Synthesis and applications of isotopically labelled compounds 1997: proceedings of the Sixth International Symposium, Philadelphia, USA, 14 - 18 September 1997
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| Format: | Book |
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| Language: | English |
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Chichester [u.a.]
Wiley
1998
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXXV, 729 S. Ill., graph. Darst. |
| ISBN: | 0471978639 |
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| 245 | 1 | 0 | |a Synthesis and applications of isotopically labelled compounds 1997 |b proceedings of the Sixth International Symposium, Philadelphia, USA, 14 - 18 September 1997 |c ed. by J. R. Heys ... |
| 246 | 1 | 3 | |a Isotopically labelled compounds 1997 |
| 264 | 1 | |a Chichester [u.a.] |b Wiley |c 1998 | |
| 300 | |a XXXV, 729 S. |b Ill., graph. Darst. | ||
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| adam_text | TABLE OF CONTENTS
Organizing
Committee xxv
International Isotope Society 1997 Officers xxv
Sponsoring Organizations xxvi
Preface xxvii
Awards xxix
Melvin Calvin A Recollection xxxii
PLENARY LECTURES
Bengt Langstrom, Upsala University
The Progress in Synthesis of Labelled Compounds Using Short Lived
Radionuclides and Their Applications to Measure Biochemistry and
Pharmacology In Vivo
Alan R. Battersby, Cambridge University
Varied and Multiple Isotopic Labeling: Powerful Techniques for
Research on the Biosynthesis of Vitamin B12 1
John S. Vogel, Lawrence Livermore National Laboratory
Accelerator Mass Spectrometry as a Bioanalytical Tool 11
Donghui Li, UT MD Anderson Cancer Center
32P Postlabeling Analysis of Chemical DNA Damage 21
Papers lacking page numbers were presented at the Symposium but
manuscripts were not submitted for this Proceedings volume
SPONSORED LECTURES
Chi Huey Wong, Scripps Institute
Chemo Enzymatic Synthesis of Carbohydrates and Glycoconjugates 33
Eric Jacobsen, Harvard University
Practical Access to Important Chiral Building Blocks by Means of
Asymmetric Catalysis
Paul Slovic, Decision Research
Perception of Risk From Radiation 41
Sidney Nelson, University of Washington
Use of Isotopes in Characterizing Reactive, Toxic Metabolites
Synthesis of Compounds Labeled With Other Isotopes
Chairman: D.C. Dean
Synthesis of Iodine 123 Agents for Use in the Detection of Alzheimer
Disease
G.W. Kabalka. M.R. Akula, and Z.Y. Zhang 59
Radioiodination of Interferon oc2b Using Bolton Hunter and PIB Reagents;
Evaluation of Label Stability Using Whole Body Autoradiography
D. Koharski, M. Thonoor, M. Wirth, and P. McNamara 63
32P Labeled Analogs of Farnesyl and Geranylgeranyl Pyrophosphate:
Synthesis and Application in Photoaffinity Labeling Experiments with
Protein Prenyltransferases
T.C. Turek, R.L. Edelstein, I. Gaon, V.A. Weller, and
M.D. Distefano 61
New Applications of High Specific Activity [35S]Sulfonamides to
Photoaffinity Labeling
D.C. Dean. M.A. McEvoy, M.M. Smith, P.T. Meinke, and
D.G. Melillo 71
Handling Isotopes: Safety/Regulatory/Political/Social
Dimensions
Chairman: J. Hicks
Ten Lessons From Research for Communicating About Radioactive Waste
Issues
A.S. Bisconti and P.H. Genoa
Low Level Radioactive Waste Disposal A European Perspective
D.J. Morecombe 75
A Practical Approach to the Destruction of Radioactive Organic Mixtures
L.E. Weaner, D.C. Hoerr. W.T. Shmayda, A.G. Heics, and
J.D. Blevins 79
Tritium Recovery From Tritiated Liquids
W.T. Shmayda. A.B. Antoniazzi, J. Blevins, L.E. Weaner, and
D.C. Hoerr
Summary of the Activities of the IIS Low Level Radioactive Waste
Committee
J.L. Hicks
Synthesis and Applications of Compounds Labeled With Short
Lived Isotopes
Chairmen: W. A..P. Breeman and M. R. Kilbourn
Studies on Tissue Distribution and the Antiproliferative Effect of
Radiolabeled Octreotide Analogs in Rats
W.A.P. Breeman. M. de Jong, D.J. Kwekkeboom, T.J. Visser,
A.Srinivasan, and E.P. Krenning 83
Radiopharmaceuticals for Imaging the Serotonin System
C.A. Mathis. Y. Huang, and N.S. Mason
Stereoselective Synthesis of [uC]6 ,7 Dihydroroten 12 ol, a Marker of
Mitochondria! Complex I Activity
S.E. Snyder. P.S. Sherman, and M.R. Kilbourn 87
Synthesis of D [6 C]glucose, 2 deoxy [l C] glucose and D [l
nC]fructose
M. Ogren and B. Langstrom 91
Applications of a New Radiopharmaceutical (99 m Technetium thymine) in
Clinical Research and Medicine
B. Gutfilen. E. Rodrigues, L.M.B. Fonseca, R. Soraggi, S.A.
Goncalves, and M. Bernardo Filho
The Use of a Fluorine 18 Labeled Agent Along With Position Emission
Tomography for Treatment Planning in the U.S. Clinical Trials of Boron
Neutron Capture Therapy
G. Kabalka. G. Smith, K. Hiibner, W. Reid, D. Longford,
J. Dykes, and T. Nichols 95
Progress in the Synthesis of Paroxetine [I8F]
S.W. Landvatter. K.T. Games, and R.F. Dannals 99
Radiolabeled 2p Methoxycarbonyl [TC 99M] cyclopentadienyltricarbonyl
3P (4 chlorophenyl)tropane (CPTTDAT): Synthesis, Characterization and
Tissue Distribution of a Radioligand for Mapping Dopamine Transporter
Sites by SPECT.
A. Xing, B. Shi, C. Kilts, D.T. Abak, V. Camp, E. Malveaux,
T. Ely, M. Owen, P. Lambert, and M.M. Goodman 103
Advances in the Analysis of Isotopically Labeled Compounds
Chairmen: F. P. Abramson and J. R. Jones
Structures of Larger Proteins and Protein Complexes by NMR
G.M. Clore and A.M. Gronenbom
Tritium Nuclear Magnetic Resonance Spectroscopy An Update
P. G. Williams
The Use of Accelerator Mass Spectrometry (AMS) Isotope Analysis in
Biomedical Studies
K.W. Turteltaub. J.S. Vogel, M.L. Roberts, RJ. Mauthe, and
K.H. Dingley
Development of a GC AMS System for Biomedical Research
B.J. Hughev. R.E. Klinkowstein, R.E. Shefer, N.A. Fried,
P.L. Skipper, S.R. Tannenbaum, and J.S. Wishnok 107
Laser Optogalvanic Effect Isotope Ratio Analysis in Carbon Dioxide
D.EMurnick. M.J. Colgan, and D.N. Stoneback Ill
High Precision Position Specific Isotope Analysis
J.T. Brenna and T.N. Corso 115
Stable Isotope Labeled Proteins for Kinetics and Metabolism Studies Using
CRIMS
B.L. Osborn and F.P. Abramson 119
Applications of Isotopes in Clinical Research and Medicine
Chairmen: J. Caldwell and P. Jones
Isotope Developments For Interventional Medicine
P.M. Lewis 123
Use of Radioisotopes in Clinical Drug Development and Evaluation
J. Caldwell
Stable Isotopes in Studies of Lipids
S. Cunnane
Applications of Mineral Stable Isotopes
K. O. O Brien 131
Estimation of Intestinal Oxalate Absorption
G.D. von Unruh. M.A.W. Langer, W.D. Paar, T. Sauerbruch
and A. Hesse 705
Naturally Occurring Deuterium May Have a Central Role in Cell Signalling
G. Somlvai. G. Laskay, T. Berkenyi, G. Jakli, and G. Jancso 137
Synthesis of Compounds Labeled With Isotopes of Carbon
Chairmen: K. M. Cable and W. J. Wheeler
Synthesis of Some Glaxo Wellcome Compounds Labelled With Isotopes of
Carbon
K.M. Cable. R.M. Carr, I. Fellows, C. Hughes, S. Montgomery,
J.J. Newman, P.W. Scott, A.H. Wadsworth,
I. Waterhouse, G.N. Wells, M.D. Wipperman, and
D.R. Sutherland 143
Synthesis and Analysis of 14C Labelled Starburst® Pamam Dendrimers
H. Fujiwara, S. Habibi Goudarzi, B.D. Maxwell, and
S.J.Logusch 149
Enantioselective Synthesis of Carbon 14 Labelled SDZ ENA 713 hta, An
