Osteoporosis:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
London [u.a.]
Chapman & Hall Medical
1998
|
| Edition: | 1. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIII, 380 S. Ill., graph. Darst. |
| ISBN: | 0412488701 |
Staff View
MARC
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| 245 | 1 | 0 | |a Osteoporosis |c ed. by John C. Stevenson ... |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a London [u.a.] |b Chapman & Hall Medical |c 1998 | |
| 300 | |a XIII, 380 S. |b Ill., graph. Darst. | ||
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| 650 | 7 | |a Osteopatias |2 larpcal | |
| 650 | 7 | |a Osteoporose |2 gtt | |
| 650 | 7 | |a Therapieën |2 gtt | |
| 650 | 4 | |a Metabolism |x Disorders | |
| 650 | 4 | |a Osteoporosis | |
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Record in the Search Index
| _version_ | 1804127027619430400 |
|---|---|
| adam_text | CONTENTS
Colour plates appear between pages 104 and 105
List of Contributors xi
Preface xv
1 Bone structure and cellular activity 1
T.J. Martin and D.W. Dempster
Bone matrix 1
Bone cell biology 2
Osteoclast function and regulation 3
Origin and properties of the osteoblast lineage 10
2 Pathogenesis of osteoporosis 29
R.M. Francis, A.M. Sutcliffe and A.C. Scane
Bone remodelling 29
Bone mass throughout life 29
Osteoporosis 31
3 Pathogenesis of postmenopausal osteoporotic fractures 53
C.C. Johnston }r and C.W. Slemenda
4 Epidemiology 65
L.J. Melton III and C. Cooper
Introduction 65
What is osteoporosis? 65
Epidemiology of low bone mass 67
Epidemiology of fractures 72
Conclusion 80
5 Bone histomorphometry 85
/. Compston
Introduction 85
Bone biopsy 85
Measurement techniques in bone histomorphometry 87
Histomorphometric indices nomenclature and units 89
Assessment of bone area 91
Assessment of mineralization 92
Assessment of bone turnover 93
Assessment of remodelling balance 95
Assessment of bone structure 97
vi Contents
Bone remodelling in osteoporosis 101
Limitations of bone histomorphometry 102
Bone histomorphometry in osteoporosis 103
Bone structure in primary osteoporosis 105
The effects of drugs on bone remodelling 107
The effects of drugs on bone structure 109
6 Biological markers of bone turnover in osteoporosis 117
P.D. Delntas and P. Garnetv
Summary 117
Introduction 117
Biochemical markers of bone formation 119
Biochemical markers of bone resorption 122
Changes of bone turnover at the menopause 126
Bone turnover in postmenopausal women with vertebral osteoporosis 128
Bone turnover in the elderly and in patients with hip fracture 129
Bone markers to monitor treatment of osteoporosis 131
Conclusion 131
7 Bone mass measurements 137
B. Lees, L.M. Banks andJ.C. Stevenson
Introduction 137
Which bone should be measured? 137
Radiographs 138
Single photon absorptiometry (SPA) 139
Single energy X ray absorptiometry (SXA) 140
Dual photon absorptiometry (DPA) 141
Dual energy X ray absorptiometry (DXA) 142
Quantitative computed tomography (QCT) 149
Neutron activation analysis (NAA) 152
Compton scattering 152
Magnetic resonance imaging (MRI) 152
Ultrasound 153
Potential errors in the measurement of bone mass 154
Conclusion 155
8 Estrogen and osteoporosis 161
R. Lindsay
Introduction 161
The effect of ovarian failure 161
The effects of estrogen 162
Treatment of established osteoporosis 165
Interactions with other treatment modalities 165
Conclusion 168
Contents vii
9 The use of bisphosphonates in osteoporosis 173
H. Fleisch
Introduction 173
Chemistry and general characteristics 173
Effects 175
Pharmacokinetics 181
Animal toxicology 183
Adverse events in the human 183
Contraindications 185
Use in osteoporosis in humans 186
Mode of action of bisphosphonates in osteoporosis 193
General considerations 194
Conclusion 195
10 Calcitonin therapy in osteoporotic syndromes 207
LV.Avioli
11 Requirements for calcium and its use in the management of osteoporosis 215
J.A. Kanis
Introduction 215
Historical perspective 216
Bone remodelling 217
Transient and steady states with respect to calcium nutrition 221
Requirements for calcium in young healthy women 223
Skeletal metabolism after the menopause 228
