Advances in serotonin receptor research: molecular biology, signal transduction and therapeutics
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York, NY
New York Acad. of Sciences
1998
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| Series: | New York Academy of Sciences: Annals of the New York Academy of Sciences
861 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIII, 297 S. graph. Darst. |
| ISBN: | 1573311707 1573311715 |
Staff View
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| 245 | 1 | 0 | |a Advances in serotonin receptor research |b molecular biology, signal transduction and therapeutics |c ed. by Graeme R. Martin ... |
| 264 | 1 | |a New York, NY |b New York Acad. of Sciences |c 1998 | |
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| 650 | 4 | |a Sérotonine - Récepteurs - Congrès | |
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 861
December 15, 1998
ADVANCES IN SEROTONIN
RECEPTOR RESEARCH
MOLECULAR BIOLOGY, SIGNAL TRANSDUCTION, AND
THERAPEUTICS
Editors and Conference Organizers
Graeme R. Martin, Richard M. Eglen, Daniel Hoyer,
Mark W. Hamblin, and Frank Yocca
CONTENTS
Preface. By G. R. Martin, R. M. Eglen, D. Hoyer, M. W. Hamblin, and
F. Yocca xiii
Plenary Lecture
5 HT4 Receptors: Gene, Transduction and Effects on Olfactory Memory. By J.
Bockaert, S. Claeysen, M. Sebben, and A. Dumuis 1
Part I. Molecular Biology
Serotonin Receptor Variants in Disease: New Therapeutic Opportunities? By
S. J. Peroutka 16
Genetic Variation in Human 5 HT Receptors: Potential Pathogenetic and
Pharmacological Role. By M. Gothert, P. Propping, H. Bonisch, M.
Bruss, and M.M. Nothen 26
Gs Protein coupled Serotonin Receptors: Receptor Isoforms and Functional
Differences. By M. W. Hamblin, C. R. Guthrie, R. Kohen, and
D. E. A. Heidmann 31
Identification and Characterization of RNA Editing Events within the 5 HT2C
Receptor. By C. M. Niswender, E. Sanders Bush, and R. B. Emeson .. 38
5 HT4 Receptors: Cloning and Expression of New Splice Variants. By S.
Claeysen, P. Faye, M. Sebben, S. Taviaux, J. Bockaert, and A.
Dumuis 49
This volume is the result of a conference entitled Advances in Serotonin Receptor Research:
Molecular Biology, Signal Transduction, and Therapeutics, organized under the auspices of the
Serotonin Club and the International Union of Pharmacology (IUPHAR) and held in San Fran¬
cisco, California on October 8 10, 1997.
Inducible Knockout Strategies to Probe the Functions of 5 HT Receptors. By
K. L. Stark, R. S. Oosting, and R. Hen 57
Mouse 5 HT2B Receptor mediated Serotonin Trophic Functions. By D. S.
Choi, O. Kellermann, S. Richard, J. F. Colas, F. Bolanos Jimenez,
C. Tournois, J. M. Launay, and L. Maroteaux 67
Epilepsy and Obesity in Serotonin 5 HT2C Receptor Mutant Mice. By L. K.
Heisler, H. M. Chu, and L. H. Tecott 74
5 HT1B Receptor Modulation of Prepulse Inhibition: Recent Findings in Wild
type and 5 HT1B Knockout Mice. By S. C. Dulawa, R. Hen, K. Scearce
Levie, and M. A. Geyer 79
Putative 5 ht5 Receptors: Localization in the Mouse CNS and Lack of Effect
in the Inhibition of Dural Protein Extravasation. By C. Waeber, R.
Grailhe, X J. Yu, R. Hen, and M. A. Moskowitz 85
The Putative 5 ht6 Receptor: Localization and Function. By A. J. Sleight, F.
G. Boess, M. Bos, and A. Bourson 91
Part II. Signal Transduction
A Three State Receptor Model: Predictions of Multiple Agonist
Pharmacology for the Same Receptor Type. By C. Scaramellini and P.
Leff 97
Pleiotropic Behavior of 5 HT2A and 5 HT2C Receptor Agonists. By K. A.
