Cytoskeletal membrane interactions and signal transduction:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
Springer [u.a.]
1997
|
| Series: | Molecular biology intelligence unit
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 237 S. Ill., graph. Darst. |
| ISBN: | 3540630791 1570594554 |
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MARC
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Record in the Search Index
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|---|---|
| adam_text | MOLECULAR
BIOLOGY
INTELLIGENCE
UNIT
Cytoskeletal-Membrane
Interactions and Signal
Transduction
Pamela Cowin
New York University Medical Center
New York City, New York, U S A
Michael W Klymkowsky
University of Colorado
Boulder, Colorado, U S A
LANDES
CHAPMAN amp; HALL
•®P An Wn-1 Thomson Pushing Company AUSTIN, TEXAS
IW York • Albany • Bonn • Boston • Cincinnati • Detroit • London • Madrid • Melbourne • un*
o City • Pacilic Grove • Paris • San Francisco Singapore • Tokyo • Toronto • Washington U O A
CONTENTS
1 Cadherins and Their Catenin Adaptors in Mouse
Embryonic Development 1
Jean-Luc Plantier and RolfKemler
Cadherins and Catenins 1
Expression of Cadherins and Catenins
in the Developing Embryo 3
Altering Cadherin and Catenin Functions
Using Genetic Tools 6
Conclusions 7
2 Plakoglobin, the Other ARM
of Vertebrates 13
Julie A Gelderloos, Lora Witcher, Pamela Cowin
and Michael W Klymkowsky
Introduction 13
Desmosomes 13
Plakoglobin Protein Structure 14
The ARM Family
of Proteins 15
Plakoglobin, p-Catenin and Armadillo as Components
of Cell-Cell Junctions 16
The Role of Plakoglobin in Desmosomes 20
The Function(s) of Plakoglobin and its Relatives
at Cell-Cell Junctions 21
Mutational Analysis of Plakoglobin Function 21
Additional Plakoglobin Interactions 22
Why Are There Two Armadillo-Like Polypeptides
in Vertebrates? 22
Plakoglobin in Signaling 23
Summary 25
3 pHO: A Src-Substrate Turned Catenin 31
Albert B Reynolds and Juliet M Daniel
Summary 31
Introduction 31
pl20 Structure and Revised Nomenclature 33
Binding and Colocalization of pi20 with
E-Cadherin Complexes 33
Stoichiometry of the Cadherin—pi 20 Interaction 34
Roles for Alternative Splicing 36
Tyrosine Phosphorylation and pi20 36
pl20 Expression 39
pl20 Subfamily 44
Conclusions 44
4 Band 6 Protein and Cytoskeletal Organization 49
Mechthild Hatzfeld
Summary 49
Introduction 49
Sequence Characteristics and Domain Organization
of B6P and Related Proteins 50
Structure of B6P Family Members 50
RNA Expression and Splice Variants of B6P
Family Members 51
Cell Type Specific Expression and Intracellular
Localization of B6P Family Members 52
B6P Binding Proteins 55
Function of B6P and Related Proteins 56
Conclusion 57
5 Components of the Wnt Signaling Pathway 61
Udo Hacker and Norbert Perrimon
Introduction 61
Segment Polarity in the Drosophila Embryonic
Ventral Epidermis 62
The Wingless Signaling Pathway in Drosophila 63
A Model for Wingless Signaling 65
A Receptor for Wingless 66
Completing the Picture 68
Perspectives 69
6 Glycogen Synthase Kinase-3: A Component of Multiple
Signaling Pathways 73
Cynthia Yost, Sarah B Pierce, Monica Torres,
Randall T Moon and David Kimelman
Introduction 73
Growth Factor and Hormonal Regulation of GSK-3 74
Wnt Pathway and the Regulation of GSK-3 75
Dorsal Axis Determination in Xenopus—
Evidence for a Novel Mode of GSK-3 Regulation? 79
How Is GSK-3 Regulated? 80
Conclusions 81
7 The Role of Patterning Genes
in Epidermal Differentiation 87
Sarah Millar
Introduction 87
The Biology of Skin 87
Control of Epidermal Proliferation and Stratification 90
Regional Patterning in the Epidermis 92
Dermal-Epidermal Interactions in Hair Follicle Induction 93
Control of Hair Growth in the Adult 94
Future Developments 96
8 Role for the Tumor Suppressor Adenomatous Polyposis
Coli Protein in Epithelial Cell Migration and
Adhesion: A Hypothesis 103
Inke S Nathke, Angela I M Barth, W James Nelson
Introduction 103
The Adenomatous Polyposis Coli Gene 104
Cell Migration and Colon Cancer 106
Role of Catenins in the Context of APC 107
9 Regulation of Cadherin Activity by G Proteins
and the Actin Cytoskeleton I l l
Carol L Williams
Introduction I l l
Cadherin Activity is Dynamically Regulated 112
Interactions with the Actin Cytoskeleton Affect
Cadherin Activity 114
Physiological Signals May Alter Cadherin Activity
by Reorganizing the Actin Cytoskeleton 117
Rho Proteins Regulate the Organization
of the Actin Cytoskeleton 119
Rho Proteins May Regulate Cadherin Activity
by Reorganizing the Actin Cytoskeleton 120
Future Directions 121
10 Interactions Between Protein Tyrosine Phosphatases
and Cell Adhesion Molecules 127
Jan Sap
Introduction 127
Protein Phosphorylation and Cell Adhesion 127
The Protein Tyrosine Phosphatase Family 128
PTPases at the Adherens Junction 129
Signaling Complexes in Neuron-Glia Junctions 133
Possible Functional Consequences of R-PTPase/CAM
Association 136
11 The LAR Subfamily of Transmembrane Protein Tyrosine
Phosphatases: Potential Regulators of Cell-Matrix
Interactions 143
Michel Streuli and Haruo Saito
Introduction 143
The LAR Subfamily of Protein Tyrosine Phosphatases
