 Beam Transport System 10
B.3.2 Shielding of the Beam Transport System 12
B.4 A Future Proton Source for Medical Applications 13
B.5 Summary: Design Criteria for Radiotherapy Proton Beams 14
B.5.1 Clinical Requirements 15
B.5.1a Beam Penetration and Precision 15
B.5.1b Radiation Dose and Dose Rate 15
B.5.2 Patient Set up 16
B.5.3 Accelerator 16
C Interaction of Protons with Matter 19
C.I EnergyLoss 19
C.I.I Energy Loss by Excitation and Ionization 20
C.1.2 Energy Loss by Nuclear Interactions 22
C. 1.2a Elastic Nuclear Interactions 22
C.1.2b Inelastic Nuclear Interactions 22
C.1.3 Energy Losses for E 0.5 MeV 22
C.1.4 Summary 23
VIII Table of Contents
C.2 Proton Scattering 24
C.2.1 Elastic Coulomb Scattering 24
C.2.la Introduction 24
C.2.1b Moliere Theory 25
C.2.1c Approximations for Moliere s Distribution 27
C.2.Id Comparison with Experiments 28
C.2.2 Inelastic Scattering 29
C.3 Energy Range Relation 30
C.3.1 Pathlength, Mean Range and Water Equivalent Ratio 30
C.3.2 Range Straggling 33
C.3.3 Range Uncertainty 34
C.4 Bragg Distribution 35
C.4.1 Shape of the Bragg Distribution 35
C.4.2 Deviations from the Bragg Distribution 37
C.4.2a Particle Beam Diameter and the Bragg Peak 37
C.4.2b Influence of Inhomogeneous Media 37
C.5 Protons Penetrating Tissue 38
C.5.1 Taking Account of Tissue Densities 38
C.5.2 Tissue Density and CT Number 40
C.5.2a Definitions 40
C.5.2b Accuracy of the CT Numbers 40
C.5.3 Influence of Edges and Inhomogeneities 41
C.5.3a EdgeEffects 42
C.5.3b Small Inhomogeneities 42
C.5.3c Narrow but Long (Thick) Inhomogeneities 43
C.6 Proton Dosimetry and Proton Dose Measurement 43
C.6.1 Dosimetry Units 44
C.6.1a Absorbed Radiation Dose 44
C.6.1b Ion Dose 44
C.6.1 c Conversion of Ion Dose
into Absorbed Radiation Dose 44
C.6.2 DoseDisplay 45
C.6.2a Isodose Lines 45
C.6.2b 3D and Beam s Eye View 46
C.6.2c Dose Volume Histogram (DVH) 47
C.6.3 Instrumentation 48
C.6.3a Ionization Chamber 48
C.6.3b FaradayCup 49
C.6.3c Silicon Diode 50
C.6.3d Calorimeter 50
C.7 Summary and Comparison with Photon Radiotherapy 50
D Modifying the Proton Beam 53
D.I Survey 53
D.2 Static Beam Shaping 53
D.2.1 Transverse Beam Shaping 53
D.2.1a Single Scatterer 53
I
I
Table of Contents IX
D.2.1b Double Scatterer 54
D.2.1c Apertures 55
D.2.2 Longitudinal Beam Shaping 55
D.2.2a Shifting the Bragg Peak 55
D.2.2b Spread Out Bragg Peak (SOBP) 56
D.2.2c Generating a Spread Out Bragg Peak 58
D.2.2d Problems connected with the SOBP 59
D.2.2e Distal Isodose Shaping Device (DISD) 59
D.2.3 Beam Shaping and the Penumbra 60
D.3 Dynamic Radiation Field Shaping 61
D.3.1 Principle of Operation 61
D.3.2 Beam Scanner 61
D.3.2a Wobbler 61
D.3.2b Linear Scanner 62
D.3.3 Advantages and Disadvantages 63
D.3.4 Summary 64
E Conformal Proton Radiotherapy Planning 65
E. 1 Introduction 65
E.I.I The Role of Inhomogeneities 65
E.1.2 Target Movements 66
E. 1.3 The Influence of Multiple Scattering 67
E.2 Planning Methods 69
E.2.1 Datalnput 69
E.2.1a Ultrasound 70
E.2.1b X rays 70
E.2.1c Computer Tomography (CT) 70
E.2.Id Magnetic Resonance Imaging (MRI) 71