Berg, S. Maayani, J. Goldfarb, and W. P. Clarke 104
Interactions between Effectors Linked to Serotonin Receptors. By K. A. Berg,
S. Maayani, and W. P. Clarke Ill
Serotonergic Antagonist Effects on Trafficking of Serotonin 5 HT2A Receptors
in Vitro and in Vivo. By D. L. Willins, L. Alsayegh, S. A. Berry, J. R.
Backstrom, E. Sanders Bush, L. Friedman, N. Khan, and B. L. Roth 121
Regulation of Levels of 5 HT2A Receptor mRNA. By K. L. Wohlpart and P.
B. Molinoff 128
Creation of a Constitutively Activated State of the 5 HT2A Receptor by Site
directed Mutagenesis: Revelation of Inverse Agonist Activity of
Antagonists. By C. Egan, K. Herrick Davis, and M. Teitler 136
Pharmacological Characterization of the Constitutively Activated State of the
Serotonin 5 HT2C Receptor. By K. Herrick Davis, E. Grinde, C.
Gauthier, and M. Teitler 140
A Putative a helical Gpy coupling Domain in the Second Intracellular Loop
of the 5 HT1A Receptor. By P. R. Albert, S. I Morris, M. H.
Ghahremani, J. M. Storring, and P. M.C. Lembo 146
Activation of the Mitogen activated Protein Kinase Pathway via the 5 HT2A
Receptor. By S. W. Watts 162
Serotonin 5 HT2A Receptor Activation Inhibits Cytokine stimulated Inducible
Nitric Oxide Synthase in C6 Glioma Cells. By K. J. Miller and
H. A. Gonzalez 169
Molecular, Cellular, and Physiological Characteristics of 5 HT Moduline, a
Novel Endogenous Modulator of 5 HT,B Receptor Subtype. By O.
Massot, J. C. Rousselle, B. Grimaldi, I. Cloez Tayarani, M.P.
Fillion, M. Plantefiol, A. Bonnin, N. Prudhomme, and G. Fillion . 174
Oleamide induced Modulation of 5 Hydroxytryptamine Receptor mediated
Signaling. By E. A. Thomas, M. J. Carson, and J. G. Sutcliffe 183
Regulation of Membrane Excitability in the Central Nervous System by
Serotonin Receptor Subtypes. By R. Andrade 190
Part III. Therapeutics
Role of Somatodendritic 5 HT Autoreceptors in Modulating 5 HT
Neurotransmission. By P. Blier, G. Pineyro, M. El Mansari, R.
Bergeron, and C. de Montigny 204
Serotonin Transporter Function in Vivo: Assessment by Chronoamperometry.
By A. Frazer and L. C. Daws 217
Poster Abstracts
Classification
Impact of the Human Genome Project on the Principles for Classification of
5 HT Receptors. By D. Hoyer, P. A. Humphrey, and E. A. Barnard .. 230
Molecular Biology/Methodology
Functional Chemical Neuroanatomy of Serotonergic Neurons and their
Targets: Antibody Production and Immunohistochemistry (IHC) for 5
HT, Its Precursor (5 HTP), and Metabolite (5HIAA), Biosynthetic
Enzyme (TPH), Transporter (SERT), and Three Receptors (5 HT2A, 5
ht5a, 5 HT7). By M.S. Brownfield, J. Yracheta, F. Chu, D. Lorenz,
and A. Diaz 232
Molecular Cloning of Alternatively Spliced Human 5 HT3 Receptor cDNAs.
By M. Bruss, M. Gothert, M. Hayer, and H. Bonisch 234
Efficient Expression of Neurotransmitter Receptors in Mammalian Cells: Use
of Inducible Expression Systems. By P. Vanhoenacker, I. Van den
bogerd, w. gommeren, w.h.m.l. lllyten, j.e. leysen. and g.
Haeoeman 236
Preferential Expression of 5 HT1D over 5 HT1B Receptors during Murine
Embryonic Development. By F. Bolanos Jimenez, D S. Choi, and L.
