Bisphosphonates in clinical oncology: the development of pamidronate ; with 15 tables
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
1999
|
| Series: | Recent results in cancer research
149 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 113 S. graph. Darst. |
| ISBN: | 3540636897 |
Staff View
MARC
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| 245 | 1 | 0 | |a Bisphosphonates in clinical oncology |b the development of pamidronate ; with 15 tables |c B. Thürlimann |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1999 | |
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Record in the Search Index
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| adam_text | Contents
Physiology and Pathophysiology of Bone 1
Introduction 1
Natural History of the Skeleton , 2
Cortical Bone 3
Trabecular Bone 3
Composition of Bone 4
Bone Cells 4
Factors Regulating Calcium Homeostasis
and Bone Resorption/Bone Formation 5
References 6
Bone Resorption 7
Introduction 7
Mechanisms of Local Bone Resorption 8
References 9
Bone Formation 9
Introduction 9
Cells of the Osteoblast Lineage 10
Osteocalcin 10
Other Bone Matrix Proteins 11
Bone Mineralization 11
References 11
Factors Regulating Bone resorbing Cells and Bone forming Cells . 12
Parathyroid Hormone 12
Calcitonin 12
Vitamin D3 13
Prostaglandins 13
lnterleukin 1 14
Tumor Necrosis Factor and Lymphotoxin 14
lnterleukin 4 15
lnterleukin 6 15
y lnterferon 16
Colony stimulating Factors 16
Osteoclast forming Factor 16
XII Contents
References 16
Factors Regulating Bone Formation 18
Transforming Growth Factor fl (TGF /?) 18
Fibroblast Growth Factors 19
Platelet derived Growth Factor 19
Bone Morphogenetic Proteins 19
Insulin like Growth Factors 19
References 20
Pharmacological Treatment of Bone Disorders 21
Estrogens and Antiestrogens 22
Calcium 22
Fluoride 23
Vitamin D3/Calcitriol 23
Phosphate Therapy 24
References 24
Bisphosphonates 26
Pamidronate: From a Detergent in Washing Powder
to a Registered Drug 26
References 28
Chemical Structure and Preclinical Evaluation 29
Chemical Structure 29
Biological Effects 29
Pharmacokinetics 32
Distribution 33
References 33
Hypercalcemia of Malignancy 33
Magnitude of the Problem 33
Pathogenesis 34
Mediators 35
Treatment 35
Rehydration and Supportive Care 36
Plicamycin (Mithramycin) 37
Dialysis 38
Bisphosphonates 38
Other Bisphosphonates 46
Gallium Nitrate 47
Cisplatin 48
References 48
Malignant Osteolytic Bone Disease 52
Magnitude of the Problem 52
Interdisciplinary Management 53
Etidronate 54
Contents XIII
Oral Formulations of Second
and Third generation Bisphosphonates 54
References 56
Pamidronate 59
Pharmacokinetics of Pamidronate in Patients
with Bone Metastases 59
References 60
Pamidronate for Pain Control in Patients
with Malignant Osteolytic Bone Disease:
A Prospective Dose Effect Study 60
Patients and Methods 60
Results 61
Discussion 64
Conclusion 67
References 67
A Prospective, Randomized, Dose finding Study of Pamidronate
in Patients with Malignant Osteolytic Bone Disease 68
Patients and Methods 68
Statistical Analysis 69
Results 71
Patients Characteristics 71
Properties of LASA Scales and PSC 72
Efficacy (LASA) 72
Efficacy (PS, PSC, and Use of Analgesics) 75
Efficacy (Laboratory Values) 76
Treatment Duration 77
Toxicity and Side Effects 78
Multivariate Analysis 78
Conclusion 81
References 81
Pamidronate Versus Controls in Patients
with Metastatic Breast Cancer and Bone Metastases 81
Pamidronate for Inhibition of Bone Progression in Patients
with Advanced Breast Cancer:
A Randomized, Multicenter Phase HI Trial 81
Patients and Methods 82
Results 82
Discussion 83
References 86
Aredia in the Indication of Osteolytic Bone Metastases
of Breast Cancer: A Model for Evaluation of Cost Benefit ... 86
References 89
XIV Contents
Prospective, Randomized, Double blind, Dose finding Study
in Patients with Malignant Osteolytic Bone Metastases
and Pain: 60 mg vs. 90 mg Pamidronate 90
Introduction 90
Aim of the Study 90
Study Design 91
Treatment 91
Statistical Considerations 91
Patient Characteristics 92
Results 93
Pain Intensity 93
Responders/Nonresponders 94
Pain Improvement 95
Pain Frequency 95
General Well being 96
Pain Score 97
Performance Status 97
Analgesic Score 99
Total Bone Mineral Density 99
Correlation of Results from Selected End Points 100
Pain Intensity and Bone Mineral Density 100
Correlation of Bone Mineral Density and Diagnosis 101
Discussion 101
References 104
