Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans: this publication represents the view and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 4 - 11 February 1997
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Geneva
1997
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| Series: | International Agency for Research on Cancer: IARC monographs on the evaluation of carcinogenic risks to humans
69 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | IX, 666 S. |
| ISBN: | 928321269X |
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Record in the Search Index
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| adam_text | CONTENTS
NOTE TO THE READER 1
LIST OF PARTICIPANTS 3
PREAMBLE
Background 9
Objective and Scope 9
Selection of Topics for Monographs 10
Data for Monographs 11
The Working Group 11
Working Procedures 11
Exposure Data 12
Studies of Cancer in Humans 14
Studies of Cancer in Experimental Animals 17
Other Data Relevant to an Evaluation of Carcinogenicity and Its Mechanisms 20
Summary of Data Reported 21
Evaluation 23
References 27
THE MONOGRAPHS
Polychlorinateddibenzo para dioxins 33
1. Exposure Data 33
1.1 Chemical and physical data 33
1.1.1 Nomenclature and molecular formulae and weights 33
1.1.2 Structural formulae 33
1.1.3 Chemical and physical properties 33
1.1.4 Methods of analysis 37
(a) General considerations 38
(b) Sampling 39
(c) Extraction. 41
(d) Clean up 41
(e) Separation 42
(f) Quantification 43
12 Formation and destruction 44
1.2.1 Formation of PCDDs 44
(a) Chemical reactions 44
(b) Thermal reactions 49
iii
iv IARC MONOGRAPHS VOLUME 69
(c) Photochemical reactions 52
(d) Biochemical reactions 52
1.2.2 Destruction of PCDDs 52
1.3 Occurrence 53
1.3.1 Occupational and accidental exposures to PCDDs 53
(a) Occupational exposures 53
(b) Population exposure due to industrial accident 63
(c) Summary table 65
1.3.2 Environmental occurrence 65
(a) Air 65
(b) Water 75
(c) Soil 77
(d) Food 87
(i) Background exposure 90
(ii) Foods from contaminated areas 95
(iii) Human intake levels from food 96
1.4 Human tissue measurements 98
1.4.1 Blood and tissue samples 98
1.4.2 Human milk 122
1.5 Regulations and guidelines 136
2. Studies of Cancer in Humans 137
2.1 Industrial exposures and industrial accidents 138
2.1.1 Exposure to 23,7,8 TCDD and higher chlorinated PCDDs/PCDFs
in chemical plants 138
(a) Two United States plants 138
(b) Comprehensive United States study 150
(c) German accident cohort 151
(d) Other German plants 153
(e) British plants 156
(f) Dutch plants 157
(g) IARC multi country study 158
2.1.2 Population exposure due to industrial accident 161
2.1.3 Industrial exposure to higher chlorinated PCDDs 162
22 Herbicide exposures 164
22.1 Applicator cohorts 165
(a) Commercial 165
(b) Military 171
22.2 Community based case control studies 172
(a) Soft tissue sarcoma 172
(b) Malignant lymphomas 180
(c) Other haematopoietic malignancies 186
(d) Other solid tumours 189
2.3 Combined evidence from high exposure human populations 191
CONTENTS v
3. Studies of Cancer in Experimental Animals 195
2,3,7,8 Tetrachlorodibenzo paia dioxin 195
3.1 Oral administration 195
3.1.1 Mouse 195
3.1.2 Rat 199
3.2 Administration to immature animals 201
3.3 Intraperitoneal or subcutaneous administration 201
3.4 Skin application 202
3.5 Exposure by immersion in water 202
3.6 Administration with known carcinogens and modifying factors 202
3.6.1 Skin 207
3.6.2 Lung 208
(a) Mouse 208
(b) Rat 209
3.6.3 Liver 209
(a) Mouse 209
(b) Rat 209
Dibenzo pam dioxin 214
Oral administration 214
(a) Mouse 214
(b) Rat 214
2,7 Dichlorodibenzo pan dioxin 215
3.1 Oral administration 215
3.1.1 Mouse 215
3.1.2 Rat 215
3.2 Administration with known carcinogens 216
1,2,3,6,7,8 Hexachlorodibenzo paia dioxin and 1,2,3,7,8,9 hexachloro
dibenzo para dioxin (mixture) 216
3.1 Oral administration 216
3.1.1 Mouse 216
3.1.2 Rat 217
3.2 Skin application 217
1,2,3,7,8 Pentachlorodibenzo parai dioxin 218
Administration with known carcinogens 218
1,2,3,4,6,7,8 Heptachlorodibenzo para dioxin 218
Administration with known carcinogens 218
Defined mixture of 49 polychlorinated dibenzo paiz dioxins 219
Administration with known carcinogens 219
4. Other Data Relevant to an Evaluation of Carcinogenicity and its Mechanisms ..219
4.1 Absorption, distribution, metabolism and excretion 219
4.1.1 Humans 219
4.12 Experimental systems 221
(a) Absorption 221
(b) Body distribution 221
vi IARC MONOGRAPHS VOLUME 69
(c) Metabolism 223
(d) Excretion 224
(e) Kinetics and toxicity 226