Maroteaux 238
Characterization of 5 HT and Ionomycin stimulated Changes in Levels of
Intracellular Calcium and PI Hydrolysis in PI 1 Cells. By K. L. Wohlpart
AND P. B. MOLINOFF 240
Residues in Transmembrane Region III and VI Contribute to the 5 ht6
Receptor Ligand Binding Site. By F.G. Boess, F.J. Monsma Jr., A.
BOURSON, C. ZWINGELSTEIN, AND A.J. SLEIGHT 242
Central Distribution and Function of 5 ht6 Receptor Subtype in the Rat
Brain. By M. Yoshioka, M. Matsumoto, H. Togashi, and K. Mori . . . 244
Distribution of 5 HT2C and 5 ht5a Receptor mRNA in Human Brain. By M.
Pasqualetti, M. Ori, D. Marazziti, M. Castagna, and I. Nardi 245
5 HT,B Receptors Are Expressed by Neuronal Precursors in the Enteric
Nervous System of Fetal Mice and Promote Neuronal Differentiation. By
E. Fiorica Howells, L. Maroteaux, and M.D. Gershon 246
Receptor Modulation/Signaling
The 5 HT2B Receptor Controls the Overall 5 HT Transport System in the
1C11 Serotonergic Cell Line. By J.M. Launay, S. Loric, V. Mutel, and
O. Kellermann 247
Signaling Pathways and Targets of the 5 HT2B Receptor in the 1C11
Serotonergic Cell Line. By O. Kellermann, C. Tournois, S. Richard, P.
Manivet, L. Maroteaux, and J.M. Launay 248
Functional Properties of 5 HT Moduline in the Immune System: A Model for
Central Nervous System Investigation. By B. Grimaldi, C. Sibella
Arguelles, A. Bonnin, M.R Fillion, O. Massot, J.C. Rousselle. J.C.
Seznec, and G. Fillion 249
Operational Studies of Synergistic Interactions with 5 HT1B/1D Receptors. By
G.R. Martin, S.J. MacLennan, M. Maxwell, and R.R. Smith 251
Calcium Influx through Voltage gated Calcium Channels Regulates 5 HT,
Receptor Channel Desensitization in NG108 15 Cells. By S. Jones and
XL. Yakel 253
Is There a Functional Response Overlap between 5 HT, and Nicotinic Ion
Channel Receptors? By L. Gyermek, X. Sun, N. Nguyen, and M. Dukat 255
Pharmacological Characterization of the Silent 5 HT1B like Receptors of
Rabbit Ear Artery. By H. Movahedi and R. E. Purdy 258
Characterization of the Silent 5 HT1B Receptors of Rabbit Iliac Artery. By
O. Yildiz, F. Ehlert, and R.E. Purdy 259
Pharmacology
5 HT Receptors in Rat Jugular Vein: Information from RT PCR and
Operational Studies. By T.M. Pulido Rios, J.J. Calixto, G.R. Martin,
and E. Leung 260
Autoradiographic Characterization, Anatomical Distribution, and
Developmental Pattern of a New 5 HT Site in Human Brain. By A.
Pazos, M.E. Castro, E. Del Olmo, T. Romon, and C. Del Arco 262
Parallel Evaluation of 5 HT]4 Receptor Localization and Functionality:
Autoradiographic Studies with p SJ GTPyS and the Novel, Selective
Radioligand, [3H] S 15535. By A. Newman Tancredi, C. Chaput, M.
Touzard, L. Verriele, and M.J. Millan 263
In Vitro Visualization of 5 HT Receptors in Rat Brain Using p SJGTPyS
Binding. By M.S. Beer and J.A. Stanton 265
[3H]5 HT Binding to Cloned Human, Dog, and Rat 5 HT1D and 5 HT1B
Receptors. By J. Stanton, L. Castro, A. MacLeod, F. Sternfeld, L.
Street, and M. Beer 266
High Affinity of SDZ HTF 919 and Related Molecules for Calf and Human
Caudate 5 HT4 Receptors. By D. Hoyer, D. Fehlmann, D.
Langenegger, J. Kummer, R. Giger, H. Mattes, A. Probst, and H. J.
