Molecular basis of medical cell biology:
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Stamford, Conn.
Appleton & Lange
1998
|
| Series: | A Lange medical book
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 231 S. graph. Darst. |
| ISBN: | 0838513840 |
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MARC
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| 100 | 1 | |a Fuller, Gerald M. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Molecular basis of medical cell biology |c Gerald M. Fuller ; Dennis Shields |
| 264 | 1 | |a Stamford, Conn. |b Appleton & Lange |c 1998 | |
| 300 | |a XIV, 231 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a A Lange medical book | |
| 650 | 2 | |a Biologie moléculaire | |
| 650 | 2 | |a Cellules | |
| 650 | 7 | |a Citologia e biologia celular |2 larpcal | |
| 650 | 2 | |a Cytologie | |
| 650 | 4 | |a Cell Biology | |
| 650 | 4 | |a Cytology | |
| 650 | 4 | |a Molecular Biology | |
| 650 | 4 | |a Pathology, Cellular | |
| 700 | 1 | |a Shields, Dennis |e Verfasser |4 aut | |
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Record in the Search Index
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| adam_text | Con
Preface Acknowledgments 1. Different Cell Phenotypes How They Form
The Evolution of a Scientific Discipline 1
Mammalian Cell Phenotypes 2
2. Molecular Architecture Functional Compor
Importance of Membranes in Cell Function 13
Where How Membranes Are Made 16
Types Function of Membrane Lipids 17
Functional Properties of Lipids 21
Specialized Membrane Lipids
in Cell Signaling 24
Protein Lipid Mosaic 29
Membrane Proteins: Physical Chemical
Properties 29
3. Structure Function of Intracellular Organel
Intracellular Movement 39
Cell Nucleus 39
Nuclear Envelope (NE) 42
Nuclear Pore Nuclear Pore Complex 42
Nuclear Localization Signal 43
Mitochondria 43
Mitochondrial Chaperones 48
Peroxisomes 49
Endoplasmic Reticulum 52
The ER Lumen 52
Retention of Proteins in the ER 56
4. Organelles Vesicle Traffic Secretory Pathway 67
Constitutive Secretory Pathway 70
Regulated Secretory Pathway 70
Default Secretion 71
Molecular Events of Vesicle Formation
Movement 72
Vesicle Budding 72
COP I 72
COP II 73
Vesicle Recycling 73
Snares Vesicle Targeting 74
Clathrin Coated Vesicles 75
Vesicle Targeting 75
GTPases: Docking Fusion 76
tents
xiii
xiv
1
Regulation of Gene Expression:
Brief Overview 7
Summary 12
lents of the Cell Membrane 13
Integral Proteins 30
Peripheral Proteins 31
Membrane Cytoskeleton 32
Membrane Faces of Polarized Cells 34
Membrane Specialization 34
Cell Membrane Surface Receptors 35
Mechanism of Transmembrane Signaling 36
Summary 37
les 39
Protein Translocation 57
Signal Recognition Particle 58
Mechanisms of Translocating Secretory
Proteins Monotypic Membrane
Proteins 59
Mechanisms That Determine Polytopic
Proteins 61
Core Glycosylation of Proteins Lipids
Occurs in the ER 61
Membrane Lipid Biosynthesis 63
Membrane Lipid Trafficking Pathways 64
67
Vesicle Transport in Sum 76
Golgi Complex 76
Polarity in the Golgi Complex 76
Biochemical Events in the Golgi 77
Glycosylation Events in the Golgi 78
Traffic Destinations from the Golgi 78
Lysosome 78
Structure Function 78
Disorders of Lysosomal Enzyme Synthesis
Storage 81
Endocytosis 83
Entry of Substances into the Cell by RME 84
Defects in Receptor Mediated Endocytosis 86
Phagocytosis 86
ix
x / CONTENTS
Mechanisms of Particle Uptake by Phagocytes 87
Transcytosis 88
Constitutive vs Regulated Compartments 89
Sorting to Different Sites on the Plasma
Membrane 89
5. Mitochondria Cellular Energy Mitochondria Energy Production 93
The Organization of Mitochondria 93
Oxidation 94
6. The Cell Cycle Cell Division General Principles of the Cell Cycle 106
Phases of the Normal Cell Cycle 106
Duration of the Cell Cycle 107
Lessons From the Frog Egg 107
Maturation Events 107
MPF: Regulator of Mitotic Events 108
Cell Cycle Engine 109
Cyclin B Degradation 110
MPF in Mitotic Events 110
Regulated Passage of Mammalian Cells
Through the Cell Cycle 111
Role of Multiple CDKs Cyclins 111
Checkpoints in Cell Cycle Regulation 112
Inhibitory Proteins of CDK Cyclin
Complexes 112
7. The Cytoskeleton Microtubules the Centrosome 124
Intermediate Filaments 125
Microtubules 128
Microtubules: Selected Clinical Correlates 131
Molecular Motors: Movement Along
Microtubules 131
Cilia Centrioles 132
Actin Filaments 135
Actin Polymerization 136
Actin Binding Proteins 136
8. Cell Junctions, Cell Cell Adhesion, the Ext
Cell Cell Attachment Communication 148
Cell Junctions Adhesion 148
Junctional Complexes 149
Tight Junctions 149
Anchoring Junctions 150
Cell Cell Adherens Junctions 151
Cell Matrix Interactions 153
Hemidesmosomes 153
Integrins 153
Gap Junctions 154
9. Molecular Mechanisms in Signal Transductic
Phosphorylation Cell Signaling 167
Kinases Phosphatases 167
GTPase Families 168
Second Messenger Molecules 168
Extracellular Routes of Signaling
Molecules 169
Medical Aspects of Cell Biology 90
Summary 90
93
Production of Acetyl CoA 97
ATP Synthesis the Respiratory Chain 103
Mitochondria Disease 104
106
