Chemistry and biology of pteridines and folates 1997: proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15 - 20, 1997
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| Language: | English |
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1997
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| Series: | Blackwell science
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| Physical Description: | XXVI, 894 S. graph. Darst. |
| ISBN: | 3826331850 |
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| adam_text | IMAGE 1
I
- -- UNIVERSFTATSBIBLIOTHEK HAMMOVER TECHNISCH EINF0RMATIONSBIBLI0THEK
EDITORS WOLFGANG PFLEIDERER * HARTMUTROKOS CHEMISTRYANDBIOLOGY OF
PTERIDINESANDFOLATES 1997 PROCEEDINGS OF THE ELEVENTH INTERNATIONAL
SYMPOSIUM ON PTERIDINES AND FOLATES, BERCHTESGADEN, GERMANY,JUNE
15-20,1997 ADVISORY COMMITTEE MEMBERS JUNEAYLING, PETER BEARDSLEY,
STEPHEN BENKOVIC, RAYMOND BLAKLEY,NENAD BLAU, GENE BROWN, RICHARD
COTTON, H.-CH. CURTIUS, JOHN GALIVAN,SANDRA GHISLA, HIROYUKI HASEGAWA,
FRANK HUENNEKENS, ROY KISLIUK,ROBERT LEVINE, MICHAEL MARIETTA, ROWENA
MATTHEWS, GOPAL NAIR, JAMES PIPER, K. V. RAJAGOPALAN, EDWARDTAYLOR,
YASUYOSHI WATANABE,MICHAEL WHITEHEAD, HAMISH WOOD, JEONGBINYIM BLACKWELL
SCIENCE BERLIN * VIENNA * OXFORD * EDINBURGH * BOSTON * LONDON MELBOURNE
* PARIS * TOKYO
IMAGE 2
CONTENTS
I CHEMISTRY
PTERIDINES AND FOLATES 1
UNEXPECTED AND FACILE BRIDGEHEAD SUBSTITUTION IN
4,5,6,7,8,9-HEXAHYDRO5,9-METHANO-PYRIMIDO[4,5B]AZOCIN-10-(LH)-ONES.
RAPID ENTRY INTO A SERIES OF POTENTIAL CHEMOTHERAPEUTIC AGENTS TAYLOR E.
C, DOWLING J. E., SCHRADER T 3
STUDIES ON INHIBITORS OF FOLATE BIOSYNTHESIS: SYNTHESIS OF 6-SUBSTITUTED
PTERINS GIBSON C. L., LANG A., SUCKLING C. J., RICE M. J 11
REGIOSELECTIVE SYNTHESIS OF 6-SUBSTITUTED LUMAZINES BY USING HIGHLY
REACTIVE
LUMAZINE 6-TRIFLATE MURATA S., MURAKAMI K., SEO C, SUGIMOTO T., KUJIME M
17
INTERACTIONS OF HYDROGENATED PTERINS WITH METAL COMPLEXES; PROBES FOR
THE REACTION CENTERS IN PTERIN DEPENDENT METALLOENZYM.ES FISCHER B., VOM
ORDE M., LEIDENBERGER K., PACHECO A., BIGLER L 23
PREDICTION OF UV-VISIBLE SPECTRA OF PTERIN PIGMENTS GREADY J. E.,
WORMELL P 29
ON THE MECHANISM OF ACTION OF GTP-TRANSFORMING ENZYMES DUFTON M. J.,
GIBSON C. L., PITT A. R., ATHMANI S., SUCKLING C. J 35
SIDE CHAIN REACTIONS OF 6-ACETYL-L,3,7-TRIMETHYLLUMAZINE KIM Y., KIM J.,
KANG Y 41
STRUCTURAL ELUCIDATIONS OF
3R,4S-DIHYDROXY-8-METHYLMERCAPTO-6-OXO3,4,4A(R,S),5,6,7,10,10A(S,R)-OCTAHYDRO-5,10H-PYRANO[3,2-P]PTERIDME
BY 2D NMR SPECTROSCOPY KIM SUNGJOONG, KIM SUNGJIN, KANG Y 45
SYNTHESIS OF V-0-, 2 -0-, AND
L ,2,~DI-0-(/?-D-GLUCOPYRANOSYL)-L-BIOPTERIN
HANAYA T., SORANAKA K., YAMAMOTO H., PFLEIDERER W 49
SYNTHESIS AND ANTI-AIDS ACTIVITY OF SEVERAL 7- AND
6-POLYHYDROXYALKYLPTERIDINES
LOPEZ M. D., QUIJANO M. L., SANCHEZ A., NOGUERAS M., LOW J. N.,
FERGUSON G 53
IMAGE 3
SYNTHESIS AND ANTIVIRAL ACTIVITY OF SEVERAL
6-(METHYLENE-CARBOMETHOXY)PTERIDIN4,7-(3#,8#)-DIONES MOLINA S., COBO J.,
MELGUIZO M., NOGUERAS M., SANCHEZ A., ORTIZ A.,
DE CLERQ E 57
CHEMICAL MODELS FOR THE ACTIVE CENTRE OF COPPER CONTAINING AMINO ACID
HYDROXYLASES
LEIDENBERGER K., VOM ORDE M., FISCHER B., KOPF M. A., LEE D. H., KARLIN
K. D 61
FUNCTIONAL MODEL SYSTEMS FOR THE REACTION CENTRE IN IRON AND PTERIN
DEPENDENT PHENYLALANINE HYDROXYLASE VOM ORDE M., LEIDENBERGER K.,
FISCHER B 65
A SIMPLE PROCEDURE TO INTRODUCE AN ARYL GROUP TO PTERIDINE RING BY
ARENEDIAZONIUM SALTS IN AN ALKALINE SOLUTION
SUGIMOTO T., SEO C, PFIEIDERER W 69
SYNTHETIC STUDIES ON 5,10-METHYLENE-5,10-DIDEAZAAMINOPTERIN DEGRAW J,
I., CHRISTIE P. H., COLWELL W. T 73
THE SYNTHESIS OF FOLIC ACID, MULTIPLY LABELLED WITH STABLE ISOTOPES, FOR
BIO-AVAILABILITY STUDIES IN HUMAN NUTRITION
MAUNDER P., FINGLAS P. M., MALLET A. I., MELLON F. A., RAZZAQUE M. A.,
RIDGE B., VAHTERISTO L., WITTHOFT C 77
II ANTIFOLATES
SYNTHESIS, BIOLOGICAL EFFECTS 81
SYNTHESIS OF
N-{4-[2-(2-AMMO-3,4-DIHYDRO-4-OXO-7#-PYRROLO[2,3-C/]-PYRIMIDIN5-YL)ETHYL]BENZOYL}-L-GLUTAMIC
ACID (LY231514) AND ANALOGUES
TAYLOR E. C, KUHNT D., SHIH C 83
THYMIDYLATE SYNTHASE AS A TARGET FOR ANTIFOLATE CANCER CHEMOTHERAPY
JACKMAN A. L 93
MUTANT DIHYDROFOLATE REDUCTASE GENES FOR THE AMELIORATION OF
ANTIFOLATE-INDUCED MYELOSUPPRESSION AND FOR IN VIVO SELECTION OF
GENE-MODIFIED HEMATOPOIETIC CELLS PATEL M., MAREYA S. M., SLEEP S. E.