Investigation^ Drug for Treatment of Alzheimer s Disease
G. Ciszewska, H. Pfefferkorn. L. Jones, R. Tarapata, and
U.B. Sunay 153
A Facile Introduction of [l4C] Carboxylic Acid Functionality, Synthesis of
Carbon 14 Labeled SB 209670 and SB 217242
M.K. Mokhallalati. S.W. Landvatter, and N.H. Baine 157
Enantioselective Syntheses of L oc Amino Acids Incorporating Stable
Isotopic Labels
M.D. Fletcher, N.M. Kelley, A. Sutherland, and C.L. Willis 161
A. General Method for the Carbon 14 Labelling of Cyclic Enones
K.E. McCarthy. K.S. Zandi, and K. Schildknegt 165
Studies into the Synthesis of C 14 Labeled Enantiopure 5,6 Dihydropyran
2 one, a Synthon for Labeled Anti HIV Pyranones
I.V. Ekhato 171
The Synthesis of Isotopically Labelled SB 207266 A
G. Badman. A. Mahoney, and D. Smith 175
Efficient Utilization of [14C]Carbon Dioxide as a Phosgene Equivalent for
Labeled Synthesis
M.A. Wallace. D.C. Dean, T.M. Marks, and D.G. Melillo 179
Palladium Catalyzed Synthesis of Labelled Aromatic Nitriles: Application to
Pharmaceuticals
A. Allentoff, G. Ciszewska, B. Markus, H. Pfefferkorn,
T. Rav. L. Jones, and T. Duelfer 185
Use of Chiral Synthons For The Preparation of Enantiomerically Pure
Isotopically Labelled Compounds: [ 314CJBABS, Scope and Limitations
R. Voges
Novel Approaches to Compounds Labeled with Isotopes of
Hydrogen
Chairmen: W. J.S. Lockley and P. G. Williams
Microwave Enhanced Deuteration and Tritiation Procedures
J.R. Jones 189
New Tritium Labelling Reagents and Techniques
M. Saljoughian. H. Morimoto, P.G. Williams, and C. Than 193
Peptide Tritiation by Homogeneous Catalysis
A. Hammadi, G. Meunier, J. L. Tarride, A. Menez, and
R. Genet 197
Convenient Synthesis of Deuteriated Cyclic Alkanes From Poly
Halophenols With Nickel Aluminum Alloy in Alkaline Deuterium Oxide
H. Tsuzuki. S. Mataka, and M. Tashiro 203
The Influence of Kinetic Isotope Effects on Tritium Labeling Reactions
U. Pleiss. U. Rosentreter, J. Stoltefuss, and O. Behner 207
Tritide Reagents in the Synthesis of Selectively Labelled Compounds
H. Andres. C. Than, H. Morimoto, and P.G. Williams 213
Express Approach to the Synthesis of Tritium Labeled Pharmaceuticals
V.P. Shevchenko, I.Y. Nagaev, N.F. Myasoedov, and
A. Susan 219
Organoiridium Mediated Hydrogen Isotope Exchange
A.Y.L. Shu and LR^JIeys 223
Tritium Labelled Peptides: New Solutions to Old Problems
B.B. Kent and D.M. James 227
Production of Stable Isotopes and Radioisotopes
Chairmen: N. R. Stevenson and H. Rakhorst
Production of Medical Isotopes for Therapy
P.M. Lewis 231
Urenco s Stable Isotope Production Programme
P.G.T. deJong. H. Rakhorst, and P.D. Dawson 239
The Use of the TRIUMFISAC Facility for the Production of Radionuclides
for Therapy
T.J. Ruth 245
Department of Energy Isotope Production Strategy
O.W. Lowe 247
R D Production of Radioisotopes and Radiopharmaceuticals in Taiwan,
ROC
G. Ting. H. Huang, and Z T. Tsai 251
Numerical Simulation and Production of Stable Isotopes By Gas
Centrifuges
V.D. Borisevich and A.V. Tikhomirov 255
Applications of Isotopes in Organic and Bio Organic Reaction
Mechanisms
Chairmen: G. Kollenz and V. L. Schramm
Isotopes in Enzymatic Radical Reactions
J. Kozarich
An Unusual Stereospecific Decarboxylation: A Key Reaction to an
Important Intermediate for 8 Methyl Carbapenem Antibiotics
W. B. Choi, H.R.O. Churchill, J.E. Lynch. A.S. Thompson,
G.R. Humphrey, R.P. Volante, P.J. Reider, I. Shinkai,
D.K Jones, and D.C. Liotta 259
Labeling Studies on Some Novel Molecular Rearrangements
G. Kollenz 263
Oxygenases and Glycosyltransferases in Combinatorial Biosynthetic
Approaches
J. Rohr 267
Mechanism and Bond Distortions in Enoyl CoA Hydratase
V. Anderson 273
Applications of Heavy Atom Isotope Effects
P. Paneth 279
Enzymatic Transition State Analysis from Kinetic Isotope Effects
V. L. Schramm 283
Isotopes in Macromolecules: Protein, Nucleic Acid and
Monoclonal Antibody Research
Chairmen: Y. Arano and D. S. Wilbur
Amphiphilic Polymers as Key Components of Contrast Agents for Gamma,
MR and CT Imaging
V.P. Torchilin 289
A Highly Efficient Synthesis of 6 Chloro [8 l3C]Purine: A Precursor to
Site Specifically Labeled Purines
C.C. Orji and L.A. Silks III
Pretargeting: Optimal Matching of Antibody Targeting and Radioactivity
Delivery
A. Fritzberg. D. Axworthy, P. Beaumier, and J. Reno
Development of Biotin Trimers as Reagents to Increase (Radio)Nuclide
Localization in Antibody Pretargeting
D.S. Wilbur. P.M. Pathare, D.K. Hamlin, P.S. Stayton, L.A.
