IgE regulation: molecular mechanisms
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester [u.a.]
Wiley
1997
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 245 S. |
| ISBN: | 0471971383 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV011717762 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 980114s1997 |||| 00||| engod | ||
| 020 | |a 0471971383 |9 0-471-97138-3 | ||
| 035 | |a (OCoLC)36713269 | ||
| 035 | |a (DE-599)BVBBV011717762 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-12 | ||
| 050 | 0 | |a QR186.8.E2 | |
| 082 | 0 | |a 616.07/98 |2 21 | |
| 245 | 1 | 0 | |a IgE regulation |b molecular mechanisms |c ed. by Donata Vercelli |
| 264 | 1 | |a Chichester [u.a.] |b Wiley |c 1997 | |
| 300 | |a XII, 245 S. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Immune response |x Molecular aspects | |
| 650 | 4 | |a Immune response |x Regulation | |
| 650 | 4 | |a Immunoglobulin Class Switching | |
| 650 | 4 | |a Immunoglobulin E | |
| 650 | 0 | 7 | |a Immunreaktion |0 (DE-588)4133841-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Immunglobulin E |0 (DE-588)4026627-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Regulation |0 (DE-588)4049075-0 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Immunglobulin E |0 (DE-588)4026627-8 |D s |
| 689 | 0 | 1 | |a Regulation |0 (DE-588)4049075-0 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Immunglobulin E |0 (DE-588)4026627-8 |D s |
| 689 | 1 | 1 | |a Immunreaktion |0 (DE-588)4133841-8 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Vercelli, Donata |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007902110&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-007902110 | ||
Datensatz im Suchindex
| _version_ | 1804126255798288384 |
|---|---|
| adam_text | Contents
List of Contributors ix
Preface xi
1 HOW T CELLS DIRECT IgE SWITCHING 1
Sergio Romagnani and Gianfranco Del Prete
1.1 Introduction 1
1.2 Signals involved in IgE production 1
1.3 Modulation of IgE synthesis 6
1.4 Th2 cells: junctional aspects and modulation of development 7
1.5 Conclusions 12
2 IgE REGULATION IN TISSUES 21
Stephen R. Durham, Hannah J. Gould and Qutayba A. Hamid
2.1 Introduction 21
2.2 Human T lymphocyte Th2 responses 21
2.3 Bronchial mucosa 22
2.4 Skin 24
2.5 Nasal mucosa 24
2.6 Local IgE 27
2.7 Influence of treatment on IgE synthesis 30
2.8 Conclusions 33
3 IgE HOMEOSTASIS: IS CD23 THE SAFETY SWITCH? 37
Hannah J. Gould, Rebecca L. Beavil, Rajko Reljic, Jianguo Shi,
Check W. Ma, Brian J. Sutton and Rodolfo Ghirlando
3.1 The starting point 37
3.2 Discovery of FceRII/CD23 and its B cell functions 37
3.3 The function of CD21 in B cell activation 44
3.4 Structure of CD23 and its complexes with IgE and CD21 46
3.5 Model of CD23 function in IgE homeostasis 51
4 GENETIC REGULATION OF TOTAL SERUM IgE LEVELS
AND LINKAGE TO CHROMOSOME 5q 61
Deborah A. Meyers and Eugene R. Bleecker
4.1 Introduction 61
4.2 Genetic epidemiology and familial aggregation 61
4.3 Segregation analysis 62
vi CONTENTS
4.4 Linkage analysis 68
4.5 Conclusions 72
5 IL 4 AND IL 13 IN ATOPY: REGULATION OF PRODUCTION
AND EFFECTS 75
Volker Brinkmann and Bernd Kinzel
5.1 Introduction 75
5.2 Regulation of IL 4 and IL 13 expression 76
5.3 Function of IL 4 and IL 13 83
5.4 Role of IL 4 and IL 13 in atopy 92
5.5 Conclusions 93
6 THE IL 4 PROMOTER IN MAST CELLS AND T CELLS 103
Melissa A. Brown
6.1 Introduction 103
6.2 Cell surface signals that modulate IL 4 expression 103
6.3 Regulatory elements of the IL 4 gene defined in T cells 106
6.4 Regulatory elements of the IL 4 gene defined in mast cells 113
6.5 Conclusions 116
7 CYTOKINE SIGNAL TRANSDUCTION AND ITS ROLE IN ISOTYPE
CLASS SWITCHING 121
Sylvia K. Chai and Paul Rothman
7.1 Introduction 121
7.2 Cytokines and class switching 123
7.3 Regulation of the germline a promoter 124
7.4 IL 4 responsive elements 125
7.5 The CD40 response element 127
7.6 The HMG I(Y) binding site 127
7.7 IL 4 induced cytokine signal transduction incorporates the
JAK/STAT pathway 127
