Integrative aspects of calcium signalling:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
Plenum
1998
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XX, 408 S. grpah. Darst. |
| ISBN: | 0306460327 |
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MARC
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Record in the Search Index
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| adam_text | Integrative Aspects of
Calcium Signalling
Edited by
Alexej Verkhratsky
Max-Delbruck Center for Molecular Medicine
Berlin, Germany
and
Emil C Toescu
Birmingham University Medical School
Birmingham, United Kingdom
Plenum Press • New York and London
, CONTENTS
Introduction: Principles of Calcium Signalling 1
E C Toescu and A Verkhratsky
1 Introduction 1
1 1 Evolutionary Aspects of Ca2+ as a Signal 2
1 2 Ca2+—From Signal to Function 3
2 Generation of Ca2+ Signal 5
2 1 Sources of Ca2+ 5
211 Intracellular Ca2+Source 6
212 Mixed Sources: Intracellular and Extracellular 6
213 Extracellular Ca2+Source 8
2 2 Magnitude of Ca2+ Signal 9
221 Ca2+Entry Systems 10
222 Ca2+ Buffering Systems 11
3 Coding of Calcium Signal 11
3 1 Coding in Spatial Domain 12
3 2 Coding in Temporal Domain 14
4 Intercellular Communication 16
5 Conclusion 16
References 17
Part One: Calcium Regulation of Cellular Systems
1 The Fate of Calcium Ions Entering a Cell: Calcium Transport through Organelles 23
Markus Hoth
1 Introduction 23
2 Basic Mechanisms of Intracellular Ca2+ Concentration Control 23
2 1 Ca2+ Release from Intracellular Stores 24
2 2 Ion Channels: The Source of Ca2+ Influx 24
2 3 Ca2+ Diffusion 24
2 4 Mobile and Immobile Ca2+ Buffers 25
2 5 Ca2+ Clearance: Across the Plasma Membrane 25
xi
xii Contents
2 6 Ca2+ Clearance: Into Internal Stores 25
3 New Roles for Mitochondria and Endoplasmic Reticulum in the Ca2+
Network 26
31A Ca2+Tunnel Made by the Endoplasmic Reticulum 26
32A Mitochondrial Ca2+Tunnel? 27
321 How Mitochondria Shape Cytosolic Ca2+Signals 27
322 Mitochondria as a Ca2+ Transport System to Generate Cytosolic
Ca2+ Signals 28
3 3 Other Stores as Transport Systems 29
4 Competition over the Fate of Ca2+ Ions 29
5 Functional Implications of Ca2+ Transport Systems 30
5 1 Spatial Aspect 30
5 2 Calcium Waves 31
5 3 Gene Expression 31
References 32
2 Calcium Regulation of Cytosolic Enzymes 35
Howard Schulman
1 Introduction 35
2 Signalling by Ca2+ as a Second Messenger 36
2 1 Spatial Aspects of Ca2+ Signals 36
2 2 Temporal Aspect of Ca2+Signalling 38
3 Calmodulin Is a Critical Ca2+ Binding Protein in Signal Transduction 38
3 1 Coordination of Cell Function by Calmodulin Is Made Possible by Its
Structure 39
4 Ca2+/Calmodulin-Dependent Protein Kinases 40
4 1 General Properties of CaM Kinase II 41
4 2 Intracellular Targeting of CaM Kinase II 41
4 3 Basic Aspects of Regulation by Autophosphorylation 43
4 4 Calmodulin May Be Buffered and Limiting for Activation of CaM
Kinase II 44
4 5 Many Signal Transduction Pathways Are Subserved by CaM Kinase II 46
4 6 CaM Kinase II Is Sensitive to the Frequency of Ca2+ Oscillations 47
4 7 CaM Kinase II Integrates Ca2+ Signals by Regulating Key Functional
