Hormonally active agents in food: symposium
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| Format: | Book |
|---|---|
| Language: | German English |
| Published: |
Weinheim
Wiley-VCH
1998
|
| Subjects: | |
| Online Access: | Publisher description Table of contents Inhaltsverzeichnis |
| Item Description: | Beitr. teilw. dt., teilw. engl. |
| Physical Description: | XVIII, 263 S. Ill., graph. Darst. |
| ISBN: | 3527271392 |
Staff View
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| adam_text | Contents
Vorwort XV
Preface XVII
I Hauptschlufifolgerungen und Empfehlungen 1
1 Einleitung 3
2 Vorkommen und Exposition 3
3 Risikoabschatzung 4
3.1 Stoffe naturlichen Ursprungs 4
3.2 Stoffe anthropogenen Ursprungs 5
3.3 Beobachtungen am Menschen 5
3.4 Zusammenfassende Risikobewertung 6
4 Erkennntnisliicken 6
5 Forschungsbedarf 7
II Main Conclusions and Recommendations 11
1 Introduction . . . 13
2 Occurrence and exposure 13
3 Risk evaluation .14
3.1 Compounds of natural origin 14
3.2 Compounds of anthropogenic origin 14
3.3 Observations in man 15
3.4 Risk evaluation summary 15
4 Gaps in knowledge 15
5 Research needs 17
V
Contents
HI Contributions lg
A General Session
1 Biochemistry and Physiology of Steroid Hormonal Action 21
Patrik Diel and Horst Michna
1.1 Abstract 21
1.2 Introduction 22
1.3 Historical background 22
1.4 Biochemistry 23
1.5 Mechanisms of steroid hormone action 24
1.5.1 Estrogen receptor mediated action 24
1.5.2 The bioflavonoid receptor 25
1.5.3 Non classical mechanisms of estrogen action 26
1.6 Physiology of estrogens action in different target tissues ... 26
1.6.1 Estrogen action on the CNS 27
1.6.2 Estrogens and the immune response 28
1.6.3 Estrogen action on liver 28
1.6.4 Estrogen action in the cardiovascular system 29
1.6.5 Action of estrogens on the bone 30
1 7 Steroid hormones and carcinogenesis 31
18 Issues in predicting the estrogenicity of substances 32
1 9 Further directions in steroid hormone research 34
110 References 34
2 Gene Regulation by Steroid Hormone Receptors 38
Ludger Klein HitpaB, Sabine Kahmann,
Christian Schwerk, and Lothar VaBen
2.1 Abstract 38
22 Steroid receptor structure 38
2.3 Mechanism of action 40
2.4 Activation of unliganded SRs through cross talk with other
signal transduction pathways 42
2.5 Antihormones 43
2.5.1 Antiestrogens .... 43
2.5.2 Antiprogestines 44
2.6 Cross talk eliciting agonist activity of antagonist loaded SRs. 45
27 Conclusions and perspectives 47
2 8 References ... 48
VI
Contents
3 Nuclear Receptors and their Interactions with
Hormonally Active Agents in Food 53
Jan Ake Gustafsson
3.1 Abstract 53
3.2 Introduction 54
3.3 Orphan receptors 55
3.4 PPAR 55
3.5 ERcc and ERp 56
3.6 TCDD receptor 57
3.7 Concluding remarks 60
3.8 References 61
4 Hormonally Active Agents: Genotoxic Effects 62
Manfred Metzler, Sabine E. Kulling, and Erika Pfeiffer
4.1 Abstract 62
4.2 Introduction 62
4.3 Genotoxicity of phytoestrogens 63
4.3.1 Effects on microtubules and induction of micronuclei 64
4.3.2 DNA strand breaks and mutations at the HPRT locus 65
4.4 Genotoxicity of bisphenols 66
4.4.1 Effects on microtubules 67
4.4.2 Metaphase arrest and induction of micronuclei 67
4.5 Discussion 68
4.6 References 69
5 Endocrine Disrupting Contaminants and Alligator Embryos:
A Lesson from Wildlife? 72
Louis J. Cuillette Jr.
5.1 Abstract 72
5.2 Introduction 72
5.3 The alligators of Lake Apopka 74
5.3.1 General biology 74
5.3.2 Population decline and egg viability problems 74
5.3.3 The alligator egg and persistent contaminants 75
5.3.4 Morphological abnormalities of the gonad 76
5.3.5 Hormonal abnormalities in hatchling alligators 76
5.3.6 Hormonal and morphological abnormalities in juveniles. ... 78
5.4 Experimental studies 79
5.4.1 Alligator egg treatments 80
5.4.2 Affinity of the alligator estrogen receptor for
DDT and its metabolites 81
5.4.3 Bioavailability of hormones and hormonally active contaminants 82
5.5 Conclusions 84
5.6 References 85
VII
Contents
6 Relating Exposures to Hormonally Active Agents to Diseases:
Reproductive and Developmental Toxicology 89
John A. McLachlan, Diane M. Klotz, Bridgette M. Collins, Peter M.
