Exploring genetic mechanisms:
Saved in:
| Format: | Book |
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| Language: | English |
| Published: |
Sausalito, Calif.
Univ. Science Books
1997
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXI, 674 S. Ill., graph. Darst. |
| ISBN: | 0935702709 |
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| 245 | 1 | 0 | |a Exploring genetic mechanisms |c ed. by Maxine Singer ... |
| 264 | 1 | |a Sausalito, Calif. |b Univ. Science Books |c 1997 | |
| 300 | |a XXI, 674 S. |b Ill., graph. Darst. | ||
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| 650 | 4 | |a Gene expression | |
| 650 | 4 | |a Genetic Engineering | |
| 650 | 4 | |a Genetic engineering | |
| 650 | 4 | |a Genetic regulation | |
| 650 | 4 | |a Molecular Biology | |
| 650 | 4 | |a Viruses |x genetics | |
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Record in the Search Index
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| adam_text | EXPLORING GENETIC MECHANISMS EDITED BY MAXINE SINGER PRESIDENT, CARNEGIE
INSTITUTION OF WASHINGTON SCIENTIST EMERITUS, NATIONAL INSTITUTES OF
HEALTH PAUL BERG ROBERT W. AND VIVIAN K. CAHILL PROFESSOR IN CANCER
RESEARCH AND BIOCHEMISTRY DIRECTOR, BECKMAN CENTER FOR MOLECULAR AND
GENETIC MEDICINE STANFORD UNIVERSITY MEDICAL CENTER TECHNISCHE
UNIVERSITAT DARMSTADT FACHBEREICH 10 * BIOLOGIE * B I B I O T H E K *
SCHNITTSPAHNSTRAFTE 10 D-6 4287 D A R M S T A D T UNIVERSITY SCIENCE
BOOKS SAUSALITO, CALIFORNIA ABBREVIATED CONTENTS LIST OF CONTRIBUTORS
VIII CONTENTS IX PREFACE XV CHAPTER 1 MAMMALIAN DNA VIRUSES:
PAPOVAVIRUSES AS MODELS OF CELLULAR GENETIC FUNCTION AND ONCOGENESIS 1
PAUL BERG ANDMAXINE SINGER CHAPTER 2 EUKARYOTIC RNA VIRUSES: A VARIANT
GENETIC SYSTEM 71 ELLEN G. STRAUSS AND JAMES H. STRAUSS CHAPTER 3
RETROVIRUSES: INFECTIOUS GENETIC ELEMENTS 133 STEPHEN P. GOFF CHAPTER 4
ONCOGENES, GROWTH SUPPRESSOR GENES, AND CANCER 20 3 TONY HUNTER CHAPTER
5 MAPPING MARKERS AND GENES IN THE HUMAN GENOME 271 RAY WHITE CHAPTER 6
MOLECULAR GENETICS OF THE HEMOGLOBIN GENES 301 HAIG H. KAZAZIAN, JR.,
AND STYLIANOS ANTONARAKIS CHAPTER 7 GENERATION OF ANTIGEN RECEPTOR
DIVERSITY 337 JIANZHU CHEN AND FREDERICK W. ALT CHAPTER 8 BIOSYNTHESIS
OF INTERCELLULAR MESSENGER PEPTIDES 405 MAXINE SINGER AND PAUL BERG
CHAPTER 9 REGULATION OF DROSOPHILA DEVELOPMENT BY TRANSCRIPTION FACTORS
AND CELL-CELL SIGNALING 459 THOMAS B. KORNBERG AND MATTHEW P. SCOTT
CHAPTER 10 MANIPULATING PROTEIN STRUCTURE 515 CYNTHIA N. KISER AND JOHN
H. RICHARDS CHAPTER 11 GENETIC MODIFICATION OF ANIMALS 565 TIM STEWART
CHAPTER 12 GENETIC MANIPULATION OF PLANTS 597 PATRICIA ZAMBRYSKI INDEX
657 VN CONTENTS PREFACE XV CHAPTER 1 MAMMALIAN DNA VIRUSES:
PAPOVAVIRUSES AS MODELS OF CELLULAR GENETIC FUNCTION AND ONCOGENESIS 1
PAUL BERG AND MAXINE SINGER 1.1 INTRODUCTION 1 1.2 GENERAL FEATURES OF
MAMMALIAN DNA VIRUSES 2 A. VIRUS-HOST SPECIFICITY 2 B. VIRION MORPHOLOGY
AND CONSTITUENTS 3 C. VIRUS LIFE CYCLES 4 D. LYTIC INFECTIONS 6 E.
