Understanding gene therapy:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Oxford
Bios Scientific Publ.
1999
|
| Ausgabe: | 1. publ. |
| Schriftenreihe: | The medical perspectives series
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 172 S. Ill., graph. Darst. |
| ISBN: | 1859961800 |
Internformat
MARC
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| 250 | |a 1. publ. | ||
| 264 | 1 | |a Oxford |b Bios Scientific Publ. |c 1999 | |
| 300 | |a XVII, 172 S. |b Ill., graph. Darst. | ||
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| 650 | 4 | |a Communicable Diseases |x therapy | |
| 650 | 4 | |a Gene Targeting | |
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| 650 | 4 | |a Gene therapy | |
| 650 | 4 | |a Genetic Vectors | |
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Datensatz im Suchindex
| _version_ | 1804126441794699264 |
|---|---|
| adam_text | Contents
Contributors ix
Abbreviations xi
Preface xvii
1 What is gene therapy? 1
J. Drew and L. A. Martin
Introduction 1
Germline gene therapy 1
Somatic gene therapy 2
Viral systems 4
Nonviral systems 6
Candidate diseases for application of gene therapy 8
Summary 9
References 9
Further reading 10
2 Why gene therapy? 11
L. A. Martin and J. Drew
Introduction 11
What makes a disease suitable for gene therapy? 11
Cystic fibrosis 12
Adenosine deaminase deficiency 13
Familial hypercholesterolemia 13
Cancer could gene therapy provide a cure? 14
Infectious diseases 16
Ethical and regulatory considerations 17
Gene therapy industry an explosion waiting to happen? 17
Future prospects for gene therapy 19
Further reading 19
v
vi Contents
3 Viral delivery systems for gene therapy 21
S.J. Murphy
Introduction 21
Retrovirus based vectors 22
Adenovirus based vectors 26
Adeno associated virus based vectors 33
Herpes simplex virus based vectors 34
Other viral vectors and hybrid vector systems 35
References 38
4 Nonviral delivery systems for gene therapy 43
A.D. Miller
Introduction 43
Cationic liposome/micelle based nonviral delivery systems 45
Cationic polymer based nonviral delivery systems 52
Alternative chemical nonviral delivery systems 57
Physical nonviral delivery systems 58
Future prospects for nonviral delivery systems 59
References 60
5 Gene therapy for monogenic diseases 71
G. Vassaux
Introduction 71
Gene therapy for adenosine deaminase deficiency 71
Gene therapy for cystic fibrosis 78
Conclusion 82
Further reading 82
6 Gene therapy for multifactorial genetic disorders 83
A.S. Rigg
Introduction 83
Colorectal cancer 83
Atherosclerotic vascular diseases 92
Diabetes mellitus 94
Summary 97
Further reading 98
7 Gene therapy for infectious diseases 99
S. Fidler and J. Weber
Introduction 99
Strategies for antiviral gene therapy 100
The use of gene therapy to manipulate the immune response 113
Conclusions 122
References 122
Contents vii
8 Targeting of gene delivery systems 125
L. A. Martin
Introduction 125
Ex vivo gene transfer 125
Transduction targeting 127
Liposome vectors 133
Molecular conjugates 134
Targeting at the transcriptional level 135
Conclusion 138
Further reading 139
9 Gene therapy in the clinic: human trials of gene therapy 141
T. Valere
Introduction 141
Gene therapy around the globe 141
Vectors and routes of administration 143
Which genes for which diseases? 143
Results: the global picture 145
Conclusion 152
References 152
Further reading 154
10 Ethical issues in gene therapy 155
N.C. Nevin
Introduction 155
Supervision of gene therapy research 156
Consent to research 157
Confidentiality 158
Medical surveillance of gene therapy patients 159
Germline gene therapy 159
In utero gene therapy 160
Conclusion 161
References 162
11 Prospects for gene therapy 163
N.R. Lemoine
Introduction 163
Mechanisms of gene transfer and expression 163
Development of models of disease and therapy 164
Cycles of clinical development beyond the phase I trial 164
References 165
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:17:31Z |
| institution | BVB |
| isbn | 1859961800 |
| language | English |
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| oclc_num | 41982248 |
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| physical | XVII, 172 S. Ill., graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
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| publisher | Bios Scientific Publ. |
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| series2 | The medical perspectives series |
| spelling | Understanding gene therapy ed. by N. R. Lemoine 1. publ. Oxford Bios Scientific Publ. 1999 XVII, 172 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier The medical perspectives series Gene Therapy cabt Communicable Diseases therapy Gene Targeting Gene Therapy Gene therapy Genetic Vectors Virus Diseases therapy Gentherapie (DE-588)4296957-8 gnd rswk-swf Gentherapie (DE-588)4296957-8 s DE-604 Lemoine, Nicholas R. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008008560&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Understanding gene therapy Gene Therapy cabt Communicable Diseases therapy Gene Targeting Gene Therapy Gene therapy Genetic Vectors Virus Diseases therapy Gentherapie (DE-588)4296957-8 gnd |
| subject_GND | (DE-588)4296957-8 |
| title | Understanding gene therapy |
| title_auth | Understanding gene therapy |
| title_exact_search | Understanding gene therapy |
| title_full | Understanding gene therapy ed. by N. R. Lemoine |
| title_fullStr | Understanding gene therapy ed. by N. R. Lemoine |
| title_full_unstemmed | Understanding gene therapy ed. by N. R. Lemoine |
| title_short | Understanding gene therapy |
| title_sort | understanding gene therapy |
| topic | Gene Therapy cabt Communicable Diseases therapy Gene Targeting Gene Therapy Gene therapy Genetic Vectors Virus Diseases therapy Gentherapie (DE-588)4296957-8 gnd |
| topic_facet | Gene Therapy Communicable Diseases therapy Gene Targeting Gene therapy Genetic Vectors Virus Diseases therapy Gentherapie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008008560&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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