Rickettsial infection and immunity:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
Plenum Press
1997
|
| Series: | Infectious agents and pathogenesis
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVII, 245 S. Ill., graph. Darst. |
| ISBN: | 0306455285 |
Staff View
MARC
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Record in the Search Index
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|---|---|
| adam_text | 1. Molecular Rickettsiology: A Short History
BURT ANDERSON
1. Introduction 1
2. Gene Structure and Expression 2
2.1. Transcription Initiation 3
2.2. Translation Initiation 4
2.3. PosttranslationaJ Modification 5
3. Identification of New Species 7
3.1. Bacillary Angiomatosis/Cat Scratch Disease 7
3.2. Ehrlichiosis 8
3.3. ELB Agent 9
4. Epidemiology and Natural History of Rickettsial Diseases 9
4.1. Ehrlichiosis 9
4.2. Bartonella 10
5. Summary/Conclusion 11
References 11
2. Immunity to Rickettsiae (Redux)
THOMAS R. JERRELLS
1. Introduction 15
2. Immune Responses to Intracellular Organisms 16
3. Role of the T Cell in Immunity to Rickettsiae 18
xi
xii CONTENTS
4. Role of Antibody in Rickettsial Immunity 20
5. Role of Cytokines in Rickettsial Immunity 21
6. Immune Responses and Chronic Infections 23
7. Summary 23
References 24
3. Cytokines Influencing Infections by Rickettsia Species
JENIFER TURCO and HERBERT H. WINKLER
1. Introduction 29
2. Studies Involving Interferons 30
2.1. Induction of Interferons by Rickettsiae 30
2.2. Effects of Interferons on Rickettsial Growth 32
2.3. Cytotoxicity of Interferon Treatment and Rickettsial Infection
for Host Cells 38
2.4. Isolation of IFN Resistant Rickettsiae from R. prowazekii Madrid
E Infected L929 Cells 40
3. Studies Involving Tumor Necrosis Factors 42
3.1. Induction of Tumor Necrosis Factors by Rickettsiae 42
3.2. Effects of Tumor Necrosis Factors on Rickettsial Growth 42
3.3. Cytotoxicity of Tumor Necrosis Factor Treatment and
Rickettsial Infection for Host Cells 43
4. Studies Involving IFN 7 plus TNF ct 43
5. Antirickettsial Effects of Crude Lymphokines and the Role of IFN 7
and Other Cytokines in Mediating These Effects 45
5.1. Studies with Crude Lymphokines 45
5.2. Role of IFN 7 and Other Factors in Crude Lymphokines .... 46
5.3. Role of Nitric Oxide Production 46
6. Evidence for Killing of Intracellular Rickettsiae in Cytokine Treated
Host Cells 47
6.1. Studies with Cultured Cells 47
6.2. Studies of R. amora Infected Mice 48
7. Concluding Remarks 48
References 49
4. Global Genetic Diversity of Spotted Fever Group Rickettsiae
VERONIQUE ROUX and DIDIER RAOULT
1. Introduction 53
CONTENTS xiii
2. Studies on Total DNA 55
2.1. DNA DNA Hybridization 55
2.2. Macro restriction Analysis by Pulsed Field Gel Electrophoresis 55
2.3. DNA Restriction Fragment Polymorphism Analysis 56
3. RFLP Analysis of PCR Amplification Products and Base Sequence
Comparison of PCR Amplification Products 57
3.1. The Gene Coding for 16 S rRNA 57
3.2. The Gene Coding for the Citrate Synthase (git A) 57
3.3. The Gene Coding for the Proteins of 17 kDa, rOmpB, and
rOmpA 58
References 62
5. Surface Components of the Spotted Fever Group Rickcttsiac
GREGORY A. MCDONALD, CAYLE C. GRAUMANN,
and JOSEPH J. TEMENAK
1. Surface Organization of the Spotted Fever Group Rickettsiae 65
2. Protein Surface Components 66
2.1. Proteins Identified with Polyclonal Antibodies 67
2.2. Surface Proteins Identified with Monoclonal Antibodies 67
2.3. Rickettsial Outer Membrane Proteins 70
2.4. 17 kDa Rickettsia Genus Common Protein 74
3. Surface Components of a Nonproteinaceous Composition 75
3.1. Lipopolysaccharide 75