Proteins 50
4 8 Coordination of Neuronal Responses to Stimulation 51
5 Summary 53
References 54
3 Function of Nuclear and Cytoplasmic Calcium in the Control of Gene Expression 59
Sangeeta Chawla and Hilmar Bading
1 Introduction 59
2 Gene Expression, Calcium, and Neuronal Plasticity 59
3 Basic Principles of Gene Regulation 60
4 How to Investigate Calcium-Regulated Gene Expression 62
5 Identification of Calcium-Responsive DNA Regulatory Elements 62
Contents xiii
6 Signalling Pathways that Activate the Transcription Factor CREB 64
7 Gene Regulation by Nuclear Calcium Signals 66
8 Differential Activation of CRE-Dependent Gene Expression by L-Type
Voltage-Gated Calcium Channels and NMDA Receptors 68
9 Gene Regulation by Cytoplasmic Calcium Signals 69
10 Calcium-Activated Transcription in Cells of the Immune System 71
11 Differential Gene Expression by Calcium Signals in the Nervous System 71
12 How Are Memories Encoded by Calcium-Induced Gene Expression? 73
13 Concluding Remarks 74
References 74
4 Calcium Regulation of Ion Channels 79
Dieter Swandulla and Hanns Ulrich Zeilhofer
1 Introduction 79
2 Calcium Channel Inactivation 80
2 1 Inactivation of High Voltage-Activated (HVA) Calcium Channels 80
2 2 Modulation of Inactivation of Calcium Channels 83
2 3 Functional Implications of Voltage- and Ca2+-Dependent Inactivation 83
3 Calcium-Activated Potassium Channels 84
3 1 Types of Calcium-Activated Potassium Channels 84
3 2 Activation of Calcium-Activated Potassium Channels 85
3 3 Functional Role of Neuronal Calcium-Activated Potassium Channels 87
3 4 Properties and Functional Role of Calcium-Activated Chloride Channels 88
4 Calcium-Activated Nonselective (CAN) Cation Channels 89
4 1 Biophysical Properties of Neuronal CAN Channels 89
4 2 Modulation of Neuronal CAN Channels 90
4 3 Functional Role of Neuronal CAN Channels 91
References 92
5 Modulation of NMDA Receptor Channels by Intracellular Calcium 99
Nail Bumashev
1 Introduction 99
2 Inhibition of the NMDA Current by Intracellular Calcium in Isolated
Neurones 100
3 Ca2+-Dependent Inactivation Is an Intrinsic Property of NMDAR Channels 101
4 Characteristic Features of the NMDAR Ca2+-Dependent Inactivation 102
5 Mechanisms Underlying Ca2+-Dependent NMDAR Inactivation 103
6 Molecular Determinants of the NMDAR Inhibition 104
7 Inhibition of the NMDAR Component of EPSCs during Synaptic
Transmission 105
References 106
6 Regulation of InsP3R by Ca2+ and Cytosolic Ca2+ Dynamics 109
Vladislav S Markin and Ilya Bezprozvanny
1 Introduction 109
xiv Contents
2 InsPjR Modulation by Cytosolic Ca2+ 110
2 1 Bell-Shaped Ca2+ Dependence of InsP3R 110
2 2 InsPjR Structure and Molecular Determinants of Sensitivity to Ca2+
Modulation 110
2 3 Parallel Pathways of Ca2+ Feedback on InsP3R 113
3 Spatio-Temporal Consequences InsP3R Modulation by Ca2+ 114
3 1 Ca2+ Waves and Oscillations 114
3 2 Simplified Model of Cytosolic Ca2+ Dynamics and Ca2+ Wave
Propagation 116
3 3 Subthreshold Ca2+Wave Propagation 120
3 4 Ca2+Buffering 122
3 5 Numerical Parameters 123
3 6 Circular and Spiral Ca2+Waves 124
3 7 Discreteness of Calcium Release and Saltatory Wave Propagation 126