Vonier, Judith M. Bergeron, David Crews, and Steven F. Arnold
Abstract 89
B Agents of Natural Origin
7 Risks and Benefits of Phytoestrogen rich Diets 91
Aedin Cassidy
7.1 Abstract 91
7.2 Introduction 92
7.3 Sources and metabolism 94
7.3.1 Isoflavones 94
7.3.2 Lignans 99
7.4 Epidemiology 101
7.5 Animal studies 102
7.6 Biological effects in humans 103
7.7 Other potential mechanisms of action 105
7.8 Potential adverse effects 1°6
7.9 Infant feeding 1°8
7.10 Other potential health benefits 1°9
7.11 Conclusions 11°
7.12 References 1H
8 Inhibition of 17p Hydroxysteroid Oxidoreductase Typ 1
by Phytoestrogens and Structurally Related Compounds H8
S. Makela, L. Salo, and Risto Santti
Abstract H8
9 Metabolic Fate of Dietary Isoflavones in Humans and Animals ... H9
Kenneth D.R. Setchell
Abstract 119
10 Regulation of Intracellular Dioxin (Aryl Hydrocarbon)
Receptor Function by Dietary Indole Derivatives 121
Lorenz Poellinger
10.1 Abstract 121
10.2 Plethora of dietary indole derivatives 121
10.3 Mechanism of signal transduction by the dioxin receptor. . . I22
10.4 Activation of dioxin receptor function 123
VIII
Contents
10.5 The dioxin receptor an orphan receptor for
as yet unidentified classes of physiological substances .... 123
10.6 Regulation of dioxin receptor function by
indolo[3,2 fa]carbazole 124
10.7 References 125
C Dietary Contaminants
11 Developmental Effects and Molecular Mechanisms of
Environmental Antiandrogens 128
W.R. Kelce, L.E. Gray, C. I. Wong, and E.M. Wilson
11.1 Abstract 128
11.2 Introduction 129
11.3 Mechanisms of androgen/antiandrogen action 130
11.4 Sex differentiation and antiandrogen exposure 130
11.5 Environmental antiandrogens: developmental effects and
molecular mechanisms 132
11.5.1 Vinclozolin 132
11.5.2 l,l Dichloro 2,2 bis(p chlorophenyl)ethylene (p,p DDE) .... 133
11.5.3 In vivo confirmation of altered AR gene expression 134
11.6 Testing strategies 136
11.7 References 137
12 Estrogenic Plasticizers and Antioxidants 142
Ana M. Soto, Carlos Sonnenschein, Mary K. Murray, and
Cheryl L. Michaelson
12.1 Abstract 142
12.2 Introduction 143
12.2.1 Explaining the effects of endocrine disruptors 144
12.2.2 Estrogens 145
12.3 Assays to measure estrogenicity 145
12.3.1 The E SCREEN assay 146
12.3.2 Animal bioassays and cell culture assays:
differences and similarities 149
12.4 Cumulative effect of xenoestrogens 150
12.5 Recently identified estrogens 150
12.5.1 Alkylphenols 151
12.5.1.1 Uses 151
12.5.1.2 Biodegradation 151
12.5.1.3 Bioaccumulation 152
12.5.1.4 Sources of human exposure 152
12.5.1.5 Estrogenic activity 152
12.5.2 Phthalates 153
12.5.2.1 Uses 153
IX
Contents
12.5.2.2 Biodegradation 153
12.5.2.3 Biodistribution and bioaccumulation 154
12.5.2.4 Sources of human exposure 154
12.5.2.5 Estrogenic activity 154
12.6 Conclusions 154
12.7 Summary 156
12.8 References 156
13 Bisphenols: In Vitro Effects 161
M. Fatima Olea Serrano, Rosa Pulgar, Pilar Perez,
Manfred Metzler, Vincente Pedraza, and Nicolas Olea
13.1 Abstract 161
13.2 Introduction 162
13.3 Study of the estrogenic effect 165
13.3.1 Cell proliferation experiments in culture 166
13.3.2 Progesterone receptor induction 168
13.3.3 Induction and secretion of pS2 169
13.3.4 Competitive binding assays 171
13.4 Xenoestrogens released from lacquer coatings 172
13.4.1 Estrogenic activity of extracts from lacquer coated cans . . . 173
13.5 Estrogenicity of resin based composites 175
13.6 Computer based study of structure function relationship . . . 176
13.7 Conclusions 177
13.8 References 179
14 Assessment of the Oestrogenic Activity of Bisphenols 181
Friedrich W. Jekat
14.1 Abstract 181
14.2 Introduction 182
14.3 Assessment of bisphenol A 184
14.3.1 Short term assays in vivo 184
14.3.2 Repeated dose studies 186
