Dynamics of bone and cartilage metabolism:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
San Diego [u.a.]
Academic Press
1999
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XX, 672 S. graph. Darst. |
| ISBN: | 0126348405 |
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| 245 | 1 | 0 | |a Dynamics of bone and cartilage metabolism |c ed. by Markus J. Seibel ... |
| 264 | 1 | |a San Diego [u.a.] |b Academic Press |c 1999 | |
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| 650 | 4 | |a Biochemical markers | |
| 650 | 4 | |a Biological Markers | |
| 650 | 4 | |a Bone and Bones |x metabolism | |
| 650 | 4 | |a Bones |x Metabolism | |
| 650 | 4 | |a Bones |x Metabolism |x Disorders | |
| 650 | 4 | |a Cartilage |x Metabolism | |
| 650 | 4 | |a Cartilage |x metabolism | |
| 650 | 4 | |a Extracellular Matrix |x metabolism | |
| 650 | 4 | |a Extracellular matrix | |
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Record in the Search Index
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| adam_text | Con
Contributors xiii
Foreword xvii
Preface xix
Part I Components of the Organic
Extracellular Matrix of Bone
and Cartilage
Chapter 1 Structure and Biosynthesis
of Collagens
Klaus von der Mark
I. Introduction 3
II. The Collagen Families 5
III. Fibril Forming Collagens 6
IV. Nonfibril Forming Collagens 9
V. Collagen Biosynthesis 11
VI. Collagen Genes and Transcriptional
Regulation 14
VII. Factors Regulating Collagen Biosynthesis 17
VIII. Conclusions 17
References 18
Chapter 2 Fibrillogenesis and Maturation
of Collagens
Simon P. Robins
I. Introduction 31
II. Fibrillogenesis 31
tents
III. Cross Linking 33
IV. Concluding Remarks 40
References 40
Chapter 3 Vitamin K Dependent Proteins of
Bone and Cartilage
Caren M. Gundberg and Satoru K. Nishimoto
I. Abstract 43
II. Introduction 43
III. Osteocalcin 44
IV. Matrix Gla Protein 47
V. Gas6 50
VI. Vitamin K/Warfarin 52
References 53
Chapter 4 Noncollageneous Proteins:
Glycoproteins and Related Molecules
Dick Heinegard, Tore Saxne, and Pilar Lorenzo
I. Introduction 59
II. Cartilage Extracellular Matrix 60
III. Bone Extracellular Matrix 63
IV. Concluding Remarks 66
References 66
Chapter 5 Proteoglycans and
Glycosaminoglycans
Tim E. Hardingham
I. Introduction 71
II. Glycosaminoglycans 71
v
vi
III. Proteoglycans in Cartilage 72
IV. Aggrecan 73
V. Leucine Rich Proteoglycans in Cartilage and
Bone 77
References 80
Chapter 6 Growth Factors
Peter I. Croucher and R. Graham G. Russell
I. Introduction 83
II. Insulin like Growth Factors 83
III. The Transforming Growth Factor Beta
Superfamily 84
IV. Fibroblast Growth Factors 87
V. Platelet Derived Growth Factors 88
VI. Additional Growth Factors 88
VII. Summary 89
References 89
Chapter 7 Cytokines and Prostaglandins
Joseph A. Lorenzo and Lawrence G. Raisz
I. Abstract 97
II. The Role of Prostaglandins and Leukotrienes in Bone
and Cartilage Metabolism 97
III. The Role of Cytokines in Bone
and Cartilage Metabolism 99
References 103
Chapter 8 Integrins and
Adhesion Molecules
Miep H. Helfrich and Michael A. Horton
I. Abstract 111
II. Introduction 111
III. Molecular Structure of Adhesion
Molecules 112
IV. Adhesion Molecules in Cells of the Osteoblast
Lineage 114
V. Adhesion Molecules in Osteoclasts 116
VI. Adhesion Molecules in Chondrocytes 118
VII. Receptor Ligand Interaction of Bone Cell Adhesion
Molecules 120