4 Conclusions 127
References 127
7 Regulation of Ca2+-Release Channels by Luminal Ca2+ 131
Ilse Sienaert, Humbert De Smedt, Jan B Parys, and Ludwig Missiaen
1 Introduction 131
2 Estimations of the [Ca2+]lum 132
2 1 InsP3-Sensitive Ca2+Stores 132
2 2 Ryanodine-Sensitive Ca2+Stores 136
3 Effects of Luminal Ca2+ on Ca2+ Release in Different Experimental
Conditions 136
3 1 Effects of Luminal Ca2+ on the InsP3R 136
311 Intact Cells 136
312 Permeabilized Cells 137
313 Single Channel Recordings 137
314 InsP3 Binding 138
3 2 Effects of Luminal Ca2+on the RyR 138
321 Intact Cells 138
322 Vesicle Experiments 138
323 Single Channel Recordings 139
4 Molecular Mechanisms Underlying the Effects of Luminal Ca2+ 139
4 1 Molecular Structure of the Channel Domains 139
411 Channel Domain of the InsP3R 139
412 Channel Domain of the RyR 140
413 Comparison of the TMDs between the InsP3R and the RyR 141
4 2 Luminal Ca2+-Binding Sites on the Ca2+-Release Channels 142
421 InsP3R 142
422 RyR 142
4 3 Cytosolic Ca2+-Binding Sites on the Ca2+-Release Channels 143
431 InsP3R 144
432 RyR 144
4 4 Interaction with Luminal Proteins 145
441 InsP3R 146
Contents xv
442 RyR 146
5 Functional Relevance 147
5 1 Quantal Ca2+Release 147
511 InsPjR 148
512 RyR 148
5 2 Generation of Elementary Ca2+ Signals 149
521 InsPjR 149
522 RyR 149
5 3 Store-Dependent Ca2+Entry 150
6 Conclusions 151
References 151
8 Mitochondrial Ca2+ Signalling 163
Guy A Rutter, Paul Burnett, Lawrence D Robb-Gaspers, Andrew P Thomas,
Richard M Denton, Elinor J Griffiths, and Rosario Rizzuto
1 Introduction 163
2 Mitochondrial Ca2+ Transport Systems 164
3 Measurements of Intramitochondrial [Ca2+] in Vitro 165
4 Measurements of Intramitochondrial [Ca2+] in Vivo 166
5 Role of Ca2+ in the Regulation of Intramitochondrial Metabolism 166
6 Molecular Properties of the Ca2+-Sensitive Intramitochondrial
Dehydrogenases 167
6 1 NAD+-Isocitrate Dehydrogenase 167
6 2 2-Oxoglutarate Dehydrogenase 167
6 3 Pyruvate Dehydrogenase (PDH) 168
6 4 Glycerol Phosphate Dehydrogenase 168
7 Correlation between [Ca2+]m, Dehydrogenase Activation, and Mitochondrial
Oxidative Metabolism in Vivo 168
7 1 Studies with Isolated Mitochondria 168
7 2 Intact Tissues 168
7 3 Single Cells 169
7 4 Liver Cells 169
8 Role of Spatial Relationship between Endoplasmic Reticulum Ca2+ Release
Sites, and Mitochondria 170
9 Role of Mitochondria in the Regulation of Cytosolic [Ca2+] 171
9 1 Propagation of Ca2+ Waves 171
9 2 Ca2+Accumulation and Ischaemia/Reperfusion 173
References 173
9 Modulation of the Cytoskeletal Architecture by Calcium: A Putative Role in
Plastic Synapses 177
Denise van Rossum
1 Introduction 177
2 Dynamic Effects of Calcium on Tubulin Dimers and Microtubule-Associated
Proteins 178
2 1 Tubulin and Calcium 178
xvi Contents
2 2 Microtubule-Associated Proteins and Calcium 179
2 3 Excitatory Amino Acids and Microtubule Stability 180
3 Dynamic Effects of Calcium on Actin and Actin-Binding Proteins 180
3 1 Actin and Calcium 180
3 2 Actin-Binding Proteins and Calcium 181
4 Cytoskeletal Dynamics in Growth Cones and Neurites 184
4 1 Cytoskeleton in Growth Cones and Neurites 184
