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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Oxford [u.a.]
Oxford Univ. Press
1997
|
| Edition: | 6. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVIII, 1260 S. zahlr. Ill., graph. Darst. |
| ISBN: | 0198577788 0198542879 0198577796 |
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Record in the Search Index
| _version_ | 1804125763240198144 |
|---|---|
| adam_text | BENJAMIN LEWIN JECHNISCHE HOCHSCHULE DARMSTADT FACKBEREICH 10 - BIOLOGIE
- BIBLIOTHEK- SCHNITTSPAHNSTRAFLE 10 0-64287 DARMSUAT, INV.-NR. OXFORD
NEW YORK TOKYO OXFORD UNIVERSITY PRESS 1997 OUTLINE INTRODUCTION: CELLS
AS MACROMOLECULAR ASSEMBLIES 1 1 PROTEINS 3 2 COMPARTMENTS 27 PART 1:
DNA AS INFORMATION 49 3 GENES ARE MUTABLE UNITS 51 4 DNA IS THE GENETIC
MATERIAL 71 5 NUCLEIC ACID STRUCTURE 97 6 ISOLATING THE GENE 115 PART 2:
FROM GENE TO PROTEIN 151 7 MESSENGER RNA 153 8 PROTEIN SYNTHESIS 179 9
INTERPRETING THE GENETIC CODE 213 10 PROTEIN LOCALIZATION 244 PART 3:
PROKARYOTIC GENE EXPRESSION 285 11 TRANSCRIPTION 287 12 THE OPERON 335
13 PHAGE STRATEGIES 395 PART 4: PERPETUATION OF DNA 427 14 THE REPLICON
429 15 DNA REPLICATION 471 16 RESTRICTION AND REPAIR 505 17
RECOMBINATION 531 18 TRANSPOSONS 563 19 RETROVIRUSES AND RETROPOSONS 597
PART 5: THE EUKARYOTIC GENOME 621 20 DNA BIOTECHNOLOGY 623 21 GENOMES
645 22 EXONS AND INTRONS 663 23 GENE NUMBERS 687 24 ORGANELLE GENOMES
713 25 SIMPLE SEQUENCE DNA 727 26 CHROMOSOMES 743 27 NUCLEOSOMES 769
PART 6: EUKARYOTIC GENE EXPRESSION 809 28 INITIATION OF TRANSCRIPTION
811 29 REGULATION OF TRANSCRIPTION 847 30 NUCLEAR SPLICING 885 31
CATALYTIC RNA 921 32 REARRANGEMENT OF DNA 947 33 IMMUNE DIVERSITY 989
PART 7: CELL GROWTH, CANCER, AND DEVELOPMENT 1025 34 PROTEIN TRAFFICKING
1027 35 SIGNAL TRANSDUCTION 1053 36 CELL CYCLE AND GROWTH REGULATION
1089 37 ONCOGENES AND CANCER 1131 38 GRADIENTS AND CASCADES 1173
EPILOGUE: LANDMARK SHIFTS IN PERSPECTIVES 1213 CONTENTS INTRODUCTION:
CELLS AS MACROMOLECULAR ASSEMBLIES 1: PROTEINS MACROMOLECULES ARE
ASSEMBLED BY POLYMERIZING SMALL MOLECULES PROTEINS CONSIST OF CHAINS OF
AMINO ACIDS PROTEIN CONFORMATION DEPENDS ON THE AQUEOUS ENVIRONMENT
PROTEIN STRUCTURES ARE EXTREMELY VERSATILE HOW DO PROTEINS FOLD INTO THE
CORRECT CONFORMATION? 2: COMPARTMENTS CELLULAR COMPARTMENTS ARE BOUNDED
BY MEMBRANES THE CYTOPLASM CONTAINS NETWORKS OF MEMBRANES CELL SHAPE IS
DETERMINED BY THE CYTOSKELETON SOME ORGANELLES ARE SURROUNDED BY AN
ENVELOPE THE ENVIRONMENT OF THE NUCLEUS AND ITS REORGANIZATION THE ROLE
OF CHROMOSOMES IN HEREDITY 3 6 8 13 17 19 27 29 33 36 39 41 43 PART 1:
DNA AS INFORMATION 3: GENES ARE MUTABLE UNITS DISCOVERY OF THE GENE
GENES LIE IN A LINEAR ARRAY ON CHROMOSOMES ONE GENE*ONE PROTEIN THE
CISTRON MAPPING MUTATIONS AT THE MOLECULAR LEVEL THE NATURE OF MULTIPLE
