Signal transduction by integrins:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York ; Berlin ; Heidelberg ; London ; Paris ; Tokyo ; Hong K
Springer [u.a.]
1997
Austin, Tex. Landes |
| Series: | Molecular biology intelligence unit
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | 188 S. Ill., graph. Darst. |
| ISBN: | 3540633618 1570594732 |
Staff View
MARC
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| 245 | 1 | 0 | |a Signal transduction by integrins |c Paola Defilippi ... |
| 264 | 1 | |a New York ; Berlin ; Heidelberg ; London ; Paris ; Tokyo ; Hong K |b Springer [u.a.] |c 1997 | |
| 264 | 1 | |a Austin, Tex. |b Landes | |
| 300 | |a 188 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Molecular biology intelligence unit | |
| 500 | |a Literaturangaben | ||
| 650 | 4 | |a Cellular signal transduction | |
| 650 | 4 | |a Integrins |x Physiological effect | |
| 650 | 4 | |a Integrins |x physiology | |
| 650 | 4 | |a Signal Transduction |x physiology | |
| 650 | 0 | 7 | |a Integrine |0 (DE-588)4278201-6 |2 gnd |9 rswk-swf |
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Record in the Search Index
| _version_ | 1804126210688548864 |
|---|---|
| adam_text | I CONTENTS =ji
1. Integrin Structure and Function 1
The Discovery of the Integrin Family 1
The $1 Group 2
The $2 Group 2
The ß7 Group 2
The aV Group 2
Other Integrins 2
Many Integrins Occur in Several Splicing Forms 5
Several Different Receptors Can Bind to the Same Ligand 6
Integrin Expression at the Cell Surface Is Regulated
by Extracellular Stimuli 8
Molecular Structure of a and ß Subunits 8
Integrin Ligand Binding: Identification of the Arg Gly Asp
Sequence 10
The Ligand Binding Pocket in the Integrin Molecule 10
Divalent Cations Regulate Ligand Binding Properties 11
Ligand Binding Can Be Regulated by Cytoplasmic Signals:
Inside Out Signaling 11
Interaction of Integrins with Cytoskeletal and Signaling
Molecules 14
Integrins Can Activate Many Different Signaling Pathways... 16
Integrin Signaling Requires Assembly of a Transduction
Machinery and of Actin Cytoskeleton 17
Integrin Associated Membrane Proteins Are Involved
in Signal Transduction 18
2. Activation of Tyrosine Kinases 29
Protein Tyrosine Kinase Families 29
Adhesion Induced Tyrosine Phosphorylation 29
Fak Family Kinases: Structure, Expression
and Distribution 30
Tyrosine Phosphorylation of Fak Family: Regulation
by Adhesive Events 33
Tyrosine Phosphorylation of Fak Family: Regulation
by Mitogens and Growth Factors 35
Pathways Leading to pl25Fak Tyrosine Phosphorylation 36
pl25Fak Tyrosine Kinase Activity 37
Tyrosine Phosphorylation of Fak Family Leads
to Interactions with SH2 Domain Containing Proteins 38
SH2 Independent Interactions of Fak Family 40
Src Kinases Family 41
Integrin Mediated Activation of Src Family Kinases 41
Zap70/Syk Family Kinases 42
Paxillin 42
pl30Cas 43
Cortactin 44
Tensin 45
Tyrosine Phosphatases Implicated in Integrin Mediated
Signaling 45
Role of PTKs in Integrin Mediated Adhesion 46
3. Lipid Kinase, Phospholipase and PKC Activation 61
Phosphoinositide (PI) Metabolism 61
Phosphoinositide Kinases 61
Regulation of Phosphoinositide Metabolism by Integrins 65
Phospholipases 68
PLCy Activation Through Integrins 71
PLA2 Activation Through Integrins 72
PLD Activation Through Integrins 73
Protein Kinases C 73
PKC Activation Through Integrins 74
4. Intracellular Calcium, pH and Membrane Potential 81
Mechanisms of Intracellular Ca2+ Control 81
Integrins Can Activate Ca2+ Transients 81
Intracellular pH Regulation by Integrins 85
Integrins Can Regulate Membrane Potential 87
5. Activation of MAPK Pathways 91
Pathways Controlling MAPK Activation 91
Integrin Stimulated Erkl/Erk2 Activation 93
Ras Involvement in Integrin Dependent Erk Activation 95
Rho Involvement in Integrin Mediated Erk Activation 97
Jnk Activation by Integrins 98
6. Rho Family GTPases in Actin Cytoskeleton Assembly 101
The Rho Family of Small GTPases 101
Effector Molecules of the Rho Family 102
Rho Regulates Stress Fiber Formation 107
Rac Mediated Lamellipodia Formation 109
