Apoptosis and cancer:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | German |
| Veröffentlicht: |
Basel ; Freiburg ; Paris [u.a]
Karger Landes Systems
1997
|
| Schriftenreihe: | Oncology
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XI, 265 Seiten Ill., graph. Darst. |
| ISBN: | 3805565798 |
Internformat
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| 245 | 1 | 0 | |a Apoptosis and cancer |c editor Seamus J. Martin |
| 264 | 1 | |a Basel ; Freiburg ; Paris [u.a] |b Karger Landes Systems |c 1997 | |
| 300 | |a XI, 265 Seiten |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
| _version_ | 1804126310777225216 |
|---|---|
| adam_text | Contents
IX Preface
XI Acknowledgment
1 1 Apoptosis and Cancer: An Overview
Seamus J. Martin
1 Introduction
2 Cell Division and Cell Death: A Delicate Balance
4 When Controls on Death Fail
6 Implications for Cancer Therapy
2 9 Apoptosis: An Introduction
Seamus J. Martin
9 Introduction
10 The Process
15 The Stimuli
16 The Machinery of Death
21 The Controls
22 Conclusion
3 25 Apoptosis and Necrosis in Tumors
Neil J. Toft and Mark J. Arends
25 Introduction
26 Morphology of Necrosis and Apoptosis
29 Cell Death and Tumor Growth
30 Control of Cell Death in Tumors
35 Angiogenesis in Tumors
37 Prognosis
38 Cell Death and Anticancer Treatments
40 Conclusions
4 45 Apoptosis and the Cell Cycle
Rati Fotedar, Ludger Diederich and Arun Fotedar
45 Introduction
45 Regulation of Cell Cycle
48 Cell Cycle Regulators, Tumor Suppressors and Apoptosis
56 Conclusion
5 64 Bcl 2 Family Proteins: Role in Dysregulation of Apoptosis
and Chemoresistance in Cancer
John C. Reed
64 Introduction
65 The Bcl 2 Family of Apoptosis Regulating Proteins
68 Interactions Among Bcl 2 Family Proteins
70 Bcl 2 Family Proteins as Determinants of Chemoresponses and Chemoresistance
73 Dysregulation of Bcl 2 Protein Production in Human Malignancies
74 Prognostic Significance of Bcl 2 Family Proteins in Cancer
76 Potential Functions of Bcl 2 Family Proteins
85 Post translational Modifications of Bcl 2 Family Proteins
86 Strategies for Inhibiting Bcl 2 Function in Cancers
88 Summary
6 98 AblTyrosine Kinase and the Control of Apoptosis
Gustavo P. Amarante Mendes and Douglas R. Green
98 Introduction
99 The Abl Family of Tyrosine Kinases
101 Abl and Cellular Transformation
104 The Anti Apoptotic Effect of Abl
7 116 The Roles of p53 in Apoptosis and Cancer
Christopher O. C. Bellamy, Roger Malcomson and Andrew H. Wyllie
116 Introduction
117 p53: Basic Biochemistry
117 The Cellular Response to DNA Damage
119 Apoptosis
120 Growth Arrest
121 DNA Repair
122 p53 Independent Pathways
122 p53 in Cancer
129 The Timing of p53 Dysfunction in Human Cancers
131 Clinical Exploitation of p53
134 Conclusion
8 141 The Retinoblastoma Gene and the Control of Apoptosis
Kay Macleod and Tyler Jacks
141 Introduction
145 Rb and Apoptosis During Development
152 Rb and Apoptosis During Tumorigenesis
156 Why Does Loss of Rb Function Lead to Apoptosis?
157 Conclusions
9 164 Programmed (Apoptotic) Cell Death and Prostate Cancer
Samuel R. Denmeade and John T. Isaacs
164 Abstract
165 Introduction
167 Programmed Cell Death of Normal Prostatic Glandular Cells
Following Androgen Ablation
170 Prostate Gene Expression During PCD Pathway
Induced by Androgen Ablation
171 Cell Kinetics During Progression of Prostate Cancer
173 Role of Cell Proliferation in PCD Process Induced by Castration
174 Therapeutic Implication of PCD For Prostatic Cancer
10 181 Cell Death Regulation in the Kidney and in Renal Neoplasms
Timothy J. McDonnell, Stephen M. Hewitt and Grady F. Saunders
181 Introduction
182 The Role of Bcl 2 in the Developing Kidney