ALLELES 4: DNA IS THE GENETIC MATERIAL THE DISCOVERY OF DNA DNA IS THE
(ALMOST) UNIVERSAL GENETIC MATERIAL THE COMPONENTS OF DNA DNA IS A
DOUBLE HELIX 51 54 56 61 63 65 67 71 74 76 79 82 X I CONTENTS DNA
REPLICATION IS SEMICONSERVATIVE THE GENETIC CODE IS READ IN TRIPLETS
MUTATIONS CHANGE THE SEQUENCE OF DNA MUTATIONS ARE CONCENTRATED AT
HOTSPOTS THE RATE OF MUTATION 5: NUCLEIC ACID STRUCTURE DNA CAN BE
DENATURED AND RENATURED NUCLEIC ACIDS HYBRIDIZE BY BASE PAIRING
SINGLE-STRANDED NUCLEIC ACIDS MAY HAVE SECONDARY STRUCTURE INVERTED
REPEATS AND SECONDARY STRUCTURE DUPLEX DNA HAS ALTERNATIVE
DOUBLE-HELICAL STRUCTURES CLOSED DNA CAN BE SUPERCOILED SUPERCOILING
INFLUENCES THE STRUCTURE OF THE DOUBLE HELIX 6: ISOLATING THE GENE A
RESTRICTION MAP IS CONSTRUCTED BY CLEAVING DNA INTO SPECIFIC FRAGMENTS
RESTRICTION SITES CAN BE USED AS GENETIC MARKERS OBTAINING THE SEQUENCE
OF DNA PROKARYOTIC GENES AND PROTEINS ARE COLINEAR M-ACTING SITES AND
TRANS-ACTING MOLECULES EUKARYOTIC GENES ARE OFTEN INTERRUPTED SOME DNA
SEQUENCES CODE FOR MORE THAN ONE PROTEIN GENETIC INFORMATION CAN BE
PROVIDED BY DNA OR RNA THE SCOPE OF THE PARADIGM 82 86 89 91 94 97 98 99
101 105 107 109 111 115 117 122 129 134 136 139 141 143 146 PART 2: FROM
GENE TO PROTEIN 7: MESSENGER RNA TRANSFER RNA IS THE ADAPTOR MESSENGER
RNA IS TRANSLATED BY RIBOSOMES THE LIFE CYCLE OF MESSENGER RNA MOST
BACTERIAL GENES ARE EXPRESSED VIA POLYCISTRONIC MESSENGERS TRANSLATION
OF EUKARYOTIC MRNA EUKARYOTIC MRNAS ARE POLYADENYLATED AT THE 3 END
EUKARYOTIC MRNAS HAVE A METHYLATED CAP AT THE 5 END PROCESSING AND
STABILITY OF MRNA 8: PROTEIN SYNTHESIS ORGANIZATION OF THE RIBOSOME THE
STAGES OF PROTEIN SYNTHESIS INITIATION IN BACTERIA NEEDS 30S SUBUNITS
AND ACCESSORY FACTORS A SPECIAL INITIATOR TRNA STARTS THE POLYPEPTIDE
CHAIN INITIATION INVOLVES BASE PAIRING BETWEEN MRNA AND RRNA SMALL
SUBUNITS MIGRATE TO INITIATION SITES ON EUKARYOTIC MRNA ELONGATION
FACTOR T BRINGS AMINOACYL-TRNA INTO THE A SITE 153 155 159 162 166 168
170 171 173 179 181 183 186 187 191 192 196 CONTENTS I XI TRANSLOCATION
MOVES THE RIBOSOME THREE CODONS TERMINATE PROTEIN SYNTHESIS RIBOSOMES
HAVE SEVERAL ACTIVE CENTERS THE ROLE OF RIBOSOMAL RNA IN PROTEIN
SYNTHESIS 9: INTERPRETING THE GENETIC CODE CODON-ANTICODON RECOGNITION
INVOLVES WOBBLING TRNA CONTAINS MODIFIED BASES THAT INFLUENCE ITS
PAIRING PROPERTIES THE GENETIC CODE IS ALTERED IN MITOCHONDRIA TRNAS ARE
CHARGED WITH AMINO ACIDS BY INDIVIDUAL SYNTHETASES ACCURACY DEPENDS ON
PROOFREADING SUPPRESSOR TRNAS HAVE MUTATED ANTICODONS THAT READ NEW
CODONS THE ACCURACY OF TRANSLATION TRNA MAY INFLUENCE THE READING FRAME
10: PROTEIN LOCALIZATION CHAPERONES MAY BE REQUIRED FOR PROTEIN FOLDING
POST-TRANSLATIONAL MEMBRANE INSERTION DEPENDS ON LEADER SEQUENCES A
HIERARCHY OF SEQUENCES DETERMINES LOCATION WITHIN ORGANELLES SIGNAL
