Herpesviruses and immunity:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Plenum Press
1998
|
| Schriftenreihe: | Infectious agents and pathogenesis
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 317 S. graph. Darst. |
| ISBN: | 030645890X |
Internformat
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| 245 | 1 | 0 | |a Herpesviruses and immunity |c ed. by Peter G. Medveczky ... |
| 264 | 1 | |a New York [u.a.] |b Plenum Press |c 1998 | |
| 300 | |a XX, 317 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Infectious agents and pathogenesis | |
| 650 | 4 | |a Herpesviridae Infections |x immunology | |
| 650 | 4 | |a Herpesviridae |x genetics | |
| 650 | 4 | |a Herpesviridae |x immunology | |
| 650 | 4 | |a Herpesvirus diseases |x Immunological aspects | |
| 650 | 0 | 7 | |a Herpesviren |0 (DE-588)4159627-4 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Medveczky, Peter G. |e Sonstige |4 oth | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-008289044 | ||
Datensatz im Suchindex
| _version_ | 1804126849596391424 |
|---|---|
| adam_text | Contents
1. Evasion and Obstruction: The Central Strategy of the
Interaction of Human Herpesviruses with Host Defenses
PATRICIA L. WARD and BERNARD ROIZMAN
1. Introduction 1
2. Immune Evasion during Latent Infection 2
2.1. Latent HSV 1, HSV 2, and VZV Infections 3
2.2. Latent HCMV, HHV 6, and HHV 7 Infections 5
2.3. Latent EBV and HHV 8 Infections 7
3. Immune Evasion during Lytic Infection 11
3.1. Interference with Antigenic Presentation 11
3.2. Interference with Innate Defense Mechanisms 14
3.3. Infection of Cells of the Immune System 15
3.4. Role of the Complement Pathway 17
3.5. Role of Cytokines 18
3.6. Interference with Host Suicide Mechanisms 20
4. Summary and Conclusions 21
References 24
2. Immunopathology of Herpesvirus Infections
BARRY T. ROUSE and SALLY S. ATHERTON
1. Introduction 33
2. Immunopathological Mechanisms against Viruses 34
3. Immunopathogenesis of HSV Infection of the Cornea 38
xiii
4. Immunopathogenesis of Herpetic Retinal Disease 41
5. Pathogenesis of Infectious Mononucleosis 45
References 46
3. HSV Gene Expression during Latent Infection and
Reactivation
EDWARD K. WAGNER and DAVID C. BLOOM
1. Introduction 53
2. The HSV Genome in the Establishment and Maintenance of Latent
Infections in Neurons 54
2.1. Establishment of Latent Infections in Sensory Neuron 54
2.2. Viral Genomes in Latently Infected Neurons 55
2.3. Most Latent HSV Genomes in Neurons Are Not Transcriptionally
Active 55
2.4. HSV Genomes Are Stably Maintained in Latently Infected
Neurons 56
3. HSV Gene Expression during Latent Infection in Neurons 56
4. The Promoter Controlling HSV Latent Phase Transcription 59
4.1. Analysis of Functional Elements of the HSV 1 Latent Phase
Promoter by Transient Expression Assay 59
4.2. Analysis of Latent Phase Promoter Elements in Vivo 60
4.3. Is There a Second Latent Phase Promoter? 61
5. The Role of Latent Phase Transcription in Latency and Reactivation 62
5.1. Latent Phase Transcription Is Required for Efficient Reactivation
in in Vivo Models 62
5.2. The Region of the Latent Phase Transcript Important in the
Efficient Reactivation Phenotype in Rabbits Is Confined to a
Region of 480 bp or Less within Its Extreme 5 End 63
5.3. Evidence mat Modulation of Expression of LAT during the Latent