7.8 Regulation of germline e transcripts by STATs 131
7.9 Other possible roles for Stat6 in IgE production 134
7.10 The mechanism of synergy between IL 4 and CD40 135
8 SWITCH TRANSCRIPTS AND CYTOKINE REGULATION OF CLASS
SWITCHING 143
Gregor Siebenkotten and Andreas Radbruch
8.1 Activation of the switch recombination machinery 143
8.2 Sequential switching 145
8.3 Control of switch transcription 145
8.4 Switch transcripts and the mechanism of recombination 146
9 LOCAL AND GENERAL CONTROL ELEMENTS OF
IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION 155
Andrea Bottaro and Frederick W. Alt
9.1 Class switch recombination: mechanism and specificity 155
CONTENTS vii
9.2 Identification and functional dissection of CSR control elements by gene
targeting 160
9.3 Perspectives 169
10 REGULATION OF e GERMLINE TRANSCRIPTION: Q A 179
Alessandra Agresti and Donata Vercelli
10.1 When and where are germline transcripts expressed? 179
10.2 Is IL 4 really necessary for e germline transcription? 180
10.3 Who does what to whom: transcription factors involved in the
regulation of the e germline promoter 182
10.4 Why only B cells? 186
11 ISOTYPE SWITCHING FROM /i TO e IMMUNOGLOBULIN HEAVY
CHAIN GENE IN HUMAN B CELLS AS DETERMINED BY SWITCH
CIRCLE ANALYSIS 191
Ke Zhang and Andrew Saxon
11.1 The rationale of a PCR strategy for detection of switch circular DNA 192
11.2 Direct switch from ^ to e 197
11.3 Sequential switch from/i to s via various y genes 198
11.4 Triple step sequential switch to e via a and y 198
11.5 Secondary deletional recombination as a mechanism for isotype
stabilization 200
11.6 Conclusions 202
12 PRODUCTION OF A FAMILY OF IgE PROTEINS BY ALTERNATIVE
SPLICING OF THE 3 END e RNA 205
Ke Zhang and Andrew Saxon
12.1 Alternative RNA splicing of human e membrane region exons generates
multiple species of e mRNA that encode a family of IgE proteins 206
12.2 Expression of e mRNA isoforms is differentially regulated and disease
associated 214
12.3 Expression of the novel human secreted IgE isoforms as genetically
engineered proteins 218
12.4 Conclusions 219
13 ANTIBODY RECOGNITION OF RECOMBINANT ALLERGENS AND
ALLERGEN FRAGMENTS: EVIDENCE FOR A PREDOMINANTLY
DIRECT CLASS SWITCH TO IgE IN ALLERGIC PATIENTS 225
Rudolf Valenta and Tanja Ball
13.1 Introduction 225
13.2 IgE and IgG recognition of recombinant plant allergens 226
13.3 IgE and IgG recognition of allergen epitopes 227
13.4 Onset of IgE and IgG responses in murine and primate models of Type I
allergy 230
13.5 Induction of IgE and IgG4 responses against allergen epitopes during
hyposensitization therapy 232
13.6 Conclusions and hypothesis 234
Index 237
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV011717762 |
| callnumber-first | Q - Science |
| callnumber-label | QR186 |
| callnumber-raw | QR186.8.E2 |
| callnumber-search | QR186.8.E2 |
| callnumber-sort | QR 3186.8 E2 |
| callnumber-subject | QR - Microbiology |
| ctrlnum | (OCoLC)36713269 (DE-599)BVBBV011717762 |
| dewey-full | 616.07/98 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.07/98 |
| dewey-search | 616.07/98 |
| dewey-sort | 3616.07 298 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01687nam a2200457 c 4500</leader><controlfield tag="001">BV011717762</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">980114s1997 |||| 00||| engod</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0471971383</subfield><subfield code="9">0-471-97138-3</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)36713269</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV011717762</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QR186.8.E2</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.07/98</subfield><subfield code="2">21</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">IgE regulation</subfield><subfield code="b">molecular mechanisms</subfield><subfield code="c">ed. by Donata Vercelli</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Chichester [u.a.]