SEQUENCES INITIATE CO-TRANSLATIONAL TRANSFER THROUGH ER MEMBRANES HOW DO
PROTEINS ENTER AND LEAVE MEMBRANES? THE TRANSLOCATION APPARATUS
INTERACTS WITH SIGNAL AND ANCHOR SEQUENCES ANCHOR SIGNALS ARE NEEDED FOR
MEMBRANE RESIDENCE BACTERIA USE BOTH CO-TRANSLATIONAL AND
POST-TRANSLATIONAL TRANSLOCATION PORES CONTROL NUCLEAR INGRESS AND
EGRESS PROTEIN DEGRADATION BY PROTEASOMES 198 202 204 207 213 215 217
221 223 228 231 235 237 244 246 251 254 257 258 263 266 269 271 278 PART
3: PROKARYOTIC GENE EXPRESSION 285 11: TRANSCRIPTION TRANSCRIPTION IS
CATALYZED BY RNA POLYMERASE RNA POLYMERASE CONSISTS OF MULTIPLE SUBUNITS
SIGMA FACTOR CONTROLS BINDING TO DNA PROMOTER RECOGNITION DEPENDS ON
CONSENSUS SEQUENCES RNA POLYMERASE BINDS TO ONE FACE OF DNA SUBSTITUTION
OF SIGMA FACTORS MAY CONTROL INITIATION SPORULATION UTILIZES A CASCADE
OF MANY SIGMA FACTORS BACTERIAL RNA POLYMERASE HAS TWO MODES OF
TERMINATION HOW DOES RHO FACTOR WORK? ANTITERMINATION DEPENDS ON
SPECIFIC SITES MORE SUBUNITS FOR RNA POLYMERASE 12: THE OPERON
STRUCTURAL GENE CLUSTERS ARE COORDINATELY CONTROLLED REPRESSOR IS
CONTROLLED BY A SMALL MOLECULE INDUCER MUTATIONS IDENTIFY THE OPERATOR
AND THE REGULATOR GENE 287 289 294 297 302 305 309 312 317 320 323 329
335 338 340 343 XII I CONTENTS REPRESSOR PROTEIN BINDS TO THE OPERATOR
AND IS RELEASED BY INDUCER THE SPECIFICITY OF PROTEIN-DNA INTERACTIONS
REPRESSION CAN OCCUR AT MULTIPLE LOCI DISTINGUISHING POSITIVE AND
NEGATIVE CONTROL CATABOLITE REPRESSION INVOLVES POSITIVE REGULATION AT
THE PROMOTER ADVERSE GROWTH CONDITIONS PROVOKE THE STRINGENT RESPONSE
AUTOGENOUS CONTROL MAY OCCUR AT TRANSLATION ALTERNATIVE SECONDARY
STRUCTURES CONTROL ATTENUATION SMALL RNA MOLECULES CAN REGULATE
TRANSLATION REGULATION BY CLEAVAGE OF MRNA CLEAVAGES ARE NEEDED TO
RELEASE PROKARYOTIC AND EUKARYOTIC RRNAS 13: PHAGE STRATEGIES LYTIC
DEVELOPMENT IS CONTROLLED BY A CASCADE FUNCTIONAL CLUSTERING IN PHAGES
T7 AND T4 THE LAMBDA LYTIC CASCADE RELIES ON ANTITERMINATION LYSOGENY IS
MAINTAINED BY AN AUTOGENOUS CIRCUIT THE DNA-BINDING FORM OF REPRESSOR IS
A DIMER REPRESSOR BINDS COOPERATIVELY AT EACH OPERATOR USING A
HELIX-TURN-HELIX MOTIF HOW IS REPRESSOR SYNTHESIS ESTABLISHED? A SECOND
REPRESSOR IS NEEDED FOR LYTIC INFECTION A DELICATE BALANCE: LYSOGENY
VERSUS LYSIS 348 354 357 359 361 365 368 374 380 385 387 395 397 400 403
407 410 412 417 421 423 PART 4: PERPETUATION OF DNA 14: THE REPLICON
ORIGINS CAN BE MAPPED BY AUTORADIOGRAPHY AND ELECTROPHORESIS THE
BACTERIAL GENOME IS A SINGLE CIRCULAR REPLICON EACH EUKARYOTIC
CHROMOSOME CONTAINS MANY REPLICONS ISOLATING THE ORIGINS OF YEAST
REPLICONS D LOOPS MAY BE MAINTAINED AT MITOCHONDRIAL ORIGINS THE PROBLEM
OF LINEAR REPLICONS ROLLING CIRCLES PRODUCE MULTIMERS OF A REPLICON
SINGLE-STRANDED GENOMES ARE GENERATED FOR BACTERIAL CONJUGATION
CONNECTING BACTERIAL REPLICATION TO THE CELL CYCLE CELL DIVISION AND
