The autoimmune diseases:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego [u.a.]
Acad. Press
1998
|
| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 895 S. Ill., graph. Darst. |
| ISBN: | 0125969236 |
Internformat
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| 245 | 1 | 0 | |a The autoimmune diseases |c ed. by Noel R. Rose ... |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a San Diego [u.a.] |b Acad. Press |c 1998 | |
| 300 | |a XVII, 895 S. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
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| adam_text | Con
Contributors xiii
Prelude
NOEL R. ROSE AND IAN R. MACKAY
I. Introduction 1
II. What Designates an Autoimmune
Disease? 1
III. What Are the Common Threads Uniting the
Autoimmune Diseases? 3
References 4
1. Four Decades of Self and Non Self:
Reflections on Autoimmunity and Tolerance
GUSTAV J. V. NOSSAL
I. Introduction 5
II. T Cells and B Cells 6
III. Central versus Peripheral Deletion and the
Question of Affinity 6
IV. Deletion versus Anergy 6
V. Multigenic Nature of Autoimmune
Diseases 6
VI. Network of Cytokines Rather Than Network
of Idiotypes? 7
VII. Antigen, the Driver in Autoimmunity 7
VIII. Conclusions 7
References 8
2. Basis and Mechanisms of Self Tolerance
A. BASTEN
I. Historical Perspectives 9
II. Cell Cell Interactions and the Two Signal
Hypothesis 10
v
itents
III. Self Tolerance in Both T and B Cell
Compartments 11
IV. Cellular Mechanisms of Self Tolerance 11
References 13
3. Transgenic Models of Peripheral T Cell
Self Tolerance and Autoimmunity
J. F. A. P. MILLER
I. Introduction 29
II. Immunological Indifference 30
III. Peripheral Deletion of Autoreactive T
Cells 33
IV. Downregulation of T Cell Receptors and
Coreceptors, Anergy, and the Influence of
Costimulation 38
V. Immunoregulation and Cytokines 39
VI. Relevance to Human Autoimmune
Diseases 40
VII. Summary and Conclusions 41
References 41
4. Antigenic Determinants Involved in
Induction and Propagation of Autoimmunity
KAMAL D. MOUDGIL AND ELI E. SERCARZ
I. Nature of Autoantigenic Determinants 46
II. Structural Features Determining the
Immunogenicity of Antigenic
Determinants 47
III. Impact of Antigen Processing on T Cell
Repertoire via the Display Hierarchy of
Determinants: Both Dominant and Cryptic
Self Determinants Shape the T Cell
Repertoire 49
IV. The Mature T Cell Repertoire and the
Immune Response to Autoantigenic
Determinants 50
V. Molecular Mimicry within Self Self and
Self Foreign Antigenic Determinants 51
VI. Spreading of T Cell Response to New
Determinants within Autoantigen(s) during
the Course of Autoimmunity 52
VII. Relevance of the Dominance/Crypticity
Relationship between Foreign Self Antigens
to Autoantigens Involved in Human
Autoimmunity 54
VIII. Analogs of Autoantigenic Determinants Can
Be Used for Treatment of Autoimmunity 54
IX. Concluding Remarks 55
References 55
5. Costimulation and the Regulation
of Autoimmunity
KEVIN J. LAFFERTY AND LAWRENCE S. GAZDA
I. Introduction 59
II. Burnet: Self Not Self Discrimination Is
Learned Early in Life 59
III. Bretscher Cohn: Associative Recognition
Facilitates Self Not Self Discrimination
throughout the Life of the Individual 60
IV. Development of the Modern Two Signal
Model for T Cell Activation 61
V. The Danger Concept 63
VI. Experimental Critique 64
VII. Autoimmunity—A Failure of
Self Tolerance 66
