Proteolytic and cellular mechanisms in prohormone and proprotein processing:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Austin, Tex.
Landes
1998
|
| Schriftenreihe: | Molecular biology intelligence unit
2 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 215 S. Ill., graph. Darst. |
| ISBN: | 1570595534 |
Internformat
MARC
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| 245 | 1 | 0 | |a Proteolytic and cellular mechanisms in prohormone and proprotein processing |c [ed. by] Vivian Y. H. Hook |
| 264 | 1 | |a Austin, Tex. |b Landes |c 1998 | |
| 300 | |a 215 S. |b Ill., graph. Darst. | ||
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| 490 | 1 | |a Molecular biology intelligence unit |v 2 | |
| 650 | 2 | |a Modifications post-traductionnelles des protéines - physiologie | |
| 650 | 2 | |a Peptide hydrolases - métabolisme | |
| 650 | 7 | |a Protéines - Métabolisme |2 ram | |
| 650 | 2 | |a Précurseurs protéine - métabolisme | |
| 650 | 4 | |a Peptide Hydrolases |x metabolism | |
| 650 | 4 | |a Peptide hormones |x Metabolism | |
| 650 | 4 | |a Peptide hormones |x Physiological transport | |
| 650 | 4 | |a Post-translational modifications | |
| 650 | 4 | |a Protein Precursors |x metabolism | |
| 650 | 4 | |a Protein Processing, Post-Translational |x physiology | |
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Datensatz im Suchindex
| _version_ | 1804127111056719872 |
|---|---|
| adam_text | MOLECULAR BIOLOGY
INTELLIGENCE
UNIT
JProteolytic and Cellular
Mechanisms in Prohormone
and Proprotein Processing
Vivian Y H Hook
Department of Medicine
University of California, San Diego
La Jolla, California, U S A
R G LANDES
COMPANY
AUSTIN, TEXAS
U S A
CONTENTS
1 Targeting and Activation of Peptide Hormones
in the Secretory Pathway 1
Ken Teter and Hsiao-Ping H Moore
Introduction 1
Trafficking and Modification of Peptide Hormone Precursors 3
Prohormone Sorting Mechanisms 8
Site of Prohormone Sorting 10
Prohormone Activation 12
Summary and Future Perspectives 15
2 The Mechanism of Sorting Proopiomelanocortin to Secretory
Granules and Its Processing by Aspartic and PC Enzymes 29
Niamh X Cawley, David R Cool, Emmanuel Normant,
Fu-Sheng Shen, Vicki Olsen and Y Peng Loh
General Introduction 29
Mechanism of Sorting POMC
to the Regulated Secretory Pathway 31
Endoproteolytic Processing of Proopiomelanocortin 34
Future Directions 42
3 The Mammalian Precursor Convertases: Paralogs of the Subtilisin/
Kexin Family of Calcium-Dependent Serine Proteinases 49
Nabil G Seidah, Majambu Mbikay, Mieczyslaw Marcinkiewicz,
Michel Chritien
Introduction 49
Subtilisin/Kexin-like Precursor Convertases (PCs):
Structural and Cellular Considerations 51
Ontogeny, Tissue Expression and Subcellular Localization 59
Structure, Loci, and Evolution of PC Genes 62
Antisense Transgene Inhibition 63
Heritable Deficiency of PC in Human and Mouse 65
Inhibitors of PCs 66
Enzymatic Cascades: ADAM Family and PCs 67
Conclusions 68
4 The Neuroendocrine Prohormone Convertases PCI, PC2 and PC5 77
Margery C Beinfeld
Introduction 77
The Discovery of the Subtilisin Family
of Prohormone Convertases 77
Distribution of PCI, PC2 and PC5 79
Biosynthesis and Activation of PCI, PC2 and PC5 79
Regulation of PC Expression 80
Experimental Systems Used to Study Processing 80
Enzymatic Activity of PCI, PC2, and PC5 81
Antisense PCI and PC2 Strategies
to Study Proneuropeptide Processing 81
Endoproteases in CCK Processing, a Case in Point 82
Processing Enzyme Knockouts and Mutations 82
Future Challenges 83
5 Prohormone Thiol Protease (PTP), a Novel Cysteine Protease
for Proenkephalin and Prohormone Processing 89
Vivian Y H Hook, Yuan-Hsu Rang, Martin Schiller,
Nikolaos Tezapsidis, Jane M Johnston and Ada Azaryan
Introduction 89
The Novel Prohormone Thiol Protease (PTP): A Major
Proenkephalin Processing Enzyme in Chromaffin Granules 92
Participation of PCI/3 and PC2 Subtilisin-Like Proteases,
and 70 kDa Aspartyl Protease (PCE) in Proenkephalin
Processing in Chromaffin Granules 100
Conclusions 100
6 Regulation of Prohormone Conversion by Coordinated Control
of Processing Endopeptidase Biosynthesis with That