CHROMOSOME SEGREGATION MULTIPLE SYSTEMS ENSURE PLASMID SURVIVAL IN
BACTERIAL POPULATIONS PLASMID INCOMPATIBILITY IS CONNECTED WITH COPY
NUMBER 15: DNA REPLICATION DNA POLYMERASES: THE ENZYMES THAT MAKE DNA
DNA SYNTHESIS IS SEMIDISCONTINUOUS AND PRIMED BY RNA THE PRIMOSOME
INITIATES SYNTHESIS OF OKAZAKI FRAGMENTS COORDINATING SYNTHESIS OF THE
LAGGING AND LEADING STRANDS THE REPLICATION APPARATUS OF PHAGE T4
CREATING THE REPLICATION FORKS AT AN ORIGIN 429 431 433 436 438 440 442
445 449 453 455 460 463 471 472 477 480 484 491 493 CONTENTS I XIII
COMMON EVENTS IN PRIMING REPLICATION AT THE ORIGIN 496 DOES METHYLATION
AT THE ORIGIN REGULATE INITIATION? 498 LICENSING FACTOR CONTROLS
EUKARYOTIC REREPLICATION 500 16: RESTRICTION AND REPAIR 505 THE
CONSEQUENCES OF MODIFICATION AND RESTRICTION 506 TYPE II RESTRICTION
ENZYMES ARE COMMON 508 THE ALTERNATIVE ACTIVITIES OF TYPE I ENZYMES
510 THE DUAL ACTIVITIES OF TYPE III ENZYMES 513 DEALING WITH INJURIES IN
DNA 515 EXCISION REPAIR SYSTEMS IN E. COLI 518 CONTROLLING THE DIRECTION
OF MISMATCH REPAIR 521 RETRIEVAL SYSTEMS IN E. COLI 523 RECA TRIGGERS
THE SOS SYSTEM 525 EUKARYOTIC REPAIR SYSTEMS 527 17: RECOMBINATION 531
BREAKAGE AND REUNION INVOLVES HETERODUPLEX DNA 534 DOUBLE-STRAND BREAKS
INITIATE RECOMBINATION 537 DOUBLE-STRAND BREAKS MAY INITIATE SYNAPSIS
539 BACTERIAL RECOMBINATION INVOLVES SINGLE-STRAND ASSIMILATION 542 GENE
CONVERSION ACCOUNTS FOR INTERALLELIC RECOMBINATION 548 TOPOLOGICAL
MANIPULATION OF DNA 550 GYRASE INTRODUCES NEGATIVE SUPERCOILS IN DNA 553
SPECIALIZED RECOMBINATION INVOLVES BREAKAGE AND REUNION AT SPECIFIC
SITES 555 18: TRANSPOSONS 563 INSERTION SEQUENCES ARE SIMPLE
TRANSPOSITION MODULES 565 COMPOSITE TRANSPOSONS HAVE IS MODULES 567
TRANSPOSITION OCCURS BY BOTH REPLICATIVE AND NONREPLICATIVE MECHANISMS
569 COMMON INTERMEDIATES FOR TRANSPOSITION . 572 REPLICATIVE
TRANSPOSITION PROCEEDS THROUGH A COINTEGRATE 574 NONREPLICATIVE
TRANSPOSITION PROCEEDS BY BREAKAGE AND REUNION 576 TNA TRANSPOSITION
REQUIRES TRANSPOSASE AND RESOLVASE 578 TRANSPOSITION OF TNLO HAS
MULTIPLE CONTROLS 580 CONTROLLING ELEMENTS IN MAIZE CAUSE BREAKAGE AND
REARRANGEMENTS 583 CONTROLLING ELEMENTS IN MAIZE FORM FAMILIES OF
TRANSPOSONS 586 SPM ELEMENTS INFLUENCE GENE EXPRESSION 588 THE ROLE OF
TRANSPOSABLE ELEMENTS IN HYBRID DYSGENESIS 589 19: RETROVIRUSES AND
RETROPOSONS 597 THE RETROVIRUS LIFE CYCLE INVOLVES TRANSPOSITION-LIKE
EVENTS 598 RETROVIRUSES MAY TRANSDUCE CELLULAR SEQUENCES 607 YEAST TY
ELEMENTS RESEMBLE RETROVIRUSES 609 MANY TRANSPOSABLE ELEMENTS RESIDE IN
D. MELANOGASTER 611 RETROPOSONS FALL INTO TWO CLASSES 613 XIV I CONTENTS
PART 5: THE EUKARYOTIC GENOME 621 20: DNA BIOTECHNOLOGY ANY DNA SEQUENCE
CAN BE CLONED IN BACTERIA OR YEAST CONSTRUCTING THE CHIMERIC DNA COPYING
MRNA INTO CDNA ISOLATING INDIVIDUAL GENES FROM THE GENOME WALKING ALONG