VIII. Conclusion 71
References 71
6. Genetic Influences: Major
Histocompatibility Complex
WILLIAM W. KWOK AND GERALD T. NEPOM
I. Introduction 75
II. The HLA Complex 75
III. Disease Associations 76
IV. HLA Peptide Interactions 78
V. HLA T Cell Interactions 81
VI. Conclusions 82
References 82
II ID
7. Non MHC Genetic Contributions to
Autoimmune Disease
TIMOTHY J. VYSE, JOHN A. TODD, AND BRIAN L. KOTZ1N
I. Introduction and Overview 85
II. Genetic Epidemiology 87 ,
III. Strategies Used to Identify Susceptibility j
Genes 88 j
IV. Gene Interaction in Disease Pathogenesis 97 ]
V. Results of Studies in Autoimmune I
Disease 98
VI. Conclusions 110
References 110
8. Environmental Determinants of
Autoimmune Disease
ANTONY ROSEN AND LIVIA CASCIOLA ROSEN
I. Introduction 119 .
II. Autoantibodies Are Probes of the Perturbed
State That Initiates and Propagates
Autoimmune Disease 119
III. Scleroderma: A Model for Studying the
Influence of Environment on the
Development of Autoimmunity 120
IV. Scleroderma Autoantigens Are Clustered in
the Nucleolus 120
V. The Nucleolus Is a Subcellular Site at Which
Metals Become Concentrated 121
VI. Fibrillarin Is the Target of a Specific
Autoimmune Response in Metal Treated
Mice 121
VII. Reversible Ischemia Reperfusion: Generator
of Reactive Oxygen Species in
Scleroderma? 122
VIII. Fragmentation Resulting from Metal
Catalyzed Oxidation Is a Unifying Feature of
Several Scleroderma Autoantigens 122
IX. Metals and Autoimmunity 124
References 124
9. Infection and Autoimmune Disease
LEONARD C. HARRISON AND GEOFFREY J. MCCOLL
I. Perspectives on Complexity 127
II. Potential Mechanisms Linking Infection and
Autoimmune Disease 129
III. Concluding Remarks 136
References 137
Cor
10. Molecular Mimicry
ROBERT S. FUJINAMI
I. Introduction 141
II. Background 141
III. Mimicry 143
IV. Animal Model 145
V. Summary 147
References 148
11. Antigen Receptors
ELLEN HEBER KATZ
I. Introduction 151
II. Early Examples of the Phylogeny of
Self Non Self Discrimination 151
III. Molecular Aspects of Antigen Receptors in
Mouse and Man 152
IV. Functional Activation of Immune Cells
through the Antigen Receptor 156
V. Regulation of Immune Responsiveness
through the Antigen Receptor 157
VI. Conclusion 158
References 158
12. T Cell Subsets (Thl, Th2) and
Cytokines in Autoimmunity
SERGIO ROMAGNANI
I. Introduction 163
II. Definition and Functional Properties of
CD4+ Thl and Th2 Cells 164
III. CD8+ Type 1 and Type 2 T Cells and Their
Functions 166
IV. Nature of Thl and Th2 Polarizing
Signals 166
V. The Thl/Th2 Balance in Autoimmune
Disorders 169
VI. Conclusions 181
References 182
13. Apoptosis, Autoantigens,
and Autoimmunity
CARLOS A. CASIANO AND ENG M. TAN
I. Introduction 193
II. Possible Role of Genes That Regulate
Apoptosis in Autoimmunity 194
III. Fate of Intracellular Autoantigens during
Apoptosis 198
tents vii
IV. Conclusions and Perspectives 206
References 207
14. Animal Models of Autoimmunity:
Spontaneous and Induced
PIERLUIGI E. BIGAZZI
I. Introduction 211
II. Spontaneous or Naturally Occurring
Autoimmune Disease 212
III. Experimentally Induced Autoimmune
Disease 218
IV. Autoimmune Diseases for Which No Models
Currently Exist 235
V. Discussion and Conclusions 236
References 237
15. Blood Cells: Autoimmune
Hemolytic Anemia
BRUCE C. GILLILAND
I. Introduction 245
II. Animal Model 246
III. Etiology 248