GENETIC TRANSFORMATION OF INFECTED CELLS 6 F. VIRAL TRANSFORMATION AS A
MODEL FOR CARCINOGENESIS 8 1.3 SV40: THE BEST UNDERSTOOD PAPOVAVIRUS 9
A. VIRION STRUCTURE 10 B. OUTCOMES OF INFECTIONS 12 C. GENETIC ANALYSIS
OF SV40 FUNCTIONS 15 D. MOLECULAR ANALYSIS OF SV40 GENES 16 . E.
TRANSCRIPTIONAL REGULATION 23 F. REPLICATION 27 G. TRANSFORMATION 34 H.
STRUCTURE-FUNCTION OF LARGE-T PROTEIN 40 I. SV40 AS A TRANSDUCING VECTOR
44 1.4 OTHER PAPOVAVIRUSES 46 A. BK AND JC VIRUSES 46 B. POLYOMA 48 C.
PAPILLOMA 54 1.5 COMPARATIVE STRATEGIES FOR CELLULAR ACTIVATION BY
PAPOVA- AND ADENOVIRUSES 60 A. CELLULAR CONTROLS OF THE GL TO S AND G2
TO M PHASE TRANSITIONS 60 B. ABROGATION OF CELLULAR CONTROL BY VIRAL
GENES 61 C. CELLULAR TRANSFORMATION AND ONCOGENESIS 63 1.6 CONCLUSION 64
FURTHER READING 65 CHAPTER EUKARYOTIC RNA VIRUSES: A VARIANT GENETIC
SYSTEM 71 ELLEN G. STRAUSS AND JAMES H. STRAUSS 2.1 REPLICATION
STRATEGIES OF EUKARYOTIC RNA VIRUSES 71 A. THE LIFE CYCLES OF THREE
TYPES OF RNA VIRUSES 73 B. GENETIC INTERACTIONS BETWEEN VIRAL RNA X
GENOMES 78 C. CLONING RNA VIRUS GENOMES 81 2.2 PLUS-STRAND RNA VIRUS
GENOMES 81 A. THE SINDBIS VIRUS SUPERFAMILY 81 B. THE POLIOVIRUS
SUPERFAMILY 90 C. FLAVIVIRUSES 93 D. CORONAVIRUSES 98 2.3 MINUS-STRAND
RNA VIRUS GENOMES 99 A. NONSEGMENTED VIRUSES 100 B. SEGMENTED VIRUSES
102 C. TRANSLATION STRATEGIES OF MINUS-STRAND RNA VIRUSES 106 2.4
DOUBLE-STRAND RNA VIRUS GENOMES 108 2.5 MANIPULATION OF CLONED VIRAL
GENOMES 110 A. EXPRESSION SYSTEMS 111 B. SITE-SPECIFIC MUTAGENESIS 117
2.6 INFECTIOUS CLONES AND THE GENETIC REVOLUTION 121 A. THE POLIOVIRUS
INFECTIOUS CLONE 121 B. INFECTIOUS CLONES OF BROME MOSAIC VIRUS 122 C.
THE SINDBIS INFECTIOUS CLONE 124 2.7 RNA VIRUSES AS VECTORS 128 A.