E.2.1e Fusion of Anatomical and Functional Data 71
E.2.2 Algorithms 71
E.2.2a Monte Carlo Method 72
E.2.2b Ray Tracing 73
E.2.2c Pencil Beam 74
E.2.2d Broad Beam 76
E.2.3 Planning for Eye Treatment 77
E.2.3a Input 77
E.2.3b Algorithms 77
E.2.4 Comparison of Treatment Planning Algorithms 79
E.2.4a Intercomparison of Different Algorithms 79
E.2.4b Comparison with Simplified Measurements 79
E.2.5 Summary 81
E.3 Overall Accuracy of Treatment Planning and Execution 83
E.3.1 General Considerations 83
E.3.2 Factors Influencing Accuracy and Precision 83
E.3.2a Accuracy 83
E.3.2b Precision 85
E.3.2c OtherFactors 85
X Table of Contents
E.3.3 Overall Accuracy 86
E.3.3a General 86
E.3.3b Overall Accuracy of Eye Treatment 86
References for Part I 87
PART II Proton Therapy and Radiotherapy
F General Aspects of Proton Therapy 93
F.I General Clinical Overview 93
F.I.I A Brief Medical History 93
F.I.1.1 Early Proton Therapy 94
El.1.2 Modern Proton Therapy 94
F.I.2 History of Non proton Radiosurgery 95
F.I.3 Indications for Proton Therapy 96
F.I.4 Imaging and Planning Requirements 96
F.I.5 Beam Delivery Requirements 98
F.1.6 Patient Positioning and Immobilisation 98
F.1.7 Positioning for Extracranial Lesions 99
F. 1.8 The Composition of Tissues and Proton Therapy Planning 99
F.I.9 Optimised Proton Beams versus
Photon Based Radiosurgery Beams 100
F.I.10 Summary 104
F.I.11 References 106
G The Rationale for Proton Therapy 109
G. 1 Introduction 109
G.2 Bragg Peak Therapy 109
G.2.1 The Conformity Index Ill
G.2.2 The Inhomogeneity Coefficient and Its Effects Ill
G.2.3 The Localisation Factor 112
G.3 Plateau Therapy 114
G.4 Definition of Radiosurgery and Stereotactic Radiotherapy 115
G.5 Large Field Proton Therapy 116
G.6 Summary 117
G.7 References 118
H Radiobiology 119
H.I Radiobiology for Fractionated Proton Therapy 119
H.I.I Introduction 119
H.1.2 Linear Energy Transfer 119
i
Table of Contents XI
H.1.3 The Therapeutic Ratio 120
H.1.4 The Relative Biological Effectiveness 121
H.I.5 Dose Response Curves 122
H.1.6 The Importance of Fractionation 125
H.1.7 The Oxygen Enhancement Ratio The OER 126
H. 1.8 The Gamma Factor, Malignant Lesions and
Fractionated Proton Therapy 126
H.1.9 Inhomogeneity of Dose and Its Effects 127
H.I.10 Radiosensitisers/Radioprotectors 128
H.I.11 Summary 128
H.I.12 References 129
H.2 The Radiobiology of Single Large Fractions 130
H.2.1 Introduction 130
H.2.2 The Effect of the RBE Variation in the
Penumbra of Proton Beams 130
H.2.3 The Cobalt Gray Equivalent Dose 132
H.2.4 The Oxygen Enhancement Ratio and
radiological effects of Large Single Doses 132
H.2.5 Inhomogeneity of Dose and Its Effects; the Volume Effect 133
H.2.6 Fractionated Dose Equivalents to Single Large Doses 133
H.2.7 Categories of Lesions in the Brain 133
H.2.7.1 Category 1: AVMs and Similar Lesions 133
H.2.7.2 Category 2: Meningiomas and Similar Lesions 134
H.2.7.3 Category 3: Low Grade Astrocytoma
and Similar Lesions 134
H.2.7.4 Category 4: Metastatic Lesions 134
H.2.8 Summary 135
H.2.9 References 135
H.3 The Biologically Effective Dose and Fractionation 136