Cost Effectiveness Analysis of Pamidronate Treatment
in Patients with Advanced Malignant Osteolytic
Bone Disease : SG 110/93 Plus 104
Introduction 104
Patients and Methods 105
Results 105
Conclusion 106
Recent Developments and Future Directions 107
Ibandronate 107
Pamidronate 107
Adjuvant Bisphosphonate Therapy 110
Future Directions U2
References 112
|
| any_adam_object | 1 |
| author | Thürlimann, Beat 1955- |
| author_GND | (DE-588)120072432 |
| author_facet | Thürlimann, Beat 1955- |
| author_role | aut |
| author_sort | Thürlimann, Beat 1955- |
| author_variant | b t bt |
| building | Verbundindex |
| bvnumber | BV012132380 |
| classification_rvk | XH 7665 |
| ctrlnum | (OCoLC)613942644 (DE-599)BVBBV012132380 |
| discipline | Medizin |
| format | Book |
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| indexdate | 2024-07-09T18:22:16Z |
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| isbn | 3540636897 |
| language | English |
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| physical | XIV, 113 S. graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
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| publisher | Springer |
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| series | Recent results in cancer research |
| series2 | Recent results in cancer research |
| spelling | Thürlimann, Beat 1955- Verfasser (DE-588)120072432 aut Bisphosphonates in clinical oncology the development of pamidronate ; with 15 tables B. Thürlimann Berlin [u.a.] Springer 1999 XIV, 113 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Recent results in cancer research 149 Hyperkalzämie (DE-588)4239846-0 gnd rswk-swf Diphosphonate (DE-588)4150083-0 gnd rswk-swf Knochenkrebs (DE-588)4031331-1 gnd rswk-swf Osteolyse (DE-588)4210410-5 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Pamidronsäure (DE-588)4242256-5 gnd rswk-swf Knochenmetastase (DE-588)4164290-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Knochenkrebs (DE-588)4031331-1 s Diphosphonate (DE-588)4150083-0 s DE-604 Krebs Medizin (DE-588)4073781-0 s Hyperkalzämie (DE-588)4239846-0 s Pamidronsäure (DE-588)4242256-5 s Knochenmetastase (DE-588)4164290-9 s Osteolyse (DE-588)4210410-5 s Recent results in cancer research 149 (DE-604)BV000000043 149 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008217018&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Thürlimann, Beat 1955- Bisphosphonates in clinical oncology the development of pamidronate ; with 15 tables Recent results in cancer research Hyperkalzämie (DE-588)4239846-0 gnd Diphosphonate (DE-588)4150083-0 gnd Knochenkrebs (DE-588)4031331-1 gnd Osteolyse (DE-588)4210410-5 gnd Krebs Medizin (DE-588)4073781-0 gnd Pamidronsäure (DE-588)4242256-5 gnd Knochenmetastase (DE-588)4164290-9 gnd |
| subject_GND | (DE-588)4239846-0 (DE-588)4150083-0 (DE-588)4031331-1 (DE-588)4210410-5 (DE-588)4073781-0 (DE-588)4242256-5 (DE-588)4164290-9 (DE-588)4143413-4 |
| title | Bisphosphonates in clinical oncology the development of pamidronate ; with 15 tables |
| title_auth | Bisphosphonates in clinical oncology the development of pamidronate ; with 15 tables |
| title_exact_search | Bisphosphonates in clinical oncology the development of pamidronate ; with 15 tables |
| title_full | Bisphosphonates in clinical oncology the development of pamidronate ; with 15 tables B. Thürlimann |
| title_fullStr | Bisphosphonates in clinical oncology the development of pamidronate ; with 15 tables B. Thürlimann |
| title_full_unstemmed | Bisphosphonates in clinical oncology the development of pamidronate ; with 15 tables B. Thürlimann |
| title_short | Bisphosphonates in clinical oncology |
| title_sort | bisphosphonates in clinical oncology the development of pamidronate with 15 tables |
| title_sub | the development of pamidronate ; with 15 tables |
| topic | Hyperkalzämie (DE-588)4239846-0 gnd Diphosphonate (DE-588)4150083-0 gnd Knochenkrebs (DE-588)4031331-1 gnd Osteolyse (DE-588)4210410-5 gnd Krebs Medizin (DE-588)4073781-0 gnd Pamidronsäure (DE-588)4242256-5 gnd Knochenmetastase (DE-588)4164290-9 gnd |
| topic_facet | Hyperkalzämie Diphosphonate Knochenkrebs Osteolyse Krebs Medizin Pamidronsäure Knochenmetastase Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008217018&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000000043 |
| work_keys_str_mv | AT thurlimannbeat bisphosphonatesinclinicaloncologythedevelopmentofpamidronatewith15tables |