A guide to the polyamines:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York [u.a.]
Oxford Univ. Press
1998
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 595 S. graph. Darst. |
| ISBN: | 0195110641 |
Staff View
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| 245 | 1 | 0 | |a A guide to the polyamines |c Seymour S. Cohen |
| 264 | 1 | |a New York [u.a.] |b Oxford Univ. Press |c 1998 | |
| 300 | |a XIV, 595 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 650 | 4 | |a Polyamines | |
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| 650 | 4 | |a Polyamines |x Physiological effect | |
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Record in the Search Index
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| adam_text | Co
Chapter 1
Historical Introduction 1
Early history of chemistry 1
Discovery of spermine phosphate 1
Fractionation of air 2
Early modern chemistry 3
Origins of biochemistry 3
Studies on amines 4
From amines to chemical industry 4
Professionalization of biochemical research 4
Microbiology and diamines 5
Essentiality of amino acids and amines 5
Structure of spermine and discovery of
spermidine 6
Spermine content of human tissues 6
Appendix—A time line: Events in chemical and
biochemical prehistory of polyamines 8
Chapter 2
Structures and Syntheses
of Polyamines 16
Isolation of diamines 16
Diamines as precursors and analogs 16
Isolation and properties of spermine 18
Structure and synthesis of spermine 18
Structure and synthesis of spermidine 19
Syntheses and reactions of amines 19
Preparing for metabolic study 21
Site specific syntheses 21
Guanidine derivatives 22
intents
Chapter 3
Properties and Analysis of Polyamines 25
Basicity of amines 26
Estimation of pK by nuclear magnetic resonance
(NMR) 26
Reactions of amines 28
Reactions of quantitative analysis 31
Other reactions 32
Oxidative reactions 32
Separation techniques 32
Paper chromatography 33
Paper electrophoresis 33
Thin layer chromatography 33
Ion exchange separation and HPLC 34
Enzymes and enzymatic assays 37
Gas liquid chromatography (GLC) and GC MS 38
Immunoassay 40
Analytical accuracy 41
Chapter 4
Macrocyclic Polyamines—A Digression? 44
Coordination compounds and some reactions
of copper 45
Platinum and palladium complexes 47
Enter the macrocyclic polyamines 47
Biological activities of macrocyclic polyamines 49
Summary 51
viii cont
Chapter 5
Free Polyamines and Their Distribution 53
Odors and amines 55
Discovery of hydroxyputrescine and
hydroxyspermidine 55
Spermine among microbes 57
Polyamines and thermophilic microorganisms 57
Polyamines in microbial evolution: The problem of the
RNA world 60
Spermine in bacteria 60
Studies with cyanobacteria 61
Polyamines in nucleated cells 61
Putrescine and homospermidine 64
Adaptation to salt 65
Summary and conclusions 66
Chapter 6
Polyamine Oxidases and
Dehydrogenases 69
Histaminase and discovery of diamine oxidase
(DAO) 69
Toxicity of spermine 70
Antibacterial action of oxidized spermine 70
Role of spermine in human prostatic fluid and
semen 70
Toxic aldehyde products of polyamine oxidation 71
Problem of primary toxic agent 72
New amine oxidases and problems
of nomenclature 73
Some characteristics of classical MAO 74
Some early copper containing proteins
and enzymes 75
Copper containing bovine plasma amine oxidase 75
Nature of organic cofactor 76
Animal enzymes: Histaminase and amiloride binding
protein 78
Peptidyl lysyl amine oxidases and copper related
cross linking 79
Some plant amine oxidases 79
Stereochemical specificity of animal and plant
enzymes 80
Fungal copper containing oxidases 80
Some bacterial enzymes 81
Methylamine dehydrogenases 81
Amine oxidation and polyamine assay 81
Organic products of copper amine oxidases 81
Organic products of some plant, fungal, and microbial
PAOs and dehydrogenases 82
H2O2 in assay of amine oxidases and polyamines 83
ENTS
Animal flavin containing PAO 84
