Acetone: first draft
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Geneva
1998
|
| Schriftenreihe: | Environmental health criteria
207 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 159 S. graph. Darst. |
| ISBN: | 9241572078 |
Internformat
MARC
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| 245 | 1 | 0 | |a Acetone |b first draft |c World Health Organization. Prepared by D. J. Reisman |
| 264 | 1 | |a Geneva |c 1998 | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-008541307 | ||
Datensatz im Suchindex
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|---|---|
| adam_text | CONTENTS
ENVIRONMENTAL HEALTH CRITERIA FOR ACETONE
PREAMBLE ix
ABBREVIATIONS xviii
1. SUMMARY 1
1.1 Properties 1
1.2 Uses and sources of exposure 1
1.2.1 Production 1
1.2.2 Uses and emissions into the environment 1
1.3 Environmental transport, distribution and
transformation 2
1.4 Environmental levels and human exposure 2
1.5 Kinetics and metabolism 3
1.6 Effects on laboratory mammals and in vitro systems 4
1.7 Effects on humans 6
1.8 Effects on other organisms in the laboratory and
field 7
2. IDENTITY, PHYSICAL AND CHEMICAL
PROPERTIES, AND ANALYTICAL METHODS 8
2.1 Chemical identity 8
2.2 Physical and chemical properties 9
2.2.1 Physical properties 9
2.2.2 Chemical properties 10
2.3 Conversion factors 10
2.4 Analytical methods 11
2.4.1 Biological media 11
2.4.2 Environmental media 13
3. SOURCES OF HUMAN AND ENVIRONMENTAL
EXPOSURE 15
3.1 Natural occurrence 15
3.2 Anthropogenic sources 15
3.2.1 Production levels and processes 16
3.2.2 Uses 18
3.2.3 Releases 19
3.2.3.1 Air 19
3.2.3.2 Water 19
3.2.3.3 Soil 20
4. ENVIRONMENTAL TRANSPORT, DISTRIBUTION
AND TRANSFORMATION 21
4.1 Transport and distribution among media 21
4.1.1 Air 21
4.1.2 Water 23
4.1.3 Soil 24
4.2 Biotransformation 25
4.2.1 Bioconcentration and biomagnification 25
4.2.2 Biodegradation 26
4.2.2.1 Microbial degradation 27
4.3 Bioavailability from environmental media 28
4.4 Interaction with other physical, chemical or
biological factors 28
4.5 Ultimate fate following use 29
5. ENVIRONMENTAL LEVELS AND HUMAN
EXPOSURE 31
5.1 Environmental levels 31
5.1.1 Air 31
5.1.1.1 Indoor air 34
5.1.2 Water 34
5.1.3 Soil and sediment 36
5.1.4 Food 36
515 Other environmental levels 36
52 General population exposure 37
5.3 Occupational exposure 40
6. KINETICS AND METABOLISM IN LABORATORY
ANIMALS AND HUMANS 42
6.1 Absorption 42
6.1.1 Inhalation exposure 42
6.1.1.1 Human studies 42
6.1.1.2 Experimental animal studies 44
6.1.2 Oral exposure 46
6.1.2.1 Human studies 46
6.1.2.2 Experimental animal studies 47
6.1.3 Dermal exposure 48
6.1.3.1 Human studies 48
6.1.3.2 Experimental animal studies 49
6.1.4 Absorption summary 49
6.2 Distribution 50
6.2.1 Inhalation exposure 50
6.2.1.1 Human studies 50
6.2.1.2 Experimental animal studies 50
6.2.2 Oral exposure 51
6.2.3 Injection exposure 51
6.2.4 Distribution summary 51
6.3 Metabolism 51
6.3.1 Human studies 51
6.3.2 Experimental animal studies 53
6.3.3 Metabolism summary 58
6.4 Elimination and excretion 58
6.4.1 Human studies 58
6.4.1.1 Occupational exposure studies 62
6.4.2 Experimental animal studies 64
6.4.3 Eliminationexcretion summary 67
6.4.4 Physiologically based pharmacokinetic
model 67
6.5 Retention and turnover 67
7. EFFECTS ON LABORATORY MAMMALS AND
IN VITRO TEST SYSTEMS 69
7.1 Short term toxicity 69
7.1.1 Skin and eye irritation 75
7.2 Longer term toxicity 75
7.3 Reproductive toxicity, embryotoxicity and
teratogenicity 79
7.4 Mutagenicity 81
7.5 Carcinogenicity 84
7.6 Immunotoxicity 84
7.7 Special studies 85
7.8 Factors modifying toxicity; toxicity of metabolites 86
7.9 Mechanisms of toxicity mode of action 87
8. EFFECTS ON HUMANS 91
8.1 Effects on humans °1
8.1.1 Non occupational exposure 91
8.1.2 Occupational exposure 96
8.2 Subpopulations at special risk ^8
9. EFFECT ON OTHER ORGANISMS IN THE
LABORATORY AND FIELD 1 °!
