Calcium hydroxide and bone regeneration: odontological aspects of induced osteogenesis in experiment and clinical practice
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| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | German |
| Published: |
Altheim
Isar-Post, Dr.- und Verl.-GmbH
1998
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 162 S. Ill., graph. Darst. |
| ISBN: | 3924943079 |
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| 245 | 1 | 0 | |a Calcium hydroxide and bone regeneration |b odontological aspects of induced osteogenesis in experiment and clinical practice |c Georg Dietz ; Peter Bartholmes. In co-operation with: Georg-Herbert Dietz jr. ; Wolfgang Röcher |
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Record in the Search Index
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| adam_text | Table of Contents
Preface 13
Abbreviations 15
Material Used for Cell and Tissue Culture Tests 16
Introduction 19
I. Basics on Osseous Tissue 19
II. Basics on Collagen 21
III. Task Setting 24
CHAPTER I:
Introduction into the Action of Calcium Hydroxide in General
as well as in Aqueous and Hardening Preparations 25
1.1. Calcium Hydroxide 25
1.2. Calcium Hydroxide in Odontology 25
1.3. Action of Calcium Hydroxide on the Dental Pulp 27
1.4. Calcium Hydroxide Action on Dental Root Development
(Apexification) 28
1.5. Actions of Aqueous Calcium Hydroxide Suspensions
Calxyl® 31
1.6. Calcium Hydroxide Action in Hardening Preparations 32
CHAPTER II:
Action of Oleaginous Calcium Hydroxide Suspensions 34
2.1. Oleaginous Calcium Hydroxide Preparations 34
2.2. Action of Oleaginous Calcium Hydroxide Suspensions 35
5
2.3. Comparison of Alkalising Properties of Aqueous and Oleaginous
Calcium Hydroxide Suspensions 37
2.3.1. Description of the Experiment 37
2.3.2. Results of the Experiment 37
2.3.3. Conclusions from the Results 39
2.3.4. Example for the Wrong Methodological Approach in Connection
with the Measurement and Interpretation of pH Values in Vitro and
in Vivo 39
2.4. Ca2+ Release from Calcium Hydroxide Preparations 42
2.4.1. Description of the Experiment 42
2.4.2. Results 42
2.5. Alkalisation and Ca2+ Release by Oleaginous Calcium
Hydroxide Preparations after Autoclaving and Long Term
Storage 43
2.6. Mixed Bacterial Culture after Stomatal Smear under the
Influence of Oleaginous Calcium Hydroxide Suspensions:
Osteoinductal®, Intradossal® and Gangraena Merz®, in
Comparison with the Aqueous Calcium Hydroxide
Suspension: Calxyl® 44
2.6.1. Description of the Experiment 44
2.6.2. Test Results 44
2.6.3. Comments and Conclusions 45
CHAPTER III:
Cell Cultures under the Influence of Oleaginous Calcium
Hydroxide Suspensions 46
3.1. Culture of Human Buccal Mucosa Fibroblasts 46
3.1.1. Description of the Experiment 46
3.1.2. Results and Discussion 47
3.2. Cell Culture with Mouse Fibroblasts and Primary Human
Osteoblasts 48
6
3.2.1. Description of the Experiment 48
3.2.2. Cell Culture Passaging 49
3.2.3. Determination of Cell Count 50
3.2.4. Cell Growth of Mouse Fibroblasts and Primary Human Osteoblasts
under the Influence of Oleaginous Calcium Hydroxide Suspen¬
sions 50
3.3. Establishing a Long term Cell Culture of Osteoblasts for
Analysing its Morphological Differentiation over a Period
of 4 Months under the Influence of Oleaginous Calcium
Hydroxide Suspensions 52
3.4. Time Sequence of Typical Markers of Bone Metabolism in
Osteoblast Culture 53
CHAPTER IV:
Osseous Tissue Cultures under the Influence of Oleaginous
Calcium Hydroxide Suspensions 55
4.1. Description of Methods and Experiments 55
4.1.1. Gaining Human Osseous Tissue 55
4.1.2. Osseous Tissue Culture 56
4.1.3. Oxygen Consumption Measurements 57
4.1.4. Extraction of de novo Synthesised Collagen 60
4.1.5. Scintillation Measurement for the Determination of Radioactivity
in the Purified Collagen Extract 60
4.1.6. SDS Polyacryl Amide Gel Electrophoresis 60
4.1.7. Fluorography 62
4.1.8. Calculation of the Collagen Synthesis Capacity 62