PROSPECTS FOR PLANT VIRUS VECTORS 129 B. ALPHAVIRUS VECTORS 130 2.8
CONCLUSION 131 FURTHER READING 132 IX CONTENTS CHAPTER RETROVIRUSES:
INFECTIOUS GENETIC ELEMENTS 133 STEPHEN P. GOFF 3.1 INTRODUCTION 133 A.
DISCOVERY AND HISTORY 134 B. TAXONOMY: VARIOUS CLASSIFICATION SYSTEMS
136 3.2 THE REPLICATION-COMPETENT RETROVIRUSES: PRACTICALLY PERFECT
PARASITES 140 A. OVERVIEW OF THE LIFE CYCLE 140 B. EARLY PHASE OF THE
LIFE CYCLE: ESTABLISHMENT OF THE INTEGRATED PROVIRUS 144 C. LATE PHASE
OF THE LIFE CYCLE: EXPRESSION OF THE INTEGRATED PROVIRUS 151 D.
LEUKEMOGENESIS: INSERTIONAL MUTAGENESIS 166 3.3 GENETIC ANALYSIS OF
RETROVIRAL REPLICATION FUNCTIONS 170 . A. ANALYSIS OF THE POL REGION 171
B. REVERSE TRANSCRIPTASE 172 C. PROTEASE 174 D. INTEGRASE 175 3.4
REPLICATION-DEFECTIVE TRANSFORMING VIRUSES 176 A. TRANSFER OF DEFECTIVE
GENOMES: DEPENDENCE ON HELPER VIRUS 176 B. GENOME STRUCTURE:
SUBSTITUTION OF CELLULAR GENES FOR VIRAL ONES 178 C. ORIGINS: MODEL FOR
TRANSDUCTION 180 3.5 HUMAN RETROVIRUSES 184 A. HTLV-I AND -II: REGULATED
RETROVIRUSES 184 B. THE AIDS VIRUSES: REGULATED AND CYTOPATHIC
RETROVIRUSES 186 C. EFFORTS AT ANTIVIRAL THERAPY FOR RETROVIRAL DISEASE
190 3.6 GENE TRANSFER AND GENE THERAPY 191 A. VECTOR GENOMES 191 B.
HELPER VIRUSES AND HELPER CELL LINES 195 C. GENE TRANSFER AND SOMATIC
CELL THERAPY 199 D. GENE TRANSFER AND GERM LINE THERAPY 200 3.7
CONCLUSION 201 FURTHER READING 201 CHAPTER ONCOGENES, GROWTH SUPPRESSOR
GENES, AND CANCER 203 TONY HUNTER 4.1 ONCOGENES 204 A. RETROVIRAL
ONCOGENES 204 B. ONCOGENES FROM TUMOR CELLS 205 C. DIVERSE ORIGINS OF
ONCOGENES 206 D. ONCOGENES, PROTOONCOGENES, AND CANCER 208 4.2 THE
FUNCTIONS OF ONCOGENE PRODUCTS 211 A. CLASS I: GROWTH FACTORS 212 B.
CLASS II: PROTEIN-TYROSINE KINASES 214 C. CLASS III: RECEPTORS LACKING
PROTEIN KINASE ACTIVITY 236 D. CLASS IV: MEMBRANE-ASSOCIATED G PROTEINS
AND THEIR REGULATORS 238 E. CLASS V: CYTOPLASMIC PROTEIN-SERINE KINASES
241 F. CLASS VI: CYTOPLASMIC REGULATORS 243 G. CLASS VII: NUCLEAR
TRANSCRIPTIONAL REGULATORS 244 H. CLASS VIII: CELL CYCLE REGULATORS 252
I. CLASS IX; ANTIAPOPTOSIS FACTORS 256 4.3 DNA TUMOR VIRUS ONCOPROTEINS
AND THE CELL CYCLE 256 4.4 GROWTH SUPPRESSOR PROTEINS 256 A.
