Statistical methods to assess gene-environment: interaction with surrogate genetic measures
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | German |
| Published: |
1999
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Dortmund, Univ., Diss., 1999 |
| Physical Description: | VII, 143 S. graph. Darst. |
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MARC
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| 245 | 1 | 0 | |a Statistical methods to assess gene-environment |b interaction with surrogate genetic measures |c vorgelegt von Silke Schmidt |
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Record in the Search Index
| _version_ | 1807323145145679872 |
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| adam_text |
CONTENTS
1
INTRODUCTION
1
1.1
MOTIVATION
.
1
1.2
OVERVIEW
.
2
2
REVIEW
OF
BASIC
CONCEPTS
6
2.1
STATISTICAL
ASSESSMENT
OF
INTERACTION
EFFECTS
.
6
2.2
REGRESSION
MODELS
FOR
EPIDEMIOLOGIC
DATA
.
12
2.2.1
LOGISTIC
REGRESSION
MODEL
FOR
CASE-CONTROL
STUDIES
.
12
2.2.2
COX
REGRESSION
MODEL
FOR
UNIVARIATE
FAILURE
TIME
DATA
.
16
3
SURROGATE
GENETIC
MEASURES
18
3.1
INCORPORATION
OF
A
FAMILY
RISK
SCORE
IN
LOGISTIC
REGRESSION
MODELS
.
19
3.2
USING
GENETIC
MODELS
TO
ESTIMATE
A
SUSCEPTIBILITY
GENOTYPE
.
23
3.2.1
MIXTURE
LIKELIHOOD
FOR
A
LOGISTIC
REGRESSION
MODEL
.
24
3.2.2
CASE-ONLY
STUDY
FOR
ESTIMATING
GENE-ENVIRONMENT
INTERACTION
.
25
3.2.3
ANALYSIS
OF
CASE-ONLY
DATA
WITH
THE
MIXTURE
LOGISTIC
MODEL
.
34
3.3
FRAILTY
MODELS
TO
ESTIMATE
GENETIC
RANDOM
EFFECTS
.
35
3.3.1
REGRESSION
ANALYSIS
OF
MULTIVARIATE
FAILURE
TIME
DATA
.
38
3.3.2
ESTIMATION
OF
FRAILTY
MODELS
VIA
THE
EM
ALGORITHM
.
43
3.3.3
THE
PENALIZED
LIKELIHOOD
APPROACH
TO
ESTIMATION
OF
FRAILTY
MODELS
.
.
48
3.3.4
IMPLEMENTATION
OF
THE
NEWTON-RAPHSON
ALGORITHM
FOR
LARGE
MATRICES
54
3.4
SUMMARY
AND
REVIEW
OF
RELATED
METHODS
.
59
4
APPLICATION
ON
SIMULATED
AND
REAL
DATA
67
4.1
SIMULATION
OF
FAMILIAL
DISEASE
DATA
WITH
VARIABLE
AGE
AT
ONSET
DUE
TO
GENETIC
AND
ENVIRONMENTAL
EFFECTS
.
67
4.2
ESTIMATION
OF
GENE-ENVIRONMENT
INTERACTION
WITH
SIMULATED
DATA:
COMPARISON
OF
THE
METHODS
.
74
V
4.3
GENETIC
AND
ENVIRONMENTAL
FACTORS
IN
BREAST
CANCER
ETIOLOGY
.
90
4.4
ESTIMATION
OF
GENE-ENVIRONMENT
INTERACTION
IN
A
CASE-CONTROL
STUDY
OF
BREAST
CANCER
.
96
5
CONCLUSIONS
AND
DISCUSSION
118
BIBLIOGRAPHY
128
LIST
OF
SYMBOLS
143 |
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| illustrated | Illustrated |
| indexdate | 2024-08-14T01:07:44Z |
| institution | BVB |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008627754 |
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| physical | VII, 143 S. graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
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| spelling | Schmidt, Silke Verfasser aut Statistical methods to assess gene-environment interaction with surrogate genetic measures vorgelegt von Silke Schmidt 1999 VII, 143 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Dortmund, Univ., Diss., 1999 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008627754&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schmidt, Silke Statistical methods to assess gene-environment interaction with surrogate genetic measures |
| subject_GND | (DE-588)4113937-9 |
| title | Statistical methods to assess gene-environment interaction with surrogate genetic measures |
| title_auth | Statistical methods to assess gene-environment interaction with surrogate genetic measures |
| title_exact_search | Statistical methods to assess gene-environment interaction with surrogate genetic measures |
| title_full | Statistical methods to assess gene-environment interaction with surrogate genetic measures vorgelegt von Silke Schmidt |
| title_fullStr | Statistical methods to assess gene-environment interaction with surrogate genetic measures vorgelegt von Silke Schmidt |
| title_full_unstemmed | Statistical methods to assess gene-environment interaction with surrogate genetic measures vorgelegt von Silke Schmidt |
| title_short | Statistical methods to assess gene-environment |
| title_sort | statistical methods to assess gene environment interaction with surrogate genetic measures |
| title_sub | interaction with surrogate genetic measures |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008627754&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT schmidtsilke statisticalmethodstoassessgeneenvironmentinteractionwithsurrogategeneticmeasures |