Nonacetylated polyamines and plant flavin containing
oxidases 85
Pyrroline oxidation products 85
Inhibitors and roles of amine oxidases 86
Hydrogen peroxide as toxic product of amine
oxidases 89
Summary 89
Chapter 7
Bacterial Metabolism and Polyamines 94
Why study bacteria? 94
A biological and biochemical context of the
bacteriological world 94
Maintaining an intact cell 97
Polyamines and the bacterial envelope 97
Ornithine and diamines as cell wall and membrane
constituents 99
Osmoregulation in bacteria 99
Early observations on transport of polyamines 101
Inorganic cations and polyamines 103
Polyamines and isolation of internal organelles:
Ribosomes 104
Nucleoid 107
Activities of bacterial chromosome: RecA and
homologous recombination 108
Repair of DNA 109
DNA replication 109
Synthesis, accumulation, regulation, and elimination in
developing cultures 110
Growth phases 110
Chemostat and control of rate of growth and cell
size 112
Acetylation in batch cultures 113
Studies on stringent and relaxed responses 114
Formation of glutathionylspermidine 115
E. coli deficient in poly amine 116
Recent observations on polyamine transport 116
Essentiality of polyamines 118
Chapter 8
Biosynthesis and Metabolism of
Diamines in Bacteria 122
Approaching metabolism 122
Early studies on decarboxylation of ornithine and
arginine 122
CON
Assay of ODC (EC 4.1.1.17) 124
Decarboxylases of basic amino acids 125
Guanine nucleotide activators and inhibitors
of ODC 127
Polyamines as inhibitors of decarboxylases 127
PLP binding sites in decarboxylases 127
Aminotransferases and metabolism of putrescine 128
PLP mediated reactions 128
Stereochemistry of enzymatic decarboxylation 129
Synthetic inhibitors of bacterial decarboxylases 129
Inhibition of E. coli bODC and bADC by E. coli
proteins 132
Biosynthesis of ornithine and arginine 132
Bacterial pathways of arginine and ornithine
catabolism 133
Genetic blocks in synthesis of putrescine 135
cAMP and expression of SpeA, SpeB, and SpeC
genes 136
Cloning and expression of SpeA (bADC), SpeB
(AUH), and SpeC (bODC) genes 136
Biosynthesis of lysine 137
LDC and sources of cadaverine 138
Other routes in metabolism of cadaverine
and lysine 139
Chapter 9
Bacterial Paths to Spermidine
and Other Polyamines 142
Escherichia coli as an experimental system 142
Discovery of enzymatic synthesis of spermidine
in E. coli 143
Expanding role of AdoMet 145
Properties of AdoMet 145
Properties of decarboxylated AdoMet 146
AdoMet synthetase (methionine
adenosyltransferase) 147
Analogues of methionine and inhibitors of AdoMet
synthetase 148
Biosynthesis of methionine 148
Other reactions of methionine 150
Isolation and properties of AdoMetDC 151
Pyruvoyl enzymes and their precursors 152
Activators and inactivation of AdoMetDC 153
Development of inactivating inhibitors of
AdoMetDC 153
Bacterial mutants deficient in AdoMetDC 154
Spermidine synthase, a bacterial propylamine
transferase 155
TENTS ix
Mechanism of spermidine synthase reaction 156
Inhibitors of spermidine synthase reaction 157
Bacterial metabolism of MTA 158
Alternative synthetic paths of spermidine and
norspermidine 160
Synthesis of homospermidine 161
Chapter 10
Microbial Eucaryotic Systems:
Fungi and Slime Molds 165
Fungal systems 165
Classifying fungi and slime molds 166
Biological properties of Saccharomyces cerevisiae and
Neurospora crassa 166
Polyamines in life of S. cerevisiae 167
Aminopropyl transfer in strains of 5. cerevisiae 171
Enzymes of polyamine pathway 172
ODC 172
AdoMet synthetase 172
AdoMetDC 172
Propylamine transferases 174
New polyamine functions in yeast systems 174
Hypusine and translation 174
Processing of tRNA precursors 175
Splicing of mRNA 175
Studies with N. crassa 175
Vacuolar cations and anions in fungi 177
Problem of concentration of free polyamines and
metabolites 177
Putrescine deficient Neurospora and polyamine
pathway 178
Regulation of ODC and polyamine pathway 179
Studies with Physarum polycephalum 179