THE CHROMOSOME EUKARYOTIC GENES CAN BE EXPRESSED IN PROKARYOTIC SYSTEMS
21: GENOMES THE C-VALUE PARADOX DESCRIBES VARIATIONS IN GENOME SIZE
REASSOCIATION KINETICS DEPEND ON SEQUENCE COMPLEXITY EUKARYOTIC GENOMES
CONTAIN SEVERAL SEQUENCE COMPONENTS NONREPETITIVE DNA COMPLEXITY CAN
ESTIMATE GENOME SIZE EUKARYOTIC GENOMES CONTAIN REPETITIVE SEQUENCES
MOST STRUCTURAL GENES LIE IN NONREPETITIVE DNA HOW MANY NONREPETITIVE
GENES ARE EXPRESSED? GENES ARE EXPRESSED AT WIDELY VARYING LEVELS 22:
EXONS AND INTRONS , ORGANIZATION OF INTERRUPTED GENES MAY BE CONSERVED
GENES SHOW A WIDE DISTRIBUTION OF SIZES ONE DNA SEQUENCE MAY CODE FOR
MULTIPLE PROTEINS EXON SEQUENCES ARE CONSERVED BUT INTRONS VARY GENES
CAN BE ISOLATED BY THE CONSERVATION OF EXONS HOW DID INTERRUPTED GENES
EVOLVE? 23: GENE NUMBERS ESSENTIAL GENES AND TOTAL GENE NUMBER GLOBIN
GENES ARE ORGANIZED IN TWO CLUSTERS UNEQUAL CROSSING-OVER REARRANGES
GENE CLUSTERS GENE CLUSTERS SUFFER CONTINUAL REORGANIZATION SEQUENCE
DIVERGENCE IS THE BASIS FOR THE EVOLUTIONARY CLOCK PSEUDOGENES ARE DEAD
ENDS OF EVOLUTION GENES FOR RRNA COMPRISE A REPEATED TANDEM UNIT AN
EVOLUTIONARY DILEMMA: HOW ARE MULTIPLE ACTIVE COPIES MAINTAINED? 24:
ORGANELLE GENOMES ORGANELLE GENOMES ARE CIRCULAR DNAS THAT CODE FOR
ORGANELLE PROTEINS THE CHLOROPLAST GENOME CODES FOR -100 PROTEINS AND
RNAS THE MITOCHONDRIAL GENOME IS LARGE IN YEAST BUT SMALL IN MAMMALS
RECOMBINATION AND REARRANGEMENT OF ORGANELLE DNA 25: SIMPLE SEQUENCE DNA
SATELLITE DNAS OFTEN LIE IN HETEROCHROMATIN ARTHROPOD SATELLITES HAVE
VERY SHORT IDENTICAL REPEATS 623 624 626 629 631 636 640 645 646 648 650
651 652 654 657 659 663 665 668 672 674 676 679 687 689 692 694 698 699
703 704 708 713 715 719 720 723 727 729 730 CONTENTS I XV MAMMALIAN
SATELLITES CONSIST OF HIERARCHICAL REPEATS EVOLUTION OF HIERARCHICAL
VARIATIONS IN THE SATELLITE THE CONSEQUENCES OF UNEQUAL CROSSING-OVER
CROSSOVER FIXATION COULD MAINTAIN IDENTICAL REPEATS MINISATELLITES ARE
USEFUL FOR GENETIC MAPPING 26: CHROMOSOMES CONDENSING VIRAL GENOMES INTO
THEIR COATS THE BACTERIAL GENOME IS A NUCLEOID WITH MANY SUPERCOILED
LOOPS LOOPS, DOMAINS, AND SCAFFOLDS IN EUKARYOTIC DNA THE CONTRAST
BETWEEN INTERPHASE CHROMATIN AND MITOTIC CHROMOSOMES THE EXTENDED STATE
OF LAMPBRUSH CHROMOSOMES TRANSCRIPTION DISRUPTS THE STRUCTURE OF
POLYTENE CHROMOSOMES THE EUKARYOTIC CHROMOSOME AS A SEGREGATION DEVICE
TELOMERES SEAL THE ENDS OF CHROMOSOMES 27: NUCLEOSOMES THE NUCLEOSOME IS
THE SUBUNIT OF ALL CHROMATIN DNA IS COILED IN ARRAYS OF NUCLEOSOMES DNA
STRUCTURE VARIES ON THE NUCLEOSOMAL SURFACE SUPERCOILING AND THE
PERIODICITY OF DNA THE PATH OF NUCLEOSOMES IN THE CHROMATIN FIBER
ORGANIZATION OF THE HISTONE OCTAMER REPRODUCTION OF CHROMATIN REQUIRES
ASSEMBLY OF NUCLEOSOMES DO NUCLEOSOMES LIE AT SPECIFIC POSITIONS? ARE
TRANSCRIBED GENES ORGANIZED IN NUCLEOSOMES? DNAASE HYPERSENSITIVE SITES