4 2 Modulation of the Cytoskeletal Dynamics by Calcium in the Growth
Cone and Neurite 184
4 3 Excitatory Amino Acids and Neuronal Outgrowth 185
5 Putative Cytoskeletal Dynamics in Dendritic Spines Triggered by Synaptic
Activity 187
5 1 Cytoskeleton and Organelles in Dendritic Spines 187
5 2 Dendritic Spine Morphology 187
5 3 Glutamate Receptors and the Cytoskeleton 189
5 4 Putative Cytoskeletal Dynamics in Dendritic Spines Evoked by
Excitatory Neurotransmission 191
References 192
Part Two: Calcium Regulation of Cellular Functions
10 Calcium and Exocytosis 199
Jana Hartmann
1 Introduction 199
2 Role of Calcium in Vesicle Biogenesis 201
3 Calcium and Vesicle Targeting 203
4 Calcium and Docking of Vesicles at the Site of Membrane Fusion 206
5 Calcium and Priming of Vesicles 211
6 Calcium and Triggering of Exocytosis 212
6 1 Calcium in Stimulus-Secretion Coupling 212
6 2 Calcium^Sensitive Elements of Exocytosis 216
6 3 Fusion between Different Membrane Compartments 219
7 Calcium and Membrane Fusion 221
8 Calcium and Membrane Retrieval 224
9 Conclusion 228
References 229
11 Calcium and Neuronal Development and Growth 239
Fabienne Archer, Rachel Ashworth, and Stephen Bolsover
1 Introduction 239
2 Calcium and Early Neuronal Development 239
2 1 Calcium and Neuronal Induction 239
2 2 Calcium and Neuronal Migration 240
3 Calcium and Neuronal Differentiation 242
3 1 Expression of Neurotrophins 242
Contents xvii
3 2 Transmitter Phenotype 242
3 3 Ion Channel Activity 242
3 4 Spontaneous Calcium Activity during Neuronal Differentiation 243
4 Calcium and Neuronal Pathfinding 244
4 1 The Recent Hypothesis on Outgrowth 244
4 2 Spontaneous Calcium Activity on Neurite Outgrowth : 246
4 3 Calcium and Axon Guidance 247
431 Calcium Artificially Increased (by Depolarization) and Axon
Growth 247
432 Axon Guidance and Biochemical Cues 248
4 4 Calcium and Turning 250
441 Galvanotropism 250
442 Turning toward Neurotransmitters 251
4 5 Calcium and Retraction/Collapse 251
451 Filopodia and Veil Growth/Retraction 251
452 Calcium and Collapse 251
5 Downstream Pathways 253
5 1 Known Target Processes 253
511 Actin Assembly-Disassembly 253
512 Calcium and Exocytosis in Neuronal Growth 253
5 2 Known Target Proteins that May Mediate These Processes 254
521 Calmodulin (CaM) 254
522 CaM Kinase 255
523 Calcineurin 256
524 Neuronal Calcium Sensor NCS-1 256
525 Ras 257
526 Protein Kinase C (PKC) 257
527 Gap-43 257
5 3 Induction of Gene Expression 258
5 4 Exocytotic Machinery 258
6 Conclusion 259
References 259
12 Calcium and Cellular Death 267
Rita Sattler and Michael Tymianski
1 Introduction 267
1 1 Historical Background of Calcium and Cytotoxicity 268
1 2 Calcium and the Excitotoxicity Hypothesis 269
2 Calcium Homeostasis in Neurons: Ca2+ Ions, Ca2+ Fluxes, and Ca2+ Stores 270
2 1 Calcium-Permeable Ion Channels 271
2 2 Calcium Buffering 272
2 3 Calcium Sequestration and Storage 272
2 4 Calcium Extrusion 273
2 5 Intracellular Calcium Diffusion 273
3 Deregulation of Calcium Homeostasis 274
4 Downstream Events Triggered by Excessive Calcium Loading 275
4 1 The Formation of Free Radical Species 275
xviii Contents