Pfannkuche 267
Absorption and Brain Penetration of a High Affinity, Highly Selective 5 HT2(
Receptor Antagonist, RS 102221. By D. W. Bonhaus, C. L. Rocha, M.
W. Dawson, and R. M. Eglen 269
The Selective 5 HTIB Receptor Inverse Agonist SB 224289, Potently Blocks
Terminal 5 HT Autoreceptor Function Both in Vitro and in Vivo. By
L.M. Gaster, P. Ham. G.F. Joiner, F.D. King, K.R. Mulholland, P.A.
Wyman, J.J. Hagan, G.W. Price, C. Roberts. C. Routledge, J.
Selkirk, P.D. Slade, and D.N. Middlemiss 270
Consequences of 5 HT Re uptake Blockade on Postsynaptic 5 HT1A Receptor
Activation: An Electrophysiological and Neurochemical Study in Guinea
Pig Dorsal Raphe and Hippocampus. By J. Sprouse, J. Braselton, L.
Reynolds, T. Clarke, and H. Rollema 272
5 HT1A Agonist Activity of Pindolol: Reversal of the Inhibitory Effects on
Cell Firing in the Dorsal Raphe Nucleus but not in the Hippocampus by
WAY 100, 635. By J. Sprouse, J. Braselton, and L. Reynolds 274
Comparison of Native 5 HT3 Receptors Purified from Various
Neuroblastoma derived Cell Lines and Bovine Brain with Recombinant
5 HT3 AL Receptors Purified after Expression in HEK293 Cells. By EG.
Boess, R.M. Creighton, B.A. Phipps, R.M. McKernan, J. Reid, and
I.L. Martin 276
Inhibition by Propofol of 5 HT, Receptors in Excised Patches of NIE 115
Cells. By M. Barann, H. Bonisch, B.W. Urban, and M. Gothert 278
Agonist and Antagonist Binding to Rabbit Cortical 5 HT2A Receptors:
Opposite Effects of Magnesium. By V. J. Aloyo, G. L. Salt, M. E.
Hoffman, and J. A. Harvey 280
Animal Studies
Pharmacological Profile of the Prejunctional 5 HT, Receptors Mediating
Inhibition of Sympathetic Vasopressor Outflow in the Pithed Rat. By
CM. Villalon, D. Centurion, G. Rabelo, and A. Sanchez Lopez ... 281
Evidence for the Putative 5 HT7 Receptor Mediating Direct Relaxation to 5
Hydroxytryptamine in Canine Cerebral Blood Vessels. By J.A. Terron . . 283
Effects of Acute and Chronic Treatment with Clozapine on Dopamine Release
in Rat Nucleus Accumbens Slice Preparations. By E.J. Mylecharane,
E. O Rourke, and H.G.E. Lloyd 284
Involvement of 5 HT1A Receptors in the Consolidation of Learning in
Cognitively Impaired Rats. By A. Meneses, J.A. Terron, and E. Hong . 286
Post Synaptic 5 HT1A and 5 HT2A Receptors Are Increased in Parkinson s
Disease Neocortex. By C.P. L H. Chen, J.T. Alder, L. Bray, A.E.
Kingsbury, P.T. Francis, and O.J.F. Foster 288
Discrepancies between the in Vitro and in Vivo 5 HT and Norepinephrine
Re uptake Blocking Properties of Venlafaxine. By J. C. Beique, G.
Debonnel, C. de Montigny, and P. Blier 290
Methiothepin but not Methysergide Antagonizes TRH Effects at the Dorsal
Vagal Complex. By S. Varanasi, J. Chi, R.C. Rogers, and R.L.