Klumb, P. Tan, R. To, R.L. Vessella, and K.R. Buhler 295
Radioiodination of a Protein for Pharmacokinetic Studies
A. Kagemoto, M. Nakao, T. Fujii, and H. Miyazaki 299
Synthesis of N Succinimidyl 4 [76Br]bromobenzoate and Its Use in
Labeling of Amino Containing Macromolecules
U. Yngve, E. Hedberg, V. Tolmachev, and Langstrom 303
A Chemical Strategy to Reduce Renal Radioactivity Levels of Antibody
Fragments
Y. Arano. K. Wakisaka, H. Akizawa, M. Ono, Y. Fujioka,
T. Uehara, T. Saga, H. Sakahara, J. Konishi, and H. Saji 307
Applications of Isotopes in Metabolism and Toxicology
Chairmen: J. Allen and S. Nelson
Applications of Stable Isotopes in Drug Discovery and Development
P.G. Pearson. R.C. Steenwyk, W.T. Stolle, R.S.P. Hsi, L.C.
Wienkers, J.A. Easter, J.P. McGrath, P.E. Sanders, and M.J.
Hauer
NMR, HPLC NMR, and HPLC NMR MS Approaches to the Study of
Drug Metabolism Using Stable Isotopes
J.K. Nicholson
Kinetic Isotope Effects and the Mechanisms of Cytochrome P450 Oxidative
Dealkylations and Aromatic Hydroxylations
J.P. Jones 311
Identification of Novel Glutathione Conjugates Derived from the Metabolic
Activation of Stable Isotope Labeled A4 Valproic Acid by LC/MS/MS
M.R. Davis. K. Kassahun, M.P. Grillo, P. Hu, L. Jin, and T.A.
Baillie
Applications of Isotopes in Pharmaceutical and Agricultural
Research
Chairmen: T. R. Browne and P. McNamara
Direct Measurements of Skeletal Calcium Kinetics With 41Ca
S.P.H.T. Freeman
Whole Body Autoradiography in Drug Discovery and Development
M. Thonoor
The Mechanism of a Sapogenin from Anemarrhenae Asphodeloides Bge in
the Treatment of Senile Dementia
N. Yi. Y. Hu. and Z. Xia 315
Evaluation of Continuous Flow Isotope Ratio Mass Spectrometry for
Quantitating Stable Isotope Labeled Compounds in Biomedical Tracer
Studies
T.R. Browne 321
Enantiospecific Pharmacokinetics of Fadrazole Using a Pseudoracemate
Technique
M. Powell
Application of Nuclear Magnetic Resonance in Brain Metabolic Research
K. Behar
Poster Presentations
Chairman: K.E. McCarthy
Stereospecific Synthesis of PNU 101387, Radiolabeled with Tritium and
Carbon 14, and Stablelabeled with Carbon 13 and Deuterium
John A. Easter. W.T. Stolle, R.S.P. Hsi, R.E. TenBrink, C.L.
Bergh, A.G. Romero, J. Sih and G. Scott 325
Synthesis of LY333068 [14C] Succinate Based on Chiral Glycerol [I4C]
Derivatives
Boris A. Czeskis 329
Synthesis of 1 125 Analog of Photoaffinity Labeled Endothelin Converting
Enzyme Antagonist
Arthur Y.L. Shu. Ashley E. Fenwick, John D. Elliot and
J. Richard Heys 333
Synthesis of [l C] l,2,3,4 Tetrahydro p carboline Derivatives by Pictet
Spengler Condensation
M.W. Nader. S.K. Zeisler, A.M. Theobald, F. Oberdorfer 337
Tritium Labelling of Deltorphin II in Val5 and D Ala2 Leu5 Enkephalin
Amide in D Ala2 Residues
Eva C. Gulyas and Geza Toth 341
Synthesis of the ACAT Inhibitor CI 1011 Labeled with Carbon 14,
Carbon 13 or Tritium
James L. Hicks and C.C. Huang 345
Synthesis of [2,2,4,4,21,21,2 l 2H7]17cc Hydroxypregnenolone
C. Solleder, J. Homoki and S.A. Wudy 349
The Synthesis of the Cognition Activator [14C]PD151832
J.D. Hartman. I.V. Ekhato and P.W.K. Woo 355
Combining the Advantages of Polymer Supported Catalysts and the
Benefits of Microwave Enhanced Reactions in the Preparation of
[2H]Labelled Compounds
J.R. Jones. S.Y. Lu and D. Zhong 359
Carbon 14 Labeled Polyhydroxyindolizidines: Synthesis of Carbon 14
Labeled Castanospermine and Anti HIV Agent 6 0 Butytylcastanospermine
Hydrochloride (MDL 28574A)
Harpal S. Gill 363
Synthesis of 3 {[4 (4 [l8F]Fluorophenyl)piperazin 1 yljmethyl} H
pyrrolo 2,3 b]pyridine; A Potential Dopamine D4 Receptor Imaging Agent
O. Eskola, J. Bergman, P. Lehikoinen, M. Haaparanta,
T. Gronroos, S. Aalto and O. Solin 367
Preparation and Evaluation of l53Sm Complexes of Organic Amine
Phosphonic Acid Ligands
Lu Gongxu and Xu Renfeng 371