RETINOBLASTOMA PROTEIN 257 B. P53 258 C. WT-1 260 D. NEUROFIBROMIN 260
E. GROWTH SUPPRESSOR GENES AND COLON CANCER 260 4.5 COOPERATION BETWEEN
GENETIC EVENTS IN TUMORIGENESIS 261 A. ONCOGENES IN TRANSGENIC MICE 264
B. THE MECHANISMS OF COOPERATION 265 4.6 TUMORIGENESIS IN HUMANS 266 4.7
VIRUSES AND HUMAN CANCER 267 4.8 CONCLUSIONS AND PROSPECTS 268 FURTHER
READING 269 CHAPTER MAPPING MARKERS AND GENES IN THE HUMAN GENOME 271
RAY WHITE 5.1 INTRODUCTION 271 A. THE GENETICS OF CANCER: DNA MARKERS AS
TOOLS FOR DISCOVERY 272 B. THE PROBLEM: IDENTIFYING AND CLONING AN
UNKNOWN GENE THAT HARBORS A DELETERIOUS MUTATION 272 5.2 VARIATIONS IN
DNA SEQUENCE: THE NEW GENETIC MARKERS 276 A. RESTRICTION FRAGMENT LENGTH
POLYMORPHISMS 276 B. OLIGONUCLEOTIDE PROBES 277 C. AMPLIFICATION OF THE
REGION 278 D. HUMAN DNA SEQUENCE VARIANTS AS GENETIC MARKERS 278 5.3
ANALYSIS OF GENETIC LINKAGE IN HUMANS 281 A. GENETIC MAPPING 281 B. THE
LINKAGE APPROACH 281 C. ANALYTICAL COMPLEXITIES 283 D. ESTIMATING
RECOMBINATION FREQUENCY 283 E. MULTILOCUS ANALYSIS 285 F. THE PROBLEM OF
GENE ORDER 285 G. COMBINING DATA FROM DIFFERENT PEDIGREES 286 5.4
LINKAGE MAPS OF HUMAN CHROMOSOMES 287 A. FAMILY PANEL FOR LINKAGE
MAPPING 287 B. LINKAGE MAPS OF AUTOSOMES 287 C. THE X CHROMOSOME AND
LINKAGE 290 5.5 MAPPING AND ISOLATING GENES RESPONSIBLE FOR HUMAN
DISEASES 291 A. LINKAGE MAPPING IN DISEASE FAMILIES 291 B. IDENTIFYING
AND ISOLATING THE GENE 292 5.6 DNA SEQUENCE VARIATIONS AS MARKERS IN
SOMATIC CELLS 293 A. THE RETINOBLASTOMA GENE 293 B. THE APC STORY 296
5.7 CONCLUSION: GENETICS AND HUMAN VARIATION 298 FURTHER READING 299
CONTENTS XI CHAPTER MOLECULAR GENETICS OF THE HEMOGLOBIN GENES 301 HAIG
H. KAZAZIAN, JR., AND STYLIANOS ANTONARAKIS 6.1 THE GLOBIN GENES AND
PROTEINS 302 A. HEMOGLOBIN PROTEIN STRUCTURE 302 B. FUNCTIONAL
PROPERTIES 305 C. THE GLOBIN GENE FAMILIES 306 D. HEMOGLOBIN ONTOGENY
309 6.2 EXPRESSION OF GLOBIN GENES 311 A. COORDINATE REGULATION OF OC-
AND (3-GLOBIN CHAIN SYNTHESIS 311 B. TRANSCRIPTIONAL CONTROL OF GLOBIN
GENE EXPRESSION 313 6.3 MOLECULAR BASIS OF HEMOGLOBINOPATHIES 320 A.
HEMOGLOBIN VARIANTS 320 B. P-THALASSEMIAS 322 C. OC-THALASSEMIAS 329 6.4
DNA POLYMORPHISMS IN THE GLOBIN GENE CLUSTER AND THEIR USE IN ANALYSIS
OF DISEASE-PRODUCING MUTATIONS 330 A. RFLPS 330 B. HAPLOTYPES 331 C.