H., SPENCER T. H., BLAKLEY R. L., ALLAY J. A., SORRENTINO B, P 99
REGULATION OF CARRIER-MEDIATED TRANSPORT OF FOLATES AND ANTIFOLATES IN
METHOTREXATE-SENSITIVE AND RESISTANT LEUKEMIA CELLS
JANSEN G., KATHMANN I., WESTERHOF G. R., SMID K., NOORDHUIS P., PETERS
G. J., SCHORNAGEL J. H., RATNAM M., MCALINDEN T. P., FREISHEIM J. H.,
BUNNI M., PRIEST D. G., SPRECHER H., ASSARAF Y. G ILL
SYNTHETIC APPROACHES TO MULTITARGETED ANTIFOLATE LY231514 BARNETT C. J.,
WILSON T. M., KOBIERSKI M. E 123
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ANALOGS OF METHOTREXATE IN RHEUMATOID ARTHRITIS DEGRAW J. I., COLWELL W.
T., PIPER J. R., WAUD W. R., SIROTNAK F. M., SMITH R. L 127
DHFR-INHIBITING INSECTICIDES: 2,4-DIAMINO-6-ARYL-QUINAZOLINES PEAKE C.
J., AVOR K. S., BENNETT B. D., BUSER J. W., BUSHMAN D. W., CHAGUTURU M.
K., CRUICKSHANK P. A., CULLEN T. G., DARGAR R. V., DYBAS J.A.,
FIORDELISO J., HENRIE II R. N., LEW A. C, LIN S. Y.,
OLIPHANT A. C, PAYNE G. T., PLUMMER E. L., PLUMMER M. J., RAY P. S.,
WILLUT J. M., YEAGER W. H 133
NOVEL CYCLOPENTA[G]QUINAZOLINE DIPEPTIDE ANTIFOLATES: THYMIDYLATE
SYNTHASE INHIBITORS WITH ACTIVITY INDEPENDENT OF THE REDUCED-FOLATE
CARRIER AND
FOLYLPOLYGLUTAMATE SYNTHETASE (FPGS) MELIN C, KIMBELL R., BRUNTON L.,
BAVETSIAS V., MARRIOTT J. H., JACKMANA. L., BOYLE F. T 139
EFFECT OFDIFFERENT LEUCOVORIN FORMULATIONS ON 5-FIUOROURACIL INDUCED
THYMIDYLATE
SYNTHASE INHIBITION IN COLON TUMORS AND NORMAL TISSUES FROM PATIENTS IN
RELATION TO RESPONSE TO 5-FLUOROURACIL PETERS G. J., VAN DER WILT C. L.,
VAN GROENINGEN C. J., PRIEST D. G., SCHMITZ J., SMID K., MEIJER S.,
NOORDHUIS P., HOEKMAN K., PINEDO H. M 145
LOSS OF HYDROGEN BONDING CAUSED BY ONE DHFR AMINO ACID MUTATION CAUSES
TRIMETHOPRIM RESISTANCE IN STAPHYLOCOCCUS AUREUS DALE G. E., HARTMAN P.
G., OEFNER C, THEN R 151
A NOVEL MECHANISM OF RESISTANCE TO POLYGLUTAMATABLE ANTIFOLATES IN HUMAN
CEM LEUKEMIA CELLS MAURITZ R., KATHMANN I., PINEDO H. M., PETERS G. J.,
JANSEN G., SCHORNAGEL J., PRIEST D. G., BUNNI M., DRORI S., SPRECHER H.,
ASSARAF Y. G.. . .157
HUMAN CIRCADIAN RHYTHMS IN ANTIFOLATE AND FLUOROPYRIMIDINE DEVELOPMENTAL
THERAPEUTICS
HRUSHESKY W. J. M., WOOD P. A 163
EFFECT OF COMBINED ANTIFOLATES-TRIMETREXATE AND SULPHONYLDERIVATIVES OF
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID ON FOLATE METABOLISM IN MURINE CELLS
CULTURED IN VITRO
BALINSKA M., BARTUZI K., JANISZEWSKA D., SZABLEWSKA L, TARNAWSKI J.,
PAWELCZAK K 169
MECHANISMS OF METHOTREXATE RESISTANCE AND ITS CIRCUMVENTION BY NOVEL
ANTIFOLATES IN CHILDHOOD LEUKEMIA
ROTS M. G., PIETERS R., VAN ZANTWIJK C. H., VEERMAN A. J. P., NOORDHUIS
P., PETERS G. J., JANSEN G 175
IMAGE 5
BIOCHEMICAL PHARMACOLOGY STUDIES OF A MULTITARGETED ANTIFOLATE: LY231514
SHIH C, BEARDSLEY G. P., CHEN V. J., EHLHARDT W. J., MACKELLAR W. C,
MENDELSOHN L. G., RATNAM M., SCHULTZ R. M., TAYLOR E. C, WORZALLA J. F.
