Programmed alternative reading of the genetic code:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | German |
| Veröffentlicht: |
New York u.a.
Springer u.a.
1997
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | 208 S. graph. Darst. |
| ISBN: | 3540624856 |
Internformat
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| 245 | 1 | 0 | |a Programmed alternative reading of the genetic code |c Philip J. Farabaugh |
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Datensatz im Suchindex
| _version_ | 1804125898631282688 |
|---|---|
| adam_text | I = CONTENTS =r
1. Introduction 1
2. The Translational Machinery 5
Translation Initiation in Prokaryotes 6
Translation Initiation in Eukaryotes 8
Translation Elongation 14
Translation Termination in Prokaryotes 16
Translation Termination in Eukaryotes 17
Error Correction in Translation 18
A Structural Basis of Error Correction in Translation 20
Rjbosome Editing: A Failsafe Error Correction Mechanism 22
Conclusions 22
3. Errors During Elongation Can Cause Translational
Frameshifting 29
Spontaneous Frameshifting Versus Programmed Frameshifting 30
Spontaneous Frameshifts Can Be Induced at Specific Codons 31
4. Programmed +1 Frameshifting 41
The prfB Gene of £ coli 41
Using theprfB System to Study General Frameshifting in E. coli 46
Ty Retrotransposons in Yeast 47
Frameshifting in Retrotransposon Tyl Occurs by tRNA Slippage 48
Frameshifting in Retrotransposon Ty3 Occurs by Out of Frame
Binding of tRNA 51
The Rat Ornithine Decarboxylase Antizyme Gene 56
Summary 62
5. Programmed 1 Frameshifting in Eukaryotes 69
Programmed 1 Frameshifting in Eukaryotes 69
1 Frameshifting Occurs on a Slippery Heptamer 71
The Simultaneous Slippage Model 72
Stimulation of 1 Frameshifting by a Downstream Pseudoknot 77
Does the Pseudoknot Only Block Passage of the Ribosome? 79
Not All Pseudoknots Which Cause Ribosomes to Pause
Can Stimulate 1 Frameshifting 84
Is There a Pseudoknot Recognizing Factor? 88
Some Simultaneous Slippage Sites Do Not Include a Stimulatory
Pseudoknot 91
Frameshifting Regulates a Morphogenetic Process 92
6. Programmed 1 Frameshift Sites in Prokaryotes 103
The dnaXGene: 1 Frameshifting Stimulated by Both Upstream
and Downstream Elements 103
Programmed 1 Frameshifts in Insertion Sequences Are
Mechanistically Diverse 110
IS1 Includes an Unusual—1 Frameshift Site Ill
IS 150: A Prokaryotic Analog of a Metazoan Simultaneous
Slippage Site 116
IS3: A Single Site Modulates Both 1 Frameshifting
and Translational Coupling 118
IS9J1: A Shine Dalgarno Interaction Stimulates Both
1 Frameshifting and Translational Initiation 120
How Generally is Frameshifting Used in IS Elements? 121
Frameshifting in Enteric Bacteriophage 127
Conclusions 130
7. tRNA Hopping 135
Nonprogrammed Translational Hops 136
Programmed Translational Hopping 137
A Bizarre Form of Programmed Hop: Translation That Hops
from One RNA to Another 142
8. Programmed Readthrough of Translational Termination
Codons 149
Readthrough of Leaky Termination Codons 150
Programmed Translational Readthrough 153
Simple Programmed Translational Readthrough Sites 154
A More Complex Programmed Translational Readthrough Site
from Moloney Murine Leukemia Virus 156
Selenocysteine Is Incorporated Cotranslationally 160
Parallels Between Prokaryotic, Archeal and Eukaryotic
Selenocysteine Systems 167
Conclusions 173
9. Programmed Alternative Decoding as Programmed
Translational Errors 183
Noncognate Decoding Can Induce Frameshift Errors 184
Programmed Translational Frameshifting Can Also Be Induced
by Noncognate Decoding 187
A Dual Error Model for Programmed +1 Frameshifting 191
Is Near Cognate Coding Involved in Alternative Decoding
in General? 193
Is There Evidence That Other Types of Frameshifts
Are Amplified Errors? 194
Summary and Perspective 197
10. Concluding Remarks 203
Index 205
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:08:53Z |
| institution | BVB |
| isbn | 3540624856 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007653301 |
| oclc_num | 845338154 |
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| owner | DE-29 DE-355 DE-BY-UBR DE-11 |
| owner_facet | DE-29 DE-355 DE-BY-UBR DE-11 |
| physical | 208 S. graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer u.a. |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Farabaugh, Philip J. Verfasser aut Programmed alternative reading of the genetic code Philip J. Farabaugh New York u.a. Springer u.a. 1997 208 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Literaturangaben Genetischer Code (DE-588)4156624-5 gnd rswk-swf Translation Genetik (DE-588)4185909-1 gnd rswk-swf Leserahmen (DE-588)4348287-9 gnd rswk-swf Genetischer Code (DE-588)4156624-5 s Leserahmen (DE-588)4348287-9 s Translation Genetik (DE-588)4185909-1 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007653301&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Farabaugh, Philip J. Programmed alternative reading of the genetic code Genetischer Code (DE-588)4156624-5 gnd Translation Genetik (DE-588)4185909-1 gnd Leserahmen (DE-588)4348287-9 gnd |
| subject_GND | (DE-588)4156624-5 (DE-588)4185909-1 (DE-588)4348287-9 |
| title | Programmed alternative reading of the genetic code |
| title_auth | Programmed alternative reading of the genetic code |
| title_exact_search | Programmed alternative reading of the genetic code |
| title_full | Programmed alternative reading of the genetic code Philip J. Farabaugh |
| title_fullStr | Programmed alternative reading of the genetic code Philip J. Farabaugh |
| title_full_unstemmed | Programmed alternative reading of the genetic code Philip J. Farabaugh |
| title_short | Programmed alternative reading of the genetic code |
| title_sort | programmed alternative reading of the genetic code |
| topic | Genetischer Code (DE-588)4156624-5 gnd Translation Genetik (DE-588)4185909-1 gnd Leserahmen (DE-588)4348287-9 gnd |
| topic_facet | Genetischer Code Translation Genetik Leserahmen |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007653301&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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