CHANGE CHROMATIN STRUCTURE DOMAINS DEFINE REGIONS THAT CONTAIN ACTIVE
GENES HETEROCHROMATIN IS CREATED BY INTERACTIONS WITH HISTONES 730 734
736 738 739 743 744 747 750 753 756 757 760 763 769 770 773 777 780 782
784 787 791 794 798 801 803 PART 6: EUKARYOTIC GENE EXPRESSION 809 28:
INITIATION OF TRANSCRIPTION EUKARYOTIC RNA POLYMERASES CONSIST OF MANY
SUBUNITS PROMOTER ELEMENTS ARE DEFINED BY MUTATIONS AND FOOTPRINTING RNA
POLYMERASE I HAS A BIPARTITE PROMOTER RNA POLYMERASE III USES BOTH
DOWNSTREAM AND UPSTREAM PROMOTERS THE BASAL APPARATUS CONSISTS OF RNA
POLYMERASE II AND GENERAL FACTORS A CONNECTION BETWEEN TRANSCRIPTION AND
REPAIR PROMOTERS FOR RNA POLYMERASE II HAVE SHORT SEQUENCE ELEMENTS
ENHANCERS CONTAIN BIDIRECTIONAL ELEMENTS THAT ASSIST INITIATION
INDEPENDENT DOMAINS BIND DNA AND ACTIVATE TRANSCRIPTION INTERACTION OF
UPSTREAM FACTORS WITH THE BASAL APPARATUS 811 814 815 817 819 822 829
831 835 839 842 XVI I CONTENTS 29: REGULATION OF TRANSCRIPTION 847
RESPONSE ELEMENTS IDENTIFY GENES UNDER COMMON REGULATION 848 THERE ARE
MANY TYPES OF DNA-BINDING DOMAINS 850 A ZINC FINGER MOTIF IS A
DNA-BINDING DOMAIN 852 STEROID RECEPTORS HAVE SEVERAL INDEPENDENT
DOMAINS 855 HOMEODOMAINS BIND RELATED TARGETS IN DNA 859
HELIX-LOOP-HELIX PROTEINS INTERACT BY COMBINATORIAL ASSOCIATION 862
LEUCINE ZIPPERS ARE INVOLVED IN DIMER FORMATION 864 DYNAMIC VERSUS
PRE-EMPTIVE MODELS FOR GENE ACTIVATION 866 LONG RANGE REGULATION AND
INSULATION OF DOMAINS 871 GENE EXPRESSION IS ASSOCIATED WITH
DEMETHYLATION 875 METHYLATION IS RESPONSIBLE FOR IMPRINTING 878 30:
NUCLEAR SPLICING 885 NUCLEAR SPLICE JUNCTIONS ARE INTERCHANGEABLE BUT
ARE READ IN PAIRS 887 NUCLEAR SPLICING PROCEEDS THROUGH A LARIAT 891
SNRNAS ARE REQUIRED FOR SPLICING AND FORM A SPLICEOSOME 893 GROUP II
INTRONS AUTOSPLICE VIA LARIAT FORMATION 901 ALTERNATIVE SPLICING
INVOLVES DIFFERENTIAL USE OF SPLICE JUNCTIONS 904 EIS-SPLICING AND
JRANS-SPLICING REACTIONS 907 YEAST TRNA SPLICING INVOLVES CUTTING AND
REJOINING 911 3 ENDS ARE GENERATED BY TERMINATION AND BY CLEAVAGE
REACTIONS 913 31: CATALYTIC RNA 921 GROUP I INTRONS UNDERTAKE
SELF-SPLICING BY TRANSESTERIFICATION 922 GROUP I INTRONS FORM A
CHARACTERISTIC SECONDARY STRUCTURE 926 RIBOZYMES HAVE VARIOUS CATALYTIC
ACTIVITIES 928 SOME INTRONS CODE FOR PROTEINS THAT SPONSOR MOBILITY 931
RNA CAN HAVE RIBONUCLEASE ACTIVITIES . 935 RNA EDITING UTILIZES
INFORMATION FROM SEVERAL SOURCES 937 32: REARRANGEMENT OF DNA 947 THE
MATING PATHWAY IS TRIGGERED BY SIGNAL TRANSDUCTION 948 YEAST CAN SWITCH
SILENT AND ACTIVE LOCI FOR MATING TYPE 952 SILENT CASSETTES AT HML AND
HMR ARE REPRESSED 956 UNIDIRECTIONAL TRANSPOSITION IS INITIATED BY THE
RECIPIENT MAT LOCUS 958 REGULATION OF HO EXPRESSION 960 TRYPANOSOMES
REARRANGE DNA TO EXPRESS NEW SURFACE ANTIGENS 962 INTERACTION OF TI
PLASMID DNA WITH THE PLANT GENOME 967 SELECTION OF AMPLIFIED GENOMIC