PRENATAL DIAGNOSIS OF THE THALASSEMIAS 333 FURTHER READING 336 CHAPTER
GENERATION OF ANTIGEN RECEPTOR DIVERSITY 337 JIANZHU CHEN AND FREDERICK
W. ALT 7.1 OVERVIEW OF THE IMMUNE SYSTEM 337 A. IMMUNOGLOBULIN STRUCTURE
338 B. T CELL RECEPTOR STRUCTURE 344 C. SOMATIC ASSEMBLY OF IG AND TCR
GENES 344 D. OVERVIEW OF B CELL DIFFERENTIATION 346 E. CLONAL SELECTION
AND ALLELIC EXCLUSION 346 7.2 CELL AND ANIMAL MODELS TO STUDY B CELL
DIFFERENTIATION 349 A. CELL LINES 349 B. TRANSGENIC AND MUTANT ANIMALS
350 7.3 ORGANIZATION AND EXPRESSION OF IG GENES 351 A. IGH LOCUS 351 B.
K-LOCUS 354 C. ^.-LOCUS 354 7.4 MECHANISM OF ANTIGEN RECEPTOR VARIABLE
REGION GENE ASSEMBLY 354 A. SEQUENCES OF GERM LINE AND REARRANGED V, D,
AND J SEGMENTS 354 B. V(D)J RECOMBINATION SUBSTRATES 357 C. THE V(D)J
RECOMBINATION MECHANISM 362 D. GENES AND ACTIVITIES INVOLVED IN V(D)J
RECOMBINATION 367 E. OVERVIEW OF THE GENERATION OF PRIMARY REPERTOIRE
DIVERSITY 374 F. PRODUCTIVE AND NONPRODUCTIVE REARRANGEMENTS 375 7.5
CONTROL OF V(D)J RECOMBINATION 376 A. CELL TYPE-SPECIFIC CONTROL OF
V(D)J RECOMBINATION 376 B. A COMMON V(D)J RECOMBINASE AND ACCESSIBILITY
CONTROL 376 C. DEVELOPMENTAL STAGE-SPECIFIC CONTROL OF V(D)J
RECOMBINATION 377 D. CONTROL OF ORDERED IG GENE REARRANGEMENT 377 E.
ALLELIC EXCLUSION 380 F. FACTORS THAT CORRELATE WITH V(D)J
RECOMBINATIONAL ACCESSIBILITY 382 G. OVERLAPPING REGULATORY STRATEGIES
IN PRECURSOR B AND T CELL DIFFERENTIATION 385 7.6 MODIFICATION OF THE
PRIMARY B CELL ANTIBODY REPERTOIRE 386 A. SELF-REACTIVE B CELL SELECTION
387 B. SOMATIC HYPERMUTATION 389 C. HEAVY CHAIN CLASS SWITCHING 395 7.7
CONCLUSION 401 FURTHER READING 403 CHAPTER 8 BIOSYNTHESIS OF
INTERCELLULAR MESSENGER PEPTIDES 405 MAXINE SINGER AND PAUL BERG 8.1 THE
SPECIAL PROPERTIES OF INTERCELLULAR MESSENGER PEPTIDES AND THEIR GENES
406 A. THE COMMUNICATIONS NETWORK 406 B. SYNTHESIS OF MESSENGER PEPTIDES
408 8.2 THE BIOCHEMISTRY OF COTRANSLATIONAL AND POSTTRANSLATIONAL
MODIFICATIONS AND PROTEOLYTIC PROCESSING 411 A. PROTEOLYTIC PROCESSING
411 B. GLYCOSYLATION 415 C. A-AMIDATION 415 D. PHOSPHORYLATION 417 E.
SULFATION 417 F. N-ACETYLATION 417 8.3 THE SECRETORY PATHWAY 418 A.
