Sphingolipid mediated signal transduction:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1997
|
| Schriftenreihe: | Molecular biology intelligente unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | 188 S. graph. Darst. |
| ISBN: | 3540627146 |
Internformat
MARC
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| 245 | 1 | 0 | |a Sphingolipid mediated signal transduction |c Yusuf A. Hannun |
| 264 | 1 | |a New York [u.a.] |b Springer [u.a.] |c 1997 | |
| 300 | |a 188 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Molecular biology intelligente unit | |
| 500 | |a Literaturangaben | ||
| 650 | 4 | |a Cellular signal transduction | |
| 650 | 4 | |a Signal Transduction |x physiology | |
| 650 | 4 | |a Sphingolipids |x Metabolism | |
| 650 | 4 | |a Sphingolipids |x Physiological effect | |
| 650 | 4 | |a Sphingolipids |x physiology | |
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| 700 | 1 | |a Hannun, Yusuf A. |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007690355&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
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Datensatz im Suchindex
| _version_ | 1807320263816118272 |
|---|---|
| adam_text |
-
CONTENTS
-
1.
INTRODUCTION
AND
OVERVIEW
.
1
YUSUF
A.
HANNUN
INTRODUCTION:
PARADIGMS
OF
SIGNAL
TRANSDUCTION
THROUGH
LIPIDS
.
1
THE
INFRASTRUCTURE
OF
SPHINGOLIPID
SIGNAL
TRANSDUCTION
.
3
PROPOSED
ROLES
FOR
SPHINGOLIPID
SIGNAL
TRANSDUCTION
IN
CELL
REGULATION
.
10
TOOLS,
APPROACHES,
AND
HAZARDS
IN
THE
STUDY
OF
SIGNALING
THROUGH
SPHINGOLIPIDS
.
11
SUMMARY
AND
FUTURE
DIRECTIONS
.
15
2.
CERAMIDE:
A
STRESS
RESPONSE
MEDIATOR
INVOLVED
IN
GROWTH
SUPPRESSION
.
19
GHASSAN
DBAIBO
AND
YUSUF
A.
HANNUN
INTRODUCTION
.
19
OVERVIEW
OF
THE
SPHINGOMYELIN
CYCLE
AND
CERAMIDE
BIOLOGY
AND
METABOLISM
.
20
THE
STRESS
RESPONSE:
AN
EMERGING
ROLE
FOR
CERAMIDE
.
21
MOLECULAR
TARGETS
OF
CERAMIDE
ACTION
.
27
CONCLUSIONS
.
28
3.
CERAMIDE
AND
INFLAMMATION
.
35
LESLIE
R.
BALLOU
INTRODUCTION
.
35
CYTOKINE-INDUCED
CERAMIDE
GENERATION,
PROSTAGLANDIN
PRODUCTION,
AND
THEIR
PHYSIOLOGIC
ROLE
IN
INFLAMMATION
.
37
THE
BIOCHEMICAL
BASIS
BY
WHICH
CERAMIDE
REGULATES
PROSTAGLANDIN
BIOSYNTHESIS:
THE
INDUCTION
OF
COX
TRANSCRIPTION
AND
TRANSLATION
.
43
SUMMARY
AND
FUTURE
DIRECTIONS
.
47
4.
A
ROLE
FOR
CERAMIDE
IN
MEIOSIS
.
53
JAY
C.
STRUM,
KATHERINE
I.
SWENSON
AND
ROBERT
M.
BELL
INTRODUCTION
.
53
EXOGENOUS
SPHINGOMYELINASES
INDUCE
NORMAL
MATURATION
.
54
SPHINGOMYELINASE-INDUCED
GVBD
REQUIRES
PROTEIN
SYNTHESIS
.
55
MOS
IS
REQUIRED
FOR
SPHINGOMYELINASE-INDUCED
GVBD
.
55
PDMP
INDUCES
NORMAL
MEIOTIC
MATURATION
.
55
BREFELDIN
A
INDUCES
NORMAL
MEIOTIC
MATURATION
.
55
MICROINJECTED
SPHINGOLIPIDS
INDUCE
GVBD
.
56
PROGESTERONE
STIMULATES
CERAMIDE
FORMATION
THROUGH
ACTIVATION
OF
A
MG
2+
-DEPENDENT
NEUTRAL
SPHINGOMYELINASE
.
56
DISCUSSION
.
57
5.
CERAMIDE,
AGING
AND
CELLULAR
SENESCENCE
.
61
JOANNA
Y.
LEE,
AND
LINA
M.
OBEID
INTRODUCTION
.
61
CELLULAR
SENESCENCE:
MECHANISMS
AND
REGULATION
.
61
SPHINGOLIPIDS
IN
AGING
.
65
SPHINGOLIPIDS
IN
SENESCENCE
.
66
CONCLUSIONS
AND
FUTURE
DIRECTIONS
.
69
6.