Phase or at the Initiation of Reactivation Has a Role in Efficient
Induction of Virus in the Rabbit Eye Model 64
5.4. Latent Phase Transcription Facilitates but Is Not Required for
Efficient Recovery of Infectious Virus from Explanted Latently
Infected Murine Ganglia 64
5.5. The HSV 1 Latent Phase Transcript May Have a Role in the
Efficiency in Establishing Latent Infection in Murine Trigeminal
Ganglia 65
5.6. Murine Explant Models Do Not Reveal a Region Critical for Virus
Recovery Equivalent to That Characterized for Rabbit
Reactivation in Vivo 65
6. The Mechanism of Action of HSV LAT in Reactivation 66
6.1. There Is No Evidence for a Major Antisense Mediated Repressive
Action in Animal Models . 66
6.2. There Is No Evidence for a Latent Phase Expressed Viral Protein
Involved in Reactivation 67
6.3. Possible ay Acting Mechanisms for the Influence of LAT on
Reactivation 68
6.4. Does Latent Phase Transcription Supply an Essential Function to
Neurons or Peripheral Cells Initiating Reactivation? 69
References 70
4. T Cell Activation and Lymphokine Induction in
Herpesvirus saimiri Immortalized Cells
PETER GECK
1. Introduction 79
1.1. The Lymphotropic Gamma Herpesviruses 79
1.2. The Biology of H. saimiri 80
2. The Molecular Environment of H. saimiri Oncogenesis: Signal
Transduction in T Cell Activation (Operational Principles, Competence
Phase, Progression Phase) 82
2.1. Operational Principles of the Cellular Immune Response
(Maintenance of Antigenic Integrity, T Cell Activation—the
Target Pathway for H. saimiri) 82
2.2. Competence Phase in T Cell Activation (Antigen Recognition, T
Cell Receptor Activation, Signal Transduction, Target Genes)... 84
2.3. Progression Phase (Cytokine Systems, Cytokine Signal
Transduction, Target Genes) 92
3. Characterization of H. saimiri Transformed Lymphocytes 95
3.1. Surface Markers 95
3.2. Cytokine Profile of H. saimiri Transformed T Cells 95
3.3. Functional Analysis of//, saimiri Transformed T Lymphocytes. . . 97
3.4. The Immunological Profile of H. saimiri Transformed Cells and
Implications in Signal Transduction 99
4. H. saimiri Pathways for T Cell Activation and Cytokine Induction. ... 100
4.1. H. saimiri Genes Involved in T Cell Activation 100
4.2. Regulation of the stp/tip mRNA Expression 101
4.3. The Function of the tip Protein 102
4.4. The Function of the stp Protein (stpA and stpC) 104
5. Conclusions 106
References 108
5. Kaposi s Sarcoma Associated Herpesvirus (KSHV/HHV8)
and the Etiology of KS
SONJA J. OLSEN and PATRICK S. MOORE
1. Introduction 115
2. Epidemiology 116
2.1. Kaposi s Sarcoma 116
2.2. Evidence for Causality 117
3. Transmission 137
3.1. Sexual 137
3.2. Nonsexual 138
3.3. Saliva 138
3.4. Vertical 139
3.5. Organ Transplantation 140
4. Conclusion 140
References 140
6. Immunobiology of Murioe Gamma Herpesvirus 68
JAMES P. STEWART, EDWARD J. USHERWOOD,
BERNADETTE DUTIA, and ANTHONY A. NASH
1. Introduction 149
2. The Virus 150
2.1. Aspects of Viral Infection 150
2.2. The Viral Genome 150
2.3. Drug Sensitivity 152
3. Infection and Pathogenesis 152
3.1. Acute Infection in the Lung 152
3.2. Persistent Infection in the Lung 152
3.3. Latent Infection in the Spleen 153
3.4. Other Consequences of MHV 68 Infection 154
4. Immunological Events during Infection 155
4.1. Influence of Adaptive Immune Response 155
4.2. Influence of the Innate Immune Response 159
