Matrix metalloproteinases:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
San Diego [u.a.]
Academic Press
1998
|
| Series: | Biology of extracellular matrix series
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XII, 362 S. Ill., graph. Darst. |
| ISBN: | 0125450907 |
Staff View
MARC
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| 245 | 1 | 0 | |a Matrix metalloproteinases |c ed. by William C. Parks ... |
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| 300 | |a XII, 362 S. |b Ill., graph. Darst. | ||
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| 650 | 4 | |a Extracellular Matrix |x enzymology | |
| 650 | 4 | |a Extracellular matrix proteins | |
| 650 | 4 | |a Metalloendopeptidases | |
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Record in the Search Index
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|---|---|
| adam_text | Contents
CONTRIBUTORS ix
PREFACE xi
The Matrix Metalloproteinase Family
J. FREDERICK WOESSNER, JR.
I. Introduction 1
II. The Position of MMPs within the Class
of Metalloproteases 3
III. The Matrixin Subfamily 4
IV. The Domain Structure of the Matrixins 7
V. The Biological Role of the Matrixins 9
VI. What the Future Might Hold 12
References 13
Interstitial Collagenases
JOHN J. JEFFERY
I. Introduction 15
II. Matrix Metalloproteinase 1: The Original
Interstitial Collagenase 16
III. Nontraditional Interstitial Collagenases 35
IV. Summary and Future Perspectives 37
References •,; 38
Stromelysins 1 and 2
HIDEAKI NAGASE
I. Introduction 43
II. Structure and Substrate Specificity 44
III. Activation Mechanisms 51
IV. Inhibitors 54
V. Regulation of Gene Expression 56
VI. Biological and Pathological Roles 60
VII. Conclusions and Future Prospects 67
References 68
v
vi CONTENTS
72 kDa Gelatinase (Gelatinase A): Structure, Activation,
Regulation, and Substrate Specificity
ANITA E. YU, ANNE N. MURPHY, and WILLIAM G. STETLER STEVENSON
I. Introduction 85
II. Matrix Metalloproteinase Family 86
III. Multilevel Regulation of Gelatinase A 88
IV. Substrate Specificity 97
V. Role of Gelatinase A in Cellular Processes 99
VI. Role of Gelatinase A in Platelet Aggregation 105
VII. Perspectives 105
References 106
Gelatinase B: Structure, Regulation, and Function
THIENNU H. VU and ZENA WERB
I. Introduction 115
II. Gene Structure 116
III. Protein Structure and Activation 119
IV. Substrates and Inhibitors 122
V. Regulation of Expression 124
VI. Function 128
VII. Conclusion and Future Directions 136
References 137
Matrilysin
CAROLE L. WILSON and LYNN M. MATRISIAN
I. Introduction 149
II. Amino Acid Sequence and Gene Organization 149
III. Regulation of Expression 152
IV. Protein Structure and Proteolytic Activities 157
V. Expression in Cancer and Other Diseases 164
VI. Role in Normal Tissue Remodeling and Homeostasis 169
VII. Summary and Concluding Remarks 174
References 177
Macrophage Elastase (MMP 12)
STEVEN D. SHAPIRO and ROBERT M. SENIOR
I. Introduction 185
II. The Gene for Macrophage Elastase and Its Expression 187
III. Activation and Processing 187
IV. Protein Preparation 188
CONTENTS vii
V. Catalytic Features 188
VI. Inhibition 190
VII. Biological Aspects 190
VIII. Summary 195
References 196
Membrane Type Matrix Metalloproteinases and Cell Surface
Associated Activation Cascades for Matrix Metalloproteinases
VERA KNAUPER and GILLIAN MURPHY
I. Introduction 199
II. Potential Activation Routes for Matrix Metalloproteinases 200
III. Structure of Membrane Type Matrix Metalloproteinases 202
IV. Cellular Sources of MT MMPs and Regulation
of Expression 204
V. Activation of MT MMPs 206
VI. Activation of Progelatinase A by MT1 MMP
andMT2 MMP 207
VII. Activation of Procollagenase 3 by MT1 MMP 210
VIII. Substrate Specificity of MT MMPs 211
LX. Summary 212
