The role of microenvironment in axonal regeneration: influences of lesion induced changes and glial implants on the regeneration of the postcommissural fornix ; with ... 6 tables
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1997
|
| Schriftenreihe: | Advances in anatomy, embryology, and cell biology
137 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VIII, 81 S. Ill., graph. Darst. |
| ISBN: | 3540627871 |
Internformat
MARC
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| 245 | 1 | 0 | |a The role of microenvironment in axonal regeneration |b influences of lesion induced changes and glial implants on the regeneration of the postcommissural fornix ; with ... 6 tables |c Christine C. Stichel-Gunkel |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1997 | |
| 300 | |a VIII, 81 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
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Datensatz im Suchindex
| _version_ | 1807229829172428800 |
|---|---|
| adam_text |
CONTENTS
I
INTRODUCTION
.
I
1.1
AXONAL
REGENERATION
IN
THE
ADULT
MAMMALIAN
CNS
.
I
1.2
BARRIERS
AND
INHIBITORS
OF
AXONAL
REGENERATION
.
I
1.3
EXPERIMENTAL
APPROACHES
TO
FOSTER
AXONAL
REGENERATION.
4
1.4
POSTCOMMISSURAL
FORNIX
-
THE
LESION
AND
IMPLANTATION
MODEL
.
7
2
AIMS
OF
THE
STUDY
.
9
3
MATERIAL
AND
METHODS
.
11
3.1
CELL
CULTURE
.
11
3.1.1
ASTROBLASTS
.
11
3.1.2
SCHWANN
CELLS
.
11
3.2
SURGICAL
PROCEDURES
.
12
3.2.1
UNILATERAL
TRANSECTION
OF
THE
POSTCOMMISSURAL
FORNIX
.
12
3.2.2
MICROIMPLANTATION
OF
GLIAL
CELLS
.
12
3.2.3
ANTEROGRADE
TRACING
.
13
3.3
TISSUE
PROCESSING
.
13
3.3.1
PERFUSION
AND
VIBRATOME
SECTIONS
.
13
3.3.2
CRYOSTAT
SECTIONS
.
14
3.3.3
EMBEDDING,
SEMI
AND
ULTRATHIN
SECTIONS
.
14
3.4
HISTOLOGICAL
METHODS
.
14
3.5
IMMUNOHISTOCHEMICAL
METHODS
.
15
3.5.1
ANTIBODIES
.
15
3.5.2
CELL
CULTURE
.
15
3.5.3
SECTIONS
.
15
3.6
IN
SITU
HYBRIDISATION
.
18
3.7
DATA
ANALYSIS
.
18
4
RESULTS
.
19
4.1
UNLESIONED
POSTCOMMISSURAL
FORNIX
.
19
4.2
SEQUENCE
OF
CELLULAR
AND
MOLECULAR
REACTIONS
TO
AXONAL
TRANSECTION
.
19
4.2.1
EARLY
RESPONSES
(1
TO
3-DAY
LESIONS)
.
19
4.2.2
MEDIUM-TERM
RESPONSES
(9
TO
14-DAYLESIONS).
.
23
4.2.3
LONG-TERM
RESPONSES
(4-WEEK
TO
28-MONTH
LESIONS)
.
25
4.3
GLIAL
CELL
IMPLANTATIONS
.
33
4.3.1
IMMATURE
ASTROCYTES
.
33
4.3.2
SCHWANN
CELLS
.
36
5
DISCUSSION
.
45
5.1
ROLE
OF
LESION-INDUCED
CELLULAR
AND
MOLECULAR
CHANGES
IN
DEGENERATION
AND
REGENERATION
PROCESSES
.
45
5.1.1
REACTIVE
ASTROCYTES
.
45
5.1.2
ACTIVATED
MICROGLIA/MACROPHAGES
.
47
5.1.3
EXTRACELLULAR
MATRIX
MOLECULES
.
48
5.1.4
MYELIN
PROTEINS
.
52
5.2
THE
IMPACT
OF
GLIAL
IMPLANTS
ON
AXONAL
REGENERATION
.
53
5.2.1
IMMATURE
ASTROCYTES
.
54
5.2.2
SCHWANN
CELLS
.
56
6
SUMMARY
AND
PERSPECTIVES
.
59
REFERENCES
.
61
SUBJECT
INDEX.