... 181
CELL CYCLE ALTERATIONS INDUCED BY LY231514: CORRELATION WITH
CYTOTOXICITY TONKINSON J. L., VIEGAS V., MENDELSOHN L. G 189
PHASE II STUDIES IN SOLID TUMORS WITH LY231514, A MULTITARGETED
ANTIFOLATE (MTA) THORNTON D. E., JOHN W., LOERHER P., EISENHAUER E 195
BRIDGE REGION VARIATION OF 2-AMINO-4-OXO-5-SUBSTITUTED
PYRROLO[2,3- F]PYRIMIDINES AS CLASSICAL AND NONCLASSICAL ANTIFOLATES
GANGJEE A., ELZEIN E., VIDWANS A., KISLIUK R. L., MCGUIRE J. J., QUEENER
S. F 201
SYNTHESIS AND ANTITUMOUR ACTIVITY OF CYCLOPENTA[G]QUINAZOLINE-BASED
ANTIFOLATES, A NOVEL CLASS OF THYMIDYLATE SYNTHASE (TS) INHIBITORS
BAVETSIAS V., MARRIOTT J. H., MELIN C, KIMBELL R., JACKMAN A. L., BOYLE
F. T 205
ARNINOMETHYL PYRIDINE ANALOGUES OF THE QUINAZOLINE ANTIFOLATE ICI 198583
WITH A FOLATE-INDEPENDENT LOCUS OF ACTION SKELTON L. A., KIMBELL R.,
JACKMAN A. L., BOYLE F. T 209
CRYSTAL-STRUCTURE-BASED DESIGN AND SYNTHESIS OF AGENTS AGAINST
PNEUMOCYSTIS CARINII AND TOXOPLASMA GONDII PIPER J. R., BORHANI D. W.,
JOHNSON C. A., KRAUTH C. A., QUEENER S. F 213
NEW INHIBITORS OF TRIMETHOPRIM-RESISTANT STAPHYLOCOCCAL DIHYDROFOLATE
REDUCTASES
GUERRY P., HARTMAN P. G., LOCHER H., JOLIDON S., BROGER C, OEFNER C,
GMUNDER H., THEN R 217
THE DESIGN, SYNTHESIS AND SELECTIVE PNEUMOCYSTIS CARINII DIHYDROFOLATE
REDUCTASE INHIBITORY ACTIVITIES OF NEW 2,4-DIAMINO-5-SUBSTITUTED FURO-
[2,3-D]PYRIMIDINES GANGJEE A., GUO X., QUEENER S. F., CODY V 221
ENZYMATIC HYDROLYSIS OF SOFT DRUG MODELS OF ANTIFOLATES
GRAFFNER-NORDBERG M., SJODIN K., TUNEK A., HALLBERG A 225
ROLE OF CELL CULTURE MEDIUM FOLATE LEVELS ON GROWTH INHIBITION BY
THYMIDYLATE SYNTHASE INHIBITORS IN SQUAMOUS CELL CANCER AND COLON CANCER
CELL LINES BACKUS H. H. J., WOUTERS D., VAN DER WILT C. L., JANSEN G.,
KUIPER C. M., VAN GROENINGEN C. J., PINEDO H. M., PETERS G.J 229
THE EFFECTS OFFOLATE DIASTEREOISOMERS ON THE BINDING OF
5-FLUORO-2 -DEOXYURIDINE5 -MONOPHOSPHATE TO BACTERIAL THYMIDYLATE
SYNTHASE SMID K., VAN DER WILT C. L., PINEDO H. M., PETERS G.J 233
IMAGE 6
MULTILAYERED TUMOR CELL LINE CULTURES AS IN VITRO DRUG SCREENING MODEL
FOR NEW THYMIDYLATE SYNTHASE (TS) INHIBITORS SMID K., SMITSKAMP-WILMS
E., JANSEN G., PINEDO H. M., PETERS G. J 237 A PHARMACODYNAMIC STUDY OF
THE ANTIFOLATE THYMIDYLATE SYNTHASE INHIBITOR TOMUDEX IN ADVANCED
COLORECTAL CANCER FARRUGIA D. C, CUNNINGHAM D., MITCHELL F-, AHERNE G.
W., MACVICAR D., MCCARTHY K., NORMAN A. R., JACKMAN A. L., DANENBERG K.,
METZGER R., LENZ H. J., DANENBERG P. V 241
COMBINATION STUDIES OF ANTIFOLATES WITH 5-FLUOROURACIL IN COLON CANCER
CELL LINES VAN DER WILT C. L., KUIPER CM., PINEDO H. M., PETERS G.J 245
IN VITRO STUDIES WITH ZD1694 (TOMUDEX) AND SN38 IN HUMAN COLON TUMOUR
CELL LINES
KIMBELL R., JACKMAN A. L 249
ALTERED METABOLISM OF (ANTI)FOLATES IN PYRIMETHAMINE RESISTANT CHINESE
HAMSTER OVARY CELLS JANSEN G., KATHMANN I., PETERS G. J., BUNNI M.,
PRIEST D. G., BARR H. M., ASSARAF Y. G 253
MECHANISMS OF RESISTANCE AGAINST METHOTREXATE AND NOVEL ANTIFOLATES IN
HUMAN CCRF-CEM LEUKEMIA CELLS KATHMANN I., MAURITZ R., NOORDHUIS P.,
VOORN D., AARDEWIJN P., PINEDO H. M., PETERS G. J., JANSEN G.,
SCHORNAGEL J. H., BUNNI M., PRIEST D. G 257
THE ROLE OF FOLATES IN THE CHEMOSENSITIVITY TO TOMUDEX, LY231514, AND
5-FLUOROURACIL/LEUCOVORIN OF MURINE COLON TUMOUR MODELS VAN DER WILT C.
L., SMID K., VEERMAN G., WOUTERS D., SCHMITZ J., PRIEST D. G., PINEDO H.
M., PETERS G.J 263
PRECLINICAL ACTIVITY OF PT523 IN RELATION TO TRANSPORT PETERS G. J.,
BRAAKHUIS B. J. M., ROSOWSKY A., ROTS M., PIETERS R., VAN DER WILT C.
L., SMID K., PINEDO H. M., JANSEN G 267
DEOXYURIDINE TRIPHOSPHATASE (DUTPASE) EXPRESSION AND CELLULAR RESPONSE
TO THYMIDYLATE SYNTHASE (TS) INHIBITORS BROWN S. D., HARDCASTLE A.,
AHERNE G. W 271
III FOLATES
A NUTRITION, NEURAL TUBE DEFECT, HOMOCYSTEINEMIA 275
GOWLAND HOPKINS LECTURE FOLATE AND THE PREVENTION OF DISEASE SCOTT J. M.
IMAGE 7
5,10-METHYLENETETRAHYDROFOLATE REDUCTASE C677T GENOTYPES ON FOLATE
RELATED RISK FACTORS FOR NEURAL TUBE DEFECTS
MOLLOY A. M., RAMSBOTTOM D., MCPARTLIN J., WHITEHEAD A. S., WEIR D. G.,
SCOTT J. M., KIRKE P. N., BURKE H., DALY S., MILLS J. L., CONLEY M 291
ELEVATED HOMOCYSTEINE IN SUBJECTS WITH A PREVIOUS NTD PREGNANCY IS
ASSOCIATED WITH INCREASED HEXAGLUTAMYL METHYLFOLATE CONSISTENT WITH
IMPAIRED B12 DEPENDENT METHIONINE SYNTHASE ACTIVITY LUCOCK M. D., LUMB
C, WILD J., OLIVER M., DASKALAKIS I., SCHORAH C, KENDALL R., LEVENE M.I
297
NUTRIENT AND HORMONAL REGULATION OF HEPATIC BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE EXPRESSION IN RATS GARROW T. A., PARK E. I., GARROW L.