VIII. A Possible Role for Bone Cell Adhesion Molecules
in Sensing Mechanical Strain 120
IX. Conclusion 121
References 122
Chapter 9 Acid and Alkaline Phosphatases
Paula Henthorn, Jose Luis Millan, and Phoebe Leboy
I. Introduction 127
II. Acid Phosphatases 127
III. Alkaline Phosphatases 130
References 134
Contents
Chapter 10 Matrix Proteases
Ian M. Clark and Gillian Murphy
I. Introduction 137
II. Aspartic Proteinases 137
III. Cysteine Proteinases 137
IV. Serine Proteinases 140
V. Metalloproteinases 141
References 146
Part II Structure and Metabolism
of the Extracellular Matrix of Bone
and Cartilage
Chapter 11 Mineralization, Structure, and
Function of Bone
Adele L. Boskey
I. Abstract 153
II. The Structure and Function of Bone 153
III. Bone Mineralization 155
IV. Bone Modeling and Remodeling 161
References 162
Chapter 12 The Cells of Bone
Jane B. Lian and Gary S. Stein
I. Abstract 165
II. Introduction 165
III. Embryonic Origins of Bone 166
IV. Bone Forming Cells 166
V. The Functional Properties and Regulated Activity
of Bone Cells Evolve during Progression along the
Osteoblast Lineage 170
VI. Molecular Mechanisms Mediating Expression of the
Osteoblast Phenotype 172
VII. The Osteoclast: A Functionally Unique Cell
for Physiologically Regulated Resorption of
Bone Mineral 173
VIII. Molecular Mechanisms Mediating Osteoclast
Differentiation 177
IX. Perspectives 177
References 177
Chapter 13 Parathyroid Hormone:
Structure, Function, and Dynamic Actions
Lorraine A. Fitzpatrick and John P. Bilezikian
I. Introduction 187
II. Structure of the PTH Gene 187
Contents
III. Chromosome Location 188
IV. Control of Gene Expression 189
V. Biosynthesis of Parathyroid Hormone 192
VI. Metabolism of Parathyroid Hormone 192
VII. Receptor Interactions of Parathyroid Hormone
and Parathyroid Hormone Related Protein 192
VIII. Structure of the PTH/PTHrP
(PTH1R) Receptor 192
IX. Activation of the Cyclic Adenosine
Monophosphate Second Messenger System
by Parathyroid Hormone 193
X. Activation of Calcium and Inositol Phosphates
by Parathyroid Hormone 194
XI. Identification of a Second PTH Receptor 194
XII. Physiological Actions of PTH 194
XIII. Cell to Cell Communication: Osteoblasts
and Osteoclasts 197
XIV. Preferential Actions of PTH at Selected
Skeletal Sites 197
References 199
Chapter 14 PTHrP: Of Molecules, Mice,
and Men
Andrew C. Karaplis and David Goltzman
I. Abstract 203
II. Introduction 203
III. Molecular Biology and Mechanism
of Action 204
IV. The Skeletal Actions of PTHrP 208
V. Summary 212
References 213
Chapter 15 The Vitamin D Hormone and Its
Nuclear Receptor: Genomic Mechanisms
Involved in Bone Biology
Geert Carmeliet, Annemieke Verstuyf, Evis Daci, and
Roger Bouillon
I. Abstract 217
II. Synthesis and Metabolism of
1,25(OH)2D3 218
III. Nuclear Vitamin D Receptor 219
IV. 1,25(OH)2D3 Regulated Gene Expression Related to
Bone Physiology 222
V. Effects of 1,25(OH)2D3 on Osteoblasts 223
VI. Effects of 1,25(OH)2D3 on Osteoclasts 224
VII. Pathology and Therapy Related to Vitamin D
Availability, Metabolism, and Function 225
VIII. Conclusions 226
References 227
vii
Chapter 16 Sex Steroid Effects
on Bone Metabolism
SUNDEEP KHOSLA, THOMAS C. SPELSBERG, AND B. LAWRENCE
RlOGS
I. Abstract 233
II. Introduction 233
III. Molecular Structures, Synthesis, and Mechanism
of Action of Major Sex Steroids 234
IV. Effects of Sex Steroids on Bone Cells
