Antifolate drugs in cancer therapy:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
1999
|
| Schriftenreihe: | Cancer drug discovery and development
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | IX, 456 S. Ill., graph. Darst. |
| ISBN: | 0896035964 |
Internformat
MARC
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| 245 | 1 | 0 | |a Antifolate drugs in cancer therapy |c ed. by Ann L. Jackman |
| 264 | 1 | |a Totowa, NJ |b Humana Press |c 1999 | |
| 300 | |a IX, 456 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 490 | 0 | |a Cancer drug discovery and development | |
| 650 | 7 | |a Antifoliques - Emploi en thérapeutique |2 ram | |
| 650 | 2 | |a Antifoliques - usage thérapeutique | |
| 650 | 7 | |a Antimétabolites - Emploi en thérapeutique |2 ram | |
| 650 | 7 | |a Cancer - Chimiothérapie |2 ram | |
| 650 | 4 | |a Cancer - Treatment | |
| 650 | 2 | |a Tumeurs - Traitement médicamenteux | |
| 650 | 4 | |a Antimetabolites |x Therapeutic use | |
| 650 | 4 | |a Cancer |x Chemotherapy | |
| 650 | 4 | |a Folic Acid Antagonists |x therapeutic use | |
| 650 | 4 | |a Folic acid |x Antagonists |x Therapeutic use | |
| 650 | 4 | |a Folic acid |x Derivatives |x Therapeutic use | |
| 650 | 4 | |a Neoplasms |x drug therapy | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-008493780 | ||
Datensatz im Suchindex
| _version_ | 1804127157010563072 |
|---|---|
| adam_text | CONTENTS Preface v
Contributors ix
1 Antifolate Drugs: Past and Future Perspectives 1
Robert C. Jackson
2 Folate Biochemistry in Relation to Antifolate Selectivity 13
Roy L. Kisliuk
3 Clinical Pharmacology and Resistance to Dihydrofolate
Reductase Inhibitors 37
Richard Gorlick and Joseph R. Bertino
4 Development of Nonpolyglutamatable DHFR Inhibitors 59
Andre Rosowsky
5 Fluoropyrimidines as Antifolate Drugs 101
G. J. Peters and C. H. Kohne
6 Raltitrexed (Tomudex™), a Highly Polyglutamatable
Antifolate Thymidylate Synthase Inhibitor:
Design and Preclinical Activity 147
Leslie R. Hughes, Trevor C. Stephens, F. Thomas Boyle,
and Ann L. Jackman
7 Tomudex: Clinical Development 167
Philip Beale and Stephen Clarke
8 Preclinical Pharmacology Studies and the Clinical
Development of a Novel Multitargeted Antifolate,
MTA (LY231514) 183
Chuan Shih and Donald E. Thornton
9 GW1843: A Potent, Noncompetitive Thymidylate Synthase
Inhibitor—Preclinical and Preliminary Clinical Studies 203
Gary K. Smith, Joseph W. Bigley, Inderjit K. Dev,
David S. Duch, Robert Ferone, and William Pendergast
10 Preclinical and Clinical Studies with the Novel Thymidylate
Synthase Inhibitor Nolatrexed Dihydrochloride
(Thymitaq™, AG337) 229
Andy Hughes and A. Hilary Calvert
11 ZD9331: Preclinical and Clinical Studies 243
F. Thomas Boyle, Trevor C. Stephens, S. D. Averbuch,
and Ann L. Jackman
vii
viii Contents
12 Preclinical and Clinical Evaluation of the Glycinamide
Ribonucleotide Formyltransferase Inhibitors
Lometrexol and LY309887 261
Laurane G. Mendelsohn, John F. Worzalla,
and Jackie M. Walling
13 AG2034: A GARFT Inhibitor with Selective Cytotoxicity
to Cells that Lack a Gl Checkpoint 281
Theodore J. Boritzki, Cathy Zhang, Charlotte A. Bartlett,
and Robert C. Jackson
14 Receptor and Carrier Mediated Transport Systems for
Folates and Antifolates: Exploitation for Folate Based
Chemotherapy and Immunotherapy 293
G. Jansen
15 Folates as Chemotherapeutic Modulators 323
Julio Barredo, Marlene A. Bunni,
Raghunathan Kamasamudram, and David G. Priest
16 Antifolate Polyglutamylation in Preclinical and
Clinical Antifolate Resistance 339
John J. McGuire
17 Antifolates in Combination Therapy 365
Stephen P. Ackland and Rosemary Kimbell
18 Pharmacodynamic Measurements and Predictors of
Response to Thymidylate Synthase Inhibitors 383
David Farrugia and Patrick G. Johnston
19 Molecular Regulation of Expression of