CDC42 Controls the Formation of Filopodia 113
GEFs and GAPs for Small GTPases Also Regulate Actin
Cytoskeleton Assembly 113
Regulation of Integrin Mediated Adhesion 116
7. Regulation of Gene Expression 125
Pathways Leading to Gene Regulation 125
Integrin Dependent Regulation of Gene Expression 126
Differentiation of Epithelial Cells Is Affected
by Cell Matrix Interaction 127
Cell Matrix Interaction Regulates the Immune
and Inflammatory Responses in Leukocytes 130
Cell Adhesion Regulates Matrix Protein Synthesis 133
Cell Matrix Interactions Regulate Synthesis
of Matrix Degrading Enzymes 134
Cell Adhesion Regulates Integrin Expression 136
8. Regulation of Cell Growth and Apoptosis 143
Pathways Regulating Cell Cycle Progression 143
Integrins Can Negatively Regulate Cell Growth 144
Specific Integrin Subunits Can Regulate Cell Growth 147
Integrins Promote Cell Growth by Regulating Cyclins
and Rb Protein 148
Integrin Dependent Regulation of Cyclins Is Abnormal
in Neoplastic Cells 151
Lymphocyte Proliferation in Response to Antigen Is
Potentiated by Integrins 152
Integrins May Synergize with Mitogenic Stimuli
in Several Ways 154
Integrins Can Regulate Apoptosis 155
9. Integrin Regulation of Hematopoietic Cell Function 165
Platelets 165
Neutrophils 167
Eosinophils 170
Basophils and Mast Cells 171
Monocytes and Macrophages 172
T Lymphocytes 173
B Lymphocytes 175
Natural Killer (NK) Cells 176
Index 183
|
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| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572/.68 |
| dewey-search | 572/.68 |
| dewey-sort | 3572 268 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Book |
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| id | DE-604.BV011675038 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:13:50Z |
| institution | BVB |
| isbn | 3540633618 1570594732 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007870844 |
| oclc_num | 37214017 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-29 DE-11 |
| owner_facet | DE-355 DE-BY-UBR DE-29 DE-11 |
| physical | 188 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer [u.a.] Landes |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Signal transduction by integrins Paola Defilippi ... New York ; Berlin ; Heidelberg ; London ; Paris ; Tokyo ; Hong K Springer [u.a.] 1997 Austin, Tex. Landes 188 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Literaturangaben Cellular signal transduction Integrins Physiological effect Integrins physiology Signal Transduction physiology Integrine (DE-588)4278201-6 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 s Integrine (DE-588)4278201-6 s DE-604 Defilippi, Paola Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007870844&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Signal transduction by integrins Cellular signal transduction Integrins Physiological effect Integrins physiology Signal Transduction physiology Integrine (DE-588)4278201-6 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| subject_GND | (DE-588)4278201-6 (DE-588)4318717-1 |
| title | Signal transduction by integrins |
| title_auth | Signal transduction by integrins |
| title_exact_search | Signal transduction by integrins |
| title_full | Signal transduction by integrins Paola Defilippi ... |
| title_fullStr | Signal transduction by integrins Paola Defilippi ... |
| title_full_unstemmed | Signal transduction by integrins Paola Defilippi ... |
| title_short | Signal transduction by integrins |
| title_sort | signal transduction by integrins |
| topic | Cellular signal transduction Integrins Physiological effect Integrins physiology Signal Transduction physiology Integrine (DE-588)4278201-6 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| topic_facet | Cellular signal transduction Integrins Physiological effect Integrins physiology Signal Transduction physiology Integrine Signaltransduktion |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007870844&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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