IV. Classification 249
V. Epidemiology 249
VI. Warm Autoantibody Type 250
VII. Combined Warm and Cold Type
Autoimmune Hemolytic Anemia 254
VIII. Cold Autoantibody Type 254
IX. Drug Induced Immune Hemolytic
Anemia 258
References 258
16. Blood Cells: Autoimmune
Thrombocytopenia Purpura
BRUCE C. GILLILAND
I. Introduction 269
II. Animal Model of Autoimmune
Thrombocytopenia 270
III. Platelet IgG and Platelet
Autoantibodies 270
IV. Pathophysiology 272
V. Clinical Features 273
VI. Thrombocytopenia Associated with Human
Immune Deficiency Virus Infection 276
References 278
17. Systemic Lupus Erythematosus
MORRIS RUCHLIN
I. Introduction 283
II. Disease Description 283
III. Pathology 284
IV. Autoimmune Features 286
V. Genetic Features 286
VI. Animal Models 290
VII. Significant Infections and Environmental
influences 292
VIII. Role of Immunologic Markers in
Diagnosis 293
IX. Treatment and Prevention 294
X. Perspectives about the Particular Feature of
Autoimmunity in Systemic Lupus
Erythematosus 295
References 297
18. Antiphospholipid/Cofactor Syndromes
DONATO AlARCON SEGOVIA AND ANTONIO R. CABRAL
I. Introduction 299
II. Classification of Antiphospholipid/Cofactor
Syndromes 300
III. Criteria 301
IV. Clinical Presentations 301
V. Pathology 303
VI. Autoimmune Features 303
VII. Genetic Features 308
VIII. Markers in Diagnosis 309
IX. Treatment 310
X. Perspectives 311
References 311
19. Systemic Sclerosis (Sderoderma)
CLAUOtO GALPERIN AND M. ERIC GERSHWIN
I. Introduction 317
II. Classification and Clinical Presentation 317
HI. Pathogenesis 318
IV. Animal Models 332
V. Perspectives 336
References 336
20. Rheumatoid Arthritis
|OHN S SUNDY AND BARTON F. HAYNES
I. Introduction 343
II. Disease Description 344
III. Pathology 349
IV. Overview of the Pathogenesis of Rheumatoid
Arthritis 355
V. Etiologic Factors in Rheumatoid
Arthritis 364
VI. Animal Models 365
VII. Role of Immunologic Markers in the
Diagnosis of Rheumatoid Arthritis 366
VIII. Treatment and Prevention of Rheumatoid
Arthritis 367
IX. Juvenile Rheumatoid Arthritis 368
References 370
21. Sjogren s Syndrome
M. N. MANOUSSAKS. N. TALAL. AND H. M. MOUTSOPOULOS
I. Disease Description 381
II. Humoral and Cellular Immune
Reactions 388
III. Pathology 392
IV. Genetic Features 395
V. Animal Models 3%
VI. Significant Infectious Influences 397
VII. Treatment 397
VIII. Perspectives on Immunopathogenesis 398
References 399
22. Autoimmune Thyroid Disease
ANTHONY P. WEETMAN
I. Autoimmune Thyroiditis 405
II. Graves Disease 416
References 424
23. Diabetes
SABINE MEG AND AKE LERNMARX
I. Diabetes 431
II. Islet Pathology 433
III. Autoimmune Features 434
IV. Genetic Features 439
V. Animal Autoimmune Diabetes 442
VI. Infectious and Environmental Influences 444
VII. Role of Immunologic Markers in
Diagnosis 445
VIII. Prediction. Treatment, and Prevention 446
IX. News. Views, and Future Direction 446
References 447
Com
24. Autoimmune Gastritis and
Pernicious Anemia
BAN HOCK TOH, PAUL A. GLEESON, SENGA WHITTINGHAM,
AND IAN R. VAN DRIEL
I. Historical Background 459
II. Disease Description 460
III. Pathology 460
IV. Autoimmune Features 463
V. Genetic Features 467
VI. Animal Models 467
VII. Pathogenetic T Cells That Induce
Autoimmune Gastritis Are Directed toward
the H+/K+ATPase 469
VIII. Mechanisms of Tolerance and Autoimmunity
to the Gastric H+/K+ ATPase 470
IX. Role of Immunologic Markers in