14.3.2.1 Investigations into fertility 187
14.3.2.1.1 Orientational study 187
14.3.2.1.2 Combined fertility and subsequent subchronic study .... 187
14.3.2.1.3 Assessment of reproducitve capacity in a
continuous breeding study 189
14.3.2.2 Investigations into teratogenicity 193
14.3.2.3 Investigations into chronic toxicity and carcinogenicity .... 194
14.3.3 Summary of repeated dose studies 195
14.4 Discussion 195
14.4.1 Screening assays are pharmacological models 196
14.4.2 Potential receptor mediated effects versus inherent toxicity. . 196
14.4.3 Metabolism 197
I
Contents
14.5 The toxicological paradigm 197
14.6 References 198
15 Estrogenic Activity of Hydroxy lated Poly chlorinated
Biphenyls (PCBs) and their Interactions 200
Stephen H. Safe, K. Connor, K. Ramamorthy, M. Moore, F. Wang,
M. Mustain, I. Chen, T. Zacharewski, B. Gillesby, A. Joyeaux,
P. Balaguer, K. Gaido, L. Leonard, S.C. Maness, and D.P. McDonnell
15.1 Abstract 200
15.2 Introduction 201
15.3 Estrogenic activity of human HO PCBs 201
15.4 Structure estrogenicity relationships for HO PCBs 203
15.5 Estrogenic activities of HO PCB (246) and HO PCB (2345):
Interactive effects 205
15.6 References 206
D Exposure Assessment and Risk Evaluation
16 Estrogenic Agents in Foods for Babies, Infants and Children .... 208
Anthony C. Huggett, Angelika M. Tritscher,
Benoit Schilter, and Elizabeth A. Offord
16.1 Abstract 208
16.2 Introduction 208
16.2.1 Definitions 208
16.2.2 Babies, infants and children versus adults
general considerations 209
16.3 Exposure and effects from estrogenic compounds in foods . . 210
16.3.1 General considerations 210
16.3.2 Natural estrogenic compounds 211
16.3.2.1 Hormones 211
16.3.2.2 Phytoestrogens 211
16.3.3 Synthetic (anti )estrogenic compounds 212
16.3.3.1 PCDDs and PCDFs 212
16.3.3.2 Polychlorinated biphenyls 213
16.3.3.3 Pesticides 214
16.3.3.4 Phthalates 215
16.3.3.5 Bisphenol A (BPA) and bisphenol A diglycidyl ether (BADGE) 215
16.3.3.6 Alkylphenol ethoxylates 216
16.4 Risk assessment 216
16.5 Concluding remarks 218
16.6 References 219
XI
Contents
17 Phytoestrogen Exposure Assessment in Adults:
Use of Urinary Excretion Patterns 222
Johanna W. Lampe, Andrea M. Hutchins,
Susan C. Kan, and Joanne L. Slavin
17.1 Abstract 222
17.2 Introduction 222
17.3 Lignan and isoflavone content of plant foods 223
17.4 Urinary phytoestrogen excretion in response to diet 224
17.5 Physiologic factors influencing phytoestrogen metabolism. . . 227
17.6 Conclusion 228
17.7 References 229
18 Activity of Weakly Estrogenic Mixtures in Mouse Uterus,
MCF7 Cells, and Yeast based Receptor Assays: Lack of Synergism . 232
Kevin W. Caido, Kavita Ramamorthy, Fan Wang,
I. Chen Chen, John D. Norris, Donald P. McDonnell,
Wayne P. Bocchinfuso, Kenneth S. Korach, and Stephen Safe
18.1 Abstract 232
18.2 Introduction 232
18.3 Methods 233
18.3.1 Animals 233
18.3.2 Cell proliferation assays 234
18.3.3 Yeast reporter system 234
18.4 Results 234
18.5 Summary 238
18.6 References 239
19 Endocrine Disrupting Chemicals in Food and the Environment
Public Health Risks and Societal Concerns 240
Janette D. Sherman
19.1 Abstract 240
19.2 Introduction 241
19.3 Teratogenicity of Dursban (Chlorpyrifos) 241
19.4 Early historical examples 245
19.5 Recommendations 248
19.6 References 250
XII
Contents
20 Male Reproductive Capacity and Exposure
to Environmental Chemicals 253
Stephen H. Safe
20.1 Abstract 253
20.2 Temporal changes in sperm quality by meta analysis 254
20.3 Hypothesis: Are estrogens and other endocrine disruptors
responsible for disorders of the male reproductive tract? . . . 254
20.4 Decreased male sperm quality: Is it a global problem?.... 255
20.5 Organochlorine compounds and male reproductive capacity . 257