(PTPases) 144
LAR Family PTPases Have Cell Adhesion Molecule
(CAM)-Like Extracellular Regions 144
Two-Subunit Structure and Shedding
of LAR-Like PTPases 145
Characterization of the LAR Family PTPase Domains 146
Tissue Expression of LAR Family Members 146
LAR Localizes to Focal Adhesions 147
LAR Binding Protein LIP l and LAR Colocalize
at Focal Adhesions 148
LAR Binds the Rac and Rho Guanine Nudeotide
Exchange Factor Trio 148
Impaired Mammary Gland Development in
LAR-Deficient Mice 149
DLAR Controls Motor Axon Guidance in Drosophila 150
Summary 150
12 The MARCKS Family of Protein Kinase C Substrates;
Versatile Regulators of Actin Structure at the Membrane 157
David Underhill and Alan Aderem
Introduction 157
The Myristoylated, Alanine-Rich, C Kinase
Substrate, MARCKS 157
The Myristoyl-Electrostatic Switch 159
Regulation of Signal Transduction by PIP2 Sequestration 159
Biological Functions 160
MacMARCKS 161
Biological Functions of MacMARCKS 161
Conclusions 163
13 Intermediate Filament Cytoarchitecture and BPAG1:
A Gene Encoding Two Different Types of Intermediate
Filament Linker Proteins 167
Elaine Fuchs, Yanmin Yang, James Dowling,
Qian-Chun Yu and Lifei Guo
Introduction 167
IF-Membrane Associations in Basal Epidermal Cells 168
What Are the Differences Between Integrins that Anchor
to Keratin IFs and Those that Associate with the Actin
Cytosketon? 171
A Novel Splice Form of BPAG1 in the Nervous System 172
What Is the Function of Proteins that Integrate IFs
to Other Cytoskeletal Components? 174
How Widespread Is Linkage Between IFs and Actin
in Mammalian Cells? 175
Summary 175
14 The Role of the Desmosomal Plaque Protein Desmoplakin
in Intermediate Filament Anchorage
and Junction Assembly 181
ElayneA Bornslaeger, Andrew P Kowalczyk, Jin-Jun Meng,
Wallace Ip and Kathleen J Green
Introduction 181
Desmosome Structure and Components 181
The Structure of Desmoplakin and Related Proteins 183
Interaction of the DP C-Terminal Domain with IF 184
Interaction of the DP N-Terminal Domain
with the Cytoplasmic Face of the Desmosomal Plaque 185
DP Is Required for Anchoring IF to the Desmosome 187
Possible Role for DP in the Segregation
of Cell-Cell Adhesive Junctions 189
Possible Roles for Desmosomes as Targets
and Transducers of Signalling Pathways 191
15 The ERM Family of Proteins and Their Roles
in Cell-Cell Interactions 199
Brooke M McCartney and Richard G Fehon
Introduction 199
ERM Proteins Associate with the Actin Cytoskeleton
and with Transmembrane Proteins 201
Regulation of ERM Function 202
In Vivo Studies of ERM Function 204
Merlin and the Regulation of Cell Proliferation 205
Conclusion 206
16 MAGUKs as Organizers of Cytoarchitecture
and Cell Signaling 211
Colleen D Hough and Peter J Bryant
Introduction 211
MAGUK Subclassification 215
Drosophila MAGUKs 217
Conclusions 221
Index 227
|
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| indexdate | 2024-07-09T18:11:49Z |
| institution | BVB |
| isbn | 3540630791 1570594554 |
| language | English |
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| physical | 237 S. Ill., graph. Darst. |
| publishDate | 1997 |
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| spelling | Cytoskeletal membrane interactions and signal transduction Pamela Cowin ... New York [u.a.] Springer [u.a.] 1997 237 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Biomembran (DE-588)4006884-5 gnd rswk-swf Zellskelett (DE-588)4121944-2 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Zellkommunikation (DE-588)4136131-3 gnd rswk-swf Zellkommunikation (DE-588)4136131-3 s Biomembran (DE-588)4006884-5 s Zellskelett (DE-588)4121944-2 s DE-604 Signaltransduktion (DE-588)4318717-1 s Cowin, Pamela 1954- Sonstige (DE-588)11568865X oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007782121&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cytoskeletal membrane interactions and signal transduction Biomembran (DE-588)4006884-5 gnd Zellskelett (DE-588)4121944-2 gnd Signaltransduktion (DE-588)4318717-1 gnd Zellkommunikation (DE-588)4136131-3 gnd |
| subject_GND | (DE-588)4006884-5 (DE-588)4121944-2 (DE-588)4318717-1 (DE-588)4136131-3 |
| title | Cytoskeletal membrane interactions and signal transduction |
| title_auth | Cytoskeletal membrane interactions and signal transduction |
| title_exact_search | Cytoskeletal membrane interactions and signal transduction |
| title_full | Cytoskeletal membrane interactions and signal transduction Pamela Cowin ... |
| title_fullStr | Cytoskeletal membrane interactions and signal transduction Pamela Cowin ... |
| title_full_unstemmed | Cytoskeletal membrane interactions and signal transduction Pamela Cowin ... |
| title_short | Cytoskeletal membrane interactions and signal transduction |
| title_sort | cytoskeletal membrane interactions and signal transduction |
| topic | Biomembran (DE-588)4006884-5 gnd Zellskelett (DE-588)4121944-2 gnd Signaltransduktion (DE-588)4318717-1 gnd Zellkommunikation (DE-588)4136131-3 gnd |
| topic_facet | Biomembran Zellskelett Signaltransduktion Zellkommunikation |
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