4.2 Toxic effects 227
4.2.1 Humans 227
(a) Chloracne and other effects on the skin 227
(b) Hepatic effects 228
(c) Other gastrointestinal effects 238
(d) Thyroid function 238
(e) Diabetes 242
(f) Immunological effects 243
(g) Neurological effects 256
(h) Circulatory system 257
(i) Pulmonary effects 262
(j) Renal effects 263
4.2.2 Experimental systems 263
(a) Species comparisons of toxic effects 263
(b) Immunological responses 281
4.3 Interactions with receptors and their early molecular consequences
and other biochemical responses 295
4.3.1 The Ah receptor 296
4.3.2 Induction of drug metabolizing enzymes 297
4.3.3 Modulation of growth factors, growth factor receptors,
transcription factors, lymphokines and related factors 300
4.3.4 Modulation of thyroid hormones, vitamin A and retinoids 301
4.3.5 Modulation of protein phosphorylation 302
4.3.6 Modulation of biochemical responses associated with glucose
metabolism and transport 302
4.3.7 Modulation of oestrogenic responses by PCDDs 303
4.3.8 Role of oxidative stress in the toxicity of PCDDs 304
4.3.9 Cell cycle regulation and apoptosis 304
4.4 Reproductive and developmental effects 305
4.4.1 Humans 305
(a) Endocrine and gonadal effects 305
(b) Effects on pregnancy 306
4.4.2 Experimental systems 315
(a) Developmental effects 315
(b) Functional developmental toxicity 318
(c) Reproductive effects 321
45 Genetic and related effects 324
4.5.1 Humans 324
4.5.2 Experimental systems 324
4.6 Mechanisms of carcinogenicity 330
4.6.1 Introduction 330
j
I
CONTENTS vii
4.6.2 General issues regarding mechanisms of carcinogenesis 330
(a) Carcinogenesis is a multistep process 330
(b) Genotoxicity 331
(c) Ah receptor 331
(d) Effects of 23,7,8 TCDD on gene expression 331
(e) Oxidative damage 331
(f) Cell transformation 332
(g) Cell proliferation and tumour promotion 332
(h) Suppression of immune surveillance 332
4.6.3 Tissue specific mechanims of carcinogenicity of 23,7,8 TCDD ....333
(a) Liver 333
(b) Other target tissues 335
4.6.4 Mechanisms for reduced cancer incidence following
23,7,8 TCDD exposure 335
5. Summary of Data Reported and Evaluation 335
5.1 Exposure data 335
5.2 Human carcinogenicity data 336
5.3 Animal carcinogenicity data 338
5.4 Other relevant data 339
5.5 Evaluation 342
Polychlorinated dibenzofurans 345
1. Exposure Data 345
1.1 Chemical and physical data 345
1.1.1 Nomenclature and molecular formulae and weights 345
1.1.2 Structural formulae 346
1.1.3 Chemical and physical properties 346
1.1.4 Methods of analysis 348
1.2 Formation and destruction 348
1.2.1 Formation of PCDFs 348
(a) Chemical reactions 348
(b) Thermal reactions 352
(c) Photochemical reactions 357
(d) Biochemical reactions 357
1.2.2 Destruction of PCDFs 357
1.3 Occurrence 358
1.3.1 Occupational and accidental exposures to PCDFs 358
(a) Occupational exposures 358
(b) Accidental exposure 362
(i) Yusho incident, Japan, 1968 362
(ii) Yucheng incident, Taiwan, 1979 362
(iii) PCB explosions and fires 362
viii IARC MONOGRAPHS VOLUME 69
1.3.2 Environmental occurrence 364
(a) Air 364
(b) Water 365
(c) Soil 365
(d) Food 366
1.4 Human tissue measurements 367
1.4.1 Blood and tissue samples 380
1.4.2 Human milk 384
1.5 Regulations and guidelines 384
2. Studies of Cancer in Humans 396
2.1 Rice oil contamination incidents 396
2.1.1 Japan 396
2.1.2 Taiwan 397
2.1.3 Comparison of Japan and Taiwan 398
2.2 Fish consumption 399
2.3 Industrial cohorts 400
3. Studies of Cancer in Experimental Animals 401
3.1 Administration with known carcinogens 401
3.1.1 Mouse skin 401
3.1.2 Rat liver 403
4. Other Data Relevant to an Evaluation of Carcinogenicity and its Mechanisms ..404
4.1 Humans 404
4.1.1 Humans 404
4.1.2 Experimental systems 404
(a) Absorption 404
(b) Distribution 405
(c) Metabolism 406
(d) Excretion 406
4.2 Toxic effects 408
4.2.1 Humans 408
(a) Non cancer effects of ingestion of rice oil contaminated
with poly chlorinated dibenzofurans, quaterphenyls and
biphenyls in Japan (yusho) and Taiwan (yucheng) 408
4.2.2 Experimental studies 411
(a) Species comparisons of toxic effects 411
(b) Immunological responses 413
(c) Biochemical responses 414
43 Interaction with Ah receptor and its early molecular consequences
and other biochemical responses 415
4.4 Reproductive and developmental effects 416
4.4.1 Humans 416
4.4.2 Experimental systems 417
i
CONTENTS ix
4.5 Genetic and related effects 418
4.5.1 Humans 418
4.5.2 Experimental systems 418
5. Summary of Data Reported and Evaluation 420
5.1 Exposure data 420
5.2 Human carcinogenicity data 421
5.3 Animal carcinogenicity data 421