4 2 The Formation of Nitric Oxide 276
4 3 Calcium Activated Proteases 277
4 4 Apoptosis and Necrosis 277
4 5 Mitochondrial Damage 278
4 6 Acidosis 278
5 Relationship between Calcium Load and Neurotoxicity 279
5 1 Calcium Load Hypothesis 281
5 2 Source Specificity Hypothesis 282
6 Summary 284
References 285
13 Calcium-Dependent Signalling in Apoptosis 291
Thottala Jayaraman and Andrew R Marks
1 Introduction 291
2 Two Forms of Neuronal Death 292
2 1 Apoptosis and Necrosis 292
3 Neuronal Apoptosis during Development 293
4 Inducers of Neuronal Apoptosis 294
4 1 Hypoxia 294
4 2 Excitotoxicity 294
5 Calcium Channels in the Nervous System 294
5 1 Calcium Influx Channels 295
5 2 Calcium Release Channels 296
6 Role of Calcium Dynamics in Neuronal Apoptosis 297
6 1 Calpain 299
6 2 Calcineurin 299
7 Calcium in Neuronal Survival 300
8 Intracellular Calcium in Neurodegeneration 300
9 Molecular and Genetic Factors Involved in the Regulation of Neuronal
Apoptosis 301
9 1 Bcl-2 Family Members in the Nervous System 301
9 2 Bax in Neuronal Apoptosis 303
9 3 Bad 303
9 4 Caspases 303
10 Concluding Remarks 304
References 304
14 The Spatial Range of Dendritic Signals for Cerebellar Long-Term Depression:
Studies with Local Photolysis of Caged Compounds 311
George J Augustine, Elizabeth A Finch, and Samuel S -H Wang
1 Signalling Pathways Involved in Long-Term Depression (LTD) 311
2 Instrumentation for Focal Uncaging 313
3 Chemical Two-Photon Uncaging Restricts the Axial Range of Light-Induced
Glutamate 315
4 Spatial Range of LTD Revealed by Chemical Two-Photon Uncaging 317
5 InsP3 as a Local Signal for LTD in Purkinje Cell Dendrites 321
Contents xix
6 Determinants of Spatially-Restricted LTD 325
References 327
15 Calcium and Activity-Dependent Synaptic Plasticity 333
Eric Hanse and Arthur Konnerth
1 Introduction 333
2 Presynaptic Ca2+ Signalling—Transmitter Release and Short-Term Synaptic
Enhancement 334
2 1 Microdomains and Phasic Release of Transmitter 334
2 2 Residual Ca2+ and Short-Term Enhancement 335
2 3 Presynaptic Ca2+ and Long-Term Synaptic Plasticity 336
3 Postsynaptic Ca2+ Signalling—Hippocampal LTP and LTD 337
3 1 Postsynaptic Ca2+Sources 337
311 Glutamate-Gated Channels 338
312 Voltage-Operated Ca2+Channels 339
313 Does the Mode of Ca2+ Entry Matter for the Type of Expression? 340
314 The Relative Contribution of Ca2+ Influx through NMDA
Receptor Channels and VOCCs, Respectively, to the Induction
of NMDA-LTP and NMDA-LTD 342
315 Intracellular Ca2+Stores 343
316 Ca2+Buffers and Pumps 344
3 2 Magnitude of Postsynaptic Ca2+ Signal 345
3 3 Temporal Aspects of the Postsynaptic Ca2+ Signal 346
3 4 Spatial Aspects of the Postsynaptic Ca2+ Signal 347
4 Perspectives 349
References 350
16 Ca2+ Waves as a Form of Glial Excitability 359
Peter B Simpson
1 Glial Ca2+ Signalling 359
2 Ca2+ Release-Based Ca2+ Waves 360
2 1 InsP3 Production in Glia 360
211 Metabotropic Neurotransmitter-Mediated Ca2+ Responses 360
212 Growth Factor-Mediated Ca2+Responses 360
2 2 Mechanisms of InsP3-Mediated Glial Wave Propagation 361
221 Wave Initiation Sites 361
222 Wave Amplification Sites 361
2 3 Ryanodine Receptors 363
