Regulatory peptides and cognate receptors:
Gespeichert in:
Format: | Buch |
---|---|
Sprache: | German |
Veröffentlicht: |
Berlin [u.a.]
Springer
1999
|
Schriftenreihe: | Results and problems in cell differentiation
26 |
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | Literaturangaben |
Beschreibung: | XIII, 366 S. Ill., graph. Darst. |
ISBN: | 3540653252 |
Internformat
MARC
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300 | |a XIII, 366 S. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
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adam_text | Contents
The Chicken and Egg? Problem of Co evolution of Peptides
and Their Cognate Receptors: Which Came First?
Mark G. Darlison and Dietmar Richter
1 Introduction 1
2 Appearance of Peptide Genes and Peptide Receptor Genes ... 2
2.1 Co evolution of Peptide and Receptor Genes 2
2.2 Did Peptide Genes Arise Before Receptor Genes or Vice Versa? . 3
3 Consequences of Genome Doubling During Vertebrate Evolution 4
3.1 Multiple Receptors for a Given Peptide Ligand 4
3.2 Existence of Peptide Families 4
4 A Model for the Evolution
of Specific Peptide Receptor Interactions 5
5 Possible Reasons for the Existence
of Families of Receptors and Peptides 6
5.1 Advantages of Having Multiple Receptors for a Given Peptide . 7
5.2 Advantages of Having Multiple Peptides for a Given Receptor . 8
6 Concluding Remarks 8
References 9
Thyrotropin Releasing Hormone (TRH), the TRH Receptor
and the TRH Degrading Ectoenzyme; Three Elements
of a Peptidergic Signalling System
Karl Bauer, Lutz Schomburg, Heike Heuer, and Martin K. H. Schafer
1 Historical Background 13
2 TRH, a Widespread and Multifunctional Signal Molecule .... 15
2.1 The Neuropeptide Hormone TRH 15
2.2 TRH, a Neuromodulator and/or Neurotransmitter 15
2.3 TRH in the Periphery 16
3 Biosynthesis of TRH 17
3.1 Molecular Aspects 17
3.2 Regulation of TRH Biosynthesis 20
4 TRH Receptor and Signal Transduction 20
4.1 Molecular Aspects of the Pituitary TRH Receptor 21
VIII Contents
4.2 Regulation of the Pituitary TRH Receptor 23
5 Inactivation of TRH 24
5.1 TRH Metabolism 24
5.2 Characteristics of the TRH Degrading Ectoenzyme (TRH DE)
and the TRH Degrading Serum Enzyme 25
5.3 Molecular Aspects 25
5.4 The TRH Degrading Serum Enzyme 27
5.5 Hormonal Regulation of TRH Inactivating Enzymes 27
6 Distribution of TRH, TRH R and TRH DE
and Cellular Localization 29
7 Future Aspects 33
References 35
Corticotropin Releasing Factor (CRF)
and its Role in the Central Nervous System
Masao Ito and Mariko Miyata
1 Introduction 43
2 Distribution of CRF and its mRNA 44
3 Distribution of CRF Receptors and Their mRNAs 45
4 CRF Mediated Mechanisms
in the Hypothalamus Pituitary System 45
5 Role of Hypothalamic CRF Neurons in Stress Responses
and Depression 47
6 CRF Neurons in the Amygdala and Bed Nucleus
of the Stria Terminalis, and Their Role in Fear and Anxiety ... 49
7 Locus Coeruleus and its Role in Stress Responses and Anxiety . 52
8 CRF Containing Climbing Fibers
and Their Role in Cerebellar Functions 54
9 Comments 56
References 59
CRF and CRF Receptors
Jelena Radulovic, Thomas Blank, Klaus Eckart, Marko Radulovic,
Oliver Stiedl, and Joachim Spiess
1 Introduction 67
2 The CRF Family, a Chemical Consideration 67
3 Molecular Analysis of CRF Binding Sites 70
4 Distribution of CRF like Peptides
and Their Binding Sites in the CNS 71
5 Distribution of CRF like Peptides
and Their Binding Sites in the Pituitary 75
6 Immunomodulatory Effects of CRF 76
7 Neurotransmitter like Actions of CRF 78
Contents IX
8 CRF and Cardiovascular Regulation 80
9 Role of the CRF System in Behavior 81
References 84
Neural Oxytocinergic Systems as Genomic Targets for Hormones
and as Modulators of Hormone Dependent Behaviors
Donald W. Pfaff, Sonoko Ogawa, and Lee Ming Kow
1 Behavioral Biology of Oxytocin 91
2 Hormonal Controls over Genes for Oxytocin and its Receptor . 94
3 Means of Execution of Oxytocinergic Actions 98
3.1 Oxytocin Mechanisms at the Cell Membrane Level 98
3.2 Mechanisms at the Systems Level 100