Stephens Jr 292
Index of Contributors 295
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| genre | (DE-588)1071861417 Konferenzschrift 1997 San Francisco Calif. gnd-content |
| genre_facet | Konferenzschrift 1997 San Francisco Calif. |
| id | DE-604.BV012356500 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:26:07Z |
| institution | BVB |
| isbn | 1573311707 1573311715 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008378371 |
| oclc_num | 39786290 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-12 DE-20 DE-188 |
| owner_facet | DE-355 DE-BY-UBR DE-12 DE-20 DE-188 |
| physical | XIII, 297 S. graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | New York Acad. of Sciences |
| record_format | marc |
| series | New York Academy of Sciences: Annals of the New York Academy of Sciences |
| series2 | New York Academy of Sciences: Annals of the New York Academy of Sciences |
| spelling | Advances in serotonin receptor research molecular biology, signal transduction and therapeutics ed. by Graeme R. Martin ... New York, NY New York Acad. of Sciences 1998 XIII, 297 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier New York Academy of Sciences: Annals of the New York Academy of Sciences 861 Serotonin cabt Receptors cabt Receptoren gtt Serotonine gtt Sérotonine - Récepteurs - Congrès Transduction du signal cellulaire - Congrès Cellular signal transduction Congresses Receptors, Serotonin physiology Congresses Serotonin Receptors Congresses Signal Transduction Congresses Serotoninrezeptor (DE-588)4181047-8 gnd rswk-swf Neuropharmakologie (DE-588)4041896-0 gnd rswk-swf Serotonin (DE-588)4054614-7 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1997 San Francisco Calif. gnd-content Serotoninrezeptor (DE-588)4181047-8 s DE-604 Serotonin (DE-588)4054614-7 s Neuropharmakologie (DE-588)4041896-0 s Martin, Graeme R. Sonstige oth New York Academy of Sciences: Annals of the New York Academy of Sciences 861 (DE-604)BV002532608 861 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008378371&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Advances in serotonin receptor research molecular biology, signal transduction and therapeutics New York Academy of Sciences: Annals of the New York Academy of Sciences Serotonin cabt Receptors cabt Receptoren gtt Serotonine gtt Sérotonine - Récepteurs - Congrès Transduction du signal cellulaire - Congrès Cellular signal transduction Congresses Receptors, Serotonin physiology Congresses Serotonin Receptors Congresses Signal Transduction Congresses Serotoninrezeptor (DE-588)4181047-8 gnd Neuropharmakologie (DE-588)4041896-0 gnd Serotonin (DE-588)4054614-7 gnd |
| subject_GND | (DE-588)4181047-8 (DE-588)4041896-0 (DE-588)4054614-7 (DE-588)1071861417 |
| title | Advances in serotonin receptor research molecular biology, signal transduction and therapeutics |
| title_auth | Advances in serotonin receptor research molecular biology, signal transduction and therapeutics |
| title_exact_search | Advances in serotonin receptor research molecular biology, signal transduction and therapeutics |
| title_full | Advances in serotonin receptor research molecular biology, signal transduction and therapeutics ed. by Graeme R. Martin ... |
| title_fullStr | Advances in serotonin receptor research molecular biology, signal transduction and therapeutics ed. by Graeme R. Martin ... |
| title_full_unstemmed | Advances in serotonin receptor research molecular biology, signal transduction and therapeutics ed. by Graeme R. Martin ... |
| title_short | Advances in serotonin receptor research |
| title_sort | advances in serotonin receptor research molecular biology signal transduction and therapeutics |
| title_sub | molecular biology, signal transduction and therapeutics |
| topic | Serotonin cabt Receptors cabt Receptoren gtt Serotonine gtt Sérotonine - Récepteurs - Congrès Transduction du signal cellulaire - Congrès Cellular signal transduction Congresses Receptors, Serotonin physiology Congresses Serotonin Receptors Congresses Signal Transduction Congresses Serotoninrezeptor (DE-588)4181047-8 gnd Neuropharmakologie (DE-588)4041896-0 gnd Serotonin (DE-588)4054614-7 gnd |
| topic_facet | Serotonin Receptors Receptoren Serotonine Sérotonine - Récepteurs - Congrès Transduction du signal cellulaire - Congrès Cellular signal transduction Congresses Receptors, Serotonin physiology Congresses Serotonin Receptors Congresses Signal Transduction Congresses Serotoninrezeptor Neuropharmakologie Konferenzschrift 1997 San Francisco Calif. |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008378371&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002532608 |
| work_keys_str_mv | AT martingraemer advancesinserotoninreceptorresearchmolecularbiologysignaltransductionandtherapeutics |