Diagnosis 470
X. Treatment and Outcome 471
XI. Concluding Remarks 471
References 472
25. Inflammatory Bowel and Celiac Disease
DAVID E. ELLIOTT, JOSEPH A. MURRAY, AND JOEL V. WEINSTOCK
I. Introduction 478
II. Normal Mucosal Anatomy, Histology, and
Immunology 478
III. Clinical and Pathological Features of
Inflammatory Bowel Disease 480
IV. Mimics of Inflammatory Bowel Disease 482
V. Autoimmune and Immunoregulatory Features
of Inflammatory Bowel Disease 483
VI. Genetic Features of Inflammatory Bowel
Disease 488
VII. Environmental Influences in Inflammatory
Bowel Disease 489
VIII. Animal Models of Inflammatory Bowel
Disease 490
IX. Role of Immunologic Markers in Diagnosis of
Inflammatory Bowel Disease 492
X. Drug Therapy in Inflammatory Bowel
Disease 492
XI. Summary of Inflammatory Bowel
Disease 494
XII. Clinical and Pathological Features of Celiac
Disease 494
XIII. Epidemiology of Celiac Disease 495
XIV. Pathological Features of Celiac Disease 495
XV. Autoimmune and Immunologic Features of
Celiac Disease 496
XVI. Genetic Features of Celiac Disease 498
tents ix
XVII. Environmental Influences in Celiac
Disease 498
XVIII. Animal Model of Celiac Disease 498
XIX. Role of Biopsy and Immunologic Markers in
Diagnosis of Celiac Disease 499
XX. Treatment of Celiac Disease 499
XXI. Summary of Celiac Disease 500
References 500
26. Autoimmune Diseases: The Liver
MICHAEL P. MANNS, BIRGIT LGTTIG,
AND PETRA OBERMAYER STRAUB
I. Autoimmune Hepatitis 511
II. Primary Biliary Cirrhosis 526
III. Primary Sclerosing Cholangitis 532
IV. Perspectives 535
References 535
27. Cutaneous Autoimmune Diseases
MONG SHANG LIN, ZHI LIU, BETH A. DROLET, AND LUIS A. DIAZ
I. Introduction 545
II. Pemphigus Vulgaris 547
III. Phemphigus Foliaceus 550
IV. Bullous Pemphigoid 554
V. Other Vesiculobullous Dermatoses 558
VI. Possible Autoimmune Mechanisms Involved
in Bullous Dermatoses 559
VII. Cutaneous Lupus Erythematosus 560
References 563
28. Autoimmune Diseases of the Central and
Peripheral Nervous Systems
BARRY G. W. ARNASON
I. Introduction 571
II. Central Nervous System Diseases 572
III. Autoimmune Diseases of Peripheral
Nerves 586
References 596
29. Autoimmune Disease in the Kidney
LORRAINE C. RACUSEN
I. Introduction 603
II. Autoimmune Kidney Diseases Due to
Immunologic Reaction to Renal
Antigens 603
III. Autoimmune Kidney Diseases as Part of
Systemic Autoimmune Diseases Independent
of Renal Autoantigens 609
References 617
30. Immune Mediated Cardiovascular Disease
NOEL R. ROSE AND KENNETH L. BAUGHMAN
I. Introduction 623
II. Disease Description 623
III. Pathology 625
IV. Viral Aspects of Myocarditis 625
V. Immunologic Aspects of Myocarditis and
Idiotypic Dilated Cardiomyopathy 626
VI. Genetic Features 628
VII. Animal Models 629
VIII. Treatment 630
IX. Other Forms of Myocarditis 631
X. Atherosclerosis 632
References 633
31. Myasthenia Gravis
DANIEL B. DRACHMAN
I. Introduction 637
II. Clinical Features of Myasthenia Gravis 638
III. The Neuromuscular Junction 638
IV. Immune Pathogenesis of Myasthenia
Gravis 641
V. Diagnosis of Myasthenia Gravis 647
VI. Treatment of Myasthenia Gravis 648
VII. Future Immunotherapy: Experimental
Approaches 652
VIII. Summary and Conclusions 656
References 656
32. Autoimmune Diseases of Muscle
PETER N. HOLLINGSWORTH, MICHAEL J. GARLEPP,
AND ROGER L. DAWK1NS
I. Introduction 663
II. Classification 664
III. Experimental Models 665