Use of Isotopic Labelling to Support the Evaluation of AR C15849KF, a
CCK A Agonist with Appetite Suppression Properties
L.P. Kingston, W.J.S. Lockley. A.N. Mather, J.R. Preston,
J. Singh, D.J. Wilkinson and V.J.C. Willson 375
The Synthesis of 8P Methylthiomethyl 6 (7V [(4 hydroxy 3
iodophenyl)propionyl] (3 aminopropyl)]ergoline [125I], a Radioligand
Potentially Useful in the Radioimmunoassay of Pergolide Mesylate
William J. Wheeler. Delise Douglas and W. Edwin Legan 379
Synthesis of Carbon 13 and Carbon 14 Isotopically Labeled PNU
101017E, a GABAA Receptor Partial Agonist, Under Development for the
Treatment of Anxiety
W.T. Stolle and R.S.P. Hsi 383
Synthesis of Five Conjugated Linoleic Acid Isomers Labelled with
Deuterium Atoms
R.O. Adlof. E.L. Walter and E.A. Emken 387
Synthesis of [4 14C]Fluocinolone Acetonide
Bo Chan Kao and Kirk Bordeaux 391
Palladium Catalyzed Synthesis of Carbonyl Labelled Benzophenone
Derivatives from [uC]Carbon Monoxide
M.W. Nader, S.K. Zeisler. A.M. Theobald and F. Oberdorfer 395
Synthesis of [14C] and [3H]SCH 27899 and Evaluation of in vivo Label
Stability
I. Gunnarsson, D. Hesk, D. Koharski, J. Schwartz,
M. Thonoor. M. Wirth and P. McNamara 399
Improved Synthesis of Enantiomerically Pure 2 (2 Cyclopentenyl) [2 3C]
L glycine
Lise Andersen and Jerzy W. Jaroszewski 403
Synthesis of 14C and 3H Labelled l,4 Dideoxy l,4 imino D arabinitol
Jacob S. Valsborg, Birgitte M. Folkersen, Inge Lundt, Allan
Winge Rasmussen, Karsten Lundgren and Christian Foged 407
Synthesis of Isotopically Labelled ICI 182,780, a Pure Oestrogen Receptor
Antagonist
J.R. Hardine and D.F. White 411
Syntheses of Isotopically Labelled Versions of the Cardioprotective Agent
GR79236
John J. Newman, Ian Fellows, Alan H. Wadsworth, Mark D.
Wipperman and Derek R. Sutherland 415
Tritium Labeling of G Actin
C.T. Peng. V.I. Gelfand, M. Kirschner and H. Morimoto 421
Synthesis of Cobalt [14C2]Mesoporphyrin bis G ycinate
Peter W.K. Woo, Roger Hayes, Vladimir G. Beylin, Stephen
Johnson, Michael Lovdahl, Yun Huang and Che C. Huang 429
Synthesis of Radiolabelled Versions of GV150013, a Novel
Cholecystokinin B Receptor Antagonist
Mario Almi and Simone Guelfi 433
Tritium Exchange Labelling Strategies for New Drug Discovery Support
D. Hesk. D. Koharski, S. Saluja, P. McNamara, C. Magatti,
D. Cesarz, S. Hendershot and J.R. Jones 439
4 [18F]Fluorophenyltributyltin, a New Precursor in 18F Cross Coupling
Reactions
T. Forngren and B. Langstrom 445
Efficient Radiolabeling of N (2 Hydroxy 4 nitrophenyl] A (2
iodophenyl)urea, an Interleukin 8 Inhibitor
Keith T. Games, Scott W. Landvatter and Katherine
Widdowson 449
Enzymatic Methods of Tritium Labeled Preparations Synthesis
N.F. Myasoedov and A. Susan 453
Synthesis of Stable and Radiolabelled Azimilide
Laura J. Greenfield. Paul Dybas, Jim Lake, Greg Bosch, Julia
Boueres and Li Sun 459
Synthesis of Tritiated Resiniferatoxin
Arthur Y.L. Shu and J. Richard Heys 463
Synthesis and Tritium Labelling of P Amyloid(25 35) Peptides
Eva C. Gulyas. Katalin Soos, Jozsef Varga, Botond Penke and
Geza Toth 467
Synthesis of a Stable Polydeutero Genistein
Sirpa Rasku and Kristiina Wahala 471
Deuteration of Estrogens Using Pd/C as a Catalyst
Paula Kiuru and Kristiina Wahala 475
A New Synthesis of [ C]Formaldehyde by Reduction of [ CJCarbon
Dioxide with Complex Hydrides
M.W. Nader. S.K. Zeisler, A.M. Theobald and F. Oberdorfer 479
Synthesis of Remacemide Hydrochloride Labelled with Carbon 14,
Carbon 13, Deuterium and Tritium
M.E. Coombs, G.E. Dawson, M. Fedorchuk, L.P. Kingston,
W.J.S. Lockley, A.N. Mather, T.R.B. McLachlan,
A.J.G. Morlin andD.J. Wilkinson 483
A novel Synthesis of LY334370, a Potent 5 HTlf Receptor Antagonist,
Useful for the Preparation of its C 14 Labeled Isotopomer
William J. Wheeler. Delise M. Douglas and Douglas D.