Dictyostelium discoideum and polyamines 180
Chapter 11
Polyamines in the Animal Cell 184
Polyamines as nutrients in clonal growth 185
Early data on tissue polyamines 185
Data on development 186
Osmotic effects on polyamine metabolism 187
Cytochemical studies 189
Cellular aging 189
Studies of suspension cultures 190
Effects of inhibitors on cell cultures 191
Enucleation and distribution of amines 192
X CONT
Studies with monolayers 193
Activation of human lymphocytes 196
Experiments with bovine lymphocytes 197
Additional dissections of cell cycle 197
Reversing tumorigenicity 199
Transformed cells 200
Summary and comment 203
Chapter 12
Pathways of Polyamine Metabolism
in Animals 208
Nitrogen metabolism, with special reference to
arginine and ornithine 209
Nitrogen metabolism, with special reference to
methionine 211
Discovery of polyamine metabolites 211
Poly amines of nerve tissue 211
Urinary excretion of poly amines 213
Urinary excretion of polyamines and their
metabolites 215
Blood polyamines and their conjugates 215
Acetylation and catabolic cycles 216
Synthesis of GAB A from putrescine 217
Brief summary scheme of biosynthesis and
catabolism 220
Discovery of regulation of ODC in liver 220
Hormonal control of polyamine synthesis in gonadal
and accessory tissues 222
Hypusine, a posttranslational product of spermidine
metabolism 224
Biosynthesis and possible role of hypusine 225
Summary 226
Chapter 13
Biosynthetic Enzymes of Animal
Tissues and Cells: Part I
Properties and Regulation of
Ornithine Decarboxylase 231
Early studies on ODC 232
Assay of tissue ODC 232
Cellular sites of ODC activity 232
Studies on role and purification of ODC 233
Properties of purified mammalian ODC 233
Charge heterogeneity and modification of ODC 234
In vitro activity of ODC 235
ODC as lysine decarboxylase (LDC) 236
ENTS
Mechanism of ODC reaction 236
Regulation of ODC by polyamines and discovery of
antizyme 237
Pursuit of antizyme and its role 238
Regulation of synthesis of antizyme 239
Exploiting mutations in polyamine metabolism 240
Roles of arginine and arginase 240
ODC overproducing mutants 241
Determination of nucleotide and amino acid
sequences 241
Phosphorylation of ODC 242
Isolation and analyses of ODC genes of mouse
and rat 242
Regulatory function of cAMP 243
Methylation of ODC gene and its expression 243
Human Ode and its effects in transgenic mice 243
Transcription of ODC gene and nature of ODC
mRNA 245
Translational controls of ODC 246
In vitro studies of translation 247
ODC degradation 248
ODC structure and its stability in cells 249
Activity and degradation of ODC 250
Proteolytic degradation of ODC 250
Inhibition of mammalian ODC 250
Summary 254
Chapter 14
Mammalian Biosynthetic Enzymes:
Part II 260
Methionine and AdoMet 261
Inhibitors of methionine adenosyltransferase 264
AdoMet synthetase 264
Transport of AdoMet 264
AdoMetDC 265
dAdoMet 266
Physiological regulation of AdoMetDC in
animals 267
Discovery and processing of enzyme precursor 268
Genetic determinants of AdoMetDC 269
Molecular regulation of enzyme expression by
polyamines and their inhibitors 270
MGBG and its toxicity 270
Propylamine transferases 273
Specificity of spermidine synthase 274
Specificity of spermine synthase 275
Human gene for spermidine synthase 276
Inhibitors of spermidine synthase 277
CON
Inhibitors of spermine synthase 278
Metabolism of MTA 279
Isolation and properties of MTA phophorylase 280
From MTA to methionine 281
Chapter 15
Thinking About Cancer:
Carcinogenesis Initiation 287
Initiation and promotion 287
Mutagenesis and alkylation 288
Detection of mutagenesis and antimutagenesis 288
Polyamines in tests of mutagenicity 289
Oncogenicity of acrolein 290
Chemical effects of nitrous acid 290
Mutagenicity of nitrosamines 291
Converting polyamines to mutagens 291
The nitrite problem and biosynthesis of nitric
oxide 292
Nitric oxide adducts and mutagenesis 293
Chapter 16
Polyamine Metabolism and Promotion