IV. Clinical Features 666
V. Pathology 667
VI. Autoantibodies 671
VII. Immunoglobulin and Complement 675
VIII. Mononuclear Cells 676
IX. Immunogenetics 677
X. Virus Infection 680
XI. Laboratory Diagnosis 681
XII. Treatment 682
XIII. Concluding Remarks 682
References 682
33. Autoimmune Disease of the Testis and
the Ovary
KENNETH S. K. TUNG
I. Introduction 687
II. Systemic Mechanisms That Prevent Gonadal
Autoimmune Diseases 690
III. Regional Immunoregulation in the Testis and
Ovary 692
IV. Events That Overcome the Immunoregulatory
Mechanisms and Lead to Gonadal
Autoimmune Diseases 693
V. Pathogenetic Mechanisms of Autoimmune
Testicular and Ovarian Diseases 695
VI. Summary and Conclusions 700
References 701
34. Vasculitis
J. CHARLES jENNETTE AND RONALD J. FALK
I. Description 705
II. Pathology and Classification 706
III. Autoimmune Features 707
IV. Genetic Factors 715
V. Animal Models 716
VI. Role of Immunologic Markers in
Diagnosis 719
VII. Treatment 720
VIII. Summary 721
References 721
35. Adrenal Autoimmunity and the
Autoimmune Polyglandular Syndromes
Types I—III: Addison s Disease,
Hypoparathyroidism, and Hypophysitis
YAO HUA SONG, YANGXIN LI, AND NOEL K. MACLAREN
I. Classification of the Autoimmune
Polyglandular Syndromes 725
II. Pathology 726
III. Detection of Disease Specific
Autoantibodies 727
IV. Identification of Autoantigens 729
V. Role of T Cells 731
Con
VI. Genetic Features 731
VII. Animal Models 732
VIII. Infectious and Environmental Influences 732
IX. Role of Autoantibodies as Markers in
Diagnosis 733
X. Treatment and Prevention 734
XL Conclusion 734
References 734
36. Autoimmune Diseases of the Eye
MrTCHELL H. FRIEDLAENDERAND HIROSHI FUJISHIMA
I. Introduction 737
II. Conjunctiva 737
III. Cornea 740
IV. Sclera 741
V. Lacrimal Gland 742
VI. Uveal Tract 744
VII. Retina 748
VIII. Lens 750
IX. Orbit 752
X. Optic Nerve 753
XI. Perspectives 755
References 755
37. Autoimmune Diseases: Cameos,
Curiosities, and Shadowlands
IAN R. MACKAY
I. Introduction 759
II. Alopecia Areata 760
III. Atherosclerosis 761
IV. Behest s Disease 762
V. Bone Marrow Aplasia: Autoimmune
Myelopathy 763
VI. Coagulopathies: Acquired Hemophilia 764
VII. Cochleolabyrinthitis: Deafness and Meniere s
Disease 765
VIII. Cystitis, Interstitial 766
IX. Diabetes Insipidus 767
X. Endometriosis 767
XI. Erythrocyte Autosensitization 768
XII. Fas Deficient Autoimmune
Lymphoproliferative Syndrome 769
XIII. Fatigue Syndrome, Chronic 770
XIV. Polychondritis, Relapsing 770
XV. Psoriasis, Psoriatic Arthritis 771
XVI. Silicone Breast Implant Syndrome 773
XVII. Spondyloarthropathies, Reactive Arthritis,
and Ankylosing Spondylitis 774
XVIII. Urticaria 775
tents xi
XIX. Conclusions 776
References 777
38. Aging and Autoimmunity
JOHN S. MANAVALAN, IRENA KIRMAN, KESHENG ZHAO, AND
MARC E. WEKSLER
I. Introduction 783
II. Overview of Immune Senescence 783
III. Age Associated Autoimmunity 785
IV. Mechanisms of Age Associated
Autoimmunity 787
V. Significance of Age Associated
Autoimmunity 790
References 791
39. Paraneoplastic Autoimmune Syndromes
GRANT J. ANHALT AND HOSSEIN C. NOUSARI
I. Introduction 795
II. Mechanisms of Induction of
Autoimmunity 795
III. Paraneoplastic Autoimmune Syndromes 796
References 803
40. Autoimmune Derangements in the
Acquired Immunodeficiency Syndrome
FRANCO SILVESTRIS, FRANCO DAMMACCO,
AND RALPH C. WILLIAMS. JR.