O Bannon 487
The Synthesis of Two Isotopomers of LY334370; 1. A Novel Circuitous
Synthesis of LY334370 [2 i4C]. 2. A Synthesis of LY334370 [N methyl
13CD,]
William J. Wheeler. Delise M. Douglas and Douglas D.
O Bannon 491
Synthesis of Deuterium Labelled Polyhydroxy Isoflavone 0 Glucosides
Philip Lewis and Kristiina Wahala 495
Radiochemical Synthesis at High Specific Activity of 17P (3 Furyl) 5P
androstane 15,16 ditritio 3py4p,17a triol (PST 2238)
G. Angelini. A. Cerri, A. Filippi, G. Lilla, A. Margonelli and
P. Melloni 499
The Synthesis of LY079820 [14C]
Douglas P. O Bannon 503
Simple Methods for the Labelling of N Methylamines Using Isotopically
Labelled Methyl Iodide
Ian Fellows, Richard M. Carr, Nigel deBoeck, Stephen
Montgomery, Ian Waterhouse and Derek R. Sutherland 507
Radiosynthesis and Biodistribution of [14C]CGS 30440
B, Markus. A. Allentoff, W. Breen, A. O Buck, P. Zane and
T. Duelfer 513
Synthesis of Stable Isotopically Labelled Antibacterial Agent Grepafloxacin
Guv N. Wells. Richard M. Carr and Derek R. Sutherland 517
Preparation of Castor Oil Labelled with I31I as a Myocardial Imaging Agent
V. Borza. E. Neascu, G. Dumitrescu and D. Chariton 521
A Convenient Synthesis of [nC]Acetate with Anatech Robot
M. Panico. D.V. Solovyov, G. Randazzo, G.F. Calicchio, R.
Roma, A. Lacagnina, C. Imparato, A. Green, L. Bazzicalupo
and M. Salvatore 525
Tritium Labeling of Benzodiazepines and Some Related Compounds
J. Hiltunen. C.T. Peng and P.G. Williams 529
Synthesis of 3H Labelled Compounds via Rapid Hydrogen Transfer
Hydrogenation Using Formate Salts
T.N. Danks. R. Garman and J.R. Jones 535
Biocompatible Polymers New Deuteriation and Tritiation Procedures
G.S. Getvoldsen. J.R. Jones and J.C. Russell 539
Chirality Transfer on Carbohydrate Template: A Versatile Approach for
Chiral Deuterium Labeling
Katsumi Kakinuma and Tadashi Eguchi 543
Preparation of 64Cu BAT Complexes as a Myocardial Perfusion Imaging
Agent
Liu Boli. Chen Huawei and Zhu Lin 547
Synthesis of Tritium Labeled Natural Diazines and Their Derivatives
N.F. Myasoedov and G.V. Sidorov 551
A Novel and Efficient Asymmetric Synthesis of Carbon 14 Labeled (S,S)
2,7 Di Boc diaminosuberic Acid (SK F 109088 [14C]) for the Synthesis
of the Hematoregulatory Agent, SK F 107647 [l4C]