5.4 Other relevant data 421
5.5 Evaluation 422
APPENDIX 1. TABLES ON OCCURRENCE (PCDDs) 425
APPENDIX 2. TABLES ON OCCURRENCE (PCDFs) 477
APPENDIX 3. GENETIC AND RELATED EFFECTS 503
A. TEST SYSTEM CODE WORDS FOR GENETIC AND RELATED
EFFECTS 505
B. SUMMARY TABLES OF GENETIC AND RELATED EFFECTS 511
C. ACTIVITY PROFILES FOR GENETIC AND RELATED EFFECTS 515
REFERENCES 525
SUMMARY OF FINAL EVALUATIONS 631
ABBREVIATIONS 633
SUPPLEMENTARY CORRIGENDA TO VOLUMES 1 68 637
CUMULATIVE INDEX TO THE MONOGRAPHS SERIES 639
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| series | International Agency for Research on Cancer: IARC monographs on the evaluation of carcinogenic risks to humans |
| series2 | International Agency for Research on Cancer: IARC monographs on the evaluation of carcinogenic risks to humans |
| spelling | Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans this publication represents the view and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 4 - 11 February 1997 World Health Organization, International Agency for Research on Cancer Geneva 1997 IX, 666 S. txt rdacontent n rdamedia nc rdacarrier International Agency for Research on Cancer: IARC monographs on the evaluation of carcinogenic risks to humans 69 Polychlorierte Dibenzodioxine (DE-588)4211625-9 gnd rswk-swf Polychlorierte Dibenzofurane (DE-588)4211624-7 gnd rswk-swf Carcinogenität (DE-588)4206051-5 gnd rswk-swf (DE-588)1071861417 Konferenzschrift gnd-content Polychlorierte Dibenzofurane (DE-588)4211624-7 s Carcinogenität (DE-588)4206051-5 s DE-604 Polychlorierte Dibenzodioxine (DE-588)4211625-9 s International Agency for Research on Cancer: IARC monographs on the evaluation of carcinogenic risks to humans 69 (DE-604)BV000878150 69 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008514551&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans this publication represents the view and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 4 - 11 February 1997 International Agency for Research on Cancer: IARC monographs on the evaluation of carcinogenic risks to humans Polychlorierte Dibenzodioxine (DE-588)4211625-9 gnd Polychlorierte Dibenzofurane (DE-588)4211624-7 gnd Carcinogenität (DE-588)4206051-5 gnd |
| subject_GND | (DE-588)4211625-9 (DE-588)4211624-7 (DE-588)4206051-5 (DE-588)1071861417 |
| title | Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans this publication represents the view and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 4 - 11 February 1997 |
| title_auth | Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans this publication represents the view and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 4 - 11 February 1997 |
| title_exact_search | Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans this publication represents the view and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 4 - 11 February 1997 |
| title_full | Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans this publication represents the view and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 4 - 11 February 1997 World Health Organization, International Agency for Research on Cancer |
| title_fullStr | Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans this publication represents the view and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 4 - 11 February 1997 World Health Organization, International Agency for Research on Cancer |
| title_full_unstemmed | Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans this publication represents the view and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 4 - 11 February 1997 World Health Organization, International Agency for Research on Cancer |
| title_short | Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans |
| title_sort | polychlorinated dibenzo para dioxins and polychlorinated dibenzofurans this publication represents the view and expert opinions of an iarc working group on the evaluation of carcinogenic risks to humans which met in lyon 4 11 february 1997 |
| title_sub | this publication represents the view and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 4 - 11 February 1997 |
| topic | Polychlorierte Dibenzodioxine (DE-588)4211625-9 gnd Polychlorierte Dibenzofurane (DE-588)4211624-7 gnd Carcinogenität (DE-588)4206051-5 gnd |
| topic_facet | Polychlorierte Dibenzodioxine Polychlorierte Dibenzofurane Carcinogenität Konferenzschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008514551&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000878150 |