Complexity in structure and function of the lung:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
Dekker
1998
|
| Series: | Lung biology in health and disease
121 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVII, 651 S. Ill., graph. Darst. |
| ISBN: | 0824798791 |
Staff View
MARC
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Record in the Search Index
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|---|---|
| adam_text | CONTENTS
Series Introduction Claude Lenfant Hi
Preface v
Contributors vii
Part One MECHANICAL PROPERTIES
1. Heterogeneity in Airways 1
Robert Brown and Wayne A. Mitzner
I. Introduction 1
II. Heterogeneity in Baseline Airway Diameters Over
Extended Periods of Time 4
in. Heterogeneity in Individual Airway Responsiveness
to Agonist Challenge In Vivo 14
IV. Heterogeneity of Relaxed Airways in Response to
Lung Inflation 21
V. Heterogeneity of Contracted Airways in Response to
Lung Inflation 24
VI. Limits of Airway Heterogeneity Along the Axis
of an Airway Branch 26
VII. Ramifications of Airway Heterogeneity on Pulmonary
Function Tests and Lung Disease 28
VIII. Summary 30
References 31
2. Alveolar Lining Layer: Functions, Composition, Structures 35
Samuel Schiirch, Hans Bachofen, and Fred Possmayer
I. Introduction 35
II. The Surface Film 37
HI. Summary 67
References 68
i
xii Contents
3. Parenchymal Macromechanics 75
Theodore A. Wilson
I. Introduction 75
II. The Pressure Volume Curve 78
III. Shear 84
IV. Lung Deformations 86
V. Small Scale Variability in Parenchymal Expansion 89
VI. Active Component of Lung Recoil 91
VII. Conclusion 94
References 95
4. Micromechanics of the Lung: From the Parenchyma to
the Cytoskeleton 99
Jeffrey J. Fredberg, Ning Wang, Dimitrije Stamenovid,
and Donald E. lngber
I. Introduction 99
II. Magnetic Twisting Cytometry—A Novel Probe of
Cytoskeletal Mechanics 105
III. Microstructural Analysis of Cytoskeletal Mechanics 110
IV. Summary 119
References 120
5. Dynamics of Pleural Liquid: Mechanical Factors Affecting
Its Formation and Regional Distribution 123
Stephen J. Lai Fook and Ping M. Wang
I. Introduction 123
II. Foundations of Pleural Mechanics 124
III. Spatial Gradients in Pleural Pressure 125
IV. Modeling Recirculation of Pleural Liquid Within the
Pleural Space 130
V. Pleural Liquid Thickness 134
VI. Microvascular Fluid Exchange of Pleural Liquid 138
VII. Mechanical Factors Contributing to Spatial Gradients
in Pleural Liquid Filtration 140
VIII. Summary 145
References 146
6. Chest Wall Mechanics 151
Stephen H. Loring and James P. Butler
Contents xiii
I. Introduction 151
II. Historical Approaches 151
III. Reexamination of Critical Assumptions 156
IV. Action of Respiratory Muscles 173
V. Summary 177
References 177
7. Diaphragm Mechanics 181
Aladin M. Boriek and Joseph R. Rodarte
I. Introduction 181
II. Model Mechanics 182
III. Complexities in Diaphragm Mechanics Theory 184
IV. Current Works in Diaphragm Mechanics 191
V. Summary 201
References 201
Part Two AIRWAY EXCHANGE OF GAS
8. Inert Gas Exchange in the Airways 205
Steven C. George, Jennifer E. Souders, and
Michael P. Hlastala
I. Introduction 205
II. Physical Principles of Airway Gas Exchange 208