3.2. Microcapsular and Slime Layers 75
4. Closing Remarks 76
References 76
6. Oxidative Cell Injury and Spotted Fever Group Rickettsiae
DAVID J. SILVERMAN
1. Introduction 79
2. Infection of Human Endothelial Cells by Rickettsia rickettsii: Light
Microscopic Observations 80
3. Electron Microscopy of Human Endothelial Cells Infected by
R. rickettsii: Morphological Manifestations of Cell Injury 82
xiv CONTENTS
4. Biochemical Evidence in Support of a Hypothesis of Oxidative Cell
Injury Caused by Rickettsial Infection: Intracellular Peroxides 85
5. Induction of Superoxide Dismutasc and the Release of Superoxide
during Infection of Endothelial Cells by R. rickettsii 88
6. Protection of R. rickettsii lnkcted Endothelial Cells by Heparin .... 90
7. Glutathione: Depiction during Rickettsial Infection of Endothelial
Cells and Role in Protection against Oxidative Injury 92
8. Activity of Key Antioxidant Enzymes Involved in Protection against
Oxidative Injury in Endothelial Cells Infected by R. rickettsii 93
9. Phospholipase A: Evidence for Its Presence on R. rickettsii, and
Prospects for Its Role in Cell Injury 94
10. Summary 96
References 96
7. Intracellular Development of Coxiella burnetii
ROBERT A. HEINZEN
1. Introduction 99
2. Host Parasite Interactions 100
3. Small Cell and Large Cell Variants 100
3.1. Purification 103
3.2. Ultrastructure 103
3.3. Infectivity 104
3.4. Resistance and Metabolic Properties 108
3.5. Similarities with Chlamydia Ill
3.6. SCV and LCV Specific Components Ill
4. Sporclike Particles 117
5. Potential Environmental Modulators of Development 121
5.1. Nutrient Availability 122
5.2. pH 122
5.3. Temperature 123
6. Conclusions and Future Prospects 124
References 126
8. The Identification of Virulence Factors of Coxiella burnetii
OSWALD G. BACA and LOUIS P. MALLAVIA
1. Introduction 131
CONTENTS xv
2. SOD and Catalase 133
3. Acid Phosphatase (ACP) 134
4. Macrophage Infectivity Potentiator (MIP) 136
5. Coml 137
6. Other Surface Proteins 138
7. LPS 138
8. Association between Plasmids and Type of Disease 139
9. Prospects 142
References 143
9. Human Granulocytic Ehrlichiosis
J. STEPHEN DUMLER and PHILIPPE BROUQUI
1. Introduction 149
2. Granulocytotropic Ehrlichia Species: Classification and Taxonomic
Considerations 150
3. Human Granulocytic Ehrlichiosis: Clinical Considerations 151
4. Immune Reactions in Recovered Hosts 152
5. Immune Function in Human Patients with Acute HGE 154
6. Immunity in Animal Models of Granulocytotropic Ehrlichioses.... 155
7. Veterinary Models of Ehrlichia phagocytophila Group Infections 155
8. Immunobiology and Antigenic Comparisons of HGE,
E. phagocytophila, and E. equi 157
9. Immunity and Persistent Infections by E. phagocytophila Group
Ehrlichiae 157
10. Summary 158
References 159
10. The Immune Response to Ehrlichia chaffeensis
PHILIPPE BROUQUI and J. STEPHEN DUMLER
1. Introduction 163
2. Epidemiology 164
3. Pathogenesis 164
4. Virulence of E. chaffeensis 165
5. Immunity to E. chaffeensis 165
5.1. The Role of Host Factors in the Clinical Presentation 166
xvi CONTENTS
5.2. TheRoleofMacrophagesinlntracellularKOlingofEhrlichiae 167
5.3. The Role of Specific Immune Response to E. chaffeensis 168
References 170
11. Clinical Aspects of Bartonella Infections
LEONARD N. SLATER and DAVID F. WELCH
1. Introduction 173
2. Taxonomy 173
3. Epidemiology 174
4. Clinical/Pathologic Manifestations 175
4.1. Oroya Fever and Verruga Peruana 175
4.2. Bacteremic Illness Related to B. quintana, B. henselae, Other
Species 177
4.3. Bacillary Angiomatosis/Peliosis Related to B. quintana and
B. henselae 178
