Signal transduction by G protein coupled receptors: bioenergetics and G protein activation: proton transfer and GTP synthesis to explain the experimental findings
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| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York, NY [u.a.]
Springer [u.a.]
1997
|
| Series: | Molecular biology intelligence unit
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 151 S. Ill., graph. Darst. |
| ISBN: | 3540624031 |
Staff View
MARC
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| 245 | 1 | 0 | |a Signal transduction by G protein coupled receptors |b bioenergetics and G protein activation: proton transfer and GTP synthesis to explain the experimental findings |c Paul H. J. Nederkoorn ; Henk Timmerman ; Gabrielle M. Donné- Op den Kelder |
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| 650 | 4 | |a Guanosine triphosphate |x Synthesis | |
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Record in the Search Index
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| adam_text | I =CONTENTS= ji
PART I: Bioenergetical Mechanisms, Hydrogen Bonded Chains
and Proton Transfer Mechanisms 1
1. Bioenergetics 3
1.1 Introduction 3
1.2 Proton Semiconductors and Energy Transduction:
Hydrogen Bonded Chains 7
1.3 The Proton Circuit 12
1.4 Summary 14
2. Primary and Secondary Proton Pumps 17
2.1 Primary Pumps—A Special Case: Bacteriorhodopsin 17
2.2 Secondary Pumps, ATP Synthases 21
2.3 Summary 24
3. ATP Hydrolysis and Synthesis Mechanisms 27
3.1 The Chemistry of ATP Hydrolysis
and Synthesis 27
3.2 Direct or Indirect Mechanism for ATP Synthesis? 30
3.3 Rotational Movement of Catalytic Sites on F, 34
3.4 Summary 37
Part II: Proton Transferring Hydrogen Bonded Chains
and the Ternary Complex: The Ternary Complex
as a GTP Synthase 41
4. G Protein Coupled Receptors and G Proteins 43
4.1 Characteristic and Structural Features of G Protein Coupled
Receptors 43
4.2 Proton Transfers in GPCRs 44
4.3 Topiol s Deletion Model 47
4.4 Characteristic Features of G Proteins 47
4.5 Structural Features of G Proteins 51
4.6 Summary 58
5. The (Extended) Ternary Complex Model ([E]TCM)
for G Protein Activation 63
5.1 The Classical Theoretical Framework 63
5.2 Components of the ETCM 64
5.3 Summary 70
6. Nucleotide Exchange Reactions and G Protein Activation 75
6.1 Survey of Experimental Evidence for an Exchange Reaction 75
6.2 Can the Current Mechanism for G Protein Activation
Be Falsified? 77
6.3 Summary 90
7. A New Mechanism for G Protein Activation 93
7.1 A Schematic View of a New Mechanism for G Protein Activation,
Proton Transporting Receptors and GTP Synthesis 93
7.2 Exchange Patterns and Non hydrolyzable GTP Analogues 102
7.3 Interpretation of Thermodynamical Data 107
7.4 Desensitization 108
7.5 Summary 109
8. Principles of a New Molecular Mechanism
for Signal Transduction 113
8.1 Postulate 1: GPCRs possess a proton wire (HBC) to translocate
protons from the extracellular space across the membrane 113
8.2 Postulate 2: G^ and Ga* correspond to the Es and Eh
forms of the Fj unit of Fj F0 ATP synthase, respectively 125
8.3 Postulate 3: GPCRs correspond to the Fo unit of
ATP synthases 126
8.4 Postulate 4: The ternary complex acts as a secondary proton
pump and as a GTP synthase 128
8.5 Postulate 5: Cytosensor microphysiometers measure primary
pump activities 134
8.6 Summary 135
9. Conclusions and Future Perspectives 143
Index 149
|
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| id | DE-604.BV011275284 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:06:59Z |
| institution | BVB |
| isbn | 3540624031 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007571413 |
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| physical | 151 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Nederkoorn, Paul H. J. Verfasser aut Signal transduction by G protein coupled receptors bioenergetics and G protein activation: proton transfer and GTP synthesis to explain the experimental findings Paul H. J. Nederkoorn ; Henk Timmerman ; Gabrielle M. Donné- Op den Kelder New York, NY [u.a.] Springer [u.a.] 1997 151 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Bioenergetics Cellular signal transduction Energy Metabolism G proteins GTP-Binding Proteins Guanosine triphosphate Synthesis Receptors, Cell Surface Signal Transduction Rezeptor (DE-588)4049722-7 gnd rswk-swf GTP-bindende Proteine (DE-588)4248354-2 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 s GTP-bindende Proteine (DE-588)4248354-2 s Rezeptor (DE-588)4049722-7 s DE-604 Timmerman, Henk Verfasser aut Donné-Op den Kelder, Gabriëlle M. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007571413&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nederkoorn, Paul H. J. Timmerman, Henk Donné-Op den Kelder, Gabriëlle M. Signal transduction by G protein coupled receptors bioenergetics and G protein activation: proton transfer and GTP synthesis to explain the experimental findings Bioenergetics Cellular signal transduction Energy Metabolism G proteins GTP-Binding Proteins Guanosine triphosphate Synthesis Receptors, Cell Surface Signal Transduction Rezeptor (DE-588)4049722-7 gnd GTP-bindende Proteine (DE-588)4248354-2 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| subject_GND | (DE-588)4049722-7 (DE-588)4248354-2 (DE-588)4318717-1 |
| title | Signal transduction by G protein coupled receptors bioenergetics and G protein activation: proton transfer and GTP synthesis to explain the experimental findings |
| title_auth | Signal transduction by G protein coupled receptors bioenergetics and G protein activation: proton transfer and GTP synthesis to explain the experimental findings |
| title_exact_search | Signal transduction by G protein coupled receptors bioenergetics and G protein activation: proton transfer and GTP synthesis to explain the experimental findings |
| title_full | Signal transduction by G protein coupled receptors bioenergetics and G protein activation: proton transfer and GTP synthesis to explain the experimental findings Paul H. J. Nederkoorn ; Henk Timmerman ; Gabrielle M. Donné- Op den Kelder |
| title_fullStr | Signal transduction by G protein coupled receptors bioenergetics and G protein activation: proton transfer and GTP synthesis to explain the experimental findings Paul H. J. Nederkoorn ; Henk Timmerman ; Gabrielle M. Donné- Op den Kelder |
| title_full_unstemmed | Signal transduction by G protein coupled receptors bioenergetics and G protein activation: proton transfer and GTP synthesis to explain the experimental findings Paul H. J. Nederkoorn ; Henk Timmerman ; Gabrielle M. Donné- Op den Kelder |
| title_short | Signal transduction by G protein coupled receptors |
| title_sort | signal transduction by g protein coupled receptors bioenergetics and g protein activation proton transfer and gtp synthesis to explain the experimental findings |
| title_sub | bioenergetics and G protein activation: proton transfer and GTP synthesis to explain the experimental findings |
| topic | Bioenergetics Cellular signal transduction Energy Metabolism G proteins GTP-Binding Proteins Guanosine triphosphate Synthesis Receptors, Cell Surface Signal Transduction Rezeptor (DE-588)4049722-7 gnd GTP-bindende Proteine (DE-588)4248354-2 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| topic_facet | Bioenergetics Cellular signal transduction Energy Metabolism G proteins GTP-Binding Proteins Guanosine triphosphate Synthesis Receptors, Cell Surface Signal Transduction Rezeptor GTP-bindende Proteine Signaltransduktion |
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