9.1 Aquatic organisms 101
9.1.1 Acute toxic effects on aquatic fauna 101
9.1.2 Chronic effects on aquatic fauna 105
9.1.3 Effects on aquatic plants 1 °5
9.2 Effects on bacteria and protozoa 106
9.3 Terrestrial organisms 108
9.3.1 Effects on fauna 1°8
9.3.2 Effects on flora 1°8
10. EVALUATION OF HUMAN HEALTH RISKS AND
EFFECTS ON THE ENVIRONMENT ! °9
10.1 Evaluation of human health effects 10
10.2 Evaluation of effects on the environment 110
11. FURTHER RESEARCH 112
12. PREVIOUS EVALUATION BY INTERNATIONAL
BODIES 113
REFERENCES 114
RESUME 142
RESUMEN 151
|
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| id | DE-604.BV012577253 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:29:59Z |
| institution | BVB |
| isbn | 9241572078 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008541307 |
| oclc_num | 159538885 |
| open_access_boolean | |
| owner | DE-12 DE-Er8 |
| owner_facet | DE-12 DE-Er8 |
| physical | XVIII, 159 S. graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| record_format | marc |
| series | Environmental health criteria |
| series2 | Environmental health criteria |
| spelling | Acetone first draft World Health Organization. Prepared by D. J. Reisman Geneva 1998 XVIII, 159 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Environmental health criteria 207 Umweltbelastung (DE-588)4061619-8 gnd rswk-swf Aceton (DE-588)4141244-8 gnd rswk-swf Toxikologie (DE-588)4060538-3 gnd rswk-swf Aceton (DE-588)4141244-8 s Toxikologie (DE-588)4060538-3 s DE-604 Umweltbelastung (DE-588)4061619-8 s Reisman, David J. Sonstige oth Environmental health criteria 207 (DE-604)BV000011459 207 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008541307&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Acetone first draft Environmental health criteria Umweltbelastung (DE-588)4061619-8 gnd Aceton (DE-588)4141244-8 gnd Toxikologie (DE-588)4060538-3 gnd |
| subject_GND | (DE-588)4061619-8 (DE-588)4141244-8 (DE-588)4060538-3 |
| title | Acetone first draft |
| title_auth | Acetone first draft |
| title_exact_search | Acetone first draft |
| title_full | Acetone first draft World Health Organization. Prepared by D. J. Reisman |
| title_fullStr | Acetone first draft World Health Organization. Prepared by D. J. Reisman |
| title_full_unstemmed | Acetone first draft World Health Organization. Prepared by D. J. Reisman |
| title_short | Acetone |
| title_sort | acetone first draft |
| title_sub | first draft |
| topic | Umweltbelastung (DE-588)4061619-8 gnd Aceton (DE-588)4141244-8 gnd Toxikologie (DE-588)4060538-3 gnd |
| topic_facet | Umweltbelastung Aceton Toxikologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008541307&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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