S., GRIFFITHS M. A 303
UNMETABOLISED FOLIC ACID IN SERA OF SUBJECTS CONSUMING FORTIFIED FOOD
AND SUPPLEMENTS MCPARTLIN J., KELLY P., WEIR D. G., SCOTT J 309
FOLATE METABOLITE PATTERN IN MICE FOLLOWING TREATMENT WITH THE
ANTIEPILEPTIC DRUG VALPROIC ACID (VPA) AND 2-EN-VPA: RELATIONSHIP TO
NEURAL TUBE DEFECT INDUCTION
BOHLMANN A. M., NAU H 313
ONE CARBON METABOLIC PARAMETERS AND NTD LUCOCK M. D., DASKALAKIS I. G.,
LUMB C, OLIVER M., WILD J., SCHORAH C, LEVENE M. 1 317
METHIONINE SYNTHASE ACTIVITY IS DEPENDENT UPON INTRACELLULAR
METHYLFOLATE LEVEL IN CONTROL BUT NOT NTD SUBJECTS WHERE UTILIZATION OF
HEXAGLUTAMYL METHYLFOLATE IS LIMITING FOR REMETHYLATION OF HOMOCYSTEINE
LUCOCK M. D., LUMB C, WILD J., OLIVER M., DASKALAKIS I. G., SCHORAH C,
KENDALL R., LEVENE M.I 321
METHYL GROUP UTILIZATION VERSUS PRODUCTION IN NTD AND CONTROL SUBJECTS:
INFLUENCE OF VITAMIN B12 LUCOCK M. D., LUMB C, WILD J., DASKALAKIS I.
G., SCHORAH C, KENDALL R., LEVENE M.I 325
A NEW GENOTYPING METHOD FOR THE THERMOLABILE VARIANT OF METHYLENE
TETRAHYDROFOLATE REDUCTASE (C677T) USING HETERODUPLEX TECHNOLOGY CLARK
Z., BOWEN D. J., WHATLEY S. D., COLLINS P. W., MCDOWELL I. F. W 329
IMAGE 8
III FOLATES B FOLATES IN TISSUES, TRANSPORT, BINDING 331
FOLATE AND FOLATE-DEPENDENT ENZYMES DETERMINED IN HUMAN AND RAT RETINA
AND CENTRAL NERVOUS SYSTEM MARTINASEVIC M. K., MILLER M. W., TEPHLY T. R
333
FOLATE PATTERNS IN MOUSE PLASMA, ERYTHROCYTES, AND EMBRYO BELZ S., NAU H
337
HPLC COUPLED WITH A MICROBIOLOGICAL ASSAY FOR THE DETERMINATION OF
FOLATES BELZ S., NAU H 341
THERMAL STABILITY OF FOLATE BINDING PROTEIN FROM COW S MILK WITH AND
WITHOUT COMPLEXATION WITH LIGANDS
SIGURSKJOLD B. W., CHRISTENSEN T., HANSEN S. I., HOLM J 345
DISTRIBUTION AND CHARACTERIZATION OF HIGH-AFFINITY FOLATE BINDING
PROTEINS IN RAT YOLK SAC AND HUMAN COELOMIC FLUID BIRN H., CHRISTENSEN
E. L, CRUGER D. G., HANSEN S. I., HOLM J., HOIER-MADSEN M 349
FOLATE-TARGETED LIPOSOMES WITH ENTRAPPED DOXORUBICIN; BINDING AND
CYTOTOXICITY STUDIES IN M109 MURINE LUNG CARCINOMA HOROWITZ A. T., GOREN
D., GABIZON A., MANDELBAUM-SHAVIT F., ZALIPSKY S. . .. 353
IV FOLATE ENZYMES A ONE CARBON METABOLISM 357
A RAPID AND SENSITIVE ASSAY FOR REDUCED FOLATE POOLS IN TISSUE EXTRACTS
KIM D. W., DELLE FRATTE S., JEONG S. S., SCHIRCH V 359
CYTOSOLIC AND MITOCHONDRIAL ENZYMES FOR 10-FORMYLTHF BIOSYNTHESIS IN
PLANTS CHEN L., CHAN S. Y., NARGANG F. E., COSSINS E. A 365
PURIFICATION AND CHARACTERIZATION OF SERINE HYDROXYMETHYLTRANSFERASE
FROM SULFOLOBUS SOLFATARICUS DELLE FRATTE S., SCHIRCH V., WHITE R.,
MARAS B* BARRA D 369
THERMODYNAMIC DESCRIPTION OF 5-FORRNYLTETRAHYDROPTEROYLPOLYGLUTAMATE
BINDING TO SERINE HYDROXYMETHYLTRANSFERASE
HUANG T., WANG C, SCHIRCH V 373
COMPARISON OF THE HUMAN MITOCHONDRIAL AND CYTOPLASMIC SERINE
HYDROXYMETHYLTRANSFERASE GENES NASRALLAH I. M., GIRGIS S., SUH J. R.,
OPPENHEIM E., MOWRY K. Z., REIG B., STOVER P. J 377
XVII
IMAGE 9
INTRACELLULAR GLYCINE CONCENTRATIONS INFLUENCE THE DISTRIBUTION OF
FOLATE ONE-CARBON FORMS IN HUMAN CELLS SUH J. R., GIRGIS S., STOVER P. J
381
IV FOLATE ENZYMES B DIHYDROFOLATE REDUCTASE, THYMIDYLATE SYNTHASE,
PURINE SYNTHESIS 385 MODULATION OF THYMIDYLATE SYNTHASE EXPRESSION BY
DIETARY FOLIC ACID-INDUCED DNA HYPOMETHYLATION IN A MOUSE MODEL TUMOR
PRIEST D. G., RAGHUNATHAN K., LIU Y., BUNNI M. A 387
THYMIDYLATE BIOSYNTHESIS IN TRICHINELLA SPIRALIS DEVELOPMENT DABROWSKA
M., ZIELINSKI Z., GOBS B., MICHALSKI R., RODE W., WRANICZ M., PAWELCZAK
K 393
CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE
COFACTOR
TERNARY COMPLEXES WITH THE SELECTIVE FUROPYRIMIDINESULFO-2-NAPHTHALENE
ANTIFOLATE AND WITH METHOTREXATE
CODY V., GALITSKY N., LUFT J. R., PANGBORN W., GANGJEE A., QUEENER S. F.
. . .399
COMPARISON OF TWO INDEPENDENT CRYSTAL STRUCTURE DETERMINATIONS OF THE
ANTITUMOR COMPOUND PT523 AND NADPH AS TERNARY COMPLEXES WITH HUMAN
DIHYDROFOLATE REDUCTASE
CODY V., GALITSKY N., LUFT J. R., PANGBORN W., ROSOWSKY A., BLAKLEY R.
