An introduction to immunotoxicology:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
London [u.a.]
Taylor & Francis
1999
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XII, 183 S. Ill. |
| ISBN: | 0748403078 074840306X |
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Record in the Search Index
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| adam_text | Contents
Preface page xi
part i Immunotoxic Effects and their Clinical Consequences 1
1 Definition and History of Immunotoxicology 3
Definition 3
History 4
Scope of immunotoxicology 7
References 9
2 Overview of the Immune System 11
Immunocompetent cells 12
The lymphoid system 14
Immune responses 15
External influences on the immune system 17
Conclusion 19
References 19
3 Immunosuppression and Immunodepression 21
Impaired resistance against microbial pathogens 21
Increased incidence of cancer 25
Other adverse consequences of immunosuppression 27
Immunosuppression and immunodepression 28
References 29
4 Immunostimulation 31
Flu like reactions 31
Exacerbation of underlying diseases 32
Dormant diseases 32
Autoimmune diseases 33
Immuno allergic reactions 34
vii
vjjj Contents
Inhibition of hepatic drug metabolism 34
Immunostimulation and immunosuppression 35
References 35
5 Hypersensitivity 37
Immunogenicity 38
Immuno allergic reactions 40
Pseudo allergic reactions 44
References 4
6 Autoimmunity 51
Organ specific autoimmune reactions 51
Systemic autoimmune reactions
Isolated auto antibodies
References 1
7 Major Immunotoxicants ^3
Medicinal products ^3
Industrial and environmental pollutants 69
References 3
part ii Immunotoxicity Evaluation 77
8 Guidelines 79
US Environmental Protection Agency ^9
Council of the European Communities °^
The Japanese authorities drug antigenicity requirement
OECD guideline 407 83
The US FDA Red Book II 84
Other guidelines *
Perspectives ^
References 86
9 Histopathology 89
Organisation of the lymphoid tissue
Histopathology of the lymphoid tissue
Non histological, non functional endpoints
References
10 Assays of Humoral Immunity
Antigenic stimulation
Measurement of specific antibody levels
The plaque forming cell assay
B lymphocyte proliferation assay
References 102
11 Assays of Cell Mediated Immunity 103
In vivo assays of cell mediated immunity
In vitro assays of cell mediated immunity
References 108
Contents ix
12 Assays of Non Specific Defences 111
Assays of phagocytosis 111
Natural killer cell activity 115
References 115
13 Host Resistance Assays 117
Experimental infection models 118
Implanted tumours 121
Other experimental diseases 123
References 123
14 Strategies for the Evaluation of Immunosuppression 125
Tiered protocols 125
Practical considerations 131
Good Laboratory Practice 134
References 134
15 Identification of Chemical Sensitisers 137
Anaphylaxis models 137
Contact sensitisation assays 140
Evaluation strategies 142
References 143
16 Prediction of Autoimmunity 145
Predictability of organ specific versus systemic autoimmune reactions 145
The popliteal lymph node assay 146
Auto antibodies in conventional toxicity studies 148
Animal models of autoimmune diseases 149
References 150
part iii Trends and Perspectives in Immunotoxicology 153
17 Immunotoxicity Risk Assessment 155
Toxicity risk assessment 155
Approaches in immunotoxicity risk assessment 156
References 157
18 New Methods in Immunotoxicology 159
In vitro methods for immunotoxicity evaluation 159
New animal models 161
Perspectives 162
References 162
19 Human Immunotoxicology 165
Identification of immunotoxicants in human beings 165
Surveillance of exposed populations 168
Validation of non clinical results 169
Biomarkers of human immunotoxicity 169
References 171
!
x Contents
20 lmmunotoxicology and Wildlife 175
Fish immunotoxicology 175
Sea mammals 178
Perspectives 179
References 179
Index 181
|
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| isbn | 0748403078 074840306X |
| language | English |
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| spelling | Descotes, Jacques 1951- Verfasser (DE-588)172041309 aut An introduction to immunotoxicology Jacques Descotes London [u.a.] Taylor & Francis 1999 XII, 183 S. Ill. txt rdacontent n rdamedia nc rdacarrier Immune System Diseases chemically induced Immune System drug effects Immunity, Cellular drug effects Immunotoxicology Immunpharmakologie (DE-588)4026639-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Immunpharmakologie (DE-588)4026639-4 s b DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008377402&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Descotes, Jacques 1951- An introduction to immunotoxicology Immune System Diseases chemically induced Immune System drug effects Immunity, Cellular drug effects Immunotoxicology Immunpharmakologie (DE-588)4026639-4 gnd |
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| title | An introduction to immunotoxicology |
| title_auth | An introduction to immunotoxicology |
| title_exact_search | An introduction to immunotoxicology |
| title_full | An introduction to immunotoxicology Jacques Descotes |
| title_fullStr | An introduction to immunotoxicology Jacques Descotes |
| title_full_unstemmed | An introduction to immunotoxicology Jacques Descotes |
| title_short | An introduction to immunotoxicology |
| title_sort | an introduction to immunotoxicology |
| topic | Immune System Diseases chemically induced Immune System drug effects Immunity, Cellular drug effects Immunotoxicology Immunpharmakologie (DE-588)4026639-4 gnd |
| topic_facet | Immune System Diseases chemically induced Immune System drug effects Immunity, Cellular drug effects Immunotoxicology Immunpharmakologie Aufsatzsammlung |
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