5. Conclusions 160
References 160
7. EBV and B Cell Lymphomas
GEORGE KLEIN
1. EBV Associated Proliferative Diseases 168
1.1. EBV and Human Malignancy 168
1.2. Burkitt s Lymphoma 170
1.3. Non Hodgkin s Lymphoma (NHL) in HIV Infected Patients 175
1.4. Hodgkin s Disease (HD) 177
1.5. EBV and T Cell Lymphomas 179
2. Conclusions 180
References 182
8. Immune Responses to Epstein Barr Viral Infection
TAKESHI SAIRENJI and TAKESHI KURATA
1. Introduction 191
2. EBV Specific Antigens 192
2.1. EBNA 192
2.2. LMP 193
2.3. Induction of Lytic Cycle by Signaling from the Cell Surface .... 193
2.4. EA 194
2.5. VCA 194
2.6. MA 195
3. Antibody Response to EBV Infection 195
3.1. Immunofluorescence Test 195
3.2. Enzyme Linked Immunosorbent Assay (ELISA) 196
3.3. Antibody Responses to EBV Specific Enzymes 196
4. Antibody Mediated Immune Mechanisms 196
4.1. Neutralizing Antibodies 196
4.2. Modulation of EBV Production with Anti EBV Antibodies 198
4.3. Inhibition of EBV Release by mAbs to gp350/220 198
5. EBV Induced Autoimmune Responses 199
6. Conclusion 199
References 201
9. EBV Persistence in Vivo: Invading and Avoiding the
Immune Response
DAVID A. THORLEY LAWSON
1. Introduction 207
2. Viral Entry and the Establishment of Infection 208
2.1. Viral Entry 208
2.2. Establishment of the Infection 214
3. Long Term Latency 217
3.1. The Site of Long Term Persistence—Resting Memory B Cells 217
3.2. Maintenance of Long Term Latency—Some Facts and Some
Speculation 218
3.3. Getting Back out Again: Viral Reactivation—More Facts and
Speculation 223
4. Final Remarks 225
4.1. Summing Up 225
4.2. The Questions that Need to Be Addressed 225
References 226
10. Epstein—Barr Virus Vaccines
HANS J. WOLF and ANDREW J. MORGAN
1. Introduction 231
2. Is an EBV Vaccine Desirable? 232
2.1. Rationale for Vaccination of Infants 233
2.2. Rationale for Vaccination of Persons Already Infected with EBV 234
2.3. Testing an EBV Vaccine 235
3. Choice of Immunogen 236
3.1. Production Systems 237
3.2. Choice of Adjuvant 238
4. live Recombinant Virus Vector Vaccines 238
5. Cell Mediated Immune Responses to gp30 239
6. Human Trials 239
7. EBV Latent Antigen Vaccines 240
8. Conclusions 241
References 241
11. Inhibition of MHC Class I Function by Cytomegalovirus
HARTMUT HENGEL and ULRICH H. KOSZINOWSKI
1. Introduction 247
2. Principles of the Immune Control of CMV Infection 248
3. The MHC Class I Pathway of Antigen Processing and Presentation 249
4. CMV Strategies for Immune Escape 250
5. MCMV Gene Functions AfTecting the MHC Class I Pathway of
Antigen Presentation 251
5.1. The ml52 Encoded Glycoprotein Retains MHC Class I
Complexes in the ERGIC 251
5.2. gp34 of MCMV Binds to MHC Class I Complexes 252
5.3. gp48 of MCMV Targets MHC Class I Complexes to the
Lysosome for Destruction 252
6. MCMV Gene Functions Affecting the MHC Class I Pathway of
Antigen Presentation 253
6.1. The HCMV UL18 Glycoprotein Binds (32m and Peptides 253
6.2. The HCMV US11 Glycoprotein Dislocates MHC Class I Heavy
Chains to the Cytosol 253
6.3. The HCMV US2 Glycoprotein Transfers MHC Class I Heavy
Chains via Sec61 to the Cytosol 254
6.4. The HCMV US3 Encoded Glycoprotein Inhibits MHC Class I
Transport 254
6.5. HCMV US6 Blocks Peptide Translocation by the MHC
Encoded Peptide Transporter TAP1 /2 254
6.6. HCMV Prevents Antigen Presentation of the 72 kDa IE Protein 255