of Tumor Growth 296
ODC and tumor promotion in mouse skin 296
Complexities of promotion and its inhibition 297
Retinoic acid and ODC induction 297
Protein kinases and control of ODC 298
Sphingosine and inhibition of PKC 299
Heterogeneity of tumor ODC 299
Essentiality of ODC to tumor formation in mouse
skin 300
Of mice, rats, and humans 301
Multistage carcinogenesis in rodent liver 301
Ethionine and the hypomethylation problem 301
ODC in human cancers 302
Other enzymes of polyamine metabolism as possible
cancer markers 302
Accumulation of polyamine in tumor cells 303
Fate of exogenous putrescine and spermidine 303
Can exogenous ornithine and arginine regulate
tumorigenesis? 305
Detecting cancer markers 305
Erythrocytic polyamines 306
Analysis of CSF and brain tumors 307
Putrescine and tumorigenesis 308
Catabolic source of putrescine 308
TENTS Xi
SSAT: The inducible W acetyl transferase 310
Nuclear polyamine and histone N acetylases 312
Deacetylation of N8 acetylspermidine 312
SSAT induction by polyamine analogues 313
SSAT protein and gene 314
Chapter 17
Surviving Cancers:
Controlling the Disease 320
Evolution of therapeutic modalities 320
Monitoring chemotherapy 320
Anticancer antibiotics: The bleomycins 320
Provoking cell death: Effects of hyperthermia 323
Phenomena of apoptosis 324
Anticancer drugs: Blocking biosynthesis
of putrescine 325
MGBG as sole or combined antitumor agent 328
New MGBG like analogues and activities 329
Inhibition of synthesis of spermidine
and spermine 330
Effects with methionine and its analogues 330
Analogues depleting and replacing normal
amines 331
Approaching chemotherapy of gastrointestinal
cancer 332
Polyamines in chemoprevention of cancer 334
Chapter 18
Mostly Protozoans:
Some Third World Parasites 340
A peek at helminths 340
Approaching Trypanosomes 341
Studies on Tetrahymena 341
Studies on Acanthamoeba 342
How polyamines entered research on
Trypanosomes 342
Relating curative effects of DFMO to effects on
polyamine metabolism 344
Synergy of DFMO and bleomycin 345
From mice to humans 345
Methionine metabolism as target in
Trypanosomes 346
AdoMet and resistance of Trypanosomes
to DFMO 348
Metabolic stability of trypanosomal ODC 348
Xii CONl
Trypanothione: Novel derivative of glutathione
(GSH) 349
Trypanothione in life of C. fasciculata 351
Trypanothione in chemotherapy of African
trypanosomiasis 351
Trypanothione reductase 352
Inhibitors of trypanothione reductase 353
Trypanothione peroxidase 353
Functions of GSH 354
Aspects of oxidative stress 354
Exploitation of oxidative stress 355
Approaching Chagas disease and
Leishmaniases 356
Kinetoplast DNA and DNA topoisomerases 357
Forays into malarial disease 358
Polyamines and vaginitis 360
Concluding remarks 360
Chapter 19
Viruses 366
Historical introduction 366
Bacterial viruses 367
Polyamines of T even bacteriophages 367
Synthesis of T even viral polymers and polyamine
biosynthesis 368
Synthesis of viral polymers in polyamine depleted
E. coli mutants 369
Early mRNA and hydrolysis of AdoMet in T3
infection 371
DNA phages and topoisomerases 372
Compaction of DNA 374
Head full hypothesis 376
DNA injection 378
Putrescinyl thymine in Pseudomonas phage 378
RNA bacteriophages 379
Animal DNA viruses 381
Vaccinia virus 381
Herpes virus Type I (HSV1) 382
HCMV 382
Animal RNA viruses 384
Data on picornaviruses 384
Multiplication of Semliki Forest virus (SFV) 385
Plant viruses 386
TMV 387
TYMV 387
Polyamine metabolism in TYMV infected plant
cells 390
Concluding remarks 391
rENTS
Chapter 20
Plant Metabolism 396
Assay of plant polyamines 397
Data on plant (and food) content of polyamines 397
Plant polyamines 398
Photosynthetic bacteria and algae 399
Polyamine distribution in tissues of higher plants 401
Putrescine biosynthesis and mineral deficiency 402
A path of nitrogen assimilation 403
Putrescine and osmotic stress 404
Light controls 405
Other environmental effects 405
Radical scavenging 405