TARGETING TO THE ENDOPLASMIC RETICULUM 418 B. TRANSFER OF PROTEINS FROM
ONE MEMBRANE TO ANOTHER 422 R C. TRANSPORT FROM THE ENDOPLASMIC
RETICULUM TO THE GOLGI 425 D. INCORPORATION OF PROTEINS INTO SECRETORY
GRANULES AND EXOCYTOSIS 426 8.4 THE A-PHEROMONE OF SACCHAROMYCES
CEREVISIAE 427 A. THE GENES FOR A-PHEROMONE 427 B. THE SECRETORY AND
PROCESSING PATHWAY 428 8.5 INSULIN: ONE GENE, TWO POLYPEPTIDES, ONE
PROTEIN 429 A. THE SYNTHESIS OF INSULIN FROM PREPROINSULIN 430 B. THE
PREPROINSULIN MULTIGENE FAMILY 430 , 8.6 MULTIPLE ACTIVE PEPTIDES FROM
SINGLE GENES BY DIFFERENTIAL POSTTRANSLATIONAL PROCESSING 434 A.
VASOPRESSIN AND OXYTOCIN 434 B. OPIOID PEPTIDES AND RELATED HORMONES 436
8.7 MULTIPLE ACTIVE PEPTIDES FROM A SINGLE GENE BY ALTERNATIVE SPLICING:
CALCITONIN AND CGRP 443 A. TWO MRNAS FROM ONE GENE 443 B. SYNTHESIS OF
CALCITONIN AND CGRP IN DIFFERENT TISSUES 445 8.8 MESSENGER PEPTIDES AND
FIXED BEHAVIORAL PATTERNS IN APLYSIA 446 A. FIXED BEHAVIORAL PATTERNS IN
APLYSIA 446 XLL CONTENTS B. THE GENES ENCODING EGG-LAYING PROTEINS 448
C. THE DEVELOPMENT AND DIFFERENTIATION OF NERVE CELLS 452 8.9 COMMENTS
453 FURTHER READING 455 CHAPTER REGULATION OF DROSOPHILA DEVELOPMENT BY
TRANSCRIPTION FACTORS AND CELL-CELL SIGNALING THOMAS B. KORNBERG AND
MATTHEW P. SCOTT 459 9.1 THE DEVELOPMENT PROGRAM OF DROSOPHILA 459 A.
EGG, EMBRYO, LARVA, ADULT 460 B. THE EMBRYO OF DROSOPHILA MELANOGASTER
46 3 9.2 MATERNAL INFLUENCES ON DEVELOPMENTAL EVENTS 464 A.
ANTERIOR-POSTERIOR SEGMENTATION AND DORSAL-VENTRAL POLARIZATION 464 B.
MATERNAL DOWRY REGULATION OF EMBRYONIC ANTERIOR- POSTERIOR PATTERN
POLARIZATION 466 C. DORSAL-VENTRAL PATTERN FORMATION 471 9.3
ANTERIOR-POSTERIOR PATTERNING 473 A. LARVAL BODY SEGMENTATION 473 B.
ELABORATING THE ANTERIOR-POSTERIOR PATTERN IN THE SYNCYTIAL BLASTODERM
483 C. REFINING THE PATTERN IN THE CELLULAR BLASTODERM: REGULATING THE
PAIR-RULE GENES 484 D. REFINING THE PATTERN AFTER CELLULARIZATION:
REGULATING THE SEGMENT POLARITY GENES 487 E. THE CELL-CELL SIGNALING
SYSTEM IN THE CELLULARIZED EMBRYO 488 9.4 THE ROLES OF TRANSCRIPTION
FACTORS IN EARLY DEVELOPMENT 491 A. THE HOMEODOMAIN TRANSCRIPTION FACTOR
SUPERFAMILY 491 B. HOMEODOMAIN STRUCTURE 492 C. FUNCTIONS OF HOMEODOMAIN
TRANSCRIPTION FACTORS 492 9.5 MOLECULAR METHODS IN DROSOPHILA
DEVELOPMENTAL GENETICS 501 A. GENE ISOLATION AND MOLECULAR CLONING 501
B. THE P ELEMENT TRANSPOSON 502 C. THE POLYTENE CHROMOSOMES 504 D.
CLONING STRATEGIES 506 9.6 PERSPECTIVES 507 FURTHER READING 509 CHAPTER
10 MANIPULATING PROTEIN STRUCTURE 515 CYNTHIA N. KISER AND JOHN H.
RICHARDS 10.1 GENERAL CONSIDERATIONS 515 A. SYNTHESIS OF ALTERED
PROTEINS B. MUTATIONAL STRATEGIES 517 516 10.2 PROTEIN FOLDING AND
STABILITY 518 A. OVERVIEW 518 B. HYDROPHOBIC INTERACTIONS 521 C.
HYDROGEN BONDING 524 D. A-HELICES 527 E. DISULFIDE BONDS 530 F. ENTROPIC
STABILIZATION 534 G. KINETICS OF FOLDING AND RESIDUES THAT DIRECT
FOLDING PATHWAYS 536 10.3 PROTEIN FUNCTION 537 A. CLASSICAL ENZYMOLOGY
AND KINETICS 539 B. SERINE PROTEASE FAMILIES 542 C. SUBSTRATE
SPECIFICITY IN THE TRYPSIN FAMILY 542 D. BINDING SPECIFICITY IN
SUBTILISIN 548 E. CATALYSIS BY SERINE PROTEASES 552 F. TRIOSE PHOSPHATE
ISOMERASE*A PERFECT ENZYME 556 G. EVOLUTIONARY IMPROVEMENT OF A DAMAGED
ENZYME 559 I. DESIGNING ENZYMES WITH NOVEL FUNCTIONS*PEPTIDE LIGASES 560
FURTHER READING 563 CHAPTER 11 GENETIC MODIFICATION OF ANIMALS TIM
STEWART 565 11.1 GENETICALLY MODIFIED RODENTS AS AN EXPERIMENTAL TOOL
565 A. HISTORY 565 B. TECHNIQUES 566 11.2 TRANSCRIPTION 573 A.
DEVELOPMENTAL REGULATION: THE GLOBIN LOCUS 573 B. DIFFERENCES IN
EXPRESSION OF GENES IN TRANSGENIC ANIMALS AND TRANSFECTED CELL CULTURES
576 * C . METHYLATION AND PARENTAL IMPRINTING 578 11.3 GROWTH AND
DEVELOPMENT 578 A. MAMMALIAN HOX GENES 578 B. HORMONAL INFLUENCES ON
DEVELOPMENT 579 11.4 IMMUNOLOGY 580 A. HUMORAL IMMUNE RESPONSES 580 B.
CELLULAR IMMUNE RESPONSES 582 C. TOLERANCE 584 11.5 ONCOGENESIS 585 A.
TUMORIGENESIS 585 B. THE NORMAL FUNCTION OF ONCOGENES 586 11.6 MUTATIONS
587 A. INSERTIONAL MUTAGENESIS 587 B. DOMINANT NEGATIVE MUTATIONS 587
11.7 MODELS OF HUMAN DISEASES 590 A. TYPE I DIABETES 590 B. HYPERTENSION
591 C. OTHER DISEASES 592 FURTHER READING 593 CONTENTS XLLL CHAPTER 12
GENETIC MANIPULATION OF PLANTS 597 PATRICIA ZAMBRYSKI 12.1
AGROBACTERIUM-TLANT CELL INTERACTION: GENERAL CONCEPTS 598 12.2
ACTIVATION AND EXPRESSION OF VIRULENCE GENES 601 12.3 DNA TRANSFER 605
A. THE T-DNA ELEMENT 605 B. PRODUCTION OF A DNA TRANSFER INTERMEDIATE
605 C. FORMATION OF A TRANSFERABLE DNA-PROTEIN COMPLEX 609 D. EXIT OF
THE T COMPLEX FROM THE BACTERIAL CELL 610 E. T COMPLEX PASSAGE THROUGH
THE PLANT CELL MEMBRANE 611 F. TARGETING THE T COMPLEX TO THE PLANT CELL
NUCLEUS 612 G. INTEGRATION OF THE T-DNA INTO THE PLANT GENOME 616 12.4
CROWN GALL TUMOR 616 A. CROWN GALL COMPARED TO ANIMAL TUMORS 616 B. THE
MOLECULAR BASIS OF THE CROWN GALL PHENOTYPE 617 C. ORIGIN OF
T-DNA-TRANSFORMING GENES 620 12.5 TI-PLASMID AS A VECTOR FOR GENE
TRANSFER TO PLANTS 621 A. NONONCOGENIC DERIVATIVES OF THE TI-PLASMID
USEFUL AS GENERALIZED VECTORS 621 B. MARKER GENES FOR PLANT CELLS 624 C.