CERAMIDE,
A
MEDIATOR
OF
CYTOSINE
ARABINOSIDE
INDUCED
APOPTOSIS
.
77
SUSAN
P.
WHITMAN
AND
LARRY
W.
DANIEL
APOPTOSIS
.
77
DIFFERENTIATION
.
78
DIACYLGLYCEROL
AND
PROTEIN
KINASE
C
.
79
SECOND
MESSENGER
ROLE
OF
CERAMIDE
.
79
CELLULAR
RESPONSES
TO
CYTOSINE
ARABINOSIDE
.
80
7.
THE
USE
OF
CEREBROSIDE
SYNTHASE
INHIBITORS
AS
PROBES
FOR
ASSESSING
THE
METABOLISM
AND
FUNCTION
OF
SPHINGOLIPIDS
.
91
JAMES
A.
SHAYMAN
AND
NORMAN
S.
RADIN
INTRODUCTION
.
91
INHIBITORS
OF
CERAMIDE
GLUCOSYLATION
BLOCK
CELL
GROWTH
.
92
IDENTIFICATION
OF
A
ROLE
FOR
CERAMIDE
IN
THE
HEAT
SHOCK
RESPONSE
FOLLOWING
AN
ATTEMPT
TO
CLONE
GLUCOSYLCERAMIDE
SYNTHASE
.
96
A
CAT
REPORTER
CONSTRUCT
OF
THE
AB-CRYSTALLIN
GENE
IDENTIFIES
CIS-ACTING
SITES
FOR
CERAMIDE-INDUCED
TRANSCRIPTION
IN
THE
-661
TO
+44
BASE
PAIR
REGION
OF
THE
GENE
.
97
SPHINGOLIPID
STRUCTURE:
TEMPERATURE
DEPENDENT
EFFECTS
ON
PHASE
TRANSITION
.
98
ESTABLISHING
PROOF
OF
PRINCIPLE
FOR
CERAMIDE
DEPENDENCE
IN
HEAT
SHOCK
RESPONSES
.
99
CONCLUSION
.
100
8.
ROLE
OF
SPHINGOLIPIDS
IN
REGULATING
THE
PHOSPHOLIPASE
D
PATHWAY
AND
CELL
DIVISION
.
103
ANTONIO
GDMEZ-MUNOZ,
ABDELKARIM
ABOUSALHAM,
YUTAKA
KIKUCHI,
DAVID
W.
WAGGONER
AND
DAVID
N.
BRINDLEY
INTRODUCTION
.
103
CELL
SIGNALING
BY
PHOSPHATIDATE,
LYSOPHOSPHATIDATE
AND
DIACYLGLYCEROL
.
103
CELL
SIGNALING
BY
SPHINGOLIPIDS
.
106
CERAMIDES
INHIBIT
THE
MITOGENIC
EFFECTS
OF
PHOSPHATIDATE,
LYSOPHOSPHATIDATE,
SPHINGOSINE
1
-PHOSPHATE
AND
CERAMIDE
1
-PHOSPHATE
.
108
CERAMIDES
INHIBIT
THE
ACTIVATION
OF
PHOSPHOLIPASE
D
.
109
EFFECTS
OF
CERAMIDES
ON
THE
METABOLISM
OF
PHOSPHATIDATE,
LYSOPHOSPHATIDATE,
SPHINGOSINE
1
-PHOSPHATE
AND
CERAMIDE
1
PHOSPHATE
.
112
EFFECTS
OF
SPHINGOSINE
ON
THE
METABOLISM
OF
PHOSPHATIDATE
AND
DIACYLGLYCEROL
.
114
CONCLUSIONS
.
115
9.
SPHINGOSINE
1
-PHOSPHATE:
MEMBER
OF
A
NEW
CLASS
OF
LIPID
SECOND
MESSENGERS
.
121
SARAH
SPIEGEL,
OLIVIER
CUVILLIER,
ELENA
FUIOR,
AND
SHELDON
MILSTIEN
INTRODUCTION
.
121
SPHINGOSINE
1
-PHOSPHATE
IN
CELL
GROWTH
REGULATION
.
121
SPHINGOSINE
1
-PHOSPHATE
INHIBITS
CERAMIDE-MEDIATED
PROGRAMMED
CELL
DEATH
.
123
INTRACELLULAR
ACTIVITIES
OF
SPHINGOSINE-1-PHOSPHATE
.
126
CONCLUDING
REMARKS
.
130
10.
FUNCTIONAL
ROLES
OF
GLYCOSPHINGOLIPIDS
AND
SPHINGOLIPIDS
IN
SIGNAL
TRANSDUCTION
.
137
SEN-ITIROH
HAKOMORI
INTRODUCTION:
EARLY
STUDIES
LEADING
TO
THE
CONCEPT
THAT
GSLS
AND
SLS
AFFECT
TRANSMEMBRANE
SIGNALING
FOR
CONTROL
OF
CELL
GROWTH
.
