Antiepileptic drug development:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Philadelphia [u.a.]
Lippincott-Raven
1998
|
| Series: | Advances in neurology
76 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVII, 276 S. Ill., graph. Darst. |
| ISBN: | 039751848X |
Staff View
MARC
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| 245 | 1 | 0 | |a Antiepileptic drug development |c ed. Jacqueline A. French ... |
| 264 | 1 | |a Philadelphia [u.a.] |b Lippincott-Raven |c 1998 | |
| 300 | |a XVII, 276 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a Advances in neurology |v 76 | |
| 650 | 7 | |a Anti-epileptica |2 gtt | |
| 650 | 4 | |a Anticonvulsants | |
| 650 | 4 | |a Anticonvulsants |x pharmacology | |
| 650 | 4 | |a Clinical Trials as Topic |x methods | |
| 650 | 4 | |a Drug Evaluation, Preclinical |x methods | |
| 650 | 4 | |a Epilepsy |x Chemotherapy | |
| 650 | 4 | |a Epilepsy |x drug therapy | |
| 650 | 4 | |a Research Design | |
| 650 | 0 | 7 | |a Arzneimittelentwicklung |0 (DE-588)4143176-5 |2 gnd |9 rswk-swf |
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Record in the Search Index
| _version_ | 1804126373742116864 |
|---|---|
| adam_text | Contents
Contributing Authors xi
Preface xv
Acknowledgments xvii
I. Preclinical Antiepileptic Drug Development
1. Mechanism of Action of New Antiepileptic Drugs 1
Marc A. Dichter
2. Mechanism Specific Pathways for New Antiepileptic Drug Discovery 11
Michael A. Rogawski
3. The National Institutes of Health Anticonvulsant Drug
Development Program: Screening for Efficacy 29
H. Steve White, Harold H. Wolf, Jose H. Woodhead, and Harvey Kupferberg
4. Pharmaceutical Industry Screening for New Antiepileptic Drugs 41
Charles P. Taylor and James L. Marks
5. Metabolic Enzymes and Antiepileptic Drug Interactions 49
Rene Levy and Gary G. Mather
II. Clinical Drug Development
6. New Drugs for Persons with Epilepsy 57
David E. Blum
7. AED Doses: From Animals to Humans 89
Ilo E. Leppik
8. Assessing Pharmacokinetic and Pharmacodynamic Drug Interactions
in Clinical Trials of Antiepileptic Drugs 95
Ross A. Reife
9. Novel Methods for Studying New Antiepileptic Drug Pharmacology 105
RichardH. Mattson, RichardD. Scheyer, OgnenA.C. Petroff,
Matthew J. During, Theresa L. Collins, and Dennis Spencer
10. The Art of Antiepileptic Trial Design 113
Jacqueline A. French
11. Reanalysis of Existing Trial Data: What Can Be Learned 125
J. Todd Sahlroot and Gordon W. Pledger
ix
x CONTENTS
12. Monotherapy Trials 133
Elizabeth A. Garofalo
13. The Impact of Foreign Data on a New Drug Application 143
Hal Galbraith and Steven D. Walker
III. Special Populations
14. Issues for Women in Antiepileptic Drug Development 149
Martha J. Morrell
15. Antiepileptic Drug Trials in Children and Adolescents: Is There a Need? .... 161
Jeffrey R. Buchhalter
16. Pediatric Trials: Practical Issues. Special Populations and Trial Design 167
John M. Pellock
17. Clinical Trials for Status Epilepticus 173
David M. Treiman
18. Clinical Trials for Seizure Prevention 179
Nancy R. Temkin, Sureyya S. Dikmen, and H. Richard Winn
IV. Special Issues
19. Alternate Endpoints for Seizure Measurement 189
Joyce A. Cramer
20. Alternate Endpoints: Studies in Quality of Life and
Health Economics of Epilepsy 195
AzmiA. Nabulsi and Karrar H. AH
21. Alternate Endpoint: EEG Assessment of Antiepileptic Drug Efficacy
and Toxicity 209
Eli M. Mizrahi
22. Routine Measurement of New Antiepileptic Drug Concentrations:
A Critique and a Prediction 223
Martin J. Brodie
23. Cognitive and Behavioral Assessments in AED Trials 231
Kimford J. Meador
24. Economic Factors in the Development of New Antiepileptic Drugs 239
Roger J. Porter
25. Recent Issues and Considerations in the Regulation of Antiepileptic Drugs . . 245
Russel G. Katz
26. Ethical and Institutional Review Board Issues 253
Brett E. Skolnick
27. Postmarketing Studies 263
Neil Sussman
Subject Index 267
|
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| id | DE-604.BV011829972 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:16:26Z |
| institution | BVB |
| isbn | 039751848X |
| language | English |
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| physical | XVII, 276 S. Ill., graph. Darst. |
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| series | Advances in neurology |
| series2 | Advances in neurology |
| spelling | Antiepileptic drug development ed. Jacqueline A. French ... Philadelphia [u.a.] Lippincott-Raven 1998 XVII, 276 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in neurology 76 Anti-epileptica gtt Anticonvulsants Anticonvulsants pharmacology Clinical Trials as Topic methods Drug Evaluation, Preclinical methods Epilepsy Chemotherapy Epilepsy drug therapy Research Design Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf Antiepileptikum (DE-588)4142656-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)1071861417 Konferenzschrift 1996 Charleston SC gnd-content Antiepileptikum (DE-588)4142656-3 s DE-604 Arzneimittelentwicklung (DE-588)4143176-5 s French, Jacqueline A. Sonstige oth Advances in neurology 76 (DE-604)BV000000622 76 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007988510&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Antiepileptic drug development Advances in neurology Anti-epileptica gtt Anticonvulsants Anticonvulsants pharmacology Clinical Trials as Topic methods Drug Evaluation, Preclinical methods Epilepsy Chemotherapy Epilepsy drug therapy Research Design Arzneimittelentwicklung (DE-588)4143176-5 gnd Antiepileptikum (DE-588)4142656-3 gnd |
| subject_GND | (DE-588)4143176-5 (DE-588)4142656-3 (DE-588)4143413-4 (DE-588)1071861417 |
| title | Antiepileptic drug development |
| title_auth | Antiepileptic drug development |
| title_exact_search | Antiepileptic drug development |
| title_full | Antiepileptic drug development ed. Jacqueline A. French ... |
| title_fullStr | Antiepileptic drug development ed. Jacqueline A. French ... |
| title_full_unstemmed | Antiepileptic drug development ed. Jacqueline A. French ... |
| title_short | Antiepileptic drug development |
| title_sort | antiepileptic drug development |
| topic | Anti-epileptica gtt Anticonvulsants Anticonvulsants pharmacology Clinical Trials as Topic methods Drug Evaluation, Preclinical methods Epilepsy Chemotherapy Epilepsy drug therapy Research Design Arzneimittelentwicklung (DE-588)4143176-5 gnd Antiepileptikum (DE-588)4142656-3 gnd |
| topic_facet | Anti-epileptica Anticonvulsants Anticonvulsants pharmacology Clinical Trials as Topic methods Drug Evaluation, Preclinical methods Epilepsy Chemotherapy Epilepsy drug therapy Research Design Arzneimittelentwicklung Antiepileptikum Aufsatzsammlung Konferenzschrift 1996 Charleston SC |
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