</subfield><subfield code="b">Wiley</subfield><subfield code="c">1997</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XII, 245 S.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immune response</subfield><subfield code="x">Molecular aspects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immune response</subfield><subfield code="x">Regulation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunoglobulin Class Switching</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunoglobulin E</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Immunreaktion</subfield><subfield code="0">(DE-588)4133841-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Immunglobulin E</subfield><subfield code="0">(DE-588)4026627-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Regulation</subfield><subfield code="0">(DE-588)4049075-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Immunglobulin E</subfield><subfield code="0">(DE-588)4026627-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Regulation</subfield><subfield code="0">(DE-588)4049075-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Immunglobulin E</subfield><subfield code="0">(DE-588)4026627-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Immunreaktion</subfield><subfield code="0">(DE-588)4133841-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vercelli, Donata</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007902110&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-007902110</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV011717762 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T18:14:33Z |
| institution | BVB |
| isbn | 0471971383 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007902110 |
| oclc_num | 36713269 |
| open_access_boolean | |
| owner | DE-12 |
| owner_facet | DE-12 |
| physical | XII, 245 S. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Wiley |
| record_format | marc |
| spelling | IgE regulation molecular mechanisms ed. by Donata Vercelli Chichester [u.a.] Wiley 1997 XII, 245 S. txt rdacontent n rdamedia nc rdacarrier Immune response Molecular aspects Immune response Regulation Immunoglobulin Class Switching Immunoglobulin E Immunreaktion (DE-588)4133841-8 gnd rswk-swf Immunglobulin E (DE-588)4026627-8 gnd rswk-swf Regulation (DE-588)4049075-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Immunglobulin E (DE-588)4026627-8 s Regulation (DE-588)4049075-0 s DE-604 Immunreaktion (DE-588)4133841-8 s Vercelli, Donata Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007902110&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | IgE regulation molecular mechanisms Immune response Molecular aspects Immune response Regulation Immunoglobulin Class Switching Immunoglobulin E Immunreaktion (DE-588)4133841-8 gnd Immunglobulin E (DE-588)4026627-8 gnd Regulation (DE-588)4049075-0 gnd |
| subject_GND | (DE-588)4133841-8 (DE-588)4026627-8 (DE-588)4049075-0 (DE-588)4143413-4 |
| title | IgE regulation molecular mechanisms |
| title_auth | IgE regulation molecular mechanisms |
| title_exact_search | IgE regulation molecular mechanisms |
| title_full | IgE regulation molecular mechanisms ed. by Donata Vercelli |
| title_fullStr | IgE regulation molecular mechanisms ed. by Donata Vercelli |
| title_full_unstemmed | IgE regulation molecular mechanisms ed. by Donata Vercelli |
| title_short | IgE regulation |
| title_sort | ige regulation molecular mechanisms |
| title_sub | molecular mechanisms |
| topic | Immune response Molecular aspects Immune response Regulation Immunoglobulin Class Switching Immunoglobulin E Immunreaktion (DE-588)4133841-8 gnd Immunglobulin E (DE-588)4026627-8 gnd Regulation (DE-588)4049075-0 gnd |
| topic_facet | Immune response Molecular aspects Immune response Regulation Immunoglobulin Class Switching Immunoglobulin E Immunreaktion Immunglobulin E Regulation Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007902110&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT vercellidonata igeregulationmolecularmechanisms |