137
EFFECTS
OF
GSLS
AND
SLS
ON
FIVE
CLASSES
OF
RECEPTORS
AND
SIGNAL
TRANSDUCERS
.
140
FUNCTION
OF
GM3
AND
ITS
PRIMARY
DEGRADATION
PRODUCTS
IN
CONTROL
OF
TRANSMEMBRANE
SIGNALING
141
EFFECT
OF
SPG
AND
GM3
ON
INSULIN-DEPENDENT
RK
.
146
PLPS
AS
A
NOVEL
TRANSMEMBRANE
SIGNAL
INDUCER
IN
NEURONAL
CELLS
.
148
ROLE
OF
SPH-1-PHOSPHATE
AS
SECOND
MESSENGER
FOR
MOTILITY
CONTROL
.
149
SPH
AND
DMS
MODULATE
MODULATOR
PROTEINS
(CHAPERONES)
OF
SIGNAL
TRANSDUCTION
.
150
GSL
AND
SL
ANALOGS
THAT
INHIBIT
CANCER
PROGRESSION
AND
INFLAMMATORY
PROCESSES:
DEVELOPMENT
OF
"
ORTHO
SIGNALING
THERAPY
"
FOR
CANCER
AND
INFLAMMATION
.
150
SYNOPSIS
.
152
11.
CERAMIDE
SYNTHASE
AND
CERAMIDASES
IN
THE
REGULATION
OF
SPHINGOID
BASE
METABOLISM
.
159
MARIANA
NIKOLOVA-KARAKASHIAN,
TERESA
R.
VALES,
ELAINE
WANG,
DAVID
S.
MENALDINO,
CHRISTOPHER
ALEXANDER,
JANE
GOH,
DENNIS
C.
LIOTTA
AND
ALFRED
H.
MERRILL,
JR.
CERAMIDE
BIOSYNTHESIS
AND
TURNOVER
.
159
CERAMIDE
VERSUS
SPHINGOSINE
IN
CELL
SIGNALING
.
164
FUMONISINS
AS
INHIBITORS
OF
CERAMIDE
SYNTHASE
IN
VITRO
AND
IN
VIVO
.
165
POSSIBLE
MECHANISMS
OF
ACTION
OF
FUMONISINS
.
167
FUTURE
PERSPECTIVES
.
168
12.
CERAMIDASE
AND
SIGNAL
TRANSDUCTION
.
173
CHARLES
P.
MCKAY
ENZYMOLOGY
.
173
CLINICAL
AND
BIOLOGICAL
SIGNIFICANCE
.
177
INDEX
.
183 |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV011435353 |
| illustrated | Illustrated |
| indexdate | 2024-08-14T00:21:55Z |
| institution | BVB |
| isbn | 3540627146 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007690355 |
| oclc_num | 36511279 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-11 |
| owner_facet | DE-355 DE-BY-UBR DE-11 |
| physical | 188 S. graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Molecular biology intelligente unit |
| spelling | Sphingolipid mediated signal transduction Yusuf A. Hannun New York [u.a.] Springer [u.a.] 1997 188 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligente unit Literaturangaben Cellular signal transduction Signal Transduction physiology Sphingolipids Metabolism Sphingolipids Physiological effect Sphingolipids physiology Sphingolipide (DE-588)4182242-0 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Signaltransduktion (DE-588)4318717-1 s Sphingolipide (DE-588)4182242-0 s DE-604 Hannun, Yusuf A. Sonstige oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007690355&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sphingolipid mediated signal transduction Cellular signal transduction Signal Transduction physiology Sphingolipids Metabolism Sphingolipids Physiological effect Sphingolipids physiology Sphingolipide (DE-588)4182242-0 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| subject_GND | (DE-588)4182242-0 (DE-588)4318717-1 (DE-588)4143413-4 |
| title | Sphingolipid mediated signal transduction |
| title_auth | Sphingolipid mediated signal transduction |
| title_exact_search | Sphingolipid mediated signal transduction |
| title_full | Sphingolipid mediated signal transduction Yusuf A. Hannun |
| title_fullStr | Sphingolipid mediated signal transduction Yusuf A. Hannun |
| title_full_unstemmed | Sphingolipid mediated signal transduction Yusuf A. Hannun |
| title_short | Sphingolipid mediated signal transduction |
| title_sort | sphingolipid mediated signal transduction |
| topic | Cellular signal transduction Signal Transduction physiology Sphingolipids Metabolism Sphingolipids Physiological effect Sphingolipids physiology Sphingolipide (DE-588)4182242-0 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| topic_facet | Cellular signal transduction Signal Transduction physiology Sphingolipids Metabolism Sphingolipids Physiological effect Sphingolipids physiology Sphingolipide Signaltransduktion Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007690355&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT hannunyusufa sphingolipidmediatedsignaltransduction |