4.1.9. Preparation of Tissue Extracts from Osseous Tissue 62
4.1.10. Cell Decomposition 62
4.1.11. Alkaline Phosphatase (ALP) Activity 63
4.1.12. Acid Phosphatase (AP) Activity 63
4.1.13. Lactate Hydrogenase (LDH) Activity 63
4.1.14. Measurement of Proteolytic Activity 63
7
4.1.15. Gelatine Gel 63
4.1.16. Collagenase Activity 64
4.1.17. Quantitative Prostaglandin E2 Detection 64
4.1.18. Quantitative Osteocalcine Detection 64
4.1.19. Hydroxyproline Determination 64
4.2. Results of the Analyses of Osseous Tissue Cultures 65
4.2.1. Results of Control Experiments in Non Stimulated Cultures 65
4.2.1.1. Analysis of the Purity of the Collagen Extract 65
4.2.1.2. Course of Typical Markers of Bone Metabolism in the Osseous
Tissue Culture 67
4.2.1.3. Oxygen Consumption Measurements 68
4.2.2. Influence of Oleaginous Calcium Hydroxide Suspensions on the
Metabolism of Human Osseous Tissue 71
4.2.2.1. Influence of Oleaginous Calcium Hydroxide Suspensions on the
Collagen Synthesis Capacity of Human Osseous Tissue 71
4.2.2.2. Stimulation of Collagen Synthesis Relative to the Age of the Tissue
Donator 75
4.2.2.3. Stimulation of Collagen Synthesis Relative to the pH Value of the
Medium 75
4.2.2.4. Stimulation of Collagen Synthesis Relative to the Calcium Con¬
centration 76
4.2.2.5. Lactate De Hydrogenase (LDH) Activity in the Osseous Tissue
under the Influence of Oleaginous Calcium Hydroxide Suspen¬
sions 77
4.2.2.6. Alkaline Phosphatase (ALP) Activity in the Osseous Tissue under
the Influence of Oleaginous Calcium Hydroxide Suspensions 78
4.2.2.7. Acid Phosphatase (AP) Activity in the Osseous Tissue under the
Influence of Oleaginous Calcium Hydroxide Suspensions 78
4.2.2.8. Osteocalcine (OC) Synthesis in the Osseous Tissue under the
Influence of Oleaginous Calcium Hydroxide Suspensions 79
4.2.2.9. Collagenase Activity in Osseous Tissue under the Influence of
Oleaginous Calcium Hydroxide Suspensions 79
8
4.2.2.10. Prostaglandin E2 Synthesis in the Osseous Tissue under the
Influence of Oleaginous Calcium Hydroxide Suspensions 80
4.3. Summary of Results 81
CHAPTER V:
Discussion of Results 82
CHAPTER VI:
Calcium Hydroxide Suspensions in Comparison with other
Osteo Inductive Substances 86
CHAPTER VII:
Bone Substitutes 89
7.1. Autologous Bone Material for Repairing Bone Defects 89
7.2. Allogenous Bone Material for Repairing Bone Defects 89
7.3. Xenogenous or Heterologous Transplant Material for
Repairing Bone Defects 90
7.4. Alloplastic Implantation Material for Repairing Bone Defects 90
7.5. Comments on the Concept of Osseo Integration 91
CHAPTER VIII:
Basic Science Research and Animal Tests Concerning the
Application of Oleaginous Calcium Hydroxide Suspensions from
a Clinical Point of View 95
CHAPTER IX:
History of the Evolution of Osteoinductal® on the Basis of
Selected Clinical Examples 100
9.1. The first Oleaginous Calcium Hydroxide Suspension was
Conceived for the Induction of Re Ossification of Bone
Defects in the Peri apical Region as a Temporary Root Canal
Inlay 101
9
9.2. Induction of Re Ossification of a Peri Apical Bone Defect
due to Pulpal Necrosis by Means of Oleaginous Calcium
Hydroxide Suspensions via Root Canal within 6 Months 104
9.3. Peri Apical Ostitis Following Vital Extirpation and Re Ossi¬
fication of the Defect by Means of Oleaginous Calcium
Hydroxide Suspensions within 6 Months 106
9.4. Re Ossification in Connection with Endodontic Pin
Implants Inside the Bone and Oleaginous Calcium Hydroxide
Suspensions 108
9.5. Apicectomy, Cystectomy and Similar Dental Surgery 110
CHAPTER X:
Current Additional Fields of Application of Osteoinductal® as a
Medicinal Product on the Basis of Selected Clinical Examples 112
10.1. Example of Tooth Extraction 112
10.2. Alveolitis or Dolor Post Extractionem 115
10.3. Immediate Implantation 117
10.3.1. Guided Osteoanagenesis in Immediate Placement of Implants
and/or Delayed Immediate Placement of Implants Versus Delayed