and Bone Turnover 236
V. Effects of Sex Steroids on Extraskeletal Calcium
Homeostasis 240
VI. Effects of Estrogens and Androgens on Bone
Metabolism in Men versus Women 241
VII. Summary 241
References 241
Chapter 17 Physiology of Calcium and
Phosphate Homeostasis
Rene Rizzoli and Jean Philippe Bonjour
I. Abstract 247
II. Introduction 247
HI. Body Distribution of Calcium 248
IV. Determinants of Extracellular
Calcium Concentration 248
V. Relative Importance of the Various Calcium Fluxes
in Controlling Extracellular
Calcium Homeostasis 250
VI. Homeostatic Responses to Hypocalcemia 251
VII. Calcium and Bone Growth 254
VIII. Body Distribution of Phosphorus 254
IX. Determinants of Extracellular
Phosphate Concentration 255
X. Homeostatic Responses to Changes in Phosphate
Supply or Demand 257
XI. Conclusions 258
References 258
Chapter 18 New Concepts in
Bone Remodeling
David W. Dempster
I. Introduction 261
II. An Overview of the Remodeling Cycle 261
III. Functions of Bone Remodeling 263
IV. The Role of Apoptosis in Regulating
Bone Balance 264
V. Possible Mechanisms Whereby a Reduction in
Activation Frequency May Protect
against Fracture 268
References 271
viii
Chapter 19 Products of Bone Collagen
Metabolism
JUHA RlSTELI AND LEILA RlSTELI
I. Introduction 275
II. Products of Bone Collagen Synthesis, the
Procollagen Propeptides 276
III. Degradation Products of Type I Collagen 281
IV. Closing Remarks 285
References 285
Chapter 20 Supramolecular Structure of
Cartilage Matrix
Eric F. Eikenberry and Peter Bruckner
I. Abstract 289
II. Introduction 289
III. Light and Electron Microscopy 290
IV. Biochemistry of Cartilage 291
V. Studies of Fibril Structures by X Ray
Diffraction 293
VI. Structure of Fibril Fragments Obtained by
Mechanical Disruption of Tissue 293
VII. Studies of Collagen Cross Linking in Cartilage
Fibrils 294
VIII. Reconstitution of Cartilage like Fibrils from Soluble
Collagens II, IX, and XI 294
IX. Studies of Transgenic Mice and of Human Genetic
Matrix Diseases 294
X. Correlating Structure with the Biomechanical Role of
Articular Cartilage 296
XI. Models of Cartilage Fibril Structure 297
XII. Future Perspectives 298
References 298
Chapter 21 Products of Cartilage
Metabolism
Daniel Henri Manicourt, Hafida El Hajjaji, Jean Pierre
Devogelaer, and Eugene J. M. A. Thonar
I. Introduction 301
II. The Chondrocyte and Its Extracellular
Matrix 302
III. Products of Collagen Metabolism 303
IV. Products of Aggrecan Metabolism 305
V. Products of the Metabolism of Link Protein
and Hyaluronan 310
VI. Products of the Metabolism of Other
Matrix Components 311
VII. Other Products of Chondrocyte
Metabolism 312
VIII. Concluding Statement 313
References 313
Contents
Chapter 22 Fluid Dynamics of the Joint
Space and Trafficking of Matrix Products
Peter A. Simkin
I. Introduction 319
II. Interpretation of Marker Data and Strategies for
Dealing with Them 319
III. Conclusions 323
References 323
Chapter 23 In Vitro Models of Cartilage
Metabolism
H. J. Hauselmann and E. Hedbom
I. Abstract 325
II. Overview of in Vitro Models of Cartilage
Metabolism 325
III. Techniques 333
IV. A Word of Caution 335
V. Future Prospects 335
References 336
Chapter 24 Animal Models of Cartilage
Breakdown
Carlos J. Lozada and Roy D. Altman
I. Introduction 339
II. Factors in Selecting an Animal Model of
Osteoarthritis (OA) 340
III. Canine Models of OA 340