of the Prohormone Substrate 105
Terence P Herbert, Cristina Alarcon, Robert H Skelly,
L Cornelius Bollheimer, George T Schuppin and Christopher J Rhodes
Introduction 105
Coordinated Regulation of Prohormone
and Processing Enzyme mRNA Levels 106
Coordinated Translational Regulation of Specific Prohormone
and Processing Enzyme Biosynthesis 110
7 Carboxypeptidase and Aminopeptidase Proteases
in Proneuropeptide Processing 121
Vivian Y H Hook and Sukkid Yasothornsrikul
Introduction 121
Neuroendocrine-specific Carboxypeptidase E/H 122
Molecular Genetic Analysis of Mutant Carboxypeptidase
E/H in fat/fat Obese Mice: Effects of Inactive CPE/H
on Prohormone Processing 129
Mutant CPE/H in fat/fat Mice Leads to Discovery
of Novel Carboxypeptidase D and Carboxypeptidase Z 130
Evidence for CPE/H as a Sorting Receptor for the Intracellular
Routing of POMC and Possibly Other Prohormones
to the Secretory Vesicle 132
Aminopeptidase(s) for Prohormone Processing 133
Conclusions and Future Perspectives 134
8 The Neuroendocrine Polypeptide 7B2 as a Molecular Chaperone
and Naturally Occurring Inhibitor
of Prohormone Convertase PC2 141
A Martin Van Horssen and Gerard J M Martens
Introduction 141
History of 7B2 141
The 7B2 Gene and Its Regulation 142
Evolutionary Aspects 144
7B2 is a Neuroendocrine-Specific Polypeptide 144
Biochemical Characteristics of 7B2 145
Posttranslational Modifications of 7B2 145
Regulated Secretion of 7B2 146
The Quest for the Role of 7B2 146
Model of the Interaction Between 7B2 and PC2 149
Implications and Future Prospects 151
9 Neuroendocrine c^-Antichymotrypsin as a Possible Regulator
of Prohormone and Neuropeptide Precursor Processing 159
Shin-Rong Hwang and Vivian Y H Hook
Introduction 159
Biochemical Evidence for a,-Antichymotrypsin (ACT) as an
Endogenous Regulator of the Prohormone Thiol Protease
(PTP) and Other Prohormone Processing Proteases 160
Molecular Cloning Reveals Multiple Isoforms of Bovine ACT
Expressed in Neuroendocrine Tissues 164
10 Proteolytic Inactivation of Secreted Neuropeptides 173
Eva Csuhai, Afshin Safavi, Michael W Thompson and Louis B Hersh
Introduction 173
Neprilysin 174
Aminopeptidases 176
Angiotensin Converting Enzyme 178
Pyroglutamyl Peptidase II 178
Proline Specific Peptidases 179
Soluble Neuropeptidases 180
Endopeptidase 24 15 and Endopeptidase 24 16 181
Summary 182
11 Stimulation of Peptidergjc Receptors by Peptide Hormones
and Neurotransmitters: Studies of Opioid Receptors 191
George Bot, Allan D Blake and Terry Reisine
Introduction 191
Opioid Receptor Types 191
Endogenous Opioids 192
Endogenous Peptide Receptor Selectivity 192
Opioid Ligands 194
Opioid Cellular Activity 195
Opioid Receptor Cloning 196
ORL1 and Nociceptin/Orphanin FQ 196
Structure-Function Analysis of Cloned Opioid Receptors 198
|l Receptor Knockout Mice Model 201
Agonist Regulation of Cloned Opioid Receptors 201
G Protein Role in Differential Agonist Activity 204
Conclusion 204
Index 213
|
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| dewey-tens | 570 - Biology |
| discipline | Biologie |
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| id | DE-604.BV012470732 |
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| indexdate | 2024-07-09T18:28:09Z |
| institution | BVB |
| isbn | 1570595534 |
| language | English |
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| series2 | Molecular biology intelligence unit |
| spelling | Proteolytic and cellular mechanisms in prohormone and proprotein processing [ed. by] Vivian Y. H. Hook Austin, Tex. Landes 1998 215 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit 2 Modifications post-traductionnelles des protéines - physiologie Peptide hydrolases - métabolisme Protéines - Métabolisme ram Précurseurs protéine - métabolisme Peptide Hydrolases metabolism Peptide hormones Metabolism Peptide hormones Physiological transport Post-translational modifications Protein Precursors metabolism Protein Processing, Post-Translational physiology Protein precursors Proteins metabolism Proteolytic enzymes Thiolprotease (DE-588)4185270-9 gnd rswk-swf Enzymkatalyse (DE-588)4152480-9 gnd rswk-swf Subtilisine (DE-588)4427538-9 gnd rswk-swf