79 |
| any_adam_object | 1 |
| author | Stichel-Gunkel, Christine C. |
| author_facet | Stichel-Gunkel, Christine C. |
| author_role | aut |
| author_sort | Stichel-Gunkel, Christine C. |
| author_variant | c c s g ccs ccsg |
| building | Verbundindex |
| bvnumber | BV011347729 |
| classification_rvk | WN 2200 |
| ctrlnum | (OCoLC)845416921 (DE-599)BVBBV011347729 |
| dewey-full | 571 573.8/519 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects 573 - Specific physiological systems in animals |
| dewey-raw | 571 573.8/519 |
| dewey-search | 571 573.8/519 |
| dewey-sort | 3571 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Book |
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| id | DE-604.BV011347729 |
| illustrated | Illustrated |
| indexdate | 2024-08-13T00:24:31Z |
| institution | BVB |
| isbn | 3540627871 |
| language | English |
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| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer |
| record_format | marc |
| series | Advances in anatomy, embryology, and cell biology |
| series2 | Advances in anatomy, embryology, and cell biology |
| spelling | Stichel-Gunkel, Christine C. Verfasser aut The role of microenvironment in axonal regeneration influences of lesion induced changes and glial implants on the regeneration of the postcommissural fornix ; with ... 6 tables Christine C. Stichel-Gunkel Berlin [u.a.] Springer 1997 VIII, 81 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in anatomy, embryology, and cell biology 137 Tiermodell (DE-588)4140660-6 gnd rswk-swf Implantation (DE-588)4026660-6 gnd rswk-swf Gliazelle (DE-588)4136721-2 gnd rswk-swf Extrazellulärraum (DE-588)4205506-4 gnd rswk-swf Axon (DE-588)4200576-0 gnd rswk-swf Nervenregeneration (DE-588)4041641-0 gnd rswk-swf Nervenverletzung (DE-588)4041648-3 gnd rswk-swf Axon (DE-588)4200576-0 s Nervenregeneration (DE-588)4041641-0 s Extrazellulärraum (DE-588)4205506-4 s DE-604 Gliazelle (DE-588)4136721-2 s Implantation (DE-588)4026660-6 s Tiermodell (DE-588)4140660-6 s Nervenverletzung (DE-588)4041648-3 s Advances in anatomy, embryology, and cell biology 137 (DE-604)BV002528506 137 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007625192&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Stichel-Gunkel, Christine C. The role of microenvironment in axonal regeneration influences of lesion induced changes and glial implants on the regeneration of the postcommissural fornix ; with ... 6 tables Advances in anatomy, embryology, and cell biology Tiermodell (DE-588)4140660-6 gnd Implantation (DE-588)4026660-6 gnd Gliazelle (DE-588)4136721-2 gnd Extrazellulärraum (DE-588)4205506-4 gnd Axon (DE-588)4200576-0 gnd Nervenregeneration (DE-588)4041641-0 gnd Nervenverletzung (DE-588)4041648-3 gnd |
| subject_GND | (DE-588)4140660-6 (DE-588)4026660-6 (DE-588)4136721-2 (DE-588)4205506-4 (DE-588)4200576-0 (DE-588)4041641-0 (DE-588)4041648-3 |
| title | The role of microenvironment in axonal regeneration influences of lesion induced changes and glial implants on the regeneration of the postcommissural fornix ; with ... 6 tables |
| title_auth | The role of microenvironment in axonal regeneration influences of lesion induced changes and glial implants on the regeneration of the postcommissural fornix ; with ... 6 tables |
| title_exact_search | The role of microenvironment in axonal regeneration influences of lesion induced changes and glial implants on the regeneration of the postcommissural fornix ; with ... 6 tables |
| title_full | The role of microenvironment in axonal regeneration influences of lesion induced changes and glial implants on the regeneration of the postcommissural fornix ; with ... 6 tables Christine C. Stichel-Gunkel |
| title_fullStr | The role of microenvironment in axonal regeneration influences of lesion induced changes and glial implants on the regeneration of the postcommissural fornix ; with ... 6 tables Christine C. Stichel-Gunkel |
| title_full_unstemmed | The role of microenvironment in axonal regeneration influences of lesion induced changes and glial implants on the regeneration of the postcommissural fornix ; with ... 6 tables Christine C. Stichel-Gunkel |
| title_short | The role of microenvironment in axonal regeneration |
| title_sort | the role of microenvironment in axonal regeneration influences of lesion induced changes and glial implants on the regeneration of the postcommissural fornix with 6 tables |
| title_sub | influences of lesion induced changes and glial implants on the regeneration of the postcommissural fornix ; with ... 6 tables |
| topic | Tiermodell (DE-588)4140660-6 gnd Implantation (DE-588)4026660-6 gnd Gliazelle (DE-588)4136721-2 gnd Extrazellulärraum (DE-588)4205506-4 gnd Axon (DE-588)4200576-0 gnd Nervenregeneration (DE-588)4041641-0 gnd Nervenverletzung (DE-588)4041648-3 gnd |
| topic_facet | Tiermodell Implantation Gliazelle Extrazellulärraum Axon Nervenregeneration Nervenverletzung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007625192&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002528506 |
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