IV. Lapine (Rabbit) Models of OA 345
V. Guinea Pig Models of OA 347
VI. Ovine Models of OA 347
VII. Simian Models of OA 347
VIII. Murine Models 348
IX. Animal Models of Rheumatoid Arthritis
(RA) 348
X. Animal Model of Seronegative
Spondylarthropathy B27 Transgenic Rat 349
XL Conclusions 349
References 350
Part III Markers of Bone and
Cartilage Metabolism
A. Quantification: Technical Aspects
Chapter 25 Genetic Approaches to Metabolic
Bone Disease
Andre G. Uitterlinden, Johannes P. T. M. van Leeuwen,
AND HUIBERT A. P. POLS
I. Abstract 355
II. Introduction 355
Contents
III. Analytical Considerations 357
IV. Perspectives 370
References 370
Chapter 26 Measurement of Calcium,
Phosphate, Parathyroid Hormone, and
Vitamin D
Heinrich Schmidt Gayk
I. Calcium and Phosphorus 375
II. Parathyroid Hormone and Parathyroid
Hormone Related Protein (PTHrP) 382
III. Vitamin D and Vitamin D Metabolites 388
References 396
Chapter 27 Measurement of Biochemical
Markers of Bone Formation
Kim E. Naylor and Richard Eastell
I. Abstract 401
II. Introduction 401
III. Alkaline Phosphatase 402
IV. Osteocalcin 404
V. Propeptides of Type I Procollagen 407
VI. Summary 408
References 408
Chapter 28 Measurement of Biochemical
Markers of Bone Resorption
Marius E. Kraenzlem and Markus J. Seibel
I. Abstract 411
II. Introduction 411
III. Hydroxyproline 412
IV. Glycosylated Hydroxylysine 413
V. Collagen Cross Links 413
VI. Tartrate Resistant Acid Phosphatase 417
VII. Bone Sialoprotein 418
VIII. Variability 419
References 422
Chapter 29 Validation of Local and Systemic
Markers of Bone Turnover
Kim Brixen and Erik F. Eriksen
I. Introduction 427
II. Validation of Biochemical Markers
by Calcium Kinetics 428
III. Validation of Biochemical Markers
by Bone Histomorphometry 431
IV. Conclusions 435
References 435
ix
Chapter 30 Genetic Markers of Joint Disease
Michel Neidhart, Renate E. Gay, and Steffen Gay
I. Abstract 437
II. Genetic Markers and Environmental
Factors 437
III. Genetic Markers Associated with the Human Major
Histocompatibility Complex 438
IV. HLA DRB1 Alleles and Rheumatoid
Arthritis 441
V. Molecular Mechanisms 443
VI. Microsatellite Alleles 446
VII. Conclusions 447
References 447
Chapter 31 Body Fluid Markers of Cartilage
Metabolism
Eugene J. M. A. Thonar, Mary Ellen Lenz, Koichi Masuda,
and Daniel Henri Manicourt
I. Abstract 453
II. Introduction 454
III. Selection of Body Fluids for Analysis 454
IV. Selection of Markers and Interpretation of the Results
of Analyses 456
V. Direct versus Indirect Markers 457
VI. Characterization of Marker Assays 458
VII. Influence of Various Factors and Processes
on Marker Levels 459
VIII. Conclusions 461
References 461
B. Clinical Applications
Chapter 32 Laboratory Assessment of
Postmenopausal Osteoporosis
Patrick Garnero and Pierre D. Delmas
I. Introduction 465
II. Peak Bone Mass 466
III. Postmenopausal Bone Loss 468
IV. Management of Postmenopausal
Osteoporosis 469
V. Conclusions 474
References 475
Chapter 33 Age Related Osteoporosis and
Skeletal Markers of Bone Turnover
Clifford J. Rosen
I. Introduction 479
II. Epidemiology and Pathogenesis of Age Related
Osteoporosis—Relationship to Bone
Turnover 480
X
III. Markers of Bone Turnover and Age Related
Osteoporosis—Clinical Implications 486
IV. Summary 489
References 489
Chapter 34 Osteoporosis in Men
Eric S. Orwoll
I. Introduction 493
II. Epidemiology of Fractures in Men 493