I. Introduction 805
II. Clinical and Laboratory Patterns of
Autoreactivity 806
III. HIV Molecular Mimicry and
Autoimmunity 812
IV. Autoimmunity and Immunopathogenesis of
AIDS 814
V. Evolution of HIV Autoimmunity and
Therapeutic Implications 816
References 818
41. Diagnosis of Autoimmune Disease
R. L. DAWKINS, O. P. MARTINEZ, E. M. FREITAS,
AND P. N. HOLLINGSWORTH
I. Introduction 821
II. Examples of Some Issues and Strategies 823
III. Generalizations 830
References 831
42. Novel Therapeutic Approaches to
Autoimmunity
REINHARD HOHLFELD AND HARTMUT WEKERLE
I. Introduction 833
II. T Cells as Targets of Therapy 833
III. Semispecific Immunotherapies 838
IV. Concluding Remarks 843
References 843
43. Autoimmunity Yesterday, Today,
and Tomorrow
IAN R. MACKAY AND NOEL R. ROSE
I. Autoimmunity Yesterday 849
II. Autoimmunity Today 854
III. Autoimmunity Tomorrow 864
References 869
Index 873
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| edition | 3. ed. |
| format | Book |
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| id | DE-604.BV012146153 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:22:28Z |
| institution | BVB |
| isbn | 0125969236 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008225922 |
| oclc_num | 39983120 |
| open_access_boolean | |
| owner | DE-29 DE-20 DE-355 DE-BY-UBR |
| owner_facet | DE-29 DE-20 DE-355 DE-BY-UBR |
| physical | XVII, 895 S. Ill., graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Acad. Press |
| record_format | marc |
| spelling | The autoimmune diseases ed. by Noel R. Rose ... 3. ed. San Diego [u.a.] Acad. Press 1998 XVII, 895 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Autoimmune Diseases Autoimmune diseases Autoaggressionskrankheit (DE-588)4003935-3 gnd rswk-swf Autoaggressionskrankheit (DE-588)4003935-3 s DE-604 Rose, Noel R. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008225922&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The autoimmune diseases Autoimmune Diseases Autoimmune diseases Autoaggressionskrankheit (DE-588)4003935-3 gnd |
| subject_GND | (DE-588)4003935-3 |
| title | The autoimmune diseases |
| title_auth | The autoimmune diseases |
| title_exact_search | The autoimmune diseases |
| title_full | The autoimmune diseases ed. by Noel R. Rose ... |
| title_fullStr | The autoimmune diseases ed. by Noel R. Rose ... |
| title_full_unstemmed | The autoimmune diseases ed. by Noel R. Rose ... |
| title_short | The autoimmune diseases |
| title_sort | the autoimmune diseases |
| topic | Autoimmune Diseases Autoimmune diseases Autoaggressionskrankheit (DE-588)4003935-3 gnd |
| topic_facet | Autoimmune Diseases Autoimmune diseases Autoaggressionskrankheit |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008225922&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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