References 214
Substrate Specificity and Mechanisms of Substrate Recognition of
the Matrix Metalloproteinases
VERA IMPER and HAROLD E. VAN WART
I. Introduction 219
II. Peptide Sequence Specificity 221
III. Protein Substrate Specificity 228
IV. Mechanisms of Substrate Recognition 233
References 238
Synthetic Inhibitors of Matrix Metalloproteinases
PETER D. BROWN
I. Introduction 243
II. Design of Synthetic Inhibitors 244
III. Role of Matrix Metalloproteinases in Cancer 247
IV. Effects of Matrix Metalloproteinase Inhibitors in
Cancer Models 249
V. Clinical Trials 253
VI. Proteinase Inhibition as Therapy 255
References 256
viii CONTENTS
Matrix Metalloproteinases in Tissue Repair
WILLIAM C. PARKS, BARRY D. SUDBECK, GLENN R. DOYLE, and
ULPU K. SAARIAHLO KERE
I. Introduction: Studying the Regulation and Function
of Metalloproteinases 263
II. Collagenase 1 in Tissue Repair 266
III. The Role of Collagenase 1 in Reepithelialization 277
IV. Expression of Other Metalloproteinases in Wound Repair 283
V. Regulation of Collagenase 1 in Wound Fibroblasts 286
VI. Metalloproteinases in Chronic Wounds 288
VII. Summary 289
References 290
Regulation of Matrix Metalloproteinase Gene Expression
M. ELIZABETH FINI, JEFFERY R. COOK, ROYCE MOHAN, and
CONSTANCE E. BRINCKERHOFF
I. Introduction 300
II. Collagenase 302
III. Stromelysins 321
IV. Gelatinase B 327
V. Gelatinase A 334
VI. Summary and Future Perspectives 338
References 339
INDEX 357
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:20:05Z |
| institution | BVB |
| isbn | 0125450907 |
| language | English |
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| physical | XII, 362 S. Ill., graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Academic Press |
| record_format | marc |
| series2 | Biology of extracellular matrix series |
| spelling | Matrix metalloproteinases ed. by William C. Parks ... San Diego [u.a.] Academic Press 1998 XII, 362 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biology of extracellular matrix series Métalloprotéinases Protéines de la matrice extracellulaire Extracellular Matrix enzymology Extracellular matrix proteins Metalloendopeptidases Metalloproteinases Grundsubstanz (DE-588)4224942-9 gnd rswk-swf Metalloproteinasen (DE-588)4284137-9 gnd rswk-swf Metalloproteinasen (DE-588)4284137-9 s Grundsubstanz (DE-588)4224942-9 s DE-604 Parks, William C. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008125917&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Matrix metalloproteinases Métalloprotéinases Protéines de la matrice extracellulaire Extracellular Matrix enzymology Extracellular matrix proteins Metalloendopeptidases Metalloproteinases Grundsubstanz (DE-588)4224942-9 gnd Metalloproteinasen (DE-588)4284137-9 gnd |
| subject_GND | (DE-588)4224942-9 (DE-588)4284137-9 |
| title | Matrix metalloproteinases |
| title_auth | Matrix metalloproteinases |
| title_exact_search | Matrix metalloproteinases |
| title_full | Matrix metalloproteinases ed. by William C. Parks ... |
| title_fullStr | Matrix metalloproteinases ed. by William C. Parks ... |
| title_full_unstemmed | Matrix metalloproteinases ed. by William C. Parks ... |
| title_short | Matrix metalloproteinases |
| title_sort | matrix metalloproteinases |
| topic | Métalloprotéinases Protéines de la matrice extracellulaire Extracellular Matrix enzymology Extracellular matrix proteins Metalloendopeptidases Metalloproteinases Grundsubstanz (DE-588)4224942-9 gnd Metalloproteinasen (DE-588)4284137-9 gnd |
| topic_facet | Métalloprotéinases Protéines de la matrice extracellulaire Extracellular Matrix enzymology Extracellular matrix proteins Metalloendopeptidases Metalloproteinases Grundsubstanz Metalloproteinasen |
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