Immunohistochemistry in the study of normal and osteoarthritic articular cartilage: with ... 12 tables
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Jena [u.a.]
Fischer
1998
|
| Series: | Progress in histochemistry and cytochemistry
33,2 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | VIII S., S. 94 - 168 Ill. |
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Record in the Search Index
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| adam_text | Contents
1 Introduction 93
2 Normal and osteoarthritic articular cartilage 94
2.1 Definition, classification and grading of osteoarthritis 94
2.1.1 Semantics 94
2.1.2 Primary and secondary osteoarthritis 94
2.1.3 Nominal definitions 95
2.1.4 Clinical classifications 95
2.1.5 Macroscopic pathoanatomical grading 96
2.1.6 Histopathological grading 96
2.2 Composition of articular cartilage 98
2.3 Extracellular matrix associated molecules 99
2.3.1 Collagens 10°
2.3.1.1 Collagen type I 10°
2.3.1.2 Collagen type II 101
2.3.1.3 Collagen type III • 101
2.3.1.4 Collagen type VI ; 101
2.3.1.5 Collagen type IX 101
2.3.1.6 CollagentypeX ¦ 103
2.3.1.7 Collagen type XI 103
2.3.2 Proteoglycans and glycosaminoglycans 1°3
2.3.3 Non collagenous/non proteoglycan glycoproteins 105
2.3.3.1 Fibronectin 105
2.3.3.2 Tenascin 105
2.3.3.3 Laminin 107
2.3.3.4 Other non collagenous/non proteoglycan glycoproteins 107
2.4 Cell membrane associated molecules 2.4.1 Cell adhesion molecules 108
2.4.1.1 Integrin superfamily 2.4.1.2 CD44 113
2.4.1.3 ICAM 1 118
2.4.2 Other cell membrane associated molecules 2.4.2.1 Anchorin 119
2.4.2.2 Chondroadherin 2.5 Intracellular compartment associated molecules 2.5.1 Cytokines 7 c , tV j • 124
z.o.i Uegradative enzymes 2.5.3 Alkaline phosphatase 2.5.4 Glutathione S transferases 2.5.5 S100 and SPARC 126
VI ¦ Contents
2.5.6 Heat shock proteins 127
2.5.7 Gangliosides 127
2.5.8 Protooncogene bcl 2 protein 127
2.6 Review sub conclusion 128
3 Sampling of cartilage for immunohistochemistry 128
3.1 Source individual 129
3.2 Topography 130
3.3 Macroscopic description of the source joint 131
4 Immunohistochemical staining 132
4.1 Enzyme labels 132
4.1.1 Sensitivity 133
4.2 Preservation and retrieval of antigens 133
4.3 Background staining 134
4.3.1 Non specific background staining 134
4.3.1.1 Endogenous enzyme activity 134
4.3.2 Specific background 135
4.3.2.1 Fc receptors 135
4.4 Adhesion of sections to slides 135
4.5 Controls 136
5 Evaluation of immunohistochemistry 136
5.1 Defining zones within articular cartilage 137
5.2 Defining compartments within articular cartilage 137
5.3 Immunohistochemical scoring 137
5.4 Histopathological classification of osteoarthritis 138
5.4.1 The histological histochemical grading system 138
5.4.1.1 Intra and interobserver reproducibilities 139
5.4.1.2 Validity 140
5.4.2 Requirements for a new histopathological grading system 143
5.4.3 Descriptive approach 143
6 Concluding remarks 144
References 146
Subject index 166
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| indexdate | 2024-07-09T18:24:28Z |
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| physical | VIII S., S. 94 - 168 Ill. |
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| series | Progress in histochemistry and cytochemistry |
| series2 | Progress in histochemistry and cytochemistry |
| spelling | Ostergaard, Keld Verfasser aut Immunohistochemistry in the study of normal and osteoarthritic articular cartilage with ... 12 tables Keld Ostergaard ; Donald M. Salter Jena [u.a.] Fischer 1998 VIII S., S. 94 - 168 Ill. txt rdacontent n rdamedia nc rdacarrier Progress in histochemistry and cytochemistry 33,2 Immuncytochemie (DE-588)4161368-5 gnd rswk-swf Osteoarthritis (DE-588)4172921-3 gnd rswk-swf Gelenkknorpel (DE-588)4156450-9 gnd rswk-swf Osteoarthritis (DE-588)4172921-3 s Gelenkknorpel (DE-588)4156450-9 s Immuncytochemie (DE-588)4161368-5 s DE-604 Salter, Donald M. Verfasser aut Progress in histochemistry and cytochemistry 33,2 (DE-604)BV000005277 33,2 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008309329&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ostergaard, Keld Salter, Donald M. Immunohistochemistry in the study of normal and osteoarthritic articular cartilage with ... 12 tables Progress in histochemistry and cytochemistry Immuncytochemie (DE-588)4161368-5 gnd Osteoarthritis (DE-588)4172921-3 gnd Gelenkknorpel (DE-588)4156450-9 gnd |
| subject_GND | (DE-588)4161368-5 (DE-588)4172921-3 (DE-588)4156450-9 |
| title | Immunohistochemistry in the study of normal and osteoarthritic articular cartilage with ... 12 tables |
| title_auth | Immunohistochemistry in the study of normal and osteoarthritic articular cartilage with ... 12 tables |
| title_exact_search | Immunohistochemistry in the study of normal and osteoarthritic articular cartilage with ... 12 tables |
| title_full | Immunohistochemistry in the study of normal and osteoarthritic articular cartilage with ... 12 tables Keld Ostergaard ; Donald M. Salter |
| title_fullStr | Immunohistochemistry in the study of normal and osteoarthritic articular cartilage with ... 12 tables Keld Ostergaard ; Donald M. Salter |
| title_full_unstemmed | Immunohistochemistry in the study of normal and osteoarthritic articular cartilage with ... 12 tables Keld Ostergaard ; Donald M. Salter |
| title_short | Immunohistochemistry in the study of normal and osteoarthritic articular cartilage |
| title_sort | immunohistochemistry in the study of normal and osteoarthritic articular cartilage with 12 tables |
| title_sub | with ... 12 tables |
| topic | Immuncytochemie (DE-588)4161368-5 gnd Osteoarthritis (DE-588)4172921-3 gnd Gelenkknorpel (DE-588)4156450-9 gnd |
| topic_facet | Immuncytochemie Osteoarthritis Gelenkknorpel |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008309329&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000005277 |
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