L. . .403
THE EFFECT OF THYMIDYLATE SYNTHASE (TS) INHIBITORS ON TS PROTEIN
EXPRESSION IN HUMAN TUMOUR CELL LINES MEASURED BY ELISA AHERNE G. W.,
HARDCASTLE A., BROWN S., SKELTON L. A., FINDLAY M. P. N., JACKMAN A. L
407
COMPARISON OF PROPERTIES OF E. CO/-EXPRESSED RAT HEPATOMA AND NORMAL
RAT THYMIDYLATE SYNTHASES CIESLA J., ZIELINSKI Z., RODE W 411
INTERACTIONS OF THYMIDYLATE SYNTHASE WITH 5-HYDROXY-DUMP AND
5-HYDROXYMETHYL-DUMP, AND THEIR 4-THIO ANALOGUES DZIK J. M., ZIELINSKI
Z., JARMULA A., MICHALSKI R., RODE W., LES A., BRETNER M., FELCZAK K.,
KULIKOWSKY T 415
ON THE IDENTITY OF THE FUNCTIONAL FORM OF THE TETRAHYDROFOLATE COFACTOR
IN THE THYMIDYLATE SYNTHASE CATALYZED REACTION: A MECHANISTIC ANALYSIS
KALMAN T. 1 419
INTERACTION OF THYMIDYLATE SYNTHASE WITH THE 5 -THIOPHOSPHATES AND
5 -H-PHOSPHONATES OF 2 -DEOXYURIDINE, THYMIDINE AND
5-FLUORO-2 -DEOXYURIDINE GOLOS B., DZIK J. M., RODE W., JANKOWSKA J.,
KRASZEWSKI A., STAWINSKI J., SHUGAR D 423
XVIII
IMAGE 10
SYNTHESIS AND BIOLOGICAL EVALUATION OF NON-GLUTAMATE CONTAINING DDATHF
ANALOGS THAT INHIBIT HUMAN GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE
(GARFT) SHIH C, GILL W. J., GOSSETT L. S., HABECK L. L., MENDELSOHN L.
G., ANDIS S., SCHULTZ R. M., WORZALLAJ. F., TAYLOR E. C 427 IV FOLATE
ENZYMES C FOLYLPOLYGLUTAMATE SYNTHETASE AND HYDROLASE,
7-GLUTAMYL HYDROLASE, METHIONINE SYNTHASE, DIHYDROPTEROATE SYNTHASE 431
MITOCHONDRIAL AND CYTOSOLIC FOLYPOLY-7-GLUTAMATE SYTHETASE:
TRANSCRIPTIONAL AND TRANLATIONAL CONTROL OF EXPRESSION OF THE HUMAN GENE
AND FUNCTION OF
ISOZYMES
QIH., CHOI Y. J., SHANE B 433
GLUTAMYL HYDROLASE GALIVAN J., YAO R., RHEE M., SCHNEIDER E., RYAN T 439
THE ACTIVE SITE OF S. AUREUS DHPS REVEALED BY X-RAY CRYSTALLOGRAPHY
OEFNER C, DARCY A., DALE G. E., HAMPELE I., KOSTREWA D., PAGE M. G. P. .
. .443 ADAPTATION TO SULFONAMIDE RESISTANCE IN NEISSERIA MENINGITIDIS
MAY HAVE REQUIRED COMPENSATORY CHANGES TO RETAIN ENZYME FUNCTION.
KINETIC ANALYSIS OF DIHYDROPTEROATE SYNTHASES FROM NEISSERIA
MENINGITIDIS FERMER C, QVARNSTROM Y., SWEDBERG G 449
PRELIMINARY RESULTS FOR THE CRYSTAL STRUCTURE OF L. CASEI
FOLYLPOLYGLUTARNATE SYNTHETASE (FPGS) CODY V., LUFT J. R., PANGBORN W.,
GALITSKY N 455
ACTIVITY OF FOLYLPOLYGLUTARNATE SYNTHETASE AND FOLYLPOLYGLUTARNATE
HYDROLASE IN CLINICAL SPECIMENS OF HEAD AND NECK TUMORS JANSEN G.,
KATHMANN I., PETERS G. J., HORDIJK G. J., SLOOTWEG P. J., VAN DER LAAN
B. F. A. M 459
FOLYLPOLYGLUTARNATE HYDROLASE (FPGH) ACTIVITY IN HUMAN LEUKEMIA CCRF-CEM
CELLS AND BLAST CELLS FROM CHILDHOOD LEUKEMIA PATIENTS NOORDHUIS P.,
ROTS M., VAN ZANTWIJK C. H., PIETERS R., VEERMAN A. J. P., PETERS G. J.,
JANSEN G 463
INHIBITION OF 7-GLUTAMYL HYDROLASE BY LEVAMISOLE AND SURAMIN RHEE M. S
467
GLUTAMYL HYDROLASE ACTIVITY DETERMINATIONS IN MURINE TISSUES AND SERUM
WOOD P. A., NIMEC Z., GALIVAN J. H 471
IMAGE 11
STUDIES OF 7-GLUTAMYL HYDROLASE: HUMAN TISSUE DISTRIBUTION AND
CHROMOSOME LOCALIZATION
YAO R 475
ORGANIZATION AND EXPRESSION OF THE HUMAN METHIONINE SYNTHASE GENE
HWANG H. Y., PENG K., SHANE B 479
TRANSCRIPTIONAL CONTROL OF THE HUMAN METHIONINE SYNTHASE GENE LIU M. L.,
SHANE B 483
V PTERIDINE ENZYMES A AROMATIC AMINO ACID HYDROXYLASES 489
MECHANISM OF OXYGEN ACTIVATION BY PHENYLALANINE HYDROXYLASE ARDELLM. M.,
BAILEY S. W., AYLING J. E 491
MECHANISTIC STUDIES OF TYROSINE HYDROXYLASE
FITZPATRICK P. F., DAUBNER S. C, HILLAS P. J., LOHSE D. L., RAMSEY A. J
497
MOLECULAR CHARACTERIZATION OF DISEASE RELATED MUTANT FORMS OF HUMAN
PHENYLALANINE HYDROXYLASE AND TYROSINE HYDROXYLASE FLATMARK T.,
KNAPPSKOG P. M., BJORGO E., MARTINEZ A 503
ACTIVATION OF TYROSINE HYDROXYLASE BY PHOSPHORYLATION. A COMPARISON OF
DIFFERENT PROTEIN KINASES AND PHOSPHORYLATION SITES HAAVIK J., THOMAS
G., SUTHERLAND C, COHEN P 509
SUBSTRATE SPECIFICITY AND PHENYLALANINE ACTIVATION OF TRUNCATED AND
CHIMERIC PROTEINS OF PHENYLALANINE HYDROXYLASE AND TYROSINE HYDROXYLASE
DAUBNER S. C, FITZPATRICK P. F 515
CORRELATION OF RAT HEPATIC PHENYLALANINE HYDROXYLASE WITH CONCENTRATIONS
OF TETRAHYDROBIOPTERIN AND OF GTP DONLON J., WALSH G. A., GUERIN T 519
HEPATIC PHENYLALANINE HYDROXYLASE OF CLETHRIONOMYS GLAREOLUS SCHREBER
AS A BIOINDICATOR OF POLLUTION
DONLON J., FALLON B., BARRETT P., CARROLL 0., HENDERSON P., FAIRLEY J. S
523
FUNCTIONAL EXPRESSION OF HUMAN PHENYLALANINE HYDROXYLASE IN ESCHERICHIA
COLI SCHRAMEK N., BACHER A., GIITLICH M 527
PHOTOLYSIS AND DEGRADATION PRODUCTS OF TETRAHYDROPTERINS ALMAS B.,