Thymidylate Synthase 397
Edward Chu, JingfangJu, and John C. Schmitz
20 The Role of Uracil Misincorporation in Thymineless Death 409
G. Wynne Aherne and Sherael Brown
21 Thymineless Death 423
Peter J. Houghton
22 Genetic Determinants of Cell Death and Toxicity 437
D. Mark Pritchard and John A. Hickman
Index 453
|
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| indexdate | 2024-07-09T18:28:53Z |
| institution | BVB |
| isbn | 0896035964 |
| language | English |
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| physical | IX, 456 S. Ill., graph. Darst. |
| publishDate | 1999 |
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| series2 | Cancer drug discovery and development |
| spelling | Antifolate drugs in cancer therapy ed. by Ann L. Jackman Totowa, NJ Humana Press 1999 IX, 456 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cancer drug discovery and development Antifoliques - Emploi en thérapeutique ram Antifoliques - usage thérapeutique Antimétabolites - Emploi en thérapeutique ram Cancer - Chimiothérapie ram Cancer - Treatment Tumeurs - Traitement médicamenteux Antimetabolites Therapeutic use Cancer Chemotherapy Folic Acid Antagonists therapeutic use Folic acid Antagonists Therapeutic use Folic acid Derivatives Therapeutic use Neoplasms drug therapy Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Therapie (DE-588)4059798-2 gnd rswk-swf Folate (DE-588)4154952-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Folate (DE-588)4154952-1 s Krebs Medizin (DE-588)4073781-0 s Therapie (DE-588)4059798-2 s DE-604 Jackman, Ann L. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008493780&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Antifolate drugs in cancer therapy Antifoliques - Emploi en thérapeutique ram Antifoliques - usage thérapeutique Antimétabolites - Emploi en thérapeutique ram Cancer - Chimiothérapie ram Cancer - Treatment Tumeurs - Traitement médicamenteux Antimetabolites Therapeutic use Cancer Chemotherapy Folic Acid Antagonists therapeutic use Folic acid Antagonists Therapeutic use Folic acid Derivatives Therapeutic use Neoplasms drug therapy Krebs Medizin (DE-588)4073781-0 gnd Therapie (DE-588)4059798-2 gnd Folate (DE-588)4154952-1 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4059798-2 (DE-588)4154952-1 (DE-588)4143413-4 |
| title | Antifolate drugs in cancer therapy |
| title_auth | Antifolate drugs in cancer therapy |
| title_exact_search | Antifolate drugs in cancer therapy |
| title_full | Antifolate drugs in cancer therapy ed. by Ann L. Jackman |
| title_fullStr | Antifolate drugs in cancer therapy ed. by Ann L. Jackman |
| title_full_unstemmed | Antifolate drugs in cancer therapy ed. by Ann L. Jackman |
| title_short | Antifolate drugs in cancer therapy |
| title_sort | antifolate drugs in cancer therapy |
| topic | Antifoliques - Emploi en thérapeutique ram Antifoliques - usage thérapeutique Antimétabolites - Emploi en thérapeutique ram Cancer - Chimiothérapie ram Cancer - Treatment Tumeurs - Traitement médicamenteux Antimetabolites Therapeutic use Cancer Chemotherapy Folic Acid Antagonists therapeutic use Folic acid Antagonists Therapeutic use Folic acid Derivatives Therapeutic use Neoplasms drug therapy Krebs Medizin (DE-588)4073781-0 gnd Therapie (DE-588)4059798-2 gnd Folate (DE-588)4154952-1 gnd |
| topic_facet | Antifoliques - Emploi en thérapeutique Antifoliques - usage thérapeutique Antimétabolites - Emploi en thérapeutique Cancer - Chimiothérapie Cancer - Treatment Tumeurs - Traitement médicamenteux Antimetabolites Therapeutic use Cancer Chemotherapy Folic Acid Antagonists therapeutic use Folic acid Antagonists Therapeutic use Folic acid Derivatives Therapeutic use Neoplasms drug therapy Krebs Medizin Therapie Folate Aufsatzsammlung |
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