4.4. Cat Scratch Disease 180
4.5. Human Immunodeficiency Virus Associated Neurologic
Syndromes 183
5. Laboratory Diagnosis 184
5.1. Culture 185
5.2. Serology 187
5.3. Detection in Tissue in the Absence of Culture 188
6. Treatment of Bartonella Related Clinical Syndromes 188
7. Future Developments 189
References 190
12. Virulence Determinants of Bartonella bacilliformis
MICHAEL F. MINNICK
1. Introduction 197
2. Establishment of Infection 198
2.1. Biphasic Disease Manifestations 198
2.2. Colonization 200
2.3. Host Immunity 200
2.4. Adherence 202
2.5. Invasion 203
CONTENTS xvii
3. Survival and Replication within the Host 206
3.1. The Erythrocyte 206
3.2. Endothelial Cells 208
4. Conclusions 209
References 209
13. Stimulation of Angiogenesis and Protection from Oxidant Damage:
Two Potential Mechanisms Involved in Pathogenesis by Bartonella
henselae and Other Bartonella Species
THOMAS D. CONLEY, MATTHEW F. WACK,
KAREN K. HAMILTON, and LEONARD N. SLATER
1. Introduction 213
2. Stimulation of Angiogenesis 214
2.1. Background 214
2.2. B. bacilliformis Stimulation of Endothelial Cells 215
2.3. B. henselae and quintana Stimulation of Endothelial Cells 217
3. Protection from Oxidant Damage 221
3.1. Background 221
3.2. Superoxide Dismutase Production by B. henselae and Other
Bartonella spp 225
3.3. B. henselae Glucose 6 phosphate (G 6 PD) Dehydrogenase Activity 226
References 230
Index 233
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| isbn | 0306455285 |
| language | English |
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| physical | XVII, 245 S. Ill., graph. Darst. |
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| series2 | Infectious agents and pathogenesis |
| spelling | Rickettsial infection and immunity ed. by Burt Anderson ... New York [u.a.] Plenum Press 1997 XVII, 245 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Infectious agents and pathogenesis Rickettsiaceae Infections immunology Rickettsial diseases Immunological aspects Infektionskrankheit (DE-588)4026879-2 gnd rswk-swf Rickettsia (DE-588)4300169-5 gnd rswk-swf Immunität Medizin (DE-588)4120476-1 gnd rswk-swf Rickettsia (DE-588)4300169-5 s Infektionskrankheit (DE-588)4026879-2 s DE-604 Immunität Medizin (DE-588)4120476-1 s Anderson, Burt Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008129234&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Rickettsial infection and immunity Rickettsiaceae Infections immunology Rickettsial diseases Immunological aspects Infektionskrankheit (DE-588)4026879-2 gnd Rickettsia (DE-588)4300169-5 gnd Immunität Medizin (DE-588)4120476-1 gnd |
| subject_GND | (DE-588)4026879-2 (DE-588)4300169-5 (DE-588)4120476-1 |
| title | Rickettsial infection and immunity |
| title_auth | Rickettsial infection and immunity |
| title_exact_search | Rickettsial infection and immunity |
| title_full | Rickettsial infection and immunity ed. by Burt Anderson ... |
| title_fullStr | Rickettsial infection and immunity ed. by Burt Anderson ... |
| title_full_unstemmed | Rickettsial infection and immunity ed. by Burt Anderson ... |
| title_short | Rickettsial infection and immunity |
| title_sort | rickettsial infection and immunity |
| topic | Rickettsiaceae Infections immunology Rickettsial diseases Immunological aspects Infektionskrankheit (DE-588)4026879-2 gnd Rickettsia (DE-588)4300169-5 gnd Immunität Medizin (DE-588)4120476-1 gnd |
| topic_facet | Rickettsiaceae Infections immunology Rickettsial diseases Immunological aspects Infektionskrankheit Rickettsia Immunität Medizin |
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