FLATMARK T., HAAVIK J., GROEHN V. , PFLEIDERER W 531
NADH STIMULATES THE ACTIVITY OF TYROSINE HYDROXYLASE IN RAT PC12 CELLS
BY ACCELERATING RECYCLING OF TETRAHYDROBIOPTERIN VRECKO K., REIBNEGGER G
535
IMAGE 12
INVOLVEMENT OF I-KB DEGRADATION BY PROTEOSOME IN THE SIGNAL TRANSDUCTION
CASCADE WHICH INDUCES TRYPTOPHAN HYDROXYLASE BIOSYNTHESIS IN RBL-2H3
CELLS IIDA Y., KOJIMA M., NAKASHIMA Y., KINOSHITA M., OGURO K., HASEGAWA
H 539
V PTERIDINE ENZYMES B GTP CYCLOHYDROLASE I AND OTHERS 545
CLONING OF RAT CDNA AND THE HUMAN GENE FOR GTP CYCLOHYDROLASE I FEEDBACK
REGULATORY PROTEIN, GFRP MILSTIEN S., BONNER T.I 547
GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN: FUNCTION AND MECHANISM
HATAKEYAMA K., YONEYAMA T 553
IGE-MEDIATED SIGNAL TRANSDUCTION REGULATES TETRAHYDROBIOPTERIN SYNTHESIS
IN MAST CELLS: A MODEL SYSTEM FOR POSTTRANSLATIONAL MODULATION OF GTP
CYCLOHYDROLASE I
HESSLINGER C, ZIEGLER I., KREMMER E., HIILTNER L 559
MECHANISM OF DEHYDRATION BY THE BIFUNCTIONAL PROTEIN,
4A-HYDROXYTETRAHYDROPTERIN DEHYDRATASE/ DCOH
AYLING J. E., REBRIN I., BAILEY S ,W., THONY B 565
STRUCTURAL AND MECHANISTIC STUDIES WITH PTERIN-4A-CARBINOLAMINE
DEHYDRATASE FROM PSEUDOMONAS AERUGINOSA. THREE-DIMENSIONAL STRUCTURE AND
COMPARISON WITH THE HUMAN ENZYME KOSTER S., CURTIUS H. C, GHISLA S.,
FICNER R., STIER G., SUCK D., SAUER U. H. .. 571
ESSENTIAL ROLE OF 3 -DOWNSTREAM REGION IN HIGH LEVEL EXPRESSION OF THE
PLASMIDENCODED DIHYDRONEOPTERIN TRIPHOSPHATE 2 -EPIMERASE GENE IN E.
COLI AHN C, KIM M., HWANG D. S., YIM J 577
CYTOKINE-INDUCED PTERIDINE BIOSYNTHESIS IN HUMAN MONOCYTES (THP-1):
ANALYSIS OF ITS MOLECULAR BASIS
WERNER-FELMAYER G., MEYER M., WERNER E. R., HEUFIER-TIEFENTHALER C,
LEIMBACHER W., THONY B 585
THE CRYSTAL STRUCTURE OFMOUSE SEPIAPTERIN REDUCTASE AUERBACH G., HUBER
R., HERRMANN A., GIITLICH M., FISCHER M., BACHER A 591
PTERIDINES AND PHOTORECEPTION - STUDIES ON NO SYNTHASE FUNGI AND PLANTS
MAIER J., NINNEMANN H 595
STUDIES ON GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I BAKER S. J., DEKHANE
M., YOUNG D. W 603
GTP CYCLOHYDROLASE I IN DEVELOPING CHICKEN EMBRYONIC RETINA GIITLICH M.,
FISCHER M., CAHILL D., BACHER A., HOLDENGREBER V., VECHOROPOULOS M.,
BENSHAUL Y., WITTER K 607
IMAGE 13
HETEROLOGOUS EXPRESSION OF RECOMBINANT HUMAN GTP CYCLOHYDROLASE I
FISCHER M., BRACHER A., LUTZ R., HERRMANN A., AUERBACH G., GRIINEBERG
S., HUBER R., LOTTSPEICH F., BACHER A., GIITLICH M 611
IMMUNOHISTOCHEMICAL LOCALIZATION AND QUANTIFICATION OF GTP
CYCLOHYDROLASE I IN RAT BRAIN MONOAMINE NEURONS
FLIRAYAMA K., KAPATOS G 615
LOCALIZATION AND FUNCTION OF GTP CYCLOHYDROLASE I FEEDBACK REGULATORY
PROTEIN (GFRP) IN RAT BRAIN HIRAYAMA K., SHIMOJI M., KOJIMA M., MILSTIEN
S., KAPATOS G 619
CHARACTERIZATION OF 6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE MESSENGER RNA
FROM HUMAN MYELOMONOCYTIC THP-1 CELLS MEYER M., WERNER-FELMAYER G.,
WERNER E. R., HEUFLER-TIEFENTHALER C, THONY B., LEIMBACHER W 623
ON THE MECHANISM OF PTERIN-4A-CARBINOLAMINE DEHYDRATASE. SYNTHESIS OF
NEW SUBSTRATE ANALOGUES AND INTERACTION WITH THE ENZYME KUBASCH N.,
HOLZER M., KOSTER S., CURTIUS H. C, GHISLA S., PFLEIDERER W 627
MECHANISTIC STUDIES OF 4A-HYDROXYTETRAHYDROPTERIN DEHYDRATASE FROM
PSEUDOMONAS AERUGINOSA REBRIN I., AYLING J. E., SONG J., JENSEN R. A 631
CA2+-DEPENDENT PHOSPHORYLATION AND PROTEOLYSIS OF TETRAHYDROBIOPTERIN
GENERATING ENZYMES KATOH S., FUJIMOTO K., INABA A., TOMOMURA A., HAINO
K., YAMAMOTO Y.,
TAKAHASHI S., NONAKA T., MITSUI Y 635
STRUCTURE OF THE MOUSE SEPIAPTERIN REDUCTASE GENE AND CHARACTERIZATION
OF ITS 5 -FLANKING REGION LEE S. W., CHUNG J. H., KOO Y. B., PARK Y. S
639
EXPRESSION, PURIFICATION AND CHARACTERIZATION OF MURINE SEPIAPTERIN
REDUCTASE HERRMANN A., GIITLICH M., FISCHER M., BACHER A., EULITZ M 643
DIHYDRONEOPTERIN TRIPHOSPHATE EPIMERASE: PROPERTIES AND PRELIMINARY
CRYSTALLOGRAPHIC ANALYSIS HAUFIMANN C, ROHDICH F., EBERHARDT S., RICHTER
G., SCHEURING J., MACKAMUL S., BACHER A., PLOOM T., AUERBACH G.,
LOTTSPEICH F., HUBER R 647
DIHYDRONEOPTERIN ALDOLASE: PROPERTIES AND PRELIMINARY CRYSTALLOGRAPHIC
ANALYSIS HAUFIMANN C, RICHTER G., ROHDICH F..BACHER A., GOMEZ-ORTIZ M.,
GRIINEBERG S., AUERBACH G., PLOOM T., HUBER R 651
PURIFICATION AND CHARACTERIZATION OF LIMIPTERIN SYNTHASE IN CHLOROBIUM
LIMICOLA F. THIOSULFATOPHILUM KIM S. J., KANG D. M., YIM J 655
IMAGE 14
V PTERIDINE ENZYMES C NITRIC OXIDE SYNTHASES 659
TETRAHYDROBIOPTERIN AND NO-SYNTHASE BOMMELH. M., KOTSONIS P., SCHMIDT H.