III. Experimental and Theoretical Evidence of Airway
Gas Exchange 222
IV. Summary 236
References 237
9. Kinetic Determinants of Inhaled Reactive Gas Absorption 243
Akhil Bidani and Edward M. Postlethwait
I. Introduction 243
II. Gas Physicochemical Properties and Tissue Dose 244
III. Effect of Ionic Equilibria on Reactive Gas Absorption 247
IV. Effect of Reaction Kinetics on Mass Transfer 251
V. Predictions of In Vivo Reactive Gas Absorption Using
Mathematical Models 260
VI. Interpretation of Experimental Data on Gas Absorption
Using Mathematical Models 274
xiv Contents
VII. Noninvasive Measurement and Analysis of Reactive
Gas Absorption in Humans 285
Vffl. Summary 289
References 292
10. Gas and Particle Transport in the Lung 297
Chantal Darquenne and Manuel Paiva
I. Introduction 297
II. Concepts 298
III. Gas and Particle Transport in the Healthy Lung 301
IV. Gas and Particle Transport in Disease 314
V. Summary 319
References 319
Part Three PULMONARY VENTILATION HETEROGENEITY
11. Characteristics of Respiratory System Complexity Captured
via X Ray Computed Tomography: Image Acquisition, Display,
and Analysis 325
Eric A. Hoffman and Lynne E. Olson
I. Introduction 325
II. High Speed X Ray CT: Overview 327
III. State of the Art: Where Have We Been? 334
IV. State of the Art: Where Are We Now? 335
V. Dynamic Measurements 340
VI. Application of the Tools in a Physiological Assessment of
V/Q Physiology 358
References 369
12. Measurement of Regional Ventilation by Aerosol Deposition 379
H. Thomas Robertson
I. Introduction 379
II. Problems with Estimation of Regional Alveolar Ventilation 381
III. Radionuclide Images of the Intact Lung 383
IV. Differences Between Aerosol Deposition and Radioactive
Gas Measurements in Abnormal Lungs 384
V. CT Measurements of Regional Ventilation 385
VI. Measurements of Regional Ventilation with Parenchymal
Markers 385
Contents xv
VII. Advantages of Destructive Studies of Regional Ventilation 386
VIII. Determinants of Aerosol Deposition in the Lung 386
IX. Ventilatory Parameters as Determinants of Deposition 388
X. Limitations of Aerosols for Scale of Measurement 388
XI. Measurement of Fluorescent Microsphere Aerosol
Deposition 389
XII. Quantitation of Ventilation Heterogeneity 391
XIII. Temporal Heterogeneity of Ventilation 391
XIV. Regional Gradients of Ventilation 392
XV. Species Differences 392
XVI. Validation Against Gas Exchange Methods 393
XVII. Scale of Regional Heterogeneity of Ventilation 395
XVIII. Conclusion 395
References 396
Part Four PULMONARY PERFUSION HETEROGENEITY
13. Complexity and Structure Function Relationships in
the Pulmonary Arterial Tree 401
Christopher A. Dawson, Gary S. Krenz, and
John H. Linehan
I. Introduction 401
II. Pulmonary Arterial Tree Morphometry 403
III. A Model of the Pulmonary Arterial Tree 406
IV. Asymmetry and the Longitudinal Distribution of Pulmonary
Arterial Resistance 411
V. Arterial Tree Morphometry From Individual Bifurcations 414
VI. Effects of Vasoconstriction 417
VII. Functional Significance of the Value of P, 420
VIII. Summary 425
References 426
14. Complexity of Perfusion in the Pulmonary Gas
Exchange Vessels 429
Wiltz W. Wagner, Jr., and Robert G. Presson, Jr.