Toxicity of paraquat 406
Metabolism of arginine 406
ADC 406
Plant ODC 407
Curing plants of fungal infections 407
Path from agmatine to putrescine 408
Guanidino compounds and transamidination 409
Biosynthetic origins of plant methionine 410
AdoMet and its biosynthesis 411
Origins of azetidine 2 carboxylic acid 411
S methylcysteine and S methylmethionine
(SMM) 412
Methylation reactions and fate of 5 adenosyl
homocysteine (AdoHcy) 412
Pathways for synthesis of spermidine
and spermine 412
Polyamines in plant cells: Dormancy break and
embryogenesis 414
Protoplasts 415
Stages of plant development 415
Floral initiation and polyamine conjugates 417
Free and bound polyamines 418
Hydroxycinnamoyl amides 420
Biosynthesis and metabolism of hydroxycinnamoyl
amides 422
Metabolic controls on synthesis of phenolic acid
amides 423
Fruit development 425
Ethylene: Multifunctional plant hormone 425
Biosynthesis of ethylene and its intermediates 427
Possible reciprocal relations of polyamines and
ethylene 430
Polyamine derived alkaloids 430
Nicotine and other putrescine derived alkaloids 431
Cadaverine derived alkaloids 434
CON
Chapter 21
Molecular Reactions at Cell Surfaces 443
Transglutaminase and polyamine participation 444
Mechanism of transglutaminase reaction 445
Tying fibrin clots to cells 446
Erythrocyte transglutaminase 447
Transglutaminase of scavenging cells 447
Membranous substrates 448
Diversity of transglutaminase functions 448
Unexpected transglutaminases of plant, microbial,
and animal origin 451
Cross linking and the y glutamyl amines 451
Some cellular systems 452
Metastasis 452
Apoptosis and isopeptide bonds 453
Psoriasis 453
Tissue or Type II transglutaminases 454
Epidermal transglutaminase 455
Matrix, membranes, and messages 456
Polyamine effects on intercellular reactions 456
Reactions with erythrocyte membranes 458
Receptors and cascades 459
Inositol derivatives and second messengers 459
Polyamines in activation and inhibition of
PKC 461
CKI and CKII 462
Data on PTKs 464
Tying inner structures to cell surface 465
Transport in animal cells 467
Mitochondria, spermine, and Ca2+ 470
Brief summary 472
Chapter 22
Molecular Effects on Internal
Cellular Polymers 481
Observations with protein enzymes 481
Protein structure and folding 482
Polyamines, protein isolation, and
characterization 482
Ryanodine receptor from skeletal muscle 482
Activation of RNase A by covalently bound
spermine 482
Nuclease function and polyamines 483
Two spermine binding proteins 484
Data on eucaryotic DNA polymerases 484
Retroviral DNA directed synthesis 485
ITENTS XiH
Additional remarks on DNA topoisomerases 485
Eucaryotic nucleus 487
Regulation of DNAases 487
Chemical cleavage of DNA 488
Polyamines and chromatin 489
Metabolic modifications of chromatin 491
Nucleolar activity 492
Transcription and bacterial RNA polymerases
(RPs) 493
Phage induced DNA dependent RNA
polymerases 493
Eucaryotic DNA dependent RNA polymerases 494
Mitochondrial DNA dependent RNA
polymerases 495
Polyamines and protein synthesis 495
Ribosomal subunits and their association 495
Polyamine deficient ribosomes 496
Additional phenomena of procaryotic protein
synthesis 497
Roles of Mg2+ and polyamines 498
Free cations and toxicity of polyamine excess 499
Aspects of eucaryotic protein synthesis 501
Eucaryotic mRNA 502
Unfolding of ribosomal subunits and ribosomal
RNA 502
Structure of ribosomal RNA and antibiotic
sensitivities 503
Polyamine dependent ribosomal systems 504
Assembly of ribosomal subunits 504
Effects of Mg2+ and polyamines on
polyribonucleotides 505
Chapter 23
Molecular Effects on Internal Cellular
Polymers:
Transfer RNA and DNA 512
Polyamines and analysis of tRNA 512
Chemical approaches to the nature of polyamine
binding sites in tRNA 513
Quantitation of tRNA binding sites for
polyamine 515
Crystallographic analysis of tRNA 517
NMR and binding to tRNA 518
Modification of tRNA bases 520
Methylation of tRNA 520