Tumor Suppressor Proteins: Clinical
Correlates 113
Apoptosis 114
Cell Senescence Aging 115
Control of the Cell Cycle in Tissues 116
Nondividing Compartment of the
Cell Cycle 117
Unregulated Cell Growth: Clinical
Correlates 117
Key Mechanisms of Cell Division 118
Microtubules, Spindle Formation,
Metaphase 121
Summary 122
124
Actin Cytoskeleton Cancer 138
Cell Signaling, Calcium, Gelsolin 139
Myosins Related Molecules 139
Muscle Like Function in Nonmuscle Cells 140
Microvilli 140
Muscle 141
Skeletal Muscle 141
Muscle Contraction 142
Contractile Machinery of Cardiac
Smooth Muscle 146
racel I ular Matrix 148
Extracellular Matrix 156
Fibroblasts Their Cellular Products 156
Extracellular Matrix in Signal Transduction
Cell Differentiation 156
Collagen 158
Fibronectin 162
Laminin 163
Entactin 164
Cell Adhesion Molecules 164
Signal Transduction Cell Adhesion 165
»n: Basic Cell Signaling Pathways 167
Cellular Responses to Signaling Molecules
by Receptors 171
Communicating Paradigms in Mammalian
Cells 172
Signaling Pathways With Receptors Not Exposed
to the Cell Surface 173
Communication Through Gap Junctions 173
Cell Signaling by Nitric Oxide 173
Lipophilic Ligands Nuclear Receptors 174
Steroid Signaling System 176
Pathways That Include Receptors Exposed
to the Cell Surface 177
G Protein Coupled Receptors Their
Signaling Pathways 177
cAMP Protein Kinase A 184
Mobilization of the Second Messenger Molecule.
Calcium 186
10. Cell Signaling Pathways: Communication
Enzyme Associated Receptors The Receptor Protein Tyrosine Kinases 195
Basic Structure of RPTK Receptors 195
The RPTK Ligands 195
Principles of RPTK Signaling 195
The Src Family of Intracellular Tyrosine
Kinases 201
Protein Phosphatases Signal
Transduction 202
Signal Pathway from Tyrosine Kinase
Associated Receptors 203
Properties of the Non Tyrosine Kinase
Receptors 204
Appendix A: Microscopy Appendix B: Amino Nucleic Acids Index
CONTENTS / xi
PKC Cell Signaling 187
Intracellular Ca2+ Release Channels 189
Calmodulin: A Ubiquitous Calcium Binding
Protein 189
Molecular Basis of Signaling Pathways of Sensory
Cells 189
Molecular Basis of Vision 189
Molecular Basis of Olfaction 191
/ia Enzyme Linked
194
Hematopoietic Cytokine Receptors 206
The Hematopoietic Cytokine Signaling
Pathways 206
Receptors With a Serine Threonine Kinase
Domain 206
Transforming Growth Factor P 206
Signaling Through Integrin Receptors 211
The ECM Integrin Cytoskeleton
Connection 211
Summary 211
213
216
221
|
| any_adam_object | 1 |
| author | Fuller, Gerald M. Shields, Dennis |
| author_facet | Fuller, Gerald M. Shields, Dennis |
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| bvnumber | BV011778226 |
| callnumber-first | Q - Science |
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| ctrlnum | (OCoLC)39786655 (DE-599)BVBBV011778226 |
| dewey-full | 616.07 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.07 |
| dewey-search | 616.07 |
| dewey-sort | 3616.07 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
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| indexdate | 2024-07-09T18:15:36Z |
| institution | BVB |
| isbn | 0838513840 |
| language | English |
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| physical | XIV, 231 S. graph. Darst. |
| publishDate | 1998 |
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| spelling | Fuller, Gerald M. Verfasser aut Molecular basis of medical cell biology Gerald M. Fuller ; Dennis Shields Stamford, Conn. Appleton & Lange 1998 XIV, 231 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier A Lange medical book Biologie moléculaire Cellules Citologia e biologia celular larpcal Cytologie Cell Biology Cytology Molecular Biology Pathology, Cellular Shields, Dennis Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007948976&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Fuller, Gerald M. Shields, Dennis Molecular basis of medical cell biology Biologie moléculaire Cellules Citologia e biologia celular larpcal Cytologie Cell Biology Cytology Molecular Biology Pathology, Cellular |
| title | Molecular basis of medical cell biology |
| title_auth | Molecular basis of medical cell biology |
| title_exact_search | Molecular basis of medical cell biology |
| title_full | Molecular basis of medical cell biology Gerald M. Fuller ; Dennis Shields |
| title_fullStr | Molecular basis of medical cell biology Gerald M. Fuller ; Dennis Shields |
| title_full_unstemmed | Molecular basis of medical cell biology Gerald M. Fuller ; Dennis Shields |
| title_short | Molecular basis of medical cell biology |
| title_sort | molecular basis of medical cell biology |
| topic | Biologie moléculaire Cellules Citologia e biologia celular larpcal Cytologie Cell Biology Cytology Molecular Biology Pathology, Cellular |
| topic_facet | Biologie moléculaire Cellules Citologia e biologia celular Cytologie Cell Biology Cytology Molecular Biology Pathology, Cellular |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007948976&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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