H.3.1 Introduction 136
H.3.2 Notational Convention for the BED 136
H.3.3 The Linear Quadratic Model of Cell and
Tissue Response to Radiation and the BED 136
H.3.4 Some Commonly Used Values for the tx/p Ratio 137
H.3.5 Inhomogeneity of Dose and the Relative Damage 138
H.3.6 Brain Tolerance 138
H.3.7 Optic Nerve and Retinal Tolerance 139
H.3.8 A Comparison of the Various Dose Levels Used to
Treat Uveal Melanoma 141
H.3.9 Age Related Macular Degeneration 141
H.3.10 The RBE of Protons 142
H.3.11 The Dose Volume Histogram 142
H.3.12 Summary 143
H.3.13 References 143
XII Table of Contents
I. Dose Volume Relationships in Proton Therapy and
Radiosurgery for Arteriovenous Malformations,
Skull Base Meningiomas and Recurrent Malignant Gliomas 145
1.1 Introduction 145
1.2 Arteriovenous Malformations 146
1.2.1 Kjellberg s Model for Protons 146
1.2.2 Dose volume Observations of Voges etal. (1996) 147
1.2.3 Flickinger s Models for the Gamma Knife 147
1.2.4 Dose volume Analysis of Lax and Karlsson (1996) 150
1.2.5 Karlsson and Lax etal (1997) 150
1.3 General Discriminants Influencing Dose volume Relationships 151
1.4 Illustration of the Effect of the Penumbra and the Prescription
Isodose on a Volume of Brain Tissue Constrained to [ 10 Gy 10 cm3 ] 154
1.5 Methodology for Calculating the Effects of the Prescription
Isodose and Penumbra on the Planning Target Volume
Treatable to Safe Doses Within the Constraints of[10Gyl0cm3] 154
1.5.1 The Critical Isodose (CI) 154
1.5.2 Direct (Computer) Determination of the PTV 156
1.6 Dose volume Graphs Based on Voges (1996) 157
1.7 Practical Implementation of the Various Dose volume
Relationships Available Presently for AVM Radiosurgery 158
1.8 Recurrent Previously Irradiated Brain Tumours 160
1.9 The Effects of Imperfect Conformation 160
1.10 Retreatment 161
1.11 Summary 161
1.12 References 161
J Low Energy Proton Beam Therapy for Eye Lesions 163
J. 1 Introduction 163
J.2 Benign Lesions 163
J.2.1 Peri orbital Lesions 163
J.2.2 Age Related Macular Degeneration 164
J.3 Malignant Lesions: Uveal Melanoma 166
J.3.1 Introduction 166
J.3.2 Proton Therapy 166
J.3.2.1 General 166
J.3.2.2 Results of Proton Therapy 167
J.3.2.3 Techniques of Proton Irradiation 167
J.3.3 Treatment of Uveal Melanoma by Gamma Knife 171
J.3.4 Plaque Techniques 172
J.4 Metastatic Lesions in the Eye 173
J.5 Complications 174
J.5.1 Neovascular Glaucoma 174
J.5.2 Retinopathy, Optic Neuropathy, Rubeosis Iridis 174
J.6 Comparison of the Various Dose Levels Used to
Treat Uveal Melanoma Using the BED 175
J.7 Tolerance of the Optic Nerve and Retina 175
Table of Contents XIII
J.8 Summary 175
J.9 References 176
K High Energy Proton Therapy for Tumours in
Body Sites other than the Brain 179
K. 1 Introduction 179
K.2 Co operative Proton Therapy Groups 179
K.2.1 The Proton Therapy Co operative Oncology Group 179
K.2.2 The Proton Radiation Oncology Group 179
K.3 Protons for Superficial Tumours 180
K.3.1 Skin and Chest Wall 180
K.3.2 Ethmoid Sinus Tumours 180
K.3.3 Chordomas, Chondromas and Chondrosarcomas 181