4 Summary 101
References 101
Vasopressin Receptors: Structural Functional Relationships
and Role in Neural and Endocrine Regulation
Oscar Schoots, Fernando Hernando, Nine V. Knoers,
and J. Peter H. Burbach
1 Introduction 107
2 Physiological Functions of Vasopressin Systems 108
2.1 Endocrine Functions 108
2.2 Functions in the Brain 109
2.3 Paracrine Functions 110
3 Vasopressin Receptor Distribution Ill
4 Structural and Functional Relationships
of Vasopressin Receptors 117
4.1 Structure 117
4.2 Post Translational Modifications 121
4.3 Ligand Receptor Interactions 122
4.4 G Protein Coupling 124
5 V2 Receptor Mutations
in Congenital Nephrogenic Diabetes Insipidus 125
6 Concluding Remarks 128
References 128
The Oxytocin Receptor
Tadashi Kimura and Richard Ivell
1 Introduction 135
2 Pharmacology of the Oxytocin Receptor
and its Signal Transduction 136
X Contents
2.1 Extracellular N Terminal Domain 137
2.2 Extracellular Loop Domains 137
2.3 Transmembrane Domains 139
2.4 Intracellular Loops, C Terminus and Signal Transduction .... 140
2.5 Summary 142
3 Expression of the Oxytocin Receptor in Vivo
and its Functional Differentiation 142
3.1 The Uterus of Pregnancy 142
3.2 The Uterus of the Estrous Cycle 147
3.3 The Cervix 148
3.4 The Mammary Gland 149
3.5 The Ovary 150
3.6 The Brain 150
3.7 The Kidney 151
3.8 The Male Reproductive System 151
3.9 Oxytocin Responsive Cell Lines 152
4 Regulation of Oxytocin Receptor Expression 153
5 Structure and Regulation of the OTR Gene 155
6 General Conclusions 159
References 160
Targeted Mutagenesis of the Murine Opioid System
Michael D. Hayward and Malcolm J. Low
1 Introduction 169
2 A Brief History of the Opioid System 169
3 Techniques in Murine Mutagenesis 171
4 Gene Deletion Studies in the Opioid System 172
4.1 Stress Induced Analgesia 173
4.2 Nociception 174
4.3 Opioid Pharmacology of Opioid System Knock out Mice .... 176
4.3.1 u Receptor Pharmacology in the u Receptor Knock out Mice . . 176
4.3.2 6 and k Pharmacology in the u Receptor Knock out Mice .... 177
4.3.3 Pharmacology in the 6 and k Receptor Knock out Mice 178
4.3.4 Opioid Pharmacology in the P Endorphin Knock out Mice . . 178
4.4 Behavioral Reinforcement and Reward 180
5 Genetic Background of Mutant Mice 181
6 Differences Between Knock out Lines 183
6.1 Construct Differences Between u Receptor Knock out Mice Lines 183
6.2 Genetic Differences Between Background Strains Used
for Producing Mutant Mice 184
7 Conclusions 185
References 186
Contents XI
Orphan Receptors and the Concept of Reverse Physiology:
Discovery of the Novel Neuropeptide Orphanin FQ/Nociceptin
Rainer K. Reinscheid, Hans Peter Nothacker, and Olivier Civelli
1 Summary 193
2 Orphan Receptors and the Concept of Reverse Physiology ... 194
3 Identification of the Natural Ligand of an Orphan GPCR:
Orphanin FQ/Nociceptin 195
4 Evidence for OFQ/NOC being a Neurotransmitter 196
4.1 Receptor Binding of OFQ/NOC 196
4.2 Cellular Responses to OFQ/NOC 197
4.3 Biosynthesis, Degradation and Release of OFQ/NOC 197
4.4 Regional Expression of OFQ/NOC and its Receptor 199
5 Physiological Effects and Behavioral Responses of OFQ/NOC . 200
6 Similarities and Differences Between the Opioid
and the OFQ/NOC Systems 204
7 Novel Peptides Derived from the OFQ/NOC Precursor 206
8 Conclusions: The Strength and the Pitfalls
of the Orphan Receptor Strategy 207
References 209
Molecular Biology of the Receptors for Somatostatin and Cortistatin
Hans Jiirgen Kreienkamp
1 Introduction 215
2 The Peptides 215
3 Clinical Aspects 217
4 Somatostatin Receptors 218
5 The Regulation of SSTR Gene Expression 221
6 Signal Transduction Through Somatostatin Receptor Subtypes . 222
7 Do we Need Even More Receptor Subtypes? 225
8 Subtype Specific Differences in Receptor Regulation
and Intracellular Distribution 225
9 Towards an Understanding of the Functional Role
of Individual Somatostatin Receptor Subtypes 229
10 Conclusion 231
References 231
Novel Neurotransmitters for Sleep and Energy Homeostasis
J. Gregor Sutcliffe and Luis de Lecea
1 Summary 239