Completing the acceptor stem of tRNA 521
Catalytic RNA in tRNA processing and splicing 522
xiv com
Synthesis of aminoacyl tRNA 522
Misacylation 524
Fidelity of translation at the ribosome 524
Errors of processivity in translation 526
Early studies of DNA polyamine complexes 527
Crystals of polyamine phosphates and early models of
DNA complexes 528
Condensed DNA, compaction, and nonspecific cationic
interaction 529
Flexibility of DNA structure 531
Crystallization of B DNA 532
rENTS
Formation and structure of Z DNA containing
polyamines 533
NMR studies of DNA in solution 536
Molecular modeling and dynamics 537
Structural distortions in DNA drug interactions 537
On the cutting edge 539
Figure and Table Credits 545
Index 555
|
| any_adam_object | 1 |
| author | Cohen, Seymour S. 1917-2018 |
| author_GND | (DE-588)139009256 |
| author_facet | Cohen, Seymour S. 1917-2018 |
| author_role | aut |
| author_sort | Cohen, Seymour S. 1917-2018 |
| author_variant | s s c ss ssc |
| building | Verbundindex |
| bvnumber | BV012041155 |
| callnumber-first | Q - Science |
| callnumber-label | QP801 |
| callnumber-raw | QP801.P683 |
| callnumber-search | QP801.P683 |
| callnumber-sort | QP 3801 P683 |
| callnumber-subject | QP - Physiology |
| classification_rvk | WD 5200 |
| ctrlnum | (OCoLC)35174769 (DE-599)BVBBV012041155 |
| dewey-full | 574.19/24 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 574 - [Unassigned] |
| dewey-raw | 574.19/24 |
| dewey-search | 574.19/24 |
| dewey-sort | 3574.19 224 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Book |
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| id | DE-604.BV012041155 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:20:37Z |
| institution | BVB |
| isbn | 0195110641 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008148673 |
| oclc_num | 35174769 |
| open_access_boolean | |
| owner | DE-703 DE-11 |
| owner_facet | DE-703 DE-11 |
| physical | XIV, 595 S. graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Oxford Univ. Press |
| record_format | marc |
| spelling | Cohen, Seymour S. 1917-2018 Verfasser (DE-588)139009256 aut A guide to the polyamines Seymour S. Cohen New York [u.a.] Oxford Univ. Press 1998 XIV, 595 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Polyamines Polyamines Metabolism Polyamines Physiological effect Polyamines Synthesis Polyamine (DE-588)4175101-2 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf Stoffwechsel (DE-588)4057699-1 gnd rswk-swf Polyamine (DE-588)4175101-2 s Stoffwechsel (DE-588)4057699-1 s DE-604 Physiologie (DE-588)4045981-0 s HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008148673&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cohen, Seymour S. 1917-2018 A guide to the polyamines Polyamines Polyamines Metabolism Polyamines Physiological effect Polyamines Synthesis Polyamine (DE-588)4175101-2 gnd Physiologie (DE-588)4045981-0 gnd Stoffwechsel (DE-588)4057699-1 gnd |
| subject_GND | (DE-588)4175101-2 (DE-588)4045981-0 (DE-588)4057699-1 |
| title | A guide to the polyamines |
| title_auth | A guide to the polyamines |
| title_exact_search | A guide to the polyamines |
| title_full | A guide to the polyamines Seymour S. Cohen |
| title_fullStr | A guide to the polyamines Seymour S. Cohen |
| title_full_unstemmed | A guide to the polyamines Seymour S. Cohen |
| title_short | A guide to the polyamines |
| title_sort | a guide to the polyamines |
| topic | Polyamines Polyamines Metabolism Polyamines Physiological effect Polyamines Synthesis Polyamine (DE-588)4175101-2 gnd Physiologie (DE-588)4045981-0 gnd Stoffwechsel (DE-588)4057699-1 gnd |
| topic_facet | Polyamines Polyamines Metabolism Polyamines Physiological effect Polyamines Synthesis Polyamine Physiologie Stoffwechsel |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008148673&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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