K.3.3.1 Photon Therapy for Chondromas and Chordomas 181
K.3.3.2 Proton Therapy 182
K.3.3.3 Surgery plus Radiotherapy 183
K.3.4 Esthesioneuroblastoma and Chemo Proton Radiation 184
K.4 Protons for Deep Seated Body Tumours 184
K.4.1 Large Field Therapy with Horizontal Beams 184
K.4.1.1 Prostate Carcinoma 184
K.4.2 Large Field Therapy with Isocentric Beams 185
K.4.2.1 Prostate Carcinoma 185
K.4.2.2 Potential Improvement in the Results
of Proton Irradiation for Prostate Cancer 186
K.4.2.3 Brachytherapy for Prostate Carcinoma 187
K.4.3 Oesophageal Carcinoma 187
K.4.4 Brain Metastases 187
K.5 Potential Gains with Protons in Various Anatomical Sites 187
K.5.1 Glioblastoma 188
K.5.2 Brain Tumours in Children 188
K.5.3 Maxillary Sinus 189
K.5.4 Cervical Carcinoma 189
K.5.5 Para aortic Lymph Nodes 190
K.5.6 Retroperitoneal Cancer in a Child with Wilm s Tumour 191
K.5.7 RectalCancer 191
K.6 Summary 191
K.7 References 192
L Radiosurgical Applications of Protons and Photons 195
L.I Vascular Malformations 195
L.I.I Introduction 195
L. 1.2 Arteriovenous Malformations 195
L.l.2.1 Clinical Features of AVMs 196
L.l.2.2 Pathology and Prognostic Factors 196
L.l.2.3 Evaluation Methods for AVMs 197
L.I.2A Treatment Options for Ateriovenous Malformations 199
L.l.2.5 Multidisciplinary Teams 200
XIV Table of Contents
L. 1.2.6 Proton Radiosurgery for AVMs and Other Methods 200
L.l.2.7 Quality Control 201
L.l.2.8 Grading the AVM 202
L.l.2.9 Assessing Treatment Outcome The Scale of Drake 202
L.I.2.10 Assessing the Radiological Outcome of Radiosurgery.... 203
L.l.2.11 Treatment Related Risks 203
L.I.2.12 Post Treatment Observation, Follow up and Medication 203
L.I.2.13 Radiosurgical Prescription
and Dose CGyE for Proton 204
L. 1.2.14 Recommended Doses for AVMs 204
L.l.2.15 Proton and Helium Ion Bragg Peak Therapy for AVMs ... 206
L. 1.2.16 The Obliteration Rate of AVMs with Particles 207
L.l.2.17 The Obliteration Rate of AVMs by Gamma Knife and
Linear Accelerator 209
L.I.2.18 Reducing the Risk of Radionecrosis 210
L.l.2.19 Side Effects of Treatment 210
L.l.2.20 Causes for Recurrence of AVMs 211
L. 1.2.21 A Critique on Radiosurgical Techniques 211
L.1.3 Summary 212
L.1.4 References 214
L.2 Acoustic and Non acoustic Neuromas 215
L.2.1 Introduction 215
L.2.2 Incidence and Symptoms 215
L.2.3 Radiation and Growth Arrest of Neuromas 215
L.2.4 Indications for Radiosurgery 216
L.2.5 Strategies for Hearing Preservation 216
L.2.6 Complications Other than Hearing Loss with Microsurgery 217
L.2.7 Clinical Results for Acoustic Neuromas 218
L.2.7.1 Proton Therapy 218
L.2.7.2 Gamma Knife and Linear Accelerator 218
L.2.7.3 Risk Factors for Complications 219
L.2.1 A Recommended Doses for Acoustic Neuromas 219
L.2.7.5 Radiological Changes After Radiosurgery 220
L.2.8 Summary 220
L.3 Meningiomas 220
L.3.1 Incidence and Pathology 220
L.3.2 Treatment Options 221
L.3.3 Results of Treatment 222
L.3.4 Recommended Doses 222
L.3.5 Complications of Radiosurgery for Meningioma 224
L.3.6 Summary 224
L.3.7 References 225
L.4 Pituitary Tumours 226