III. Determinants of Fracture in Men 493
IV. The Evaluation of Osteoporosis in Men 499
V. Summary 501
References 501
Chapter 35 Steroid Induced Osteoporosis
Ian R. Reid
I. Abstract 505
II. Introduction 505
III. Pathogenesis of Steroid Induced
Osteoporosis 506
IV. Effects of Glucocorticoids on Histological Indices of
Bone Turnover 508
V. Effects of Glucocorticoids on Markers of Bone
Turnover 508
VI. Evaluation of Steroid Treated Patients 510
VII. Treatment and Follow up 510
References 511
Chapter 36 Transplantation Osteoporosis
Carolina A. Moreira Kulak and Elizabeth Shane
I. Introduction 515
II. Kidney Transplantation 516
III. Cardiac Transplantation 518
IV. Liver Transplantation 521
V. Lung Transplantation 522
VI. Bone Marrow Transplantation 522
VII. Conclusions 523
References 523
Chapter 37 Secondary Osteoporosis
Jean E. Mulder, Carolina A. Moreira Kulak, and
Elizabeth Shane
I. Introduction 527
II. Hyperthyroidism and Osteoporosis 527
III. Osteoporosis Secondary to Hypogonadism 533
IV. Anticonvulsant Drugs and Osteoporosis 539
References 541
Chapter 38 Osteomalacia and Rickets
Marc K. Drezner
I. Definition 547
II. Normal and Abnormal Mineralization 549
Contents
III. Incidence, Epidemiology, and Clinical
Findings 550
IV. Calciopenic Rickets and Osteomalacia 550
V. Phosphopenic Rickets and Osteomalacia 557
VI. Normal Mineral Rickets and Osteomalacia 557
References 558
Chapter 39 Assessment of Bone and Joint
Diseases: Renal Osteodystrophy
Esther A. Gonzalez and Kevin J. Martin
I. Introduction 561
II. Biochemical Assessment of Renal
Osteodystrophy 563
III. Skeletal Imaging in Renal Osteodystrophy 566
IV. Summary 567
References 567
Chapter 40 Primary Hyperparathyroidism
Shonni J. Silverberg and John P. Bilezikian
I. Introduction 571
II. Etiology 571
III. Clinical Presentation 572
IV. Treatment of Primary Hyperthyroidism 573
V. Bone Markers in Primary
Hyperparathyroidism 574
VI. Cytokines in Primary
Hyperparathyroidhsm 576
VII. Summary 577
References 577
Chapter 41 Paget s Disease of Bone
Andreas Grauer and Ethel Siris
I. Introduction 581
II. Etiology and Pathogenesis 581
III. Diagnosis 583
IV. Treatment 584
References 587
Chapter 42 Metastatic Bone Disease
Jean Jacques Body
I. Abstract 591
II. Introduction 591
III. Use of Markers of Bone Turnover for the Diagnosis
of Tumor Induced Bone Disease 593
IV. Use of Markers of Bone Turnover for the Monitoring
of Tumor Induced Bone Disease 599
V. Prediction of the Development of Bone
Metastases 600
References 601
Contents
Chapter 43 Rare Bone Diseases
Michael P. Whyte
I. Introduction 605
II. Osteopenia 605
III. Osteosclerosis and Hyperostosis 609
IV. Ectopic Calcification 615
V. Other Disorders 617
References 618
Chapter 44 Rheumatoid Arthritis and Other
Inflammatory Joint Pathologies
Steven R. Goldring and Mary B. Goldring
I. Abstract 623
II. Introduction 623
III. Effects of Joint Inflammation on Skeletal
Remodeling 624
IV. Effects of Joint Inflammation on Cartilage
Remodeling 629
References 632
Chapter 45 Osteoarthritis and Degenerative
Spine Pathologies
Kristina Akesson
I. Introduction 637
II. Characteristics of Osteoarthritis (OA) 638
xi
III. Etiology 638
IV. Treatment Options 639
V. Current Diagnostic Procedures 639
VI. Biochemical Aspects of Osteoarthritis 639
VII. Markers of Bone Turnover 640
VIII. Markers of Cartilage Turnover 643
IX. Conclusions 646
