Metastatic disease to the lung:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Saunders
1998
|
| Schriftenreihe: | Chest surgery clinics of North America
8,1 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 206 S. Ill., graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a Metastatic disease to the lung |c Patricia M. McCormack, guest ed. |
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| 650 | 2 | |a Métastase tumorale | |
| 650 | 2 | |a Tumeurs du poumon | |
| 650 | 4 | |a Lung Neoplasms |x secondary | |
| 650 | 4 | |a Neoplasm Metastasis | |
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Datensatz im Suchindex
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| adam_text | METASTATIC DISEASE TO THE LUNG
CONTENTS
Preface xiii
Patricia M. McCormack
Biology of Metastatic Disease 1
Harvey I. Pass and Barbara A. Temeck
Metastasis is highly organized and organ selective, a process
involving multiple sequential steps. It occurs through complex
interactions between tumor cells and the host. The surviving
metastatic cells have heterogeneous biologic and antigenic or
immunogenic properties, and the metastatic cells take over the
homeostatic mechanisms of the host. Investigations at the genetic
level are necessary to make advances in the early diagnosis,
treatment, and prevention of metastatic disease.
Evolution of the Surgical Management of Pulmonary
Metastases 13
Nael Martini and Patricia M. McCormack
Surgical excision of lung metastases has proven to prolong sur¬
vival in many organ cancers. Surgery for these metastases is
predicated on the absence of effective treatment by other means.
Except in germ cell tumors, combined chemotherapy and surgery
or surgical resection alone are still insufficient to control pulmo¬
nary metastases in most patients. Until continued efforts to de¬
velop new regimens with better response are more fruitful, resec¬
tion of these metastases remains a valid option in many cancers.
Imaging Characteristics of Metastatic Disease to the Chest 29
Bradley J. Snyder and Robert D. Pugatch
The radiographic appearance of metastatic disease is classic, but
nonspecific. The differentiating characteristics of radiographic
CHEST SURGERY CLINICS OF NORTH AMERICA
VOLUME 8 • NUMBER 1 • FEBRUARY 1998 vii
patterns of metastatic disease are discussed in this article, as
well as the relative advantages of different imaging modalities.
Recommendations for radiologic evaluation are also presented.
The Role of Endoscopy in the Staging and Management of
Lung Metastases 49
Michael R. Johnston and Sean Grondin
Endoscopic evaluation of the patient with lung metastases takes
on many forms depending upon the extent of disease and the
intent of treatment, be that curative or palliative. Thorascopy,
and occasionally mediastinoscopy, may be helpful in assessing
operability in patients with extensive disease on a preoperative
computed tomography scan. However, when in doubt, explora¬
tion is always indicated in the young, good risk patient. Palliative
efforts usually concern airway obstruction and malignant effects.
A variety of technologies, including laser, brachytherapy, and
endoluminal stents, helps manage symptomatic bronchial or tra
cheal lesions.
The Role of Video Assisted Thoracic Surgery in
Pulmonary Metastases 59
Peter F. Ferson, Robert J. Keenan, and James D. Luketich
Video assisted thoracic surgery (VATS) is useful in the manage¬
ment of patients with pulmonary metastasis. When a needle
biopsy cannot be performed, or if the biopsy fails to yield a
diagnosis, VATS can obtain sufficient tissue for analysis with a
high degree of success. However, the role of VATS in potential
therapeutic resections is uncertain and needs to be clarified fur¬
ther.
Osteosarcoma 77
Michael P. LaQuaglia
The survival rate of patients with osteogenic sarcoma has greatly
improved with the institution of a multidisciplinary approach
that combines multi agent chemotherapy and limb sparing sur¬
gery. Presently, 80% of those patients who do not have distant
metastases at presentation will become long term survivors, com¬
pared to 20% prior to 1970. For patients with metastases at diag¬
nosis, or who develop metastases after initiation of treatment,
long term survival is also possible if all primary and metastatic
disease is removed. The data presented in this article supports
aggressive resection of pulmonary metastases in osteogenic sar¬
coma patients.
Soft Part Sarcomas Metastases 97
Joe B. Putnam, Jr.
Pulmonary metastases may be resected safely with associated
long term survival. Regardless of histology, complete resection is
viii CONTENTS
associated with improved survival in most series. Various prog¬
nostic indicators may help clinicians select the optimal treatment
for patients with pulmonary metastases. Novel treatment meth¬
ods such as regional drug delivery or genetic manipulation may
further enhance disease free and overall survival.