Neurochemie (DE-588)4041872-8 gnd rswk-swf Prohormon (DE-588)4227907-0 gnd rswk-swf Enzymatische Regulation (DE-588)4136839-3 gnd rswk-swf Endopeptidasen (DE-588)4070806-8 gnd rswk-swf Neuropeptide (DE-588)4041895-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Neuropeptide (DE-588)4041895-9 s Prohormon (DE-588)4227907-0 s Enzymkatalyse (DE-588)4152480-9 s Endopeptidasen (DE-588)4070806-8 s DE-604 Subtilisine (DE-588)4427538-9 s Neurochemie (DE-588)4041872-8 s Thiolprotease (DE-588)4185270-9 s Enzymatische Regulation (DE-588)4136839-3 s Hook, Vivian Yuan-Hen Ho Sonstige oth Molecular biology intelligence unit 2 (DE-604)BV012379718 2 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008463140&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Proteolytic and cellular mechanisms in prohormone and proprotein processing Molecular biology intelligence unit Modifications post-traductionnelles des protéines - physiologie Peptide hydrolases - métabolisme Protéines - Métabolisme ram Précurseurs protéine - métabolisme Peptide Hydrolases metabolism Peptide hormones Metabolism Peptide hormones Physiological transport Post-translational modifications Protein Precursors metabolism Protein Processing, Post-Translational physiology Protein precursors Proteins metabolism Proteolytic enzymes Thiolprotease (DE-588)4185270-9 gnd Enzymkatalyse (DE-588)4152480-9 gnd Subtilisine (DE-588)4427538-9 gnd Neurochemie (DE-588)4041872-8 gnd Prohormon (DE-588)4227907-0 gnd Enzymatische Regulation (DE-588)4136839-3 gnd Endopeptidasen (DE-588)4070806-8 gnd Neuropeptide (DE-588)4041895-9 gnd |
| subject_GND | (DE-588)4185270-9 (DE-588)4152480-9 (DE-588)4427538-9 (DE-588)4041872-8 (DE-588)4227907-0 (DE-588)4136839-3 (DE-588)4070806-8 (DE-588)4041895-9 (DE-588)4143413-4 |
| title | Proteolytic and cellular mechanisms in prohormone and proprotein processing |
| title_auth | Proteolytic and cellular mechanisms in prohormone and proprotein processing |
| title_exact_search | Proteolytic and cellular mechanisms in prohormone and proprotein processing |
| title_full | Proteolytic and cellular mechanisms in prohormone and proprotein processing [ed. by] Vivian Y. H. Hook |
| title_fullStr | Proteolytic and cellular mechanisms in prohormone and proprotein processing [ed. by] Vivian Y. H. Hook |
| title_full_unstemmed | Proteolytic and cellular mechanisms in prohormone and proprotein processing [ed. by] Vivian Y. H. Hook |
| title_short | Proteolytic and cellular mechanisms in prohormone and proprotein processing |
| title_sort | proteolytic and cellular mechanisms in prohormone and proprotein processing |
| topic | Modifications post-traductionnelles des protéines - physiologie Peptide hydrolases - métabolisme Protéines - Métabolisme ram Précurseurs protéine - métabolisme Peptide Hydrolases metabolism Peptide hormones Metabolism Peptide hormones Physiological transport Post-translational modifications Protein Precursors metabolism Protein Processing, Post-Translational physiology Protein precursors Proteins metabolism Proteolytic enzymes Thiolprotease (DE-588)4185270-9 gnd Enzymkatalyse (DE-588)4152480-9 gnd Subtilisine (DE-588)4427538-9 gnd Neurochemie (DE-588)4041872-8 gnd Prohormon (DE-588)4227907-0 gnd Enzymatische Regulation (DE-588)4136839-3 gnd Endopeptidasen (DE-588)4070806-8 gnd Neuropeptide (DE-588)4041895-9 gnd |
| topic_facet | Modifications post-traductionnelles des protéines - physiologie Peptide hydrolases - métabolisme Protéines - Métabolisme Précurseurs protéine - métabolisme Peptide Hydrolases metabolism Peptide hormones Metabolism Peptide hormones Physiological transport Post-translational modifications Protein Precursors metabolism Protein Processing, Post-Translational physiology Protein precursors Proteins metabolism Proteolytic enzymes Thiolprotease Enzymkatalyse Subtilisine Neurochemie Prohormon Enzymatische Regulation Endopeptidasen Neuropeptide Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008463140&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV012379718 |
| work_keys_str_mv | AT hookvivianyuanhenho proteolyticandcellularmechanismsinprohormoneandproproteinprocessing |