185 Oncogene and Tumor Suppressor Gene Involvement in Cell Death Regulation
in the Kidney
187 Bcl 2 and Renal Neoplasms
11 192 Apoptosis in Leukemia
Sharon L. McKenna and Thomas G. Cotter
192 Introduction
193 Morphological and Biochemical Features of Apoptosis
194 Molecular Mechanisms in Apoptosis
195 bcl 2 Gene Family
199 Abl Tyrosine Kinases
199Fas/Apo l
200 Apoptosis in Hematopoiesis
205 Apoptosis and Leukemogenesis
210 Apoptosis and Drug Resistance
211 Future Perspectives
12 222 Cell Death In Neuroblastoma Tumors
Gerry Melino, Margherita Annicchiarico Petruzzelli, Penny Lovat,
Maria Grazia Farrace, Lucia Piredda and Mauro Piacentini
222 Neuroblastoma: Characteristic and Prognostic Features
225 Role of Insulin Like Growth Factors in the Survival of Neuroblastoma
228 Apoptosis in Neuroblastomas
231 Retinoic Acid Induces Apoptosis in Human Neuroblastoma Cell Lines
234 Post Translational Regulation of Tissue Transglutaminase:
A Hypothesis for the Regulation of Apoptosis
239 Clinical Perspectives
13 245 TNF Based Strategies for Manipulating Apoptosis:
Adjuncts to CancerTherapy
Grace H. W. Wong, Gordon Vehar and Roger L. Kaspar
245 Introduction
247 TNF Signaling of Apoptosis
248 Paradoxical Action of TNF/LT: Protecting Normal Tissue and Sensitizing Tumor Cells
to Chemotherapy or Radiation Treatment
249 Possible Mechanisms of LT Protection Against Oxidative Stress:
Induction of Protective Proteins
250 Potential Mechanisms for Tumor Sensitization:
Activation of Apoptosis Associated Proteases
251 Potential Therapeutic Indications of Modulating Apoptosis
252 Summary and Conclusions
258 Subject Index
|
| any_adam_object | 1 |
| author2 | Martin, Seamus J. 1966- |
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| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.99/407 |
| dewey-search | 616.99/407 |
| dewey-sort | 3616.99 3407 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:15:26Z |
| institution | BVB |
| isbn | 3805565798 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007941316 |
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| physical | XI, 265 Seiten Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Karger Landes Systems |
| record_format | marc |
| series2 | Oncology |
| spelling | Apoptosis and cancer editor Seamus J. Martin Basel ; Freiburg ; Paris [u.a] Karger Landes Systems 1997 XI, 265 Seiten Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Oncology Literaturangaben Krebszelle (DE-588)4128704-6 gnd rswk-swf Apoptosis (DE-588)4291096-1 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Apoptosis (DE-588)4291096-1 s Krebs Medizin (DE-588)4073781-0 s DE-604 Krebszelle (DE-588)4128704-6 s Martin, Seamus J. 1966- (DE-588)118090615 edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007941316&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Apoptosis and cancer Krebszelle (DE-588)4128704-6 gnd Apoptosis (DE-588)4291096-1 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4128704-6 (DE-588)4291096-1 (DE-588)4073781-0 (DE-588)4143413-4 |
| title | Apoptosis and cancer |
| title_auth | Apoptosis and cancer |
| title_exact_search | Apoptosis and cancer |
| title_full | Apoptosis and cancer editor Seamus J. Martin |
| title_fullStr | Apoptosis and cancer editor Seamus J. Martin |
| title_full_unstemmed | Apoptosis and cancer editor Seamus J. Martin |
| title_short | Apoptosis and cancer |
| title_sort | apoptosis and cancer |
| topic | Krebszelle (DE-588)4128704-6 gnd Apoptosis (DE-588)4291096-1 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Krebszelle Apoptosis Krebs Medizin Aufsatzsammlung |
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