Implants 117
10.3.2. Example for Immediate Implantation in Tooth 36 119
10.3.3. Problems associated with Periodonitis Marginalis in Connection
with Immediate Implantation on the Basis of an Example of a Molar 123
10.3.4. Problems with Hyper Extensive Extra Osseous Lever Arm and
Associated Non Physiological Strain on the Bone in Immediate
Implants 126
10.4. Example for Delayed Implantation in a Total Prosthesis
Wearer 130
10.5. Induced Osteogenesis in Profound Chronic Marginal Peri
odontitis ( Periodontosis ) Therapy 132
10
Outlook 135
Annex 137
Bibliography 146
11
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| language | German |
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| spelling | Dietz, Georg Verfasser aut Calcium hydroxide and bone regeneration odontological aspects of induced osteogenesis in experiment and clinical practice Georg Dietz ; Peter Bartholmes. In co-operation with: Georg-Herbert Dietz jr. ; Wolfgang Röcher Altheim Isar-Post, Dr.- und Verl.-GmbH 1998 162 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Knochenbildung (DE-588)4031317-7 gnd rswk-swf Zahnersatz (DE-588)4190494-1 gnd rswk-swf Dentalwerkstoff (DE-588)4133661-6 gnd rswk-swf Calciumhydroxid (DE-588)4147179-9 gnd rswk-swf Knochenregeneration (DE-588)4122236-2 gnd rswk-swf Knochenregeneration (DE-588)4122236-2 s Calciumhydroxid (DE-588)4147179-9 s Dentalwerkstoff (DE-588)4133661-6 s DE-604 Zahnersatz (DE-588)4190494-1 s Knochenbildung (DE-588)4031317-7 s Bartholmes, Peter Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008349818&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dietz, Georg Bartholmes, Peter Calcium hydroxide and bone regeneration odontological aspects of induced osteogenesis in experiment and clinical practice Knochenbildung (DE-588)4031317-7 gnd Zahnersatz (DE-588)4190494-1 gnd Dentalwerkstoff (DE-588)4133661-6 gnd Calciumhydroxid (DE-588)4147179-9 gnd Knochenregeneration (DE-588)4122236-2 gnd |
| subject_GND | (DE-588)4031317-7 (DE-588)4190494-1 (DE-588)4133661-6 (DE-588)4147179-9 (DE-588)4122236-2 |
| title | Calcium hydroxide and bone regeneration odontological aspects of induced osteogenesis in experiment and clinical practice |
| title_auth | Calcium hydroxide and bone regeneration odontological aspects of induced osteogenesis in experiment and clinical practice |
| title_exact_search | Calcium hydroxide and bone regeneration odontological aspects of induced osteogenesis in experiment and clinical practice |
| title_full | Calcium hydroxide and bone regeneration odontological aspects of induced osteogenesis in experiment and clinical practice Georg Dietz ; Peter Bartholmes. In co-operation with: Georg-Herbert Dietz jr. ; Wolfgang Röcher |
| title_fullStr | Calcium hydroxide and bone regeneration odontological aspects of induced osteogenesis in experiment and clinical practice Georg Dietz ; Peter Bartholmes. In co-operation with: Georg-Herbert Dietz jr. ; Wolfgang Röcher |
| title_full_unstemmed | Calcium hydroxide and bone regeneration odontological aspects of induced osteogenesis in experiment and clinical practice Georg Dietz ; Peter Bartholmes. In co-operation with: Georg-Herbert Dietz jr. ; Wolfgang Röcher |
| title_short | Calcium hydroxide and bone regeneration |
| title_sort | calcium hydroxide and bone regeneration odontological aspects of induced osteogenesis in experiment and clinical practice |
| title_sub | odontological aspects of induced osteogenesis in experiment and clinical practice |
| topic | Knochenbildung (DE-588)4031317-7 gnd Zahnersatz (DE-588)4190494-1 gnd Dentalwerkstoff (DE-588)4133661-6 gnd Calciumhydroxid (DE-588)4147179-9 gnd Knochenregeneration (DE-588)4122236-2 gnd |
| topic_facet | Knochenbildung Zahnersatz Dentalwerkstoff Calciumhydroxid Knochenregeneration |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008349818&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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