References 646
Chapter 46 Normal and Abnormal Skeletal
Growth
Joseph M. Gertner
I. Introduction 649
II. The Structure of the Epiphyseal Growth
Plate 649
III. Hormonal Control of Skeletal Growth 650
IV. Fetal Skeletal Development 650
V. Postnatal Skeletal Growth 651
VI. The Control of Mineral Accretion during Skeletal
Growth 653
VII. Quantitative Imaging during Skeletal
Growth 653
VIII. Biochemical Markers of Skeletal Growth 654
IX. Abnormal Patterns of Skeletal Growth 655
References 656
Index 657
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| id | DE-604.BV012687927 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:31:57Z |
| institution | BVB |
| isbn | 0126348405 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008624242 |
| oclc_num | 41928660 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XX, 672 S. graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Academic Press |
| record_format | marc |
| spelling | Dynamics of bone and cartilage metabolism ed. by Markus J. Seibel ... San Diego [u.a.] Academic Press 1999 XX, 672 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biochemical markers Biological Markers Bone and Bones metabolism Bones Metabolism Bones Metabolism Disorders Cartilage Metabolism Cartilage metabolism Extracellular Matrix metabolism Extracellular matrix Knorpelstoffwechsel (DE-588)4534911-3 gnd rswk-swf Knochenstoffwechsel (DE-588)4216200-2 gnd rswk-swf Knorpelstoffwechsel (DE-588)4534911-3 s DE-604 Knochenstoffwechsel (DE-588)4216200-2 s Seibel, Markus J. Sonstige (DE-588)115432884 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008624242&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dynamics of bone and cartilage metabolism Biochemical markers Biological Markers Bone and Bones metabolism Bones Metabolism Bones Metabolism Disorders Cartilage Metabolism Cartilage metabolism Extracellular Matrix metabolism Extracellular matrix Knorpelstoffwechsel (DE-588)4534911-3 gnd Knochenstoffwechsel (DE-588)4216200-2 gnd |
| subject_GND | (DE-588)4534911-3 (DE-588)4216200-2 |
| title | Dynamics of bone and cartilage metabolism |
| title_auth | Dynamics of bone and cartilage metabolism |
| title_exact_search | Dynamics of bone and cartilage metabolism |
| title_full | Dynamics of bone and cartilage metabolism ed. by Markus J. Seibel ... |
| title_fullStr | Dynamics of bone and cartilage metabolism ed. by Markus J. Seibel ... |
| title_full_unstemmed | Dynamics of bone and cartilage metabolism ed. by Markus J. Seibel ... |
| title_short | Dynamics of bone and cartilage metabolism |
| title_sort | dynamics of bone and cartilage metabolism |
| topic | Biochemical markers Biological Markers Bone and Bones metabolism Bones Metabolism Bones Metabolism Disorders Cartilage Metabolism Cartilage metabolism Extracellular Matrix metabolism Extracellular matrix Knorpelstoffwechsel (DE-588)4534911-3 gnd Knochenstoffwechsel (DE-588)4216200-2 gnd |
| topic_facet | Biochemical markers Biological Markers Bone and Bones metabolism Bones Metabolism Bones Metabolism Disorders Cartilage Metabolism Cartilage metabolism Extracellular Matrix metabolism Extracellular matrix Knorpelstoffwechsel Knochenstoffwechsel |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008624242&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT seibelmarkusj dynamicsofboneandcartilagemetabolism |