SEQUENCES 975 EXOGENOUS SEQUENCES CAN BE INTRODUCED INTO CELLS AND
ANIMALS BY TRANSFECTION 979 33: IMMUNE DIVERSITY 989 CLONAL SELECTION
AMPLIFIES LYMPHOCYTES THAT RESPOND TO INDIVIDUAL ANTIGENS 992
IMMUNOGLOBULIN GENES ARE ASSEMBLED FROM THEIR PARTS IN LYMPHOCYTES 994
THE DIVERSITY OF GERMLINE INFORMATION 1000 RECOMBINATION BETWEEN V AND C
GENES GENERATES DELETIONS AND REARRANGEMENTS 1002 ALLELIC EXCLUSION IS
TRIGGERED BY PRODUCTIVE, REARRANGEMENT 1007 DNA RECOMBINATION CAUSES
CLASS SWITCHING 1009 EARLY HEAVY CHAIN EXPRESSION CAN BE CHANGED BY RNA
PROCESSING 1011 CONTENTS I XVII SOMATIC MUTATION GENERATES ADDITIONAL
DIVERSITY T-CELL RECEPTORS ARE RELATED TO IMMUNOGLOBULINS THE MAJOR
HISTOCOMPATIBILITY LOCUS CODES FOR MANY GENES OF THE IMMUNE SYSTEM 1012
1015 1019 PART 7: CELL GROWTH, CANCER, AND DEVELOPMENT 102B 34: PROTEIN
TRAFFICKING OLIGOSACCHARIDES ARE ADDED TO PROTEINS IN THE ER AND GOLGI
COATED VESICLES TRANSPORT BOTH EXPORTED AND IMPORTED PROTEINS PROTEIN
LOCALIZATION DEPENDS ON FURTHER SIGNALS RECEPTORS RECYCLE VIA
ENDOCYTOSIS 35: SIGNAL TRANSDUCTION CARRIERS AND CHANNELS FORM
WATER-SOLUBLE PATHS THROUGH THE MEMBRANE G PROTEINS MAY ACTIVATE OR
INHIBIT TARGET PROTEINS PROTEIN TYROSINE KINASES INDUCE PHOSPHORYLATION
CASCADES THE RAS PATHWAY ACTIVATING MAP KINASE PATHWAYS CYCLIC AMP AND
ACTIVATION OF CREB THE JAR-STAT PATHWAY 36: CELL CYCLE AND GROWTH
REGULATION CYCLE PROGRESSION DEPENDS ON DISCRETE CONTROL POINTS M PHASE
KINASE IS A DIMER THAT REGULATES ENTRY INTO MITOSIS PROTEIN
PHOSPHORYLATION AND DEPHOSPHORYLATION CONTROL THE CELL CYCLE P34 (CDC2
OR CDC28) IS THE KEY REGULATOR IN YEASTS CDC28 ACTS AT BOTH START AND
MITOSIS IN 5. CEREVISIAE MANY CDK-CYCLIN COMPLEXES ARE FOUND IN ANIMAL
CELLS FUNCTIONS OF CDC2-CYCLIN AND CDK-CYCLIN DIMERS G0/G1 AND GL/S
TRANSITIONS INVOLVE CDK INHIBITORS REORGANIZATION OF THE CELL AT MITOSIS
APOPTOSIS 37: ONCOGENES AND CANCER TRANSFORMING VIRUSES CARRY ONCOGENES
RETROVIRAL ONCOGENES HAVE CELLULAR COUNTERPARTS RAS PROTO-ONCOGENES CAN
BE ACTIVATED BY MUTATION INSERTION, TRANSLOCATION, OR AMPLIFICATION MAY
ACTIVATE PROTO-ONCOGENES ONCOGENES CODE FOR COMPONENTS OF SIGNAL
TRANSDUCTION CASCADES GROWTH FACTOR RECEPTOR KINASES AND CYTOPLASMIC
TYROSINE KINASES ONCOPROTEINS MAY REGULATE GENE EXPRESSION RB IS A TUMOR
SUPPRESSOR THAT CONTROLS THE CELL CYCLE THE TUMOR SUPPRESSOR P53
SUPPRESSES GROWTH OR TRIGGERS APOPTOSIS IMMORTALIZATION AND
TRANSFORMATION 1027 1030 1033 1042 1044 1053 1056 1061 1064 1070 1076
1081 1082 1089 1090 1095 1098 1100 1108 1111 1113 1116 1119 1122 1131
1135 1139 1141 1144 1149 1151 1156 1160 1162 1167 XVIII I CONTENTS 38:
GRADIENTS AND CASCADES 1173 A GRADIENT MUST BE CONVERTED INTO DISCRETE
COMPARTMENTS 1175 MATERNAL GENE PRODUCTS ESTABLISH GRADIENTS IN EARLY
EMBRYOGENESIS 1177 ANTERIOR-POSTERIOR DEVELOPMENT USES LOCALIZED GENE