Is osteoporosis a calcium deficiency disease? 231
Effects of calcium in osteoporosis 232
Who and how to treat 234
Conclusion 236
12 Vitamin D treatment in osteoporosis and osteomalacia 243
J.C. Gallagher
Introduction 243
Vitamin D metabolism 243
Calcium absorption: effects of dietary calcium, 1,25(OH)2D and age 244
Calcium absorption in osteoporotics 245
Vitamin D deficiency 246
Seasonal changes in serum 25 OHD 246
Effect of vitamin D supplementation on serum 25 hydroxyvitamin D
and parathyroid hormone 248
Vitamin D2 or D3 treatment in type I postmenopausal osteoporosis 250
Vitamin D2 or D3 treatment in type II senile osteoporosis 251
Metabolites or analogs of vitamin D in osteoporosis treatment 252
Safety of vitamin D administration in osteoporosis 256
viii Contents
13 Anabolic steroids 263
C. Christiansen
Introduction 263
The effect on the human bone cell 263
The effects on the ovariectomized rat 264
Effects on trabecular bone mass 264
Effects on cortical bone mass 264
The effects of anabolic steroids in man 265
14 Fluoride therapy for postmenopausal osteoporosis 277
M. Kleerekoper and D.A. Nelson
Introduction 277
Absorption, metabolism and plasma levels of fluoride 278
Mechanism of action 280
Effect of NaF on bone mass 282
Sodium fluoride and vertebral fractures 284
Slow release sodium fluoride 286
Sodium fluoride and hip fractures 286
Other side effects of NaF 287
Conclusion 288
15 Parathyroid hormone as an anabolic treatment 293
F. Cosman and R. Lindsay
Introduction 293
Parallels with primary hyperparathyroidism 293
Possible mechanisms of action 294
Animal studies 295
Human studies 298
Conclusion 301
16 Physical activity and osteoporosis 309
R. Marcus and B.f. Kiratli
Introduction 309
The relationship of mechanical loading to bone mass 309
Relationship of disuse to bone mass 311
Relationship of exercise to bone mass 316
17 Physical medicine and rehabilitation 327
F.J. Bonner
Introduction 327
Outcome of fracture 328
Rehabilitation interventions 328
Program evaluation 329
Site for provision of rehabilitation services 330
Role of team members 331
History and physical examination 333
Rehabilitation following acute fractures 333
Contents ix
Rehabilitation of osteoporosis related disability 335
Chronic pain management 336
Costal iliac impingement syndrome 338
Development of spinal arthritis 339
Conservative pain management 339
Spinal supports 339
Fall and fracture prevention 346
Conclusion 347
18 Orthopaedic management 351
P.R. Allen
Introduction 351
Mechanism of fracture 351
Nature of bone strength 351
Osteoporotic fractures 352
Vertebral fractures 354
Hip fractures 356
19 Future strategies for osteoporosis 365
G.R. Mundy
Introduction 365
Resorption inhibitors 366
Bone growth stimulators 369
ADFR or coherence therapy 370
Conclusion 373
Index 377
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| spelling | Osteoporosis ed. by John C. Stevenson ... 1. ed. London [u.a.] Chapman & Hall Medical 1998 XIII, 380 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Osteopatias larpcal Osteoporose gtt Therapieën gtt Metabolism Disorders Osteoporosis Osteoporose (DE-588)4044021-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Osteoporose (DE-588)4044021-7 s DE-604 Stevenson, John C. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008407655&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Osteoporosis Osteopatias larpcal Osteoporose gtt Therapieën gtt Metabolism Disorders Osteoporosis Osteoporose (DE-588)4044021-7 gnd |
| subject_GND | (DE-588)4044021-7 (DE-588)4143413-4 |
| title | Osteoporosis |
| title_auth | Osteoporosis |
| title_exact_search | Osteoporosis |
| title_full | Osteoporosis ed. by John C. Stevenson ... |
| title_fullStr | Osteoporosis ed. by John C. Stevenson ... |
| title_full_unstemmed | Osteoporosis ed. by John C. Stevenson ... |
| title_short | Osteoporosis |
| title_sort | osteoporosis |
| topic | Osteopatias larpcal Osteoporose gtt Therapieën gtt Metabolism Disorders Osteoporosis Osteoporose (DE-588)4044021-7 gnd |
| topic_facet | Osteopatias Osteoporose Therapieën Metabolism Disorders Osteoporosis Aufsatzsammlung |
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