A.J. Villani. J.R. Heys, D. Saunders and A.Y.L. Shu 555
Radiosynthesis of [3 14C]Indole 3 pyruvic Acid, A New Putative
Anxiolytic Drug. Characterisation of a Trace Radiochemical Impurity
A. Margonelli. L. Mannina and G. DiStazio 559
A Comparison of Radioimmunoassay and Dissociation Enhanced
Lanthanide Fluorescence Immunoassay for the Analysis of a Novel
Development Candidate in Human Plasma
J. Singh. W.J.S. Lockley, J.R. Preston, A.N. Mather, V.J.C.
Willson, CM. Gilbert and M.A.J. Bayliss 563
Systematic Investigations of 14C AMS Measurements and First Results of a
Forensic Study in Humans
W. Rom. R. Golser, W. Kutschera, A. Priller, S. Puchegger,
P. Steier, W. Vycudilik and E. Wild 567
Quick Detection and Identification of Clinical Microorganisms by a
Combined Use of a Medium Containing Stable Isotope Labeled Carbon
Source and NMR Spectroscopy
H. Suzuki. A. Maeda, M. Fujiike, Y. Murakami, M. Ikedo,
K. Furihata and H. Seto 571
Clinical Steroid Hormone Analysis by Stable Isotope Dilution/Gas
Chromatography Mass Spectrometry
S.A. Wudy. M. Hartmenn, C. Solleder, U.A. Wachter and
J. Homoki 575
Metabolite Analysis Using Packed Capillary Column LC MS
B. Hyllbrant. N. Tyrefors, K.E. Markides and B. Langstrom 581
A Compact Liquid Scintillation Counter for Benchtop and Field Use
Seth P. Shulman 585
Computerized Database for Recording Analytical and Inventory Information
for Isotopically Labeled Compounds
S. Levinson. B. Pang and M. Stroukoff 589
Glucose Metabolism and Insulin Resistance in Tissues of DMBA Tumor
Rats: In vivo Study Using Microdialysis and [18F]FDG
T. Gronroos. M. Haaparanta, J. Bergman, O. Solin, S. Aalto,
R. Paul and H. Minn 593
Application of Deuterated Benzoyl Peroxide in an in vitro Model of
Percutaneous Absorption and Dermal Metabolism of Chemical Substances
B. Blume, M. Kietzmann, M. Moder, P. Kranke and
M. Wahren 597
Diagnosis of Inherited Disorders in Humans with Fish Odour Smell Using
Stable Isotopes
D.W. Johnson. J.M. Fletcher and D.W. Thomas 601
Human Folate Metabolism Using 14C Accelerator Mass Spectrometry
A.J. Clifford. A. Arjomand, S.R. Dueker, H. Johnson, P.D.
Schneider, R.A. Zulim, B.A. Buchholz and J.S. Vogel 605
Biodistribution and Dehalogenation Studies of Two Radiohalogenated
Kynurenic Acid Derivatives, Potent Antagonists of the N Methyl D
aspartate Receptor
F. Dumont and G. Siegers 609
The Binding of 99mTechnetium Radiopharmaceutical on Blood Elements:
Evaluation Using Precipitation with Trichloroacetic Acid
R.S. Freitas, B. Gutfilen, M. Bernardo Filho 613
New Method of Drug Design for Dopamine D2 Receptor Imaging Agent
Liu Boli. Meng Zhaoxing, Tang Zhigang 619
Relation Between Human Cardiac Acidic Isoferritin and Hepatoma
Jian Jin. Man da Zhang, Bo cheng Wang, Hua long Xiao and
Jun ming Sun 623
Validity of the BC Urea Breath Test for the Diagnosis of Helicobacter pylori
Infection
Masahiro Kajiwara. Katsumi Iida, Kazuhiko Takatori, Yushi
Taniguchi and Ken Kimura 627
Scintigraphical Evaluation of the Pharmacological Response to the Drug
Alflutop in the Treatment of Arthritis
Valeria Viorica Lungu. Gabriela Mihailescu and Nicolae Verga 633
Preclinical Pharmacology Study of Neutral Myocardial Imaging Agent
99mTcN(NOEt)2
Bo Cheng Wang. Ping Fang, Chun Ying Wu 637
Evaluation of Radiosensitivity by Positron Emission Tomography with 18
Fluoro 2 deoxy D glucose in the Patients Affected by Uterine Neoplasms
P. Frezza. G. Silvestro, M. Elmo, M. Panico and C. Mainolfi 641
New 99mTcO NS3 Complexes for Brain Imaging
Jin Yutai, Liu Boli. Tu Zhude, Ni Zhigang and Zhou Shouming 645
Hydrogen Isotope Exchange Studies of Pt(II) Purine Complexes
Erwin Buncel, Lewin Li and Omoshile Clement 649
The Mechanism of Isotopic Exchange with Spillover Tritium and HSCIE
Applications
Yu.A. Zolotarev. Yu.A. Borisov and N.F. Myasoedov 653
Photocatalytic Degradation of 14C Trinitrotoluene
Gregor Fels. Sandy Linnemann, Alice Klapproth and Detlef
Bahnemann 657
A Survey of Low Level Radioactive Waste
Hiromi Morimoto. Philip G. Williams and Larry Weaner 661
Panorama and Outlook for the Manufacture of Stable Isotopes in Russia
A. Pokidychev and M. Pokidycheva 663
A New Water Target System for the Production of I8F and I3N to be Used
in Plant Study
N.S. Ishioka, H. Matsuoka, S. Watanabe, A. Osa, M. Koizumi
and T. Sekine 669
Nitrogen 15 Fractionation in Countercurrent System Formed by Nitric Acid
and Gaseous Nitrogen(II) Oxide at Low Temperatures
M.S. Safronov, V.I. Gorshkov, V.A. Ivanov, N.E. Tamm,
T.G. Abzianidze, A.S. Egiazarov and G.V. Hatchishvili 673
Development of the Wasteless Technology of Nitrogen Isotope Separation
A.M. Tolmachev, E.N. Egorov, A.A. Razmadze, A.S.