7. Discussion 255
8. Summary 259
References 260
12. Cell Mediated Immunity against Varicella Zoster Virus
ANN M. ARVIN
1. Introduction 265
2. The Virus 266
3. Methods for Assessing Cellular Immunity to VZV 267
4. Cell Mediated Immunity in the Control of Primary VZV Infection 269
5. Components of the Memory T Cell Response to VZV and Its Protein
Specificity 272
6. Alterations in Memory Cell Mediated Immunity and Susceptibility to
VZV Reactivation 274
7. Mechanisms for Preserving Memory T Cell Immunity to VZV 275
8. Cell Mediated Immunity in the Control of VZV Reactivation 276
9. Cell Mediated Immune Responses against VZV Elicited by Primary
Immunization with Varicella Vaccine 277
10. Memory T Cell Immunity to VZV following Immunization and
Protection against Varicella 280
11. Enhancement of Memory T Cell Immunity by Vaccination of
Naturally Immune Individuals 282
12. Summary 284
References 284
13. Complement Control Proteins of Rhadinoviruses
JENS CHRISTIAN ALBRECHT, FRANK NEIPEL, and
BERNHARD FLECKENSTEIN
1. Introduction 291
2. Genomic Organization of Rhadinoviruses 292
3. The C3 Convertase Inhibitor of H. saimiri 293
4. The Complement Control Protein of H. aides 299
5. The Complement Regulator of Kaposi s Sarcoma Associated
Herpesvirus HHV 8 300
6. The Terminal Complement Inhibitor of//, saimiri 300
7. Concluding Remarks 304
References 306
Index 309
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| spelling | Herpesviruses and immunity ed. by Peter G. Medveczky ... New York [u.a.] Plenum Press 1998 XX, 317 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Infectious agents and pathogenesis Herpesviridae Infections immunology Herpesviridae genetics Herpesviridae immunology Herpesvirus diseases Immunological aspects Herpesviren (DE-588)4159627-4 gnd rswk-swf Immunität Medizin (DE-588)4120476-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Herpesviren (DE-588)4159627-4 s Immunität Medizin (DE-588)4120476-1 s DE-604 Medveczky, Peter G. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008289044&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Herpesviruses and immunity Herpesviridae Infections immunology Herpesviridae genetics Herpesviridae immunology Herpesvirus diseases Immunological aspects Herpesviren (DE-588)4159627-4 gnd Immunität Medizin (DE-588)4120476-1 gnd |
| subject_GND | (DE-588)4159627-4 (DE-588)4120476-1 (DE-588)4143413-4 |
| title | Herpesviruses and immunity |
| title_auth | Herpesviruses and immunity |
| title_exact_search | Herpesviruses and immunity |
| title_full | Herpesviruses and immunity ed. by Peter G. Medveczky ... |
| title_fullStr | Herpesviruses and immunity ed. by Peter G. Medveczky ... |
| title_full_unstemmed | Herpesviruses and immunity ed. by Peter G. Medveczky ... |
| title_short | Herpesviruses and immunity |
| title_sort | herpesviruses and immunity |
| topic | Herpesviridae Infections immunology Herpesviridae genetics Herpesviridae immunology Herpesvirus diseases Immunological aspects Herpesviren (DE-588)4159627-4 gnd Immunität Medizin (DE-588)4120476-1 gnd |
| topic_facet | Herpesviridae Infections immunology Herpesviridae genetics Herpesviridae immunology Herpesvirus diseases Immunological aspects Herpesviren Immunität Medizin Aufsatzsammlung |
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