L.4.1 Introduction 226
L.4.2 Anatomy 227
L.4.3 Classification 227
L.4.4 The Aims of Therapy 228
Table of Contents XV
L.4.5 Signs and Symptoms 228
L.4.6 Diagnosis 228
L.4.7 Treatment 229
L.4.7.1 Conventional Radiation Therapy 229
L.4.7.2 Radiosurgery for Pituitary Tumours 230
L.4.7.3 Dose Response and Dose Volume Relationships 231
L.4.7.4 Clinical Results 231
L.4.7.5 Complications 233
L.4.8 Summary 233
L.4.9 References 234
L.5 Proton and Stereotactic Radiotherapy for Primary and
Secondary Brain Tumours 235
L.5.1 Introduction 235
L.5.2 The Importance of Fractionation 235
L.5.3 Clinical Results Obtained with Primary Malignant Brain
Tumours with Radiosurgery 236
L.5.4 Selection Factors for Glioma Patients and the
Hazard Ratio Model for Radiosurgey 237
L.5.5 Dose Response for Brain Tumours 238
L.5.6 Brain Tolerance 239
L.6 Secondary Malignant Brain Tumours 239
L.6.1 Conventional Radiotherapy (Whole Brain) 239
L.6.2 Radiosurgery 240
L.6.3 Radiosurgery for Metastases versus Surgery 241
L.6.4 Complications of Radiosurgery for Brain Tumours 241
L.7 Summary 242
L.8 References 242
M The Complications of Single Large Intracranial
Doses of Radiation and their Management 245
M.I Introduction 245
M.2 Classification of Radiation Effects 245
M.2.1 AcuteEffects 245
M.2.2 LateEffects 247
M.2.2.1 Cerebral Oedema 247
M.2.2.2 Cerebral Radionecrosis 249
M.2.2.3 Vascular Occlusion and Aneurysms 250
M.2.2.4 Other Reported Complications 251
M.2.2.5 Cranial Nerve Complications 251
M.2.2.6 Radiation Induced Complications from Pituitary
Lesions, Skull Base Tumours, Uveal Melanoma,
Nasopharyngeal Carcinomas and Sarcomas of the
Skull Base 253
M.2.2.7 Cavernous Sinus Meningiomas 253
M.2.2.8 Parasagittal Meningiomas 253
M.3 Summary 253
M.4 References 254
XVI Table of Contents
N Alternatives to Proton Therapy for Radiosurgery 257
N.I Introduction 257
N.I.I The Linear Accelerator 257
N. 1.1.1 Ease of Conversion 257
N.I.1.2 Versatility and Flexibility 258
N.I.1.3 Relocatable Frames 258
N.I.1.4 Thermoplastic Masks 258
N.I.1.5 Good Beam Delivery and Planning 259
N.I.1.6 Extracranial Radiosurgery 259
N.I.1.7 Miniature Multileaf Collimators 259
N.1.2 The Leksell Gamma Knife 260
N.l.2.1 Limited Choice of Collimators 260
N.l.2.2 Fractionated Treatment 260
N.1.3 The Photon Radiosurgery System 261
N.I.4 A Comparison of the Fall off in Dose 262
N.I.5 Comparative Clinical Results 262
N.2 Large Field Therapy and Alternatives to Protons 262
N.3 Eye Lesions and Protons 263
N.4 Reliability of Equipment 263
N.5 Summary 263
N.6 References 264
O Costs of Proton Therapy and Radiosurgery 267
O.I Introduction 267
0.2 Patient Fees for Stereotactic Treatment 268
0.2.1 Linear Accelerator 268
0.2.2 GammaKnife 268
0.2.3 Proton Therapy 268
0.3 Installation Costs 269
0.4 Maintenance Costs 269
0.5 Life Span of Treatment Units 269
0.6 Cost Comparison: Surgery versus Radiosurgery 269
0.7 Summary 270
0.8 References 271
P Appendix 273
P. 1 The Spetzler Martin Grading System (with Some Remarks) 273
P.2 A Proposed Grading System for AVMs for Radiosurgery 274
P.3 Planning Target Volumes 276