Egiazarov, T.G. Abzianidze and G.V. Hatchishvili 679
The Production of Highly Enriched Rare Isotopes Based on Centrifugal
Method
A.K. Laliteevski. O.N. Godisov and V.V. Kuraev 683
Development of Two Stage Laser Centrifugal Technology for Production of
Highly Enriched C 13 Isotope
A.K. Kaliteevsky, E.N. Sokolov, O.N. Godisov. A.A.
Barabeashikov, S.V. Fedichev, P.K. Shepelev, V.D. Gluchich,
G.A. Baranov, A.V. Astahov, V.V. Kuchinsky, U.I
Shevchenko, V.U. Baranov, E.A. Rjabov and A.P. Dijdkin 687
Production of 166Holmium by Szilard Chalmers Reaction
S.K. Zeisler. K. Weber and F. Oberdorfer 691
Photochemical Method Application for the Production of Mercury Isotopes
with Overlapping Contours of a Resonance Line
N.V. Viazovetskaia. Yu.V. Viazovetski and A.P. Senchenkov 695
Study of Production Possibility of No Carrier Added l86Re via Proton
Induced Reaction on Tungsten for Use in Radiotherapy
F. Szelecsenyi. S. Takacs, F. Tarkanyi, M. Sonck and
A. Hermanne 701
Estimation of Intestinal Oxalate Absorption
G.E. von Unruh, M.A.W. Langer, W.D. Paar, T. Sauerbruch
and A. Hesse 705
Author Index 709
Keyword Index 715
|
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| spelling | Synthesis and applications of isotopically labelled compounds 1997 proceedings of the Sixth International Symposium, Philadelphia, USA, 14 - 18 September 1997 ed. by J. R. Heys ... Isotopically labelled compounds 1997 Chichester [u.a.] Wiley 1998 XXXV, 729 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biomolecules Isotopes Congresses Chemische Synthese (DE-588)4133806-6 gnd rswk-swf Isotopenmarkierung (DE-588)4176811-5 gnd rswk-swf (DE-588)1071861417 Konferenzschrift gnd-content Isotopenmarkierung (DE-588)4176811-5 s Chemische Synthese (DE-588)4133806-6 s DE-604 Heys, J. Richard Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008282227&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Synthesis and applications of isotopically labelled compounds 1997 proceedings of the Sixth International Symposium, Philadelphia, USA, 14 - 18 September 1997 Biomolecules Isotopes Congresses Chemische Synthese (DE-588)4133806-6 gnd Isotopenmarkierung (DE-588)4176811-5 gnd |
| subject_GND | (DE-588)4133806-6 (DE-588)4176811-5 (DE-588)1071861417 |
| title | Synthesis and applications of isotopically labelled compounds 1997 proceedings of the Sixth International Symposium, Philadelphia, USA, 14 - 18 September 1997 |
| title_alt | Isotopically labelled compounds 1997 |
| title_auth | Synthesis and applications of isotopically labelled compounds 1997 proceedings of the Sixth International Symposium, Philadelphia, USA, 14 - 18 September 1997 |
| title_exact_search | Synthesis and applications of isotopically labelled compounds 1997 proceedings of the Sixth International Symposium, Philadelphia, USA, 14 - 18 September 1997 |
| title_full | Synthesis and applications of isotopically labelled compounds 1997 proceedings of the Sixth International Symposium, Philadelphia, USA, 14 - 18 September 1997 ed. by J. R. Heys ... |
| title_fullStr | Synthesis and applications of isotopically labelled compounds 1997 proceedings of the Sixth International Symposium, Philadelphia, USA, 14 - 18 September 1997 ed. by J. R. Heys ... |
| title_full_unstemmed | Synthesis and applications of isotopically labelled compounds 1997 proceedings of the Sixth International Symposium, Philadelphia, USA, 14 - 18 September 1997 ed. by J. R. Heys ... |
| title_short | Synthesis and applications of isotopically labelled compounds 1997 |
| title_sort | synthesis and applications of isotopically labelled compounds 1997 proceedings of the sixth international symposium philadelphia usa 14 18 september 1997 |
| title_sub | proceedings of the Sixth International Symposium, Philadelphia, USA, 14 - 18 September 1997 |
| topic | Biomolecules Isotopes Congresses Chemische Synthese (DE-588)4133806-6 gnd Isotopenmarkierung (DE-588)4176811-5 gnd |
| topic_facet | Biomolecules Isotopes Congresses Chemische Synthese Isotopenmarkierung Konferenzschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008282227&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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