REGULATORS 1180 DORSAL-VENTRAL DEVELOPMENT USES LOCALIZED
RECEPTOR-IIGAND INTERACTIONS 1184 CELL FATE IS DETERMINED BY
COMPARTMENTS THAT FORM BY THE BLASTODERM STAGE 1191 COMPLEX LOCI ARE
EXTREMELY LARGE AND INVOLVED IN REGULATION 1198 THE HOMEOBOX IS A COMMON
CODING MOTIF IN HOMEOTIC GENES 1205 EPILOGUE: LANDMARK SHIFTS IN
PERSPECTIVES 1213 GLOSSARY 1217 INDEX 1241
|
| any_adam_object | 1 |
| author | Lewin, Benjamin |
| author_facet | Lewin, Benjamin |
| author_role | aut |
| author_sort | Lewin, Benjamin |
| author_variant | b l bl |
| building | Verbundindex |
| bvnumber | BV011260336 |
| classification_tum | BIO 180f BIO 750f BIO 450f BIO 220f |
| ctrlnum | (OCoLC)451817287 (DE-599)BVBBV011260336 |
| discipline | Biologie |
| edition | 6. ed. |
| format | Book |
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| genre_facet | Lehrbuch |
| id | DE-604.BV011260336 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:06:43Z |
| institution | BVB |
| isbn | 0198577788 0198542879 0198577796 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007559360 |
| oclc_num | 451817287 |
| open_access_boolean | |
| owner | DE-29 DE-19 DE-BY-UBM DE-20 DE-355 DE-BY-UBR DE-12 DE-M49 DE-BY-TUM DE-11 |
| owner_facet | DE-29 DE-19 DE-BY-UBM DE-20 DE-355 DE-BY-UBR DE-12 DE-M49 DE-BY-TUM DE-11 |
| physical | XVIII, 1260 S. zahlr. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Oxford Univ. Press |
| record_format | marc |
| spelling | Lewin, Benjamin Verfasser aut Genes Benjamin Lewin Genes VI 6. ed. Oxford [u.a.] Oxford Univ. Press 1997 XVIII, 1260 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Gen (DE-588)4128987-0 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf Molekulargenetik (DE-588)4039987-4 gnd rswk-swf 1\p (DE-588)4123623-3 Lehrbuch gnd-content Genetik (DE-588)4071711-2 s DE-604 Molekulargenetik (DE-588)4039987-4 s 2\p DE-604 Gen (DE-588)4128987-0 s 3\p DE-604 HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007559360&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Lewin, Benjamin Genes Gen (DE-588)4128987-0 gnd Genetik (DE-588)4071711-2 gnd Molekulargenetik (DE-588)4039987-4 gnd |
| subject_GND | (DE-588)4128987-0 (DE-588)4071711-2 (DE-588)4039987-4 (DE-588)4123623-3 |
| title | Genes |
| title_alt | Genes VI |
| title_auth | Genes |
| title_exact_search | Genes |
| title_full | Genes Benjamin Lewin |
| title_fullStr | Genes Benjamin Lewin |
| title_full_unstemmed | Genes Benjamin Lewin |
| title_short | Genes |
| title_sort | genes |
| topic | Gen (DE-588)4128987-0 gnd Genetik (DE-588)4071711-2 gnd Molekulargenetik (DE-588)4039987-4 gnd |
| topic_facet | Gen Genetik Molekulargenetik Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007559360&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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