I. Introduction 429
II. The Effect of Pulmonary Microvascular Anatomy on Perfusion 435
References 457
xvi Contents
15. Regional Differences in the Lung: A Changing Perspective
on Blood Flow Distribution 461
Robb W. Glenny and H. Thomas Robertson
I. Introduction 461
II. Kuhn s Model of Scientific Progress 462
III. Initial Model and Supporting Observations 464
IV. Formulation of the Gravitational Paradigm 464
V. Model Predictions 466
VI. Anomalies 467
VII. New Observations 470
VIII. New Model 473
IX. New Perspectives 478
References 479
Part Five MATCHING OF VENTILATION AND PERFUSION
16. Noninvasive Measurement of Local VA, Q, and
Va/Q Distributions by PET 483
Jose G. Venegas
I. Introduction 483
II. Imaging Techniques 486
III. Image Analysis 498
IV. Regulation on VA,Q, and VA/Q Distributions 505
V. Summary 508
References 508
17. Physiological Effects of Oxygen and Carbon Dioxide
on Va/0 Heterogeneity 511
Erik R. Swenson, Karen B. Domino, and Michael P. Hlastala
I. Introduction 511
II. Oxygen 512
in. Carbon Dioxide 520
IV. Summary 535
References 535
18. Ventilation Perfusion Heterogeneity:
Insights from Comparative Physiology 549
Susan R. Hopkins and Frank L. Powell
Contents xvii
I. Introduction 549
II. Lesson One: Although Lung Structure Differs Between
Species, Spatial Ventilation Perfusion Heterogeneity
Is Similar 551
III. Comparative Effects of V/Q Heterogeneity on O2
Exchange at Rest 555
IV. Lesson Two: Mammals at Rest Define the Optimal
Conditions for Minimizing V/Q Heterogeneity in
Ventilated Pool Lungs of Mammals and Reptiles 557
V. Lesson Three: Alterations in Metabolic Rate Increase
the Complexity of Pulmonary Gas Exchange,
Independent of Lung Structure 559
VI. Summary 565
References 566
19. Heterogeneity in the Lung: Concepts and Measures 571
Robb W. Glenny
I. Introduction 571
II. Changing Perspectives 572
III. Statistical Measures of Heterogeneity 574
IV. Measurement Resolution 576
V. Contour Measuring Method 579
VI. Box Counting Method 581
VII. Fractal Characterization of Spatial Heterogeneity
Using Relative Dispersion Analysis 583
VIII. Spatial Correlation of Blood Flow and of Ventilation 589
IX. Statistical Analyses of Spatially Distributed
Point Processes 593
X. Fractal Processes, Temporal Heterogeneity, and
Temporal Correlation 598
XI. Dispersion Analysis 599
XII. Summary 606
References 607
Author Index 611
Subject Index 643
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| indexdate | 2024-07-09T18:27:23Z |
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| isbn | 0824798791 |
| language | English |
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| series | Lung biology in health and disease |
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| spelling | Complexity in structure and function of the lung ed. by Michael P. Hlastala ... New York [u.a.] Dekker 1998 XVII, 651 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 121 Biomécanique ram Poumon - Physiologie Poumon - Physiologie ram Respiration ram Biomechanics Lung physiology Lungs Physiology Pulmonary gas exchange Lunge (DE-588)4036651-0 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Lunge (DE-588)4036651-0 s Physiologie (DE-588)4045981-0 s DE-604 Hlastala, Michael P. Sonstige oth Lung biology in health and disease 121 (DE-604)BV000008326 121 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008431470&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Complexity in structure and function of the lung Lung biology in health and disease Biomécanique ram Poumon - Physiologie Poumon - Physiologie ram Respiration ram Biomechanics Lung physiology Lungs Physiology Pulmonary gas exchange Lunge (DE-588)4036651-0 gnd Physiologie (DE-588)4045981-0 gnd |
| subject_GND | (DE-588)4036651-0 (DE-588)4045981-0 (DE-588)4143413-4 |
| title | Complexity in structure and function of the lung |
| title_auth | Complexity in structure and function of the lung |
| title_exact_search | Complexity in structure and function of the lung |
| title_full | Complexity in structure and function of the lung ed. by Michael P. Hlastala ... |
| title_fullStr | Complexity in structure and function of the lung ed. by Michael P. Hlastala ... |
| title_full_unstemmed | Complexity in structure and function of the lung ed. by Michael P. Hlastala ... |
| title_short | Complexity in structure and function of the lung |
| title_sort | complexity in structure and function of the lung |
| topic | Biomécanique ram Poumon - Physiologie Poumon - Physiologie ram Respiration ram Biomechanics Lung physiology Lungs Physiology Pulmonary gas exchange Lunge (DE-588)4036651-0 gnd Physiologie (DE-588)4045981-0 gnd |
| topic_facet | Biomécanique Poumon - Physiologie Respiration Biomechanics Lung physiology Lungs Physiology Pulmonary gas exchange Lunge Physiologie Aufsatzsammlung |
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