Current Management of Colorectal Metastases to Lung 119
Patricia M. McCormack and Robert J. Ginsberg
Colorectal carcinoma is the second most common visceral cancer
in the United States, in both incidence and fatality rate. Of pa¬
tients with colorectal carcinoma, 45% undergo resection and are
cured. In cases of recurrence, 2% are restricted to lung only. A
select group of 287 patients over 30 years at Memorial Sloan
Kettering Cancer Center underwent a surgical approach, which
produced a survival rate of 40% at 5 years and 32% at 10 years.
Kidney Metastases 127
Carolyn M. Dresler
Renal cell carcinoma is not a common malignancy. Unfortunately,
it remains difficult to cure, with small improvements being made
in chemo/immunotherapuetic areas. Surgery remains the most
successful approach for curative treatment in both primary and
metastatic disease. Prospective studies are critically needed to
definitively determine appropriate prognostic indicators for oper¬
ation.
Medical and Surgical Management of Pulmonary
Metastases from Germ Cell Tumors 131
Han Xiao, David Liu, Dean F. Bajorin, Michael Burt, and
George W. Bosl
Cisplatin based chemotherapy is the primary treatment for pa¬
tients with pulmonary metastases from germ cell tumors. Surgical
intervention has an adjuvant role in the management of patients
with residual radiographic findings or patients with progression
of disease despite optimal chemotherapy. The experiences with
pulmonary metastasectomy for disseminated germ cell tumors at
a tertiarty cancer center are presented.
Breast Carcinoma Metastases 145
Gordon A. Bodzin, Edgar D. Staren, and L. Penfield Faber
With careful selection of patients, complete resection of pulmo¬
nary metastases from breast carcinoma may be a useful therapeu¬
tic option. Such a treatment appears to offer a significant survival
benefit when compared with medical treatment alone, or with
incomplete resection.
CONTENTS ix
Isolated Lung Perfusion with Antineoplastic Agents for
Pulmonary Metastases 157
Benny Weksler and Michael Burt
Lung metastases is a major cause of death in cancer patients. A
technique of isolated lung perfusion that uses infusions of high
doses of local chemotherapy was developed in an attempt to
control local disease. This technique prevents systemic side ef¬
fects. Animal experiments have been encouraging and human
trials are pending.
Surgical Resection as the Treatment of Choice for
Melanoma Metastatic to the Lung 183
David W. Ollila and Donald L. Morton
Surgical resection is the only potentially curative treatment for
pulmonary metastases. Operative candidates are patients who
had long disease free interval between excision of the primary
tumor and detection of pulmonary metastases, and whose pulmo¬
nary lesions are slow growing and not accompanied by extrapul
monary involvement. Multiple pulmonary lesions are not an ab¬
solute contraindication to resection.
A New Staging Proposal for Pulmonary Metastases 197
Ugo Pastorino, Patricia M. McCormack, and
Robert J. Ginsberg
In 1991, the International Registry of Lung Metastases was
formed by 18 thoracic surgery departments in Europe and North
America. Statistical analysis of combined data from the Registry
revealed significant variables in patient selection, which helped
to guide treatment modalities for specific patients. A simple sys¬
tem of stage classification is presented in this article as a basis for
discussions on future results and for clinical trial design.
Index 203
Subscription Information Inside back cover
X CONTENTS
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| spelling | Metastatic disease to the lung Patricia M. McCormack, guest ed. Philadelphia [u.a.] Saunders 1998 X, 206 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Chest surgery clinics of North America 8,1 Métastase tumorale Tumeurs du poumon Lung Neoplasms secondary Neoplasm Metastasis Lungenmetastase (DE-588)4168321-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Lungenmetastase (DE-588)4168321-3 s DE-604 McCormack, Patricia M. Sonstige oth Chest surgery clinics of North America 8,1 (DE-604)BV005455558 8,1 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008005095&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Metastatic disease to the lung |
| title_auth | Metastatic disease to the lung |
| title_exact_search | Metastatic disease to the lung |
| title_full | Metastatic disease to the lung Patricia M. McCormack, guest ed. |
| title_fullStr | Metastatic disease to the lung Patricia M. McCormack, guest ed. |
| title_full_unstemmed | Metastatic disease to the lung Patricia M. McCormack, guest ed. |
| title_short | Metastatic disease to the lung |
| title_sort | metastatic disease to the lung |
| topic | Métastase tumorale Tumeurs du poumon Lung Neoplasms secondary Neoplasm Metastasis Lungenmetastase (DE-588)4168321-3 gnd |
| topic_facet | Métastase tumorale Tumeurs du poumon Lung Neoplasms secondary Neoplasm Metastasis Lungenmetastase Aufsatzsammlung |
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