2 Introduction 240
3 Cortistatin 240
XII Contents
3.1 A Novel Somatostatin Like Neuropeptide 240
3.2 Cortistatin in Cortical Interneurons 241
3.3 Partial Coexpression with Somatostatin, Parvalbumin
andCalbindin 242
3.4 Late Onset and Transient Expression 243
3.5 Binding to Somatostatin Receptors 243
3.6 Neuronal Depressant Activity 244
3.7 Cortistatin Has Sleep Promoting Properties 245
3.8 Cortistatin Antagonizes Acetylcholine 245
3.9 Cortistatin: A Pressure for Sleep 247
3.10 Cortistatin: Not an Alternative Somatostatin 247
4 The Hypocretins (Orexins) 248
4.1 Two Hypothalamus Specific Peptides 248
4.2 Hypocretin in Cell Bodies, Fibers and Synaptic Vesicles 250
4.3 Hcrt2 Is Neuroexcitatory 251
4.4 Endogenous Peptides and Their Receptors 251
4.5 A Role in Feeding 252
4.6 Hypocretins in Many Physiological Systems 252
5 Peptides as Pressures for Voluntary but Necessary Behaviors . . 253
References 254
Galanin and Galanin Receptors
Tiina P. Iismaa and John Shine
1 Introduction 257
2 Galanin 258
2.1 Peptide Sequence 258
2.2 Preprogalanin Gene Structure and Chromosomal Localisation . 260
2.3 Sites and Regulation of Galanin Expression 262
2.3.1 Developmental Expression and Sexual Dimorphism 262
2.3.2 Transcriptional Regulation 262
3 Galanin Receptors 263
3.1 Cloning, Pharmacology, Signalling Properties
and Sites of Expression 264
3.1.1 GALR1 264
3.1.2 GALR2 265
3.1.3 GALR3 267
3.2 Other Galanin Binding Sites 268
3.3 Galanin Receptor Gene Structure 271
3.4 Chromosomal Localisation of Galanin Receptor Genes 272
4 Physiological Effects and Therapeutic Indications 273
4.1 Learning, Memory and Cognition 273
4.2 Feeding Behaviour and Obesity 274
4.3 Neuroendocrine Responses 275
Contents XIII
4.4 Analgesia and Neuropathic Pain 277
4.5 Nerve Injury and Regeneration 278
4.6 Mitogenesis: Development and Tumourigenesis 279
5 Summary and Conclusions 280
References 280
The Cholecystokinin Gastrin Family of Peptides and Their Receptors
Jens F. Rehfeld
1 Introduction 293
2 Structure Function Relationships 294
3 Gastrin and Cholecystokinin Genes and mRNAs 299
4 Progastrin Maturation 302
5 Procholecystokinin Maturation 306
6 Gastrin and Cholecystokinin Receptors 309
7 Summary and Perspective 312
References 313
Function of the Neuropeptide Head Activator for Early Neural
and Neuroendocrine Development
Wolfgang Hampe, Irm Hermans Borgmeyer, and H. Chica Schaller
1 Introduction 323
2 Action of HA as Morphogen in Hydra 323
3 HA Signal Transduction to Initiate Mitosis 324
4 Corelease of HA with a Carrier Complex 326
5 HA Binding Protein 327
6 HAB Expression in Mouse Development 330
7 HAB Function 334
References 335
Invertebrate Neurohormones and Their Receptors
Cornelis J. P. Grimmelikhuijzen, Frank Hauser,
Kathrine Krageskov Eriksen, and Michael Williamson
1 Introduction 339
2 Cnidarians 339
3 Neurohormones in Cnidarians 340
4 Biosynthesis of Neurohormones in Cnidarians 343
5 Neurohormone Receptors in Cnidarians 349
6 Neurohormone Receptors in Insects 351
7 Conclusion 358
References 358
Subject Index 363
|
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dewey-tens | 570 - Biology |
discipline | Biologie |
format | Book |
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genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
genre_facet | Aufsatzsammlung |
id | DE-604.BV012555853 |
illustrated | Illustrated |
indexdate | 2024-07-09T18:29:36Z |
institution | BVB |
isbn | 3540653252 |
language | German |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008525538 |
oclc_num | 41096101 |
open_access_boolean | |
owner | DE-12 |
owner_facet | DE-12 |
physical | XIII, 366 S. Ill., graph. Darst. |
publishDate | 1999 |
publishDateSearch | 1999 |
publishDateSort | 1999 |
publisher | Springer |
record_format | marc |
series | Results and problems in cell differentiation |
series2 | Results and problems in cell differentiation |