H. H. W 661
BINDING OF PTERIDINES TO NITRIC OXIDE SYNTHASE. CLUES FOR THE MECHANISM
OF STIMULATION OF NITRIC OXIDE SYNTHASE BY TETRAHYDROBIOPTERIN WERNER E.
R., MAYER B 669
RELAXATION OF VASCULAR SMOOTH MUSCLE AND STIMULATION OF CYCLIC GMP
PRODUCTION BY TETRAHYDROBIOPTERIN BUT NOT BIOPTERIN VAN AMSTERDAM J. G.
C, EIGEMAN L., VAN DE KUIL A., WERNER J 675
V PTERIDINE ENZYMES D MOLYBDOPTERIN, METHAN0PTERIN, RIBOFLAVIN 679
MOLYBDENUM COFACTOR BIOSYNTHESIS IN PLANTS AND HUMANS MENDEL R. R.,
BRINKMANN H., GREGER K., NERLICH A., NIEDER J., SCHLEDZEWSKI K., SCHULZE
J., SCHWARZ G., STALLMEYER B 681
SYNTHETIC APPROACHES TO THE MOLYBDENUM COFACTOR DAVIES E. S., DINSMORE
A., GARNER C. D., JOULE J. A 693
THE PLANT PROTEIN CNXL BINDS MOLYBDOPTERIN WITH HIGH AFFINITY AND IS
INVOLVED IN THE LAST STEP OF MOLYBDENUM COFACTOR BIOSYNTHESIS SCHWARZ
G., MENDEL R. R., BOXER D. H 697
THE PRODUCT OF THE MOLYBDENUM COFACTOR GENE MOBB OF ESCHERICHIA COLI IS
A GTP BINDING PROTEIN HECK I. S., EAVES D. J., BOXER D. H., PALMER T 703
VI TETRAHYDROBIOPTERIN A DEFICIENCY 707
MUTATION DATABASES: THEIR IMPORTANCE AND RELEVANCE TO PTERIN AND FOLATE
ENZYMES
COTTON R. G. H 709
MOLECULAR ANALYSIS OF TETRAHYDROBIOPTERIN DEFICIENCY DUE TO
6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE MUTATIONS: 2-D-GEL ANALYSIS OF THE
IN VIVO PHOSPHO
RYLATION STATE
THONY B., LEIMBACHER W., SCHERER-OPPLIGER T., HEIZMANN C. W., BLAU N 713
BIODEF AND BIOMDB INTERNATIONAL DATABASES OF TETRAHYDROBIOPTERIN
DEFICIENCIES
BLAU N., DHONDT J. L., DIANZANI L, THONY B 719
IMAGE 15
MOLECULAR MECHANISM OF DOPA-RESPONSIVE DYSTONIA ICHINOSE H., NAGATSU T
727
TRANSIENT HYPERPHENYLALANINEMIA AND HIGH LEVELS OF URINARY 7-BIOPTERIN
ARE ASSOCIATED WITH MUTATIONS IN THE PCBD GENE ENCODING THE BIFUNCTIONAL
PROTEIN PTERIN-4A-CARBINOLAMINE DEHYDRATASE (PCD) AND TRANSCRIPTIONAL
COACTIVATOR (DCOH) THONY B., NEUHEISER F., HEIZMANN C. W., REBRIN I.,
AYLING J., BLAU N 733
ALTERNATIVE GENE THERAPEUTIC APPROACHES TO TREATMENT OF
TETRAHYDROBIOPTERIN DEFICIENCY BY GENE TRANSFER: GENERATION OF
RETROVIRAL VEKTORS LAUFS S., LEIMBACHER W., KIM S., BLAU N., THONY B 737
CELLULAR DISTRIBUTION AND QUANTITATION OF GTP CYCLOHYDROLASE I MRNA IN
THREE MONOAMINERGIC CELL GROUPS OF THE HPH-1 MOUSE BRAIN SHIMOJI M.,
HIRAYAMA K., HYLAND K., KAPATOS G 741
VI TETRAHYDROBIOPTERIN B EFFECTS 745
TETRAHYDROBIOPTERIN METABOLISM IN CELL DEATH BY APOPTOSIS BEZIN L.,
ANASTASIADIS P. Z., NYGAARD T. G., CORCORAN G. B., LEVINE R. A 747
SYNAPTIC PLASTICITY IN THE VISUAL CORTEX ENHANCED BY
6R-TETRAHYDROBIOPTERIN TREATMENT
WATANABE Y., MATAGA N., MUGURUMA K., SHIOMITSU T., IMAMURA K 755
UPTAKE OF TETRAHYDROBIOPTERIN BY CELLS IN MONOLAYER CULTURES OF RBL2H3
AND PC12 CELL LINES YAMAMOTO K., NAKAZAWA N., HASEGAWA H., NAKANISHI N
759
ANTI-HYPERTENSIVE EFFECTS OF TETRAHYDROBIOPTERIN (BH4) ON DOCA-SALT
HYPERTENSION IN RATS SHINTAKU H., INOUE K., OKAMURA M., CHOI K. Y.,
HARAGUCHI M., KONISHI M., NEGORO N., INOUE T., KANAYAMA Y., YOSHIKAWA J
765
SELF-PROTECTION BY 6R-TETRAHYDROBIOPTERIN FROM NITRIC OXIDE-INDUCED
NEURONAL CELL DEATH
KOSHIMURA K., MURAKAMI Y., TANAKA J., KATO Y 771
CELLULAR UPTAKE OF TETRAHYDROBIOPTERIN BY PC12 CELLS AND ITS RELEASE:
INHIBITION OF THE OUTWARD FLOW BY RESERPINE NAKANISHI N., HASEGAWA H 777
IMAGE 16
VII PTERIDINES NEW FUNCTIONS, IMMUNOLOGY, SKIN 781
PTERIDINES AS MODULATORS OF FREE RADICAL-INDUCED REACTIONS: AN OVERVIEW
REIBNEGGER G., HOREJSI R., OETTL K 783
PTERINS AND A-MSH IN THE CONTROL OF PIGMENTATION IN THE HUMAN EPIDERMIS
SCHALLREUTER K. U., MOORE J., JENNER T., LINDSEY N. J., WOOD J. M.,
THODY A. J., GRAHAM A 791
NEOPTERIN DERIVATIVES INTERFERE WITH REDOX-REGULATED INTRACELLULAR
PATHWAYS FUCHS D., BAIER-BITTERLICH G., WIDNER B., WIRLEITNER B.,
WACHTER H., SCHOBERSBERGER W 797
NEOPTERIN AND 7,8-DIHYDRONEOPTERIN MODULATE PEROXYNITRITE-INDUCED
INHIBITION OF MITOCHONDRIAL FUNCTION
WEDEL.FUCHS D., BARKER J. E., CLARK J. B., HEALES S. J. R 803
NEOPTERIN AND 7,8-DIHYDRONEOPTERIN INFLUENCE THE REACTION OF
PEROXYNITRITE WITH TYROSINE WIDNER B., BAIER-BITTERLICH G., WEDE I.,
WIRLEITNER B., WACHTER H., FUCHS D. . .807
A POSSIBLE ROLE FOR PTERINS IN CONTROL OF THE HAIR CYCLE BEAZLEY W. D.,
TOBIN D. J., SCHALLREUTER K. U., PAUS R 811
EFFECT OF PTERIDINES AND KYNURENINE ON MEMBRANE FLUIDITY RUDZITE V.,
JURIKA E., BAIER-BITTERLICH G., FUCHS D., WACHTER H 815
INHIBITION OF XANTHINE OXIDASE BY DIFFERENT PTERIDINE DERIVATIVES OETTL
K., KOPPEL., REIBNEGGER G 819
PTERIDINE DERIVATIVES INTERACT WITH THE SOLUBLE CYTOCHROME P450 PURIFIED
FROM
PSEUDOMONAS PUTIDA HOREJSI R., PAYERL D., REIBNEGGER G., ROBRA K. H.,
ERBER C, SOMITSCH W 823
DEFECTIVE EPIDERMAL 6-BH4-HOMEOSTASIS IN TYROSINASE POSITIVE ALBINISM