P.4 Lateral Dose Fall off of Various Stationary Radiation Beams 279
P.5 Expanded Tables Based on the Tables of Brenner, Martell and Hall (1991)
for Fractionated Therapy for Recurrent Malignant Brain Tumours 279
P.6 Fractionated Treatment for AVMs 280
P.7 The Stereophotogrammetric System of Patient
Positioning and Immobilisation 281
Subject Index 285
|
| any_adam_object | 1 |
| author | Breuer, Hans Smit, Berend J. 1935- |
| author_GND | (DE-588)121096025 |
| author_facet | Breuer, Hans Smit, Berend J. 1935- |
| author_role | aut aut |
| author_sort | Breuer, Hans |
| author_variant | h b hb b j s bj bjs |
| building | Verbundindex |
| bvnumber | BV012715187 |
| classification_rvk | XH 8550 |
| ctrlnum | (OCoLC)845313344 (DE-599)BVBBV012715187 |
| discipline | Medizin |
| format | Book |
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| id | DE-604.BV012715187 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:32:24Z |
| institution | BVB |
| isbn | 3540641009 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008643830 |
| oclc_num | 845313344 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-29 |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-29 |
| physical | XVI, 288 S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Springer |
| record_format | marc |
| spelling | Breuer, Hans Verfasser aut Proton therapy and radiosurgery with 60 tables Hans Breuer ; Berend J. Smit Berlin [u.a.] Springer 2000 XVI, 288 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Protonenbestrahlung (DE-588)4341228-2 gnd rswk-swf Hirntumor (DE-588)4072521-2 gnd rswk-swf Hirntumor (DE-588)4072521-2 s Protonenbestrahlung (DE-588)4341228-2 s DE-604 Smit, Berend J. 1935- Verfasser (DE-588)121096025 aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008643830&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Breuer, Hans Smit, Berend J. 1935- Proton therapy and radiosurgery with 60 tables Protonenbestrahlung (DE-588)4341228-2 gnd Hirntumor (DE-588)4072521-2 gnd |
| subject_GND | (DE-588)4341228-2 (DE-588)4072521-2 |
| title | Proton therapy and radiosurgery with 60 tables |
| title_auth | Proton therapy and radiosurgery with 60 tables |
| title_exact_search | Proton therapy and radiosurgery with 60 tables |
| title_full | Proton therapy and radiosurgery with 60 tables Hans Breuer ; Berend J. Smit |
| title_fullStr | Proton therapy and radiosurgery with 60 tables Hans Breuer ; Berend J. Smit |
| title_full_unstemmed | Proton therapy and radiosurgery with 60 tables Hans Breuer ; Berend J. Smit |
| title_short | Proton therapy and radiosurgery |
| title_sort | proton therapy and radiosurgery with 60 tables |
| title_sub | with 60 tables |
| topic | Protonenbestrahlung (DE-588)4341228-2 gnd Hirntumor (DE-588)4072521-2 gnd |
| topic_facet | Protonenbestrahlung Hirntumor |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008643830&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT breuerhans protontherapyandradiosurgerywith60tables AT smitberendj protontherapyandradiosurgerywith60tables |