Oligonucleotides as therapeutic agents: [proceedings of the Symposium on Oligonucleotides as Therapeutic Agents, held at Ciba Fundation on 7 - 9 January 1997]
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester [u.a.]
Wiley
1997
|
| Schriftenreihe: | Ciba Foundation: Ciba Foundation symposium
209 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | IX, 250 S. Ill., graph. Darst. |
| ISBN: | 0471972797 |
Internformat
MARC
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Datensatz im Suchindex
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| adam_text | Contents
Symposium on Oligonucleotides as therapeutic agents, held at the Ciba Foundation on 7 9 January 1997
This symposium is based on a proposal made by Ed Irving
Editors: Derek]. Chadwick (Organiser) and GailCardew
M. H. Caruthers Introduction 1
M. Matteucci Oligonucleotide analogues: an overview 5
Discussion 14
K. L. Fearon, B. L. Hirschbein, C. Y. Chiu, M. R. Quijano and G. Zon
Phosphorothioate oligodeoxynucleotides: large scale synthesis and analysis,
impurity characterization, and the effects of phosphorus stereochemistry 19
Discussion 31
E. M. Southern, N. Milner and K. U. Mir Discovering antisense reagents by
hybridization of RNA to oligonucleotide arrays 38
Discussion 44
B. Lebleu, I. Robbins, L. Bastide, E.Vives and J. E. Gee Pharmacokinetics of
oligonucleotides in cell culture 47
Discussion 54
S. Agrawal and R. Zhang Pharmacokinetics of oligonucleotides 60
Discussion 75
C. A. Stein Controversies in the cellular pharmacology of
oligodeoxynucleotides 79
Discussion 89
C. Helene, C. Giovannangeli, A. L. Guieysse Peugeot and D. Praseuth
Sequence specific control of gene expression by antigene and clamp
oligonucleotides 94
Discussion 102
v
vi CONTENTS
B. P. Monia First and second generation antisense oligonucleotide inhibitors
targeted against human c r z^kinase 107
Discussion 119
E. Wickstrom and F. L. Tyson Differential oligonucleotide activity in cell culture
versus mouse models 124
Discussion 137
R.W.Wagner Structure—activity relationships in cell culture 142
Discussion 154
S.T. Crooke Progress in antisense therapeutics discovery and development 158
Discussion 164
A. M. Gewirtz Oligonucleotide therapeutics for human leukaemia 169
Discussion 191
J. J. Rossi Therapeutic applications of catalytic antisense RNAs (ribozymes) 195
Discussion 204
F. Eckstein Exogenous application of ribozymes for inhibiting gene
expression 207
Discussion 212
W. Pieken Efficient process technologies for the preparation of
oligonucleotides 218
Discussion 222
M. Inouye, J. R. Mao,T. Shimamoto and S. Inouye In vivo production of
oligodeoxyribonucleotides of specific sequences: application to antisense
DNA 224
Discussion 233
M. H. Caruthers Summary 235
Index of contributors 240
Subject index 242
j
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| id | DE-604.BV011772857 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:15:30Z |
| institution | BVB |
| isbn | 0471972797 |
| language | English |
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| physical | IX, 250 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
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| publisher | Wiley |
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| series | Ciba Foundation: Ciba Foundation symposium |
| series2 | Ciba Foundation: Ciba Foundation symposium |
| spelling | Oligonucleotides as therapeutic agents [proceedings of the Symposium on Oligonucleotides as Therapeutic Agents, held at Ciba Fundation on 7 - 9 January 1997] [ed.: Derek J. Chadwick ...] Chichester [u.a.] Wiley 1997 IX, 250 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Ciba Foundation: Ciba Foundation symposium 209 Pharmakologie (DE-588)4045687-0 gnd rswk-swf Antisense-Oligonucleotide (DE-588)4371006-2 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1997 London gnd-content Antisense-Oligonucleotide (DE-588)4371006-2 s Pharmakologie (DE-588)4045687-0 s DE-604 Chadwick, Derek J. 1948- Sonstige (DE-588)132635860 oth Ciba Foundation: Ciba Foundation symposium 209 (DE-604)BV000000362 209 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007944914&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Oligonucleotides as therapeutic agents [proceedings of the Symposium on Oligonucleotides as Therapeutic Agents, held at Ciba Fundation on 7 - 9 January 1997] Ciba Foundation: Ciba Foundation symposium Pharmakologie (DE-588)4045687-0 gnd Antisense-Oligonucleotide (DE-588)4371006-2 gnd |
| subject_GND | (DE-588)4045687-0 (DE-588)4371006-2 (DE-588)1071861417 |
| title | Oligonucleotides as therapeutic agents [proceedings of the Symposium on Oligonucleotides as Therapeutic Agents, held at Ciba Fundation on 7 - 9 January 1997] |
| title_auth | Oligonucleotides as therapeutic agents [proceedings of the Symposium on Oligonucleotides as Therapeutic Agents, held at Ciba Fundation on 7 - 9 January 1997] |
| title_exact_search | Oligonucleotides as therapeutic agents [proceedings of the Symposium on Oligonucleotides as Therapeutic Agents, held at Ciba Fundation on 7 - 9 January 1997] |
| title_full | Oligonucleotides as therapeutic agents [proceedings of the Symposium on Oligonucleotides as Therapeutic Agents, held at Ciba Fundation on 7 - 9 January 1997] [ed.: Derek J. Chadwick ...] |
| title_fullStr | Oligonucleotides as therapeutic agents [proceedings of the Symposium on Oligonucleotides as Therapeutic Agents, held at Ciba Fundation on 7 - 9 January 1997] [ed.: Derek J. Chadwick ...] |
| title_full_unstemmed | Oligonucleotides as therapeutic agents [proceedings of the Symposium on Oligonucleotides as Therapeutic Agents, held at Ciba Fundation on 7 - 9 January 1997] [ed.: Derek J. Chadwick ...] |
| title_short | Oligonucleotides as therapeutic agents |
| title_sort | oligonucleotides as therapeutic agents proceedings of the symposium on oligonucleotides as therapeutic agents held at ciba fundation on 7 9 january 1997 |
| title_sub | [proceedings of the Symposium on Oligonucleotides as Therapeutic Agents, held at Ciba Fundation on 7 - 9 January 1997] |
| topic | Pharmakologie (DE-588)4045687-0 gnd Antisense-Oligonucleotide (DE-588)4371006-2 gnd |
| topic_facet | Pharmakologie Antisense-Oligonucleotide Konferenzschrift 1997 London |
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