TRANSGENIC PLANTS 627 D. DNA TRANSFER AS A TOOL TO IDENTIFY PLANT GENES
628 E. PLANT CULTURE METHODS DURING GENE TRANSFER EXPERIMENTS 629 F.
GENETIC ENGINEERING OF PLANTS 634 12.6 ARABIDOPSIS THALIANA, A MODEL
PLANT SYSTEM 635 A. REPRODUCTION, DEVELOPMENT, AND DIFFERENTIATION IN
PLANTS 638 B. FLOWERING 641 C. GENETIC DISSECTION OF FLOWER DEVELOPMENT
646 12.7 EVOLUTIONARY CONSIDERATIONS AND FLORAL DEVELOPMENT 653 FURTHER
READING 655 INDEX 657
|
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| discipline | Biologie |
| format | Book |
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| id | DE-604.BV011379291 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:08:44Z |
| institution | BVB |
| isbn | 0935702709 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007647246 |
| oclc_num | 35110171 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-29 DE-20 DE-11 |
| owner_facet | DE-355 DE-BY-UBR DE-29 DE-20 DE-11 |
| physical | XXI, 674 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Univ. Science Books |
| record_format | marc |
| spelling | Exploring genetic mechanisms ed. by Maxine Singer ... Sausalito, Calif. Univ. Science Books 1997 XXI, 674 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Gene expression Genetic Engineering Genetic engineering Genetic regulation Molecular Biology Viruses genetics Genregulation (DE-588)4122166-7 gnd rswk-swf Gentechnologie (DE-588)4071722-7 gnd rswk-swf Genregulation (DE-588)4122166-7 s Gentechnologie (DE-588)4071722-7 s DE-604 Singer, Maxine Sonstige oth HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007647246&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Exploring genetic mechanisms Gene expression Genetic Engineering Genetic engineering Genetic regulation Molecular Biology Viruses genetics Genregulation (DE-588)4122166-7 gnd Gentechnologie (DE-588)4071722-7 gnd |
| subject_GND | (DE-588)4122166-7 (DE-588)4071722-7 |
| title | Exploring genetic mechanisms |
| title_auth | Exploring genetic mechanisms |
| title_exact_search | Exploring genetic mechanisms |
| title_full | Exploring genetic mechanisms ed. by Maxine Singer ... |
| title_fullStr | Exploring genetic mechanisms ed. by Maxine Singer ... |
| title_full_unstemmed | Exploring genetic mechanisms ed. by Maxine Singer ... |
| title_short | Exploring genetic mechanisms |
| title_sort | exploring genetic mechanisms |
| topic | Gene expression Genetic Engineering Genetic engineering Genetic regulation Molecular Biology Viruses genetics Genregulation (DE-588)4122166-7 gnd Gentechnologie (DE-588)4071722-7 gnd |
| topic_facet | Gene expression Genetic Engineering Genetic engineering Genetic regulation Molecular Biology Viruses genetics Genregulation Gentechnologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007647246&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT singermaxine exploringgeneticmechanisms |