(HERMANSKY-PUDLAK SYNDROME) HIBBERTS N. A., BEAZLEY W. D., PITTLEKOW M.
R., SWANSON N. N., SCHALLREUTER K. U 827
STUDIES ON THE STRUCTURE OF THE TETRAHYDROBIOPTERIN / A-MELANOCYTE
STIMULATING
HORMONE COMPLEX FORMATION USING FOURIER TRANSFORM RAMAN SPECTROSCOPY
MOORE J., WOOD J. M., SCHALLREUTER K. U 831
PTERIDINES IN HUMAN HAIR
SAWADA Y., KAIHARA A., MURATA R., SHINTAKU H., ASADA M., ISSHIKI G.,
HASE Y., OURA T 837
IMAGE 17
NEOPTERIN AND HEMOPHAGOCYTIC SYNDROME SHINTAKU H., ASADA M.,ISSHIKI G.,
SAWADA Y., SAKO M., HOSOI G., ISHII T., TOGAWA M., SHIOMI S., KURIMASA
H., MURATA R 841
AUTHOR INDEX 847
SUBJECT INDEX 855
PARTICIPANTS 871
XXVI
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV011515538 |
| classification_rvk | VK 7208 |
| ctrlnum | (OCoLC)39862631 (DE-599)BVBBV011515538 |
| discipline | Chemie / Pharmazie |
| format | Conference Proceeding Book |
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| genre | (DE-588)1071861417 Konferenzschrift 1997 Berchtesgaden gnd-content |
| genre_facet | Konferenzschrift 1997 Berchtesgaden |
| id | DE-604.BV011515538 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:11:05Z |
| institution | BVB |
| institution_GND | (DE-588)2165446-3 |
| isbn | 3826331850 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007750413 |
| oclc_num | 39862631 |
| open_access_boolean | |
| owner | DE-703 DE-12 |
| owner_facet | DE-703 DE-12 |
| physical | XXVI, 894 S. graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Blackwell Wiss.-Verl. |
| record_format | marc |
| series2 | Blackwell science |
| spelling | Chemistry and biology of pteridines and folates 1997 proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15 - 20, 1997 eds. Wolfgang Pfleiderer ; Hartmut Rokos Berlin [u.a.] Blackwell Wiss.-Verl. 1997 XXVI, 894 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Blackwell science Folic Acid Congresses Folic acid Congresses Prosthetic groups (Enzymes) Congresses Pteridines Congresses Pteridine (DE-588)4047751-4 gnd rswk-swf Folate (DE-588)4154952-1 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1997 Berchtesgaden gnd-content Pteridine (DE-588)4047751-4 s DE-604 Folate (DE-588)4154952-1 s Pfleiderer, Wolfgang Sonstige oth International Symposium on Chemistry and Biology of Pteridines and Folates 11 1997 Berchtesgaden Sonstige (DE-588)2165446-3 oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007750413&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chemistry and biology of pteridines and folates 1997 proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15 - 20, 1997 Folic Acid Congresses Folic acid Congresses Prosthetic groups (Enzymes) Congresses Pteridines Congresses Pteridine (DE-588)4047751-4 gnd Folate (DE-588)4154952-1 gnd |
| subject_GND | (DE-588)4047751-4 (DE-588)4154952-1 (DE-588)1071861417 |
| title | Chemistry and biology of pteridines and folates 1997 proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15 - 20, 1997 |
| title_auth | Chemistry and biology of pteridines and folates 1997 proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15 - 20, 1997 |
| title_exact_search | Chemistry and biology of pteridines and folates 1997 proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15 - 20, 1997 |
| title_full | Chemistry and biology of pteridines and folates 1997 proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15 - 20, 1997 eds. Wolfgang Pfleiderer ; Hartmut Rokos |
| title_fullStr | Chemistry and biology of pteridines and folates 1997 proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15 - 20, 1997 eds. Wolfgang Pfleiderer ; Hartmut Rokos |
| title_full_unstemmed | Chemistry and biology of pteridines and folates 1997 proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15 - 20, 1997 eds. Wolfgang Pfleiderer ; Hartmut Rokos |
| title_short | Chemistry and biology of pteridines and folates 1997 |
| title_sort | chemistry and biology of pteridines and folates 1997 proceedings of the eleventh international symposium on pteridines and folates berchtesgaden germany june 15 20 1997 |
| title_sub | proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15 - 20, 1997 |
| topic | Folic Acid Congresses Folic acid Congresses Prosthetic groups (Enzymes) Congresses Pteridines Congresses Pteridine (DE-588)4047751-4 gnd Folate (DE-588)4154952-1 gnd |
| topic_facet | Folic Acid Congresses Folic acid Congresses Prosthetic groups (Enzymes) Congresses Pteridines Congresses Pteridine Folate Konferenzschrift 1997 Berchtesgaden |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007750413&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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