2 4 Mitochondria in Glial Ca2+ Waves 363
2 5 Structure of Glial Ca2+ Stores 366
3 Ca2+ Entry-Based Waves 366
3 1 Mechanisms of Glial Ca2+ Entry 366
3 2 Mechanisms of Ionotropic Ca2+ Waves 367
4 Intercellular Ca2+ Waves 368
4 1 Gap Junctions 368
411 Direct Glial Coupling 368
XX Contents
412 The Nature of the Diffusible Messenger 368
4 2 Extracellular Propagation of Glial Ca2+ Waves 369
5 Possible Roles of Glial Ca2+ Waves 370
5 1 Conveyance of Encoded Information over Long Distances 370
511 Neurones Activate Glial Responses 370
512 Glia Activate Neuronal Responses 372
5 2 Conveyance of Information to the Nucleus 372
5 3 Regulation of Glial Functionality 373
5 4 Subcellular Control of Glial Activity 373
541 Cytoskeletal Alterations 373
542 Glial Migration 374
6 Conclusions 375
References 375
17 Local Control in Calcium Signalling during Cardiac E-C Coupling 381
M B Cannell and C Soeller
1 Introduction 381
2 Molecular Basis of E-C Coupling 382
3 Properties of E-C Coupling Revealed by Photometric Calcium Measurements 382
4 Local Control and Calcium Sparks 385
5 Contribution of Mathematical Modeling to Local Control Theories 390
6 Conclusions 392
References 393
Index 399
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| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XX, 408 S. grpah. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Plenum |
| record_format | marc |
| spelling | Integrative aspects of calcium signalling ed. by Alexej Verkhratsky ... New York [u.a.] Plenum 1998 XX, 408 S. grpah. Darst. txt rdacontent n rdamedia nc rdacarrier Calcium (DE-588)4069806-3 gnd rswk-swf Calciumkanal (DE-588)4205050-9 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Calciumkanal (DE-588)4205050-9 s DE-604 Calcium (DE-588)4069806-3 s Signaltransduktion (DE-588)4318717-1 s Verkhratsky, Alexej Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008280923&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Integrative aspects of calcium signalling Calcium (DE-588)4069806-3 gnd Calciumkanal (DE-588)4205050-9 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| subject_GND | (DE-588)4069806-3 (DE-588)4205050-9 (DE-588)4318717-1 (DE-588)4143413-4 |
| title | Integrative aspects of calcium signalling |
| title_auth | Integrative aspects of calcium signalling |
| title_exact_search | Integrative aspects of calcium signalling |
| title_full | Integrative aspects of calcium signalling ed. by Alexej Verkhratsky ... |
| title_fullStr | Integrative aspects of calcium signalling ed. by Alexej Verkhratsky ... |
| title_full_unstemmed | Integrative aspects of calcium signalling ed. by Alexej Verkhratsky ... |
| title_short | Integrative aspects of calcium signalling |
| title_sort | integrative aspects of calcium signalling |
| topic | Calcium (DE-588)4069806-3 gnd Calciumkanal (DE-588)4205050-9 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| topic_facet | Calcium Calciumkanal Signaltransduktion Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008280923&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT verkhratskyalexej integrativeaspectsofcalciumsignalling |