20.6 References 258
21 Environmental Oestrogens An Industry Viewpoint 260
Sandy J. Kennedy
Abstract 260
Authors Addresses 262
XIII
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| genre | (DE-588)1071861417 Konferenzschrift 1996 Kaiserslautern gnd-content |
| genre_facet | Konferenzschrift 1996 Kaiserslautern |
| id | DE-604.BV011775334 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:15:33Z |
| institution | BVB |
| institution_GND | (DE-588)2007744-0 |
| isbn | 3527271392 |
| language | German English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007946971 |
| oclc_num | 39652953 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-29 DE-29T DE-M49 DE-BY-TUM DE-703 DE-19 DE-BY-UBM DE-739 DE-12 DE-824 DE-473 DE-BY-UBG DE-20 DE-706 DE-521 DE-634 DE-83 |
| owner_facet | DE-355 DE-BY-UBR DE-29 DE-29T DE-M49 DE-BY-TUM DE-703 DE-19 DE-BY-UBM DE-739 DE-12 DE-824 DE-473 DE-BY-UBG DE-20 DE-706 DE-521 DE-634 DE-83 |
| physical | XVIII, 263 S. Ill., graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Hormonally active agents in food symposium Deutsche Forschungsgemeinschaft. Ed.: Gerhard Eisenbrand ... Weinheim Wiley-VCH 1998 XVIII, 263 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Beitr. teilw. dt., teilw. engl. Food contamination -- Congresses Hormones -- Congresses Lebensmittelinhaltsstoff (DE-588)4123619-1 gnd rswk-swf Endokriner Effekt (DE-588)4585797-0 gnd rswk-swf Hormon (DE-588)4025864-6 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1996 Kaiserslautern gnd-content Lebensmittelinhaltsstoff (DE-588)4123619-1 s Hormon (DE-588)4025864-6 s DE-604 Endokriner Effekt (DE-588)4585797-0 s Eisenbrand, Gerhard 1940- Sonstige (DE-588)107304392 oth Deutsche Forschungsgemeinschaft Sonstige (DE-588)2007744-0 oth http://www.loc.gov/catdir/description/wiley033/99194609.html Publisher description http://www.loc.gov/catdir/toc/wiley022/99194609.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007946971&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hormonally active agents in food symposium Food contamination -- Congresses Hormones -- Congresses Lebensmittelinhaltsstoff (DE-588)4123619-1 gnd Endokriner Effekt (DE-588)4585797-0 gnd Hormon (DE-588)4025864-6 gnd |
| subject_GND | (DE-588)4123619-1 (DE-588)4585797-0 (DE-588)4025864-6 (DE-588)1071861417 |
| title | Hormonally active agents in food symposium |
| title_auth | Hormonally active agents in food symposium |
| title_exact_search | Hormonally active agents in food symposium |
| title_full | Hormonally active agents in food symposium Deutsche Forschungsgemeinschaft. Ed.: Gerhard Eisenbrand ... |
| title_fullStr | Hormonally active agents in food symposium Deutsche Forschungsgemeinschaft. Ed.: Gerhard Eisenbrand ... |
| title_full_unstemmed | Hormonally active agents in food symposium Deutsche Forschungsgemeinschaft. Ed.: Gerhard Eisenbrand ... |
| title_short | Hormonally active agents in food |
| title_sort | hormonally active agents in food symposium |
| title_sub | symposium |
| topic | Food contamination -- Congresses Hormones -- Congresses Lebensmittelinhaltsstoff (DE-588)4123619-1 gnd Endokriner Effekt (DE-588)4585797-0 gnd Hormon (DE-588)4025864-6 gnd |
| topic_facet | Food contamination -- Congresses Hormones -- Congresses Lebensmittelinhaltsstoff Endokriner Effekt Hormon Konferenzschrift 1996 Kaiserslautern |
| url | http://www.loc.gov/catdir/description/wiley033/99194609.html http://www.loc.gov/catdir/toc/wiley022/99194609.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007946971&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT eisenbrandgerhard hormonallyactiveagentsinfoodsymposium AT deutscheforschungsgemeinschaft hormonallyactiveagentsinfoodsymposium |