spelling | Regulatory peptides and cognate receptors Dietmar Richter (ed.) Berlin [u.a.] Springer 1999 XIII, 366 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Results and problems in cell differentiation 26 Literaturangaben Hormones peptidiques Hormones peptidiques - Récepteurs Hormones peptidiques - Récepteurs ram Hormones peptidiques ram Neuropeptides Neuropeptides - Physiologie Neuropeptides - Récepteurs Neuropeptides - Récepteurs - Physiologie Neuropeptides - Récepteurs ram Neuropeptides ram Récepteur neuropeptide - Physiologie Neuropeptides Receptors Neuropeptides physiology Peptide hormones Peptide hormones Receptors Receptors, Neuropeptide physiology Neurotransmitter-Rezeptor (DE-588)4171601-2 gnd rswk-swf Ligand (DE-588)4035711-9 gnd rswk-swf Hormonrezeptor (DE-588)4138900-1 gnd rswk-swf Peptidhormon (DE-588)4045127-6 gnd rswk-swf Neurohormon (DE-588)4125626-8 gnd rswk-swf Neuropeptide (DE-588)4041895-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Neuropeptide (DE-588)4041895-9 s DE-604 Neurotransmitter-Rezeptor (DE-588)4171601-2 s Neurohormon (DE-588)4125626-8 s Peptidhormon (DE-588)4045127-6 s Hormonrezeptor (DE-588)4138900-1 s Ligand (DE-588)4035711-9 s Richter, Dietmar Sonstige oth Results and problems in cell differentiation 26 (DE-604)BV000022913 26 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008525538&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Regulatory peptides and cognate receptors Results and problems in cell differentiation Hormones peptidiques Hormones peptidiques - Récepteurs Hormones peptidiques - Récepteurs ram Hormones peptidiques ram Neuropeptides Neuropeptides - Physiologie Neuropeptides - Récepteurs Neuropeptides - Récepteurs - Physiologie Neuropeptides - Récepteurs ram Neuropeptides ram Récepteur neuropeptide - Physiologie Neuropeptides Receptors Neuropeptides physiology Peptide hormones Peptide hormones Receptors Receptors, Neuropeptide physiology Neurotransmitter-Rezeptor (DE-588)4171601-2 gnd Ligand (DE-588)4035711-9 gnd Hormonrezeptor (DE-588)4138900-1 gnd Peptidhormon (DE-588)4045127-6 gnd Neurohormon (DE-588)4125626-8 gnd Neuropeptide (DE-588)4041895-9 gnd |
subject_GND | (DE-588)4171601-2 (DE-588)4035711-9 (DE-588)4138900-1 (DE-588)4045127-6 (DE-588)4125626-8 (DE-588)4041895-9 (DE-588)4143413-4 |
title | Regulatory peptides and cognate receptors |
title_auth | Regulatory peptides and cognate receptors |
title_exact_search | Regulatory peptides and cognate receptors |
title_full | Regulatory peptides and cognate receptors Dietmar Richter (ed.) |
title_fullStr | Regulatory peptides and cognate receptors Dietmar Richter (ed.) |
title_full_unstemmed | Regulatory peptides and cognate receptors Dietmar Richter (ed.) |
title_short | Regulatory peptides and cognate receptors |
title_sort | regulatory peptides and cognate receptors |
topic | Hormones peptidiques Hormones peptidiques - Récepteurs Hormones peptidiques - Récepteurs ram Hormones peptidiques ram Neuropeptides Neuropeptides - Physiologie Neuropeptides - Récepteurs Neuropeptides - Récepteurs - Physiologie Neuropeptides - Récepteurs ram Neuropeptides ram Récepteur neuropeptide - Physiologie Neuropeptides Receptors Neuropeptides physiology Peptide hormones Peptide hormones Receptors Receptors, Neuropeptide physiology Neurotransmitter-Rezeptor (DE-588)4171601-2 gnd Ligand (DE-588)4035711-9 gnd Hormonrezeptor (DE-588)4138900-1 gnd Peptidhormon (DE-588)4045127-6 gnd Neurohormon (DE-588)4125626-8 gnd Neuropeptide (DE-588)4041895-9 gnd |
topic_facet | Hormones peptidiques Hormones peptidiques - Récepteurs Neuropeptides Neuropeptides - Physiologie Neuropeptides - Récepteurs Neuropeptides - Récepteurs - Physiologie Récepteur neuropeptide - Physiologie Neuropeptides Receptors Neuropeptides physiology Peptide hormones Peptide hormones Receptors Receptors, Neuropeptide physiology Neurotransmitter-Rezeptor Ligand Hormonrezeptor Peptidhormon Neurohormon Neuropeptide Aufsatzsammlung |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008525538&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
volume_link | (DE-604)BV000022913 |
work